Гиперчувствительность (включая и к производным пирролидона), выраженная почечная недостаточность (при клиренсе креатинина меньше 20 мл/мин), геморрагический инсульт, болезнь Гентингтона, ажитированная депрессия, кормление грудью, беременность, возраст до 1 года.
Пирацетам активирует в центральной нервной системе ассоциативные процессы, улучшает настроение, память и ментальность у больных и здоровых людей. Стимулирует интеллектуальную активность и интегративную деятельность мозга, облегчает процессы обучения, улучшает связи между полушариями головного мозга и синаптическую проводимость в коре, повышает умственную работоспособность, стабилизирует и восстанавливает нарушенные функции мозга (память, сознание, речь). Пирацетам нормализует соотношение АДФ и АТФ (ингибирует нуклеотидфосфатазу и активирует аденилатциклазу), повышает активность фосфолипазы А, стимулирует в нервной ткани биоэнергетические и пластические процессы, ускоряет обмен нейромедиаторов.
Пирацетам увеличивает устойчивость ткани мозга к токсическим воздействиям и гипоксии, усиливает синтез фосфолипидов и ядерной РНК, усиливает гликолитические процессы и утилизацию глюкозы в головном мозге. Пирацетам блокирует агрегацию тромбоцитов, улучшает микроциркуляцию, оптимизирует способность эритроцитов к прохождению через микрососуды и конформационные свойства оболочки эритроцитов, в ишемизированных участках мозга увеличивает регионарный кровоток. Пирацетам усиливает на ЭЭГ бета - и альфа-активность и понижает дельта-активность. Уменьшает вестибулярный нистагм. Во время гипоксии, интоксикации, травмы, электросудорожном воздействии оказывает нейропротекторное действие.
В связи с антигипоксическим воздействием пирацетам эффективен в комплексном лечении инфаркта миокарда. Анксиолитическое и седативное действие у пирацетама отсутствуют.
Почти полностью и быстро пирацетам всасывается после приема внутрь. Биодоступность равна 100%. При приеме внутрь 2 г препарата максимальная концентрация в плазме составляет 40–60 мкг/мл через 30 минут. Пирацетам не связывается с белками плазмы. Через 2–8 часов создается максимальная концентрация в ликворе. Пирацетам проникает во все ткани и органы, проникает и через плацентарный барьер. Почти не метаболизируется. Избирательно накапливается в коре головного мозга, в основном в теменных, лобных и затылочных долях, базальных ганглиях и мозжечке. Период полувыведения пирацетама из плазмы равен 4–5 часам; из ликвора составляет 6–8 часов. Более 95% препарата выводится в неизмененном виде почками через 30 часов. У больных с почечной недостаточностью период полувыведения увеличивается.
Показания к применению
Хроническая цереброваскулярная недостаточность (гипертоническая болезнь, атеросклероз, сосудистый паркинсонизм), которая сопровождается нарушением внимания, памяти, речи, головной болью и головокружением;
интоксикация (восстановительный период, коматозное и субкоматозное состояние);
болезни нервной системы, которые сопровождаются уменьшением уровня бодрствования, интеллектуально-мнестических функций, нарушением поведения и эмоционально-волевой сферы;
головокружение;
вестибулярный нистагм;
вяло-апатическое состояние;
афазия;
кортикальная миоклония;
эпилепсия (как вспомогательное средство);
сенильные и атрофические процессы;
депрессивные состояния, которые устойчивы к лечению антидепрессантами;
предотвращение или устранение неврологических, соматовегетативных, психических осложнений лечения нейролептиками и прочими психотропными препаратами;
невротическая депрессия с преобладанием в клинической картине сенесто-ипохондрических и астенических нарушений, адинамии, явлений идеомоторной заторможенности;
психоорганический синдром при хроническом алкоголизме;
купирование пре - и делириозных, абстинентных состояний при наркомании и алкоголизме;
у детей — детский церебральный паралич, последствия перинатального поражения центральной нервной системы, задержка умственного развития, низкая обучаемость при психоорганическом синдроме, расстройство речи, олигофрения, нарушение памяти, церебрастения, интеллектуальная недостаточность;
серповидно-клеточная анемия (в составе комплексного лечения).
Противопоказания
Гиперчувствительность (включая и к производным пирролидона), выраженная почечная недостаточность (при клиренсе креатинина меньше 20 мл/мин), геморрагический инсульт, болезнь Гентингтона, ажитированная депрессия, кормление грудью, беременность, возраст до 1 года.
Способ применения и дозы
Внутрь во время приема пищи или натощак, запивая жидкостью.
Симптоматическое лечение психоорганического синдрома: 2,4 - 4,8 г в сутки в 2-3 приема.
Лечение головокружения и связанного с ним нарушения равновесия: 2,4 - 4,8 г в сутки в 2-3 приема.
Лечение кортикальной миоклонии: начинают с дозы 7,2 г в сутки, каждые 3-4 дня дозу увеличивают на 4,8 г в сутки до достижения максимальной дозы 24 г в сутки в 2 -3 приема. Лечение продолжают на протяжении всего периода заболевания. Каждые 6 месяцев следует предпринимать попытки уменьшения дозы или отмены препарата, постепенно сокращая дозу на 1,2 г в сутки каждые 2 дня.
Лечение серповидно-клеточной анемии: суточная профилактическая доза составляет 160 мг/кг массы тела, разделенная на 4 равные дозы.
Лечение дислексии у детей (в комплексе с другими методами лечения): рекомендуемая суточная доза для детей от 8 лет и подростков - 3,2 г, разделенная на 2 приема.
Побочное действие
Нервная система и органы чувств: гиперкинезия, сонливость, повышенная раздражительность, депрессия, возбуждение, астения, агрессивное поведение, головокружение, расстройство сна, головная боль, тремор, повышение сексуальности;
Система пищеварения: тошнота, диарея, рвота, боли в животе;
Обмен веществ: увеличение массы тела;
Система кровообращения: обострение коронарной недостаточности, артериальная гипертензия или гипотензия;
Кожные покровы: реакции гиперчувствительности.
Передозировка
При передозировке пирацетамом усиливаются побочные эффекты.
Лечение: промывание желудка, прием активированного угля, симптоматическое лечение; специфического антидота нет, возможно проведение гемодиализа (эффективность составляет 50–60%).
Взаимодействие с другими лекарственными средствами
Усиливается выраженность экстрапирамидных расстройств при совместном приеме пирацетама с нейролептиками.
Форма выпуска
Таблетки
Условия хранения
В сухом, защищенном от света месте. Хранить в местах, недоступных для детей.
Срок годности
3 года
Условия отпуска
По рецепту
Производитель
Озон, Россия
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препарата","slug":"","body":[{"type":"paragraph","data":{"text":"Пирацетам, таблетки 800 мг"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eДействующее вещество:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"пирацетам — 800 мг."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества (ядро)\u003c/i\u003e:"}},{"type":"paragraph","data":{"text":" кроскармеллоза натрия,"}},{"type":"paragraph","data":{"text":"крахмал прежелатинизированный,"}},{"type":"paragraph","data":{"text":"повидон (поливинилпирролидон),"}},{"type":"paragraph","data":{"text":"магния стеарат."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества (оболочка)\u003c/i\u003e:"}},{"type":"paragraph","data":{"text":"гипромеллоза,"}},{"type":"paragraph","data":{"text":"макрогол,"}},{"type":"paragraph","data":{"text":"титана диоксид."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/drugs/neurology/brain/?indications=sotryasenie_mozga_i_drugie_cherepno_mozgovye_travmy\"\u003e \u003c/a\u003e\u003ca href=\"https://www.eapteka.ru/goods/drugs/neurology/brain/?appointment=dlya_pozhilykh_lyudey\"\u003eДля пожилых людей\u003c/a\u003e, \u003ca href=\"https://www.eapteka.ru/goods/drugs/neurology/brain/?appointment=dlya_vzroslykh\"\u003eДля взрослых\u003c/a\u003e"}},{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/drugs/neurology/brain/?appointment=dlya_vzroslykh\"\u003e\u003c/a\u003e\u003ca href=\"https://www.eapteka.ru/goods/drugs/neurology/brain/?indications=sotryasenie_mozga_i_drugie_cherepno_mozgovye_travmy\"\u003eСотрясение мозга и другие черепно-мозговые\u003c/a\u003e, \u003ca href=\"https://www.eapteka.ru/goods/drugs/neurology/brain/?indications=bolezn_altsgeymera\"\u003eБолезнь Альцгеймера\u003c/a\u003e, \u003ca href=\"https://www.eapteka.ru/goods/drugs/neurology/brain/?indications=priobretennoe_slaboumie\"\u003eПриобретенное слабоумие\u003c/a\u003e, \u003ca href=\"https://www.eapteka.ru/goods/drugs/neurology/brain/?indications=alkogolizm\"\u003eАлкоголизм\u003c/a\u003e, \u003ca href=\"https://www.eapteka.ru/goods/drugs/neurology/brain/?indications=posledstviya_insulta\"\u003eПоследствия инсульта\u003c/a\u003e"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Пирацетам активирует в центральной нервной системе ассоциативные процессы, улучшает настроение, память и ментальность у больных и здоровых людей. Стимулирует интеллектуальную активность и интегративную деятельность мозга, облегчает процессы обучения, улучшает связи между полушариями головного мозга и синаптическую проводимость в коре, повышает умственную работоспособность, стабилизирует и восстанавливает нарушенные функции мозга (память, сознание, речь). Пирацетам нормализует соотношение АДФ и АТФ (ингибирует нуклеотидфосфатазу и активирует аденилатциклазу), повышает активность фосфолипазы А, стимулирует в нервной ткани биоэнергетические и пластические процессы, ускоряет обмен нейромедиаторов."}},{"type":"paragraph","data":{"text":"Пирацетам увеличивает устойчивость ткани мозга к токсическим воздействиям и гипоксии, усиливает синтез фосфолипидов и ядерной РНК, усиливает гликолитические процессы и утилизацию глюкозы в головном мозге. Пирацетам блокирует агрегацию тромбоцитов, улучшает микроциркуляцию, оптимизирует способность эритроцитов к прохождению через микрососуды и конформационные свойства оболочки эритроцитов, в ишемизированных участках мозга увеличивает регионарный кровоток. Пирацетам усиливает на ЭЭГ бета - и альфа-активность и понижает дельта-активность. Уменьшает вестибулярный нистагм. Во время гипоксии, интоксикации, травмы, электросудорожном воздействии оказывает нейропротекторное действие."}},{"type":"paragraph","data":{"text":"В связи с антигипоксическим воздействием пирацетам эффективен в комплексном лечении инфаркта миокарда. Анксиолитическое и седативное действие у пирацетама отсутствуют."}},{"type":"paragraph","data":{"text":"Почти полностью и быстро пирацетам всасывается после приема внутрь. Биодоступность равна 100%. При приеме внутрь 2 г препарата максимальная концентрация в плазме составляет 40–60 мкг/мл через 30 минут. Пирацетам не связывается с белками плазмы. Через 2–8 часов создается максимальная концентрация в ликворе. Пирацетам проникает во все ткани и органы, проникает и через плацентарный барьер. Почти не метаболизируется. Избирательно накапливается в коре головного мозга, в основном в теменных, лобных и затылочных долях, базальных ганглиях и мозжечке. Период полувыведения пирацетама из плазмы равен 4–5 часам; из ликвора составляет 6–8 часов. Более 95% препарата выводится в неизмененном виде почками через 30 часов. У больных с почечной недостаточностью период полувыведения увеличивается."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"list","data":{"style":"ordered","items":["Хроническая цереброваскулярная недостаточность (гипертоническая болезнь, атеросклероз, сосудистый паркинсонизм), которая сопровождается нарушением внимания, памяти, речи, головной болью и головокружением;","ишемический инсульт и его последствия;","психоорганические расстройства;","деменция (сенильная деменция, болезнь Альцгеймера, сосудистая деменция);","черепно-мозговая травма;","острая вирусная нейроинфекция;","интоксикация (восстановительный период, коматозное и субкоматозное состояние);","болезни нервной системы, которые сопровождаются уменьшением уровня бодрствования, интеллектуально-мнестических функций, нарушением поведения и эмоционально-волевой сферы;","головокружение;","вестибулярный нистагм;","вяло-апатическое состояние;","афазия;","кортикальная миоклония;","эпилепсия (как вспомогательное средство);","сенильные