Кровотечения после ранений или хирургических вмешательств; кровотечение желудочно-кишечное; геморроидальные и длительные носовые кровотечения; маточные кровотечения; легочные кровотечения на фоне туберкулеза.
Противопоказания
повышенная чувствительность к компонентам препарата;
повышенная свертываемость крови, тромбоэмболии;
гемолитическая болезнь новорожденных.
С осторожностью: дефицит-6-фосфатдегидрогеназы, печеночная недостаточность.
1 мл раствора для внутримышечного введения содержит: действующее вещество: 10 мг менадиона натрия бисульфит.
Описание
Фармакологическое действие:Гемостатическое, К-витаминное.Кровоточивость (кровотечения), Нарушения свертываемости крови, пурпура и другие геморрагические состояния.В/м. Вводят по 0,01-0,015 г 1 раз в сутки в течение 3-4 дней подряд, через 4 дня цикл повторяют.Высшие дозы (в/м): разовая - 0,015 г, суточная - 0,03 г.
Фармакологические свойства
Викасол -
синтетический водорастворимый аналог витамина K (витамин К3),
способствует синтезу протромбина и проконвертина, повышает
свертываемость крови за счет усиления синтеза II, VII, IX, X факторов
свертывания.
Обладает гемостатическим действием (при дефиците витамина К возникает повышенная кровоточивость).
В крови протромбин (фактор II) в присутствии тромбопластина и
кальция, при участии проконвертина (фактор VII), факторов IX
(Кристмасс-фактора), X (фактора Стюарта-Прауера) переходит в тромбин,
под влиянием которого фибриноген превращается в фибрин, составляющий
основу сгустка крови (тромба).
Субстратно стимулирует K-витаминредуктазу, активирующую витамин К и
обеспечивающую его участие в печеночном синтезе K-витаминзависимых
плазменных факторов гемостаза.
Начало эффекта - через 8 - 24 часа.
Фармакокинетика
После внутримышечного введения легко и быстро всасывается. В
незначительных количествах накапливается в тканях. Пройдя цикл
метаболической активации, окисляется до диоловой формы.
Выводятся почками (до 70 %) и с желчью исключительно в виде метаболитов.
Высокие концентрации витамина К в кале обусловлены его синтезом кишечной микрофлорой.
Показания к применению
Кровотечения после ранений или хирургических вмешательств; кровотечение желудочно-кишечное; геморроидальные и длительные носовые кровотечения; маточные кровотечения; легочные кровотечения на фоне туберкулеза.
Противопоказания
повышенная чувствительность к компонентам препарата;
повышенная свертываемость крови, тромбоэмболии;
гемолитическая болезнь новорожденных.
С осторожностью: дефицит-6-фосфатдегидрогеназы, печеночная недостаточность.
Способ применения и дозы
Взрослым Викасол назначают внутримышечно - 10 -30 мг в сутки.
Детям в возрасте до 1 года - по 2-5 мг в сутки, от 1 до 2-х лет - 6
мг в сутки, 3-4 лет - 8 мг в сутки, 5-9 лет - 10 мг в сутки, 10-14 лет -
15 мг в сутки. Кратность приема - 2-3 раза в сутки.
Максимальная суточная доза препарата для новорожденных - 4 мг.
Продолжительность лечения 3-4 дня.
Курс лечения повторяют после 4-х дней перерыва.
Побочное действие
Аллергические реакции: гиперемия лица, зуд кожи, кожная сыпь, бронхоспазм. Со стороны системы крови: гемолитическая анемия, гемолиз у новорожденных детей с врожденным дефицитом глюкозо-6-фосфатдегидрогеназы, гемолитическая болезнь новорожденных. Местные реакции: боль и отек в месте введения, поражение кожи в виде пятен при повторных инъекциях в одно и то же место. Прочие: гипербилирубинемия, желтуха (в том числе ядерная желтуха у грудных детей), головокружение, транзиторное снижение артериального давления, «профузный» пот, тахикардия, «слабое» наполнение пульса, изменение вкусовых ощущений.
Передозировка
Редко – гипервитаминоз К, проявляющийся гиперпротромбин- и гипертромбинемией, гипербилирубинемией, повышенной свертываемостью крови, тромбоэмболией. Лечение симптоматическое.
Взаимодействие с другими лекарственными средствами
Антациды снижают абсорбцию вследствие осаждения солей желчных кислот в начальном отделе тонкого кишечника. Не влияет на антикоагулянтную активность гепарина. Одновременное назначение с антибиотиками широкого спектра действия, хинидином, хинином, салицилатами в высоких дозах, антибактериальными сульфонамидами требует увеличения дозы витамина К. Колестирамин, колестипол, минеральные масла, сукральфат, дактиномицин снижают абсорбцию витамина К, что требует увеличения его дозы. Одновременное назначение с гемолитическими лекарственными средствами увеличивает риск проявления побочных эффектов.
Особые указания
При
заболеваниях, приводящих к нарушению оттока желчи, рекомендуется
парентеральное введение. При гемофилии и болезни Верльгофа препарат
неэффективен.
Ослабляет эффекты непрямых антикоагулянтов.
Для профилактики геморрагической болезни новорожденных фитонадион
более предпочтителен, чем менадиона натрия бисульфит, поскольку реже
вызывает у новорожденных (включая недоношенных) гипербилирубинемию и
гемолитическую анемию.
Влияние на способность к вождению автотранспорта и управлению механизмами.
В период лечения препаратом следует воздержаться от управления
автотранспортом и занятий другими потенциально опасными видами
деятельности, требующими повышенной концентрации внимания и быстроты
психомоторных реакций.
Форма выпуска
Раствор для внутримышечного введения.
Условия хранения
В защищенном от света месте, при температуре не выше 25 °С.
Срок годности
2 года.
Условия отпуска
По рецепту.
Производитель
Эллара, Россия.
Для описания товара использована информация от партнера ЗдравСити
Мобильное приложение «Все аптеки»
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В \nнезначительных количествах накапливается в тканях. Пройдя цикл \nметаболической активации, окисляется до диоловой формы."}},{"type":"paragraph","data":{"text":"Выводятся почками (до 70 %) и с желчью исключительно в виде метаболитов."}},{"type":"paragraph","data":{"text":"Высокие концентрации витамина К в кале обусловлены его синтезом кишечной микрофлорой."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Кровотечения после ранений или хирургических вмешательств; кровотечение желудочно-кишечное; геморроидальные и длительные носовые кровотечения; маточные кровотечения; легочные кровотечения на фоне туберкулеза."}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["повышенная чувствительность к компонентам препарата;","повышенная свертываемость крови, тромбоэмболии;","гемолитическая болезнь новорожденных."]}},{"type":"paragraph","data":{"text":"С осторожностью: дефицит-6-фосфатдегидрогеназы, печеночная недостаточность."}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Взрослым Викасол назначают внутримышечно - 10 -30 мг в сутки."}},{"type":"paragraph","data":{"text":"Детям в возрасте до 1 года - по 2-5 мг в сутки, от 1 до 2-х лет - 6 \nмг в сутки, 3-4 лет - 8 мг в сутки, 5-9 лет - 10 мг в сутки, 10-14 лет -\n 15 мг в сутки. 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Колестирамин, колестипол, минеральные масла, сукральфат, дактиномицин снижают абсорбцию витамина К, что требует увеличения его дозы. Одновременное назначение с гемолитическими лекарственными средствами увеличивает риск проявления побочных эффектов."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При\n заболеваниях, приводящих к нарушению оттока желчи, рекомендуется \nпарентеральное введение. 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