Норфлоксацин Таблетки, 20 шт, 400 мг, для внутреннего применения, для взрослых, в пленочной оболочке, цвет белый

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Staphylococcus aureus)."}},{"type":"paragraph","data":{"text":"К норфлоксацину устойчивы анаэробные бактерии, малочувствительны Enterococcus spp. и Acinetobacter spp."}},{"type":"paragraph","data":{"text":"Устойчив к действию β-лактамаз."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"При приеме внутрь всасывается около 30-40%, прием пищи уменьшает скорость абсорбции. Связывание с белками плазмы крови составляет 14%. Норфлоксацин хорошо распределяется в тканях урогенитальной системы. Проникает через плацентарный барьер. Около 30% выводится с мочой в неизмененном виде."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Заболевания мочевыводящих путей, предстательной железы, ЖКТ, гонорея, профилактика рецидивов инфекций мочевыводящих путей, бактериальных инфекций у больных с гранулоцитопенией, \"диареи путешественников\"."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Беременность, лактация (грудное вскармливание), детский и подростковый возраст (до 15 лет), дефицит глюкозо-6-фосфатдегидрогеназы, повышенная чувствительность к норфлоксацину и другим препаратам хинолонового ряда."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь. "}},{"type":"paragraph","data":{"text":"При инфекциях мочевыводящих путей - по 400 мг 2 раза в день в течение 7-10 дней; при неосложненном цистите - 3-7 дней; при хронической рецидивирующей инфекции мочевыводящих путей - до 12 недель. "}},{"type":"paragraph","data":{"text":"При остром бактериальном гастроэнтерите - 5 дней. "}},{"type":"paragraph","data":{"text":"При остром гонококковом уретрите, фарингите, проктите, цервиците - однократно 800 мг. "}},{"type":"paragraph","data":{"text":"При брюшном тифе - по 400 мг 3 раза в сутки в течение 14 дней. "}},{"type":"paragraph","data":{"text":"Для профилактики сепсиса - по 400 мг 2 раза в сутки. "}},{"type":"paragraph","data":{"text":"Для профилактики бактериальных гастроэнтеритов - по 400 мг/сут. "}},{"type":"paragraph","data":{"text":"Для профилактики диареи путешественников - по 400 мг/сут за 1 день до отъезда и в течение всего периода пути (не более 21 дня). "}},{"type":"paragraph","data":{"text":"Для профилактики рецидивов инфекций мочевыводящих путей - по 200 мг/сут. "}},{"type":"paragraph","data":{"text":"У пациентов с нарушениями функции почек при КК более 20 мл/мин коррекции режима дозирования не требуется. При КК ниже 20 мл/мин (или концентрации сывороточного креатинина более 5 мг/100 мл) и пациентам, находящимся на гемодиализе, назначают 1/2 терапевтической дозы 2 раза в сутки или полную дозу 1 раз в сутки."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны центральной нервной системы (ЦНС): головокружение, головная боль, покалывание в пальцах рук, сонливость, тревога, депрессия, бессонница, нарушение сна. "}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: тошнота, боль в животе, анорексия, диарея, боль в прямой кишке или анусе, запор, диспепсия, метеоризм, рвота, сухость слизистой оболочки полости рта, изжога, неоформленный стул, горький привкус во рту, изъязвление слизистой оболочки полости рта, зуд ануса. "}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: лейкопения, тромбоцитопения, эозинофилия, нейтропения. "}},{"type":"paragraph","data":{"text":"Со стороны кожных покровов: зуд, сыпь, эритема, крапивница. "}},{"type":"paragraph","data":{"text":"Со стороны органов чувств: нечеткость зрительного восприятия. "}},{"type":"paragraph","data":{"text":"Со стороны опорно-двигательного аппарата: бурсит, отечность кистей и стоп. "}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы (ССС): инфаркт миокарда, ощущение сердцебиения. "}},{"type":"paragraph","data":{"text":"Со стороны мочевыделительной системы: почечная колика. "}},{"type":"paragraph","data":{"text":"Лабораторные показатели: повышение активности АСТ, АЛТ, ЩФ, ЛДГ, протеинурия, снижение гематокрита и Hb, повышение концентрации мочевины в крови, гиперкреатининемия, глюкозурия. "}},{"type":"paragraph","data":{"text":"Прочие: гипергидроз, астения, боль в спине, лихорадка, озноб, боль в груди, дисменорея, отеки, аллергические реакции."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"В случае передозировки желудок необходимо очистить, вызвав рвоту или путем промывания желудка с помощью зонда, и пациент должен быть тщательно осмотрен и подвергнут симптоматическому и поддерживающему лечению."}},{"type":"paragraph","data":{"text":"Необходимо следить за водно-солевым обменом, пациент должен получать большое количество жидкости, чтобы избежать образования камней в мочевых путях."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении норфлоксацина с варфарином усиливается антикоагулянтный эффект последнего."}},{"type":"paragraph","data":{"text":"При одновременном применении норфлоксацина с циклоспорином отмечается увеличение концентрации последнего в плазме крови."}},{"type":"paragraph","data":{"text":"При одновременном приеме норфлоксацина и антацидных средств или препаратов, содержащих железо, цинк, магний, кальций или сукральфат, снижается абсорбция норфлоксацина за счет образования комплексонов с ионами металлов (интервал между их приемом должен быть не менее 4 ч)."}},{"type":"paragraph","data":{"text":"При одновременном приеме норфлоксацин снижает клиренс теофиллина на 25%, поэтому при одновременном применении следует уменьшать дозу теофиллина."}},{"type":"paragraph","data":{"text":"Одновременное введение норфлоксацина с лекарственными средствами, обладающими потенциальной способностью снижать АД, может вызвать резкое его снижение. В связи с этим в таких случаях, а также при одновременном введении барбитуратов, анестезирующих средств, следует контролировать ЧСС, АД, показатели ЭКГ. Одновременное применение с препаратами, снижающими эпилептический порог, может привести к развитию эпилептиформных припадков."}},{"type":"paragraph","data":{"text":"Снижает эффект нитрофуранов."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"C осторожностью применять препарат при следующих заболеваниях:"}},{"type":"paragraph","data":{"text":"Эпилепсия, судорожный синдром, почечная/печеночная недостаточность, миастения gravis."}},{"type":"paragraph","data":{"text":"В период лечения больные должны получать достаточное количество жидкости (под контролем диуреза)."}},{"type":"paragraph","data":{"text":"В период терапии возможно увеличение протромбинового индекса (при проведении хирургических вмешательств следует контролировать состояние системы свертывания крови)."}},{"type":"paragraph","data":{"text":"Во время лечения следует избегать воздействия прямого солнечного света."}},{"type":"paragraph","data":{"text":"Норфлоксацин, как и другие фторхинолоны, может вызывать тендинит и разрыв сухожилий. Факторы риска: возраст старше 60 лет, прием глюкокортикостероидов, трансплантация почки, сердца или легкого, повышенная физическая активность, ХПН, поражение сухожилий в анамнезе (в т.ч. ревматоидный артрит). Данные явления могут возникать и через несколько месяцев после завершения приема препарата. При первых признаках тендинита или разрыва сухожилия следует прекратить прием норфлоксацина и обратиться к врачу."}},{"type":"paragraph","data":{"text":"Норфлоксацин может снижать порог судорожной готовности и вызывать судороги; фторхинолоны могут также стимулировать ЦНС, вызывая тремор, токсические психозы, беспокойство, спутанность сознания и галлюцинации; повышение внутричерепного давления."}},{"type":"paragraph","data":{"text":"Норфлоксацин может приводить к развитию псевдомембранозного колита, вызванному Clostridium difficile. В этом случае необходимо отменить препарат и назначить соответствующее лечение (применение ванкомицина внутрь или метронидазола)."}},{"type":"paragraph","data":{"text":"Не эффективен при сифилисе."}},{"type":"paragraph","data":{"text":"Норфлоксацин может вызвать периферическую нейропатию (парестезии, гипестезия, дизестизии, мышечная слабость). При первых признаках нейропатии (боль, покалывание, онемение или слабость в конечностях, нарушение прочих видов чувствительности) во избежание необратимых изменений препарат следует отменить."}},{"type":"paragraph","data":{"text":"Во избежание образования кристаллов норфлоксацина в почках не следует превышать рекомендованных доз; необходимо записать таблетки достаточным количеством жидкости."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/drugs/antibacterial/antibiotic/?drug_form=tabletki\"\u003eтаблетки\u003c/a\u003e"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Препарат хранить при температуре не выше 25°С в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/manufacturer/verteks/\"\u003eВертекс, Россия\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"Норфлоксацин - противомикробное синтетическое средство группы фторхинолонов широкого спектра действия. Оказывает бактерицидное действие. Подавляя ДНК-гиразу, нарушает процесс суперспирализации ДНК. Высокоактивен в отношении большинства грамотрицательных бактерий: Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Morganella morganii, Klebsiella spp. (в т.ч. Klebsiella pneumoniae), Enterobacter spp., Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Neisseria meningitidis. Активен в отношении некоторых грамположительных бактерий (в т.ч. Staphylococcus aureus). К норфлоксацину устойчивы анаэробные бактерии, малочувствительны Enterococcus spp. и Acinetobacter spp. Устойчив к действию β-лактамаз. Фармакокинетика При приеме внутрь всасывается около 30-40%, прием пищи уменьшает скорость абсорбции. Связывание с белками плазмы крови составляет 14%. Норфлоксацин хорошо распределяется в тканях урогенитальной системы. Проникает через плацентарный барьер. Около 30% выводится с мочой в неизмененном виде.","substance":[{"id":136,"title":"Норфлоксацин","title_latin":"Norfloxacinum","slug":"norfloksatsin_136"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Норфлоксацин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70534/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70534/share_default/"}},"diseases":[],"other_packages":[{"id":167842,"title":"НОРФЛОКСАЦИН","subtitle":{"full":"Таблетки, 10 шт, 400 мг, для взрослых, в пленочной оболочке","short":"Таблетки, 10 шт, 400 мг","package":"10 шт, 400 мг"},"prescription":true,"catalog_section_id":91,"manufacturer":{"id":375,"title":"Озон","slug":"ozon_375","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Таблетки","slug":"167842-norfloksatsin","attributes":{"count":"10 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