Синтетический аналог природного ГнРГ. Конкурентно связывается с рецепторами клеток передней доли гипофиза, вызывая кратковременное повышение уровня половых гормонов в плазме крови.
Применение препарата в терапевтических дозах приводит (в среднем через 12-14 дней) к полной блокаде гонадотропной функции гипофиза, ингибируя, таким образом, выделение ЛГ и ФСГ. В результате наблюдается подавление синтеза половых гормонов в яичниках и снижение концентрации эстрадиола (Е2) в плазме крови до постклимактерических значений.
Показания к применению
Гормонозависимая патология репродуктивной системы обусловленная абсолютной или относительной гиперэстрогенией:
-эндометриоз (пред- и послеоперационный периоды);
-миома матки;
-гиперпластические процессы эндометрия;
-лечение бесплодия (при проведении программы экстракорпорального оплодотворения (ЭКО)).
Противопоказания
беременность;
-период кормления грудью;
-повышенная чувствительность к компонентам препарата.
С осторожностью
С осторожностью применять при артериальной гипертензии сахарном диабете депрессии.
Применение при беременности и в период грудного вскармливания
Противопоказано.
Способ применения и дозы
Разовая доза препарата при полном нажатии помпы составляет 150 мкг.
-При лечении эндометриоза миомы матки гиперпластических процессов эндометрия:
Препарат вводят в носовые ходы после их очищения в дозе 900 мкг в сутки.
Суточную дозу препарата вводят равными порциями по одному впрыскиванию в каждый носовой ход 3 раза в день через равные промежутки времени (6-8 часов) утром днем и вечером. Лечение препаратом Бусерелин следует начинать в первый или второй день менструального цикла введение непрерывное на протяжении всего курса лечения.
Курс лечения 4-6 месяцев.
-При лечении бесплодия методом экстракорпорального оплодотворения (ЭКО): Бусерелин спрей вводится интраназально по одному впрыскиванию (150 мкг) в каждую ноздрю 3-4 раза в день через равные промежутки времени. Суточная доза 900 - 1200 мкг. Бусерелин назначается в начале фолликулиновой (на 2-й день менструального цикла) или в середине лютеиновой фазы (21-24 дни) менструального цикла предшествующего стимуляции. Через 14-17 дней при снижении эстрадиола в сыворотке крови пациенток не менее чем на 50 % от исходного уровня отсутствии кист в яичниках толщине эндометрия не более 5 мм начинается стимуляция суперовуляции гонадотропными гормонами под ультразвуковым мониторингом и контролем уровня эстрадиола в сыворотке крови. При необходимости может проводиться коррекция дозы Бусерелина.
Побочное действие
Со стороны ЦНС: головная боль головокружение нервозность усталость нарушение сна сонливость снижение памяти и способности к концентрации внимания эмоциональная лабильность развитие депрессии или ухудшение ее течения.
Со стороны органов чувств: шум в ушах нарушение слуха и зрения (неясное видение) чувство давления на глазное яблоко.
Со стороны эндокринной системы: "приливы" крови к коже лица и верхней части грудной клетки повышенное потоотделение сухость влагалища снижение либидо боли внизу живота деминерализация костей редко - менструальноподобное кровотечение (как правило в течение первых недель лечения).
Со стороны сердечно-сосудистой системы (ССС): сердцебиение повышение АД (у больных с артериальной гипертензией).
Аллергические реакции: крапивница кожный зуд гиперемия кожи очень редко -бронхоспазм анафилактический и/или анафилактоидный шок ангионевротический отек.
Со стороны ЖКТ: тошнота рвота жажда диарея запор нарушение аппетита увеличение или уменьшение массы тела.
Со стороны лабораторных показателей: снижение толерантности к глюкозе гипергликемия; изменения в липидном спектре; увеличение активности сывороточных трансаминаз гипербилирубинемия; тромбоцитопения или лейкопения.
Прочие: в единичных случаях - носовые кровотечения; тромбоэмболия легочной артерии; отеки в области лодыжек и стоп; ослабление или усиление роста волос на голове и на теле; боли в спине суставах.
Местные реакции - раздражение слизистой оболочки носа сухость и боль в носу.
Передозировка
В настоящее время о случаях передозировки препаратом Бусерелин не сообщалось.
Взаимодействие с другими лекарственными средствами
Одновременное применение препарата Бусерелин с препаратами содержащими половые гормоны (например в режиме индукции овуляции) может способствовать возникновению синдрома гиперстимуляции яичников.
При одновременном применении Бусерелин может снижать эффективность гипогликемических средств.
Особые указания
Пациентки с какой-либо формой депрессии в период лечения препаратом Бусерелин должны находиться под тщательным наблюдением врача.
Индукцию овуляции следует проводить под строгим медицинским наблюдением.
В начальной стадии лечения препаратом возможно развитие кисты яичника.
Повторный курс лечения следует начинать только после тщательной оценки соотношения ожидаемой пользы и потенциального риска развития остеопороза.
У пациенток пользующихся контактными линзами возможно появление признаков раздражения глаз.
Учитывая интраназальный способ применения возможно раздражение слизистой оболочки носа иногда носовое кровотечение. Препарат можно применять при рините однако перед его применением следует очистить носовые ходы.
Применение препарата Бусерелин в комбинации с хирургическим лечением при эндометриозе уменьшает размеры патологических очагов и их кровоснабжение воспалительные проявления и следовательно сокращает время операции а послеоперационная терапия улучшает результаты снижая частоту послеоперационных рецидивов и уменьшая образование спаек.
До начала лечения препаратом рекомендуется исключить беременность и прекратить прием гормональных контрацептивов однако в течение первых двух месяцев применения препарата необходимо применять другие (негормональные) методы контрацепции.
Влияние на способность управлять автомобилем и движущимися механизмами
В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Спрей назальный дозированный 015 мг/доза: по 175 мл (не менее 187 доз).
Условия хранения
В защищенном от света месте при температуре от 8 до 25° С. Хранить в недоступном для детей месте
Срок годности
3 года.
Не использовать после срока указанного на упаковке.
Для описания товара использована информация от партнера 36.6
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свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Синтетический аналог природного ГнРГ. Конкурентно связывается с рецепторами клеток передней доли гипофиза, вызывая кратковременное повышение уровня половых гормонов в плазме крови."}},{"type":"paragraph","data":{"text":"Применение препарата в терапевтических дозах приводит (в среднем через 12-14 дней) к полной блокаде гонадотропной функции гипофиза, ингибируя, таким образом, выделение ЛГ и ФСГ. В результате наблюдается подавление синтеза половых гормонов в яичниках и снижение концентрации эстрадиола (Е2) в плазме крови до постклимактерических значений."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Гормонозависимая патология репродуктивной системы обусловленная абсолютной или относительной гиперэстрогенией:"}},{"type":"paragraph","data":{"text":"-эндометриоз (пред- и послеоперационный периоды);"}},{"type":"paragraph","data":{"text":"-миома матки;"}},{"type":"paragraph","data":{"text":"-гиперпластические процессы эндометрия;"}},{"type":"paragraph","data":{"text":"-лечение бесплодия (при проведении программы экстракорпорального оