Недостаточность функции паращитовидных желез, повышенный вывод кальция из организма (в частности при продолжительном обезвоживании),
как вспомогательное средство при аллергических заболеваниях (сывороточная болезнь, крапивница, ангионевротический отек) и аллергических осложнениях медикаментозной терапии,
для уменьшения проницаемости сосудов при патологических процессах разнообразного генезиса (экссудативная фаза воспалительного процесса, геморрагический васкулит, лучевая болезнь);
при паренхиматозном гепатите, токсичных поражениях печени, нефрите, эклампсии, гиперкалиемии, гиперкалиемической форме пароксизмальной миоплегии, при кожных заболеваниях (зуд кожи, экзема, псориаз),
Ионы кальция принимают участие в передаче нервных импульсов, сокращении гладких и поперечно-полосатых мышц, функционировании миокарда, свертывании крови; они необходимы для формирования костной ткани, функционирования других систем и органов.
Концентрация ионов кальция в крови уменьшается при многих патологических процессах; выраженная гипокальциемия способствует возникновению тетании. Кроме устранения гипокальциемии соединения кальция уменьшают проницаемость сосудов, оказывают противоаллергическое, противовоспалительное, гемостатическое действие.
Фармакокинетика
После парентерального введение препарат равномерно распределяется во всех тканях и органах. В плазме крови кальций находится в ионизированном состоянии. Проходит через плацентарный барьер, выделяется в грудное молоко. Выводится из организма, в основном, почками.
Показания к применению
Недостаточность функции паращитовидных желез, повышенный вывод кальция из организма (в частности при продолжительном обезвоживании),
как вспомогательное средство при аллергических заболеваниях (сывороточная болезнь, крапивница, ангионевротический отек) и аллергических осложнениях медикаментозной терапии,
для уменьшения проницаемости сосудов при патологических процессах разнообразного генезиса (экссудативная фаза воспалительного процесса, геморрагический васкулит, лучевая болезнь);
при паренхиматозном гепатите, токсичных поражениях печени, нефрите, эклампсии, гиперкалиемии, гиперкалиемической форме пароксизмальной миоплегии, при кожных заболеваниях (зуд кожи, экзема, псориаз),
как кровоостанавливающее средство,
как антидот при отравлениях солями магния, щавелевой кислотой или ее растворимыми солями, растворимыми солями фтористой кислоты.
Противопоказания
Индивидуальная непереносимость,
склонность к тромбозам,
гиперкальциемия,
выраженный атеросклероз,
повышенное свертывание крови.
Применение при беременности и в период грудного вскармливания
У беременных женщин, принимающих препараты кальция совместно с витамином D, повышается вероятность развития гиперкальциемии.
В рекомендованных дозах прием препаратов кальция не вызывает каких-либо отрицательных последствий для плода, безопасно применение и при кормлении грудью.
Способ применения и дозы
Внутривенно или внутримышечно взрослым и детям старше 14 лет вводят по 5–10 мл Кальция глюконата ежедневно, через сутки или через 2 суток, в зависимости от характера заболевания и состояния пациента.
Ампулу с раствором перед введением подогревают до температуры тела. Раствор вводят медленно, на протяжении 2–3 мин.
Детям внутривенно, в зависимости от возраста, 10 % раствор глюконата кальция вводят в следующих дозах: в возрасте до 6 месяцев – 0,1–1 мл, 6–12 месяцев – 1–1,5 мл, 1–3 года – 1,5–2 мл, 4–6 лет – 2–2,5 мл, 7–14 лет – 3–5 мл.
Для введения раствора в количестве меньше 1 мл разовую дозу доводят до соответствующего объема (объем шприца) 0,9 % изотоническим раствором натрия хлорида или 5 % раствором глюкозы.
Побочное действие
Иногда могут наблюдаться тошнота, рвота, диарея, брадикардия, ощущение жара в ротовой полости, а впоследствии – во всем теле, которые быстро проходят самостоятельно.
Передозировка
Симптомы: Возможно развитие гиперкальциемии.
Лечение: Как антидот применяют кальцитонин, который вводят внутривенно из расчета 5–10 МЕ на 1 кг массы тела в сутки (препарат разводят в 500 мл 0,9 % раствора натрия хлорида, вводят капельно на протяжении 6 часов в 2–4 приема).
Взаимодействие с другими лекарственными средствами
Кальция глюконат устраняет угнетение нервно-мышечной передачи после применения антибиотиков ряда аминогликозидов. При совместном применении с тиазидовыми диуретиками приводит к развитию гиперкальциемии.
Во время лечения сердечными гликозидами парентеральное применение препарата способствует усилению кардиотоксических эффектов сердечных гликозидов. При одновременном применении с фенигидином препараты кальция ослабляют его эффект. Препараты кальция повышают токсичность хинидина.
Тиазидные диуретики снижают экскрецию кальция с мочой, что повышает риск развития гиперкальциемии.
Препараты кальция могут уменьшить всасывание препаратов тетрациклинового ряда в ЖКТ, в связи с этим интервал между приемом этих препаратов должен быть не меньше 3 часов.
Особые указания
Больным с гиперкальциурией, снижением клубочковой фильтрации или с нефроуролитиазом в анамнезе препарат необходимо назначать с осторожностью и под контролем содержания кальция в моче.
Для снижения риска развития нефроуролитиаза рекомендуется употребление внутрь достаточного количества жидкости.
Перед наполнением шприца раствором кальция глюконата необходимо убедится, что в нем отсутствуют остатки спирта этилового, потому что вследствие их взаимодействия кальция глюконат выпадает в осадок.
Способность влиять на скорость реакций при управлении автотранспортом или работе с другими механизмами. Нет ссылок на то, что Кальция глюконат может влиять на скорость психомоторных реакций.
Препараты кальция следует с осторожностью назначать пациентам с заболеваниями сердца или саркоидозом. Необходим тщательный контроль количества кальция в крови экскреции кальция с мочой при назначении высоких доз препарата, особенно у детей. Лечение должно быть приостановлено, если уровень кальция в крови превышает 2,625 – 2,75 ммоль/л или если экскреции кальция с мочой превышает 5 мг/кг. Следует избегать высокого потребления витамина D во время терапии кальция.
Больным с незначительной гиперкальциурией, снижением клубочковой фильтрации или с нефролитиазом в анамнезе назначение должно проводиться с осторожностью и под контролем содержания кальция в моче. Для снижения риска развития нефролитиаза рекомендуется обильное питье.
Форма выпуска
Раствор для инъекций
Условия хранения
В защищенном от влаги месте, при температуре не выше 25ºС.
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href=\"https://www.eapteka.ru/goods/drugs/metabolism/osteoporosis/?drug_form=rastvor_dlya_inektsiy\"\u003eраствор для инъекций\u003c/a\u003e"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"1 мл раствора для инъекций содержит:"}},{"type":"paragraph","data":{"text":"\u003ci\u003eдействующее вещество:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"кальция глюконата 10 мг"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eФармакодинамика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Ионы кальция принимают участие в передаче нервных импульсов, сокращении гладких и поперечно-полосатых мышц, функционировании миокарда, свертывании крови; они необходимы для формирования костной ткани, функционирования других систем и органов."}},{"type":"paragraph","data":{"text":"Концентрация ионов кальция в крови уменьшается при многих патологических процессах; выраженная гипокальциемия способствует возникновению тетании. Кроме устранения гипокальциемии соединения кальция уменьшают проницаемость сосудов, оказывают противоаллергическое, противовоспалительное, гемостатическое действие."}},{"type":"paragraph","data":{"text":" \u003cb\u003eФармакокинетика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"После парентерального введение препарат равномерно распределяется во всех тканях и органах. В плазме крови кальций находится в ионизированном состоянии. Проходит через плацентарный барьер, выделяется в грудное молоко. Выводится из организма, в основном, почками."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"list","data":{"style":"ordered","items":["Недостаточность функции паращитовидных желез, повышенный вывод кальция из организма (в частности при продолжительном обезвоживании),","как вспомогательное средство при аллергических заболеваниях (сывороточная болезнь, крапивница, ангионевротический отек) и аллергических осложнениях медикаментозной терапии,","для уменьшения проницаемости сосудов при патологических процессах разнообразного генезиса (экссудативная фаза воспалительного процесса, геморрагический васкулит, лучевая болезнь);","при паренхиматозном гепатите, токсичных поражениях печени, нефрите, эклампсии, гиперкалиемии, гиперкалиемической форме пароксизмальной миоплегии, при кожных заболеваниях (зуд кожи, экзема, псориаз),","как кровоостанавливающее средство,","как антидот при отравлениях солями магния, щавелевой кислотой или ее растворимыми солями, растворимыми солями фтористой кислоты."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["Индивидуальная непереносимость,","склонность к тромбозам,","гиперкальциемия,","выраженный атеросклероз,","повышенное свертывание крови."]}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"У беременных женщин, принимающих препараты кальция совместно с витамином D, повышается вероятность развития гиперкальциемии."}},{"type":"paragraph","data":{"text":"В рекомендованных дозах прием препаратов кальция не вызывает каких-либо отрицательных последствий для плода, безопасно применение и при кормлении грудью."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутривенно или внутримышечно взрослым и детям старше 14 лет вводят по 5–10 мл Кальция глюконата ежедневно, через сутки или через 2 суток, в зависимости от характера заболевания и состояния пациента."}},{"type":"paragraph","data":{"text":"Ампулу с раствором перед введением подогревают до температуры тела. Раствор вводят медленно, на протяжении 2–3 мин."}},{"type":"paragraph","data":{"text":"Детям внутривенно, в зависимости от возраста, 10 % раствор глюконата кальция вводят в следующих дозах: в возрасте до 6 месяцев – 0,1–1 мл, 6–12 месяцев – 1–1,5 мл, 1–3 года – 1,5–2 мл, 4–6 лет – 2–2,5 мл, 7–14 лет – 3–5 мл."}},{"type":"paragraph","data":{"text":"Для введения раствора в количестве меньше 1 мл разовую дозу доводят до соответствующего объема (объем шприца) 0,9 % изотоническим раствором натрия хлорида или 5 % раствором глюкозы."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Иногда могут наблюдаться тошнота, рвота, диарея, брадикардия, ощущение жара в ротовой полости, а впоследствии – во всем теле, которые быстро проходят самостоятельно."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eСимптомы:\u003c/b\u003e Возможно развитие гиперкальциемии."}},{"type":"paragraph","data":{"text":"\u003cb\u003eЛечение:\u003c/b\u003e Как антидот применяют кальцитонин, который вводят внутривенно из расчета 5–10 МЕ на 1 кг массы тела в сутки (препарат разводят в 500 мл 0,9 % раствора натрия хлорида, вводят капельно на протяжении 6 часов в 2–4 приема)."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Кальция глюконат устраняет угнетение нервно-мышечной передачи после применения антибиотиков ряда аминогликозидов. При совместном применении с тиазидовыми диуретиками приводит к развитию гиперкальциемии."}},{"type":"paragraph","data":{"text":"Во время лечения сердечными гликозидами парентеральное применение препарата способствует усилению кардиотоксических эффектов сердечных гликозидов. При одновременном применении с фенигидином препараты кальция ослабляют его эффект. Препараты кальция повышают токсичность хинидина."}},{"type":"paragraph","data":{"text":"Тиазидные диуретики снижают экскрецию кальция с мочой, что повышает риск развития гиперкальциемии."}},{"type":"paragraph","data":{"text":"Пациентам, получающим сердечные гликозиды, препараты кальция противопоказаны."}},{"type":"paragraph","data":{"text":"Препараты кальция могут уменьшить всасывание препаратов тетрациклинового ряда в ЖКТ, в связи с этим интервал между приемом этих препаратов должен быть не меньше 3 часов."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Больным с гиперкальциурией, снижением клубочковой фильтрации или с нефроуролитиазом в анамнезе препарат необходимо назначать с осторожностью и под контролем содержания кальция в моче."}},{"type":"paragraph","data":{"text":"Для снижения риска развития нефроуролитиаза рекомендуется употребление внутрь достаточного количества жидкости."}},{"type":"paragraph","data":{"text":"Перед наполнением шприца раствором кальция глюконата необходимо убедится, что в нем отсутствуют остатки спирта этилового, потому что вследствие их взаимодействия кальция глюконат выпадает в осадок."}},{"type":"paragraph","data":{"text":"Способность влиять на скорость реакций при управлении автотранспортом или работе с другими механизмами. Нет ссылок на то, что Кальция глюконат может влиять на скорость психомоторных реакций."}},{"type":"paragraph","data":{"text":"Препараты кальция следует с осторожностью назначать пациентам с заболеваниями сердца или саркоидозом. Необходим тщательный контроль количества кальция в крови экскреции кальция с мочой при назначении высоких доз препарата, особенно у детей. Лечение должно быть приостановлено, если уровень кальция в крови превышает 2,625 – 2,75 ммоль/л или если экскреции кальция с мочой превышает 5 мг/кг. Следует избегать высокого потребления витамина D во время терапии кальция."}},{"type":"paragraph","data":{"text":"Больным с незначительной гиперкальциурией, снижением клубочковой фильтрации или с нефролитиазом в анамнезе назначение должно проводиться с осторожностью и под контролем содержания кальция в моче. Для снижения риска развития нефролитиаза рекомендуется обильное питье."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для инъекций"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от влаги месте, при температуре не выше 25ºС."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/manufacturer/b_braun_medikal_ag/\"\u003eБ.Браун Мельзунген АГ, Германия\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаИоны кальция принимают участие в передаче нервных импульсов, сокращении гладких и поперечно-полосатых мышц, функционировании миокарда, свертывании крови; они необходимы для формирования костной ткани, функционирования других систем и органов. 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