и атрофические процессы;","депрессивные состояния, которые устойчивы к лечению антидепрессантами;","предотвращение или устранение неврологических, соматовегетативных, психических осложнений лечения нейролептиками и прочими психотропными препаратами;","невротическая депрессия с преобладанием в клинической картине сенесто-ипохондрических и астенических нарушений, адинамии, явлений идеомоторной заторможенности;","психоорганический синдром при хроническом алкоголизме;","купирование пре - и делириозных, абстинентных состояний при наркомании и алкоголизме;","острая интоксикация морфином, этанолом, амфетамином, барбитуратами;","у детей — детский церебральный паралич, последствия перинатального поражения центральной нервной системы, задержка умственного развития, низкая обучаемость при психоорганическом синдроме, расстройство речи, олигофрения, нарушение памяти, церебрастения, интеллектуальная недостаточность;","серповидно-клеточная анемия (в составе комплексного лечения)."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность (включая и к производным пирролидона), выраженная почечная недостаточность (при клиренсе креатинина меньше 20 мл/мин), геморрагический инсульт, болезнь Гентингтона, ажитированная депрессия, кормление грудью, беременность, возраст до 1 года."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь во время приема пищи или натощак, запивая жидкостью."}},{"type":"paragraph","data":{"text":"Симптоматическое лечение психоорганического синдрома: 2,4 - 4,8 г в сутки в 2-3 приема."}},{"type":"paragraph","data":{"text":"Лечение головокружения и связанного с ним нарушения равновесия: 2,4 - 4,8 г в сутки в 2-3 приема."}},{"type":"paragraph","data":{"text":"Лечение кортикальной миоклонии: начинают с дозы 7,2 г в сутки, каждые 3-4 дня дозу увеличивают на 4,8 г в сутки до достижения максимальной дозы 24 г в сутки в 2 -3 приема. Лечение продолжают на протяжении всего периода заболевания. Каждые 6 месяцев следует предпринимать попытки уменьшения дозы или отмены препарата, постепенно сокращая дозу на 1,2 г в сутки каждые 2 дня."}},{"type":"paragraph","data":{"text":"Лечение серповидно-клеточной анемии: суточная профилактическая доза составляет 160 мг/кг массы тела, разделенная на 4 равные дозы."}},{"type":"paragraph","data":{"text":" Лечение дислексии у детей (в комплексе с другими методами лечения): рекомендуемая суточная доза для детей от 8 лет и подростков - 3,2 г, разделенная на 2 приема."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Нервная система и органы чувств: гиперкинезия, сонливость, повышенная раздражительность, депрессия, возбуждение, астения, агрессивное поведение, головокружение, расстройство сна, головная боль, тремор, повышение сексуальности;"}},{"type":"paragraph","data":{"text":"Система пищеварения: тошнота, диарея, рвота, боли в животе;"}},{"type":"paragraph","data":{"text":"Обмен веществ: увеличение массы тела;"}},{"type":"paragraph","data":{"text":"Система кровообращения: обострение коронарной недостаточности, артериальная гипертензия или гипотензия;"}},{"type":"paragraph","data":{"text":"Кожные покровы: реакции гиперчувствительности."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При передозировке пирацетамом усиливаются побочные эффекты."}},{"type":"paragraph","data":{"text":"Лечение: промывание желудка, прием активированного угля, симптоматическое лечение; специфического антидота нет, возможно проведение гемодиализа (эффективность составляет 50–60%)."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Пирацетам усиливает эффекты непрямых антикоагулянтов, психостимуляторов, центральные эффекты гормонов щитовидной железы (беспокойство, тремор, нарушение сна, раздражительность, спутанность сознания)."}},{"type":"paragraph","data":{"text":"Усиливается выраженность экстрапирамидных расстройств при совместном приеме пирацетама с нейролептиками."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте. 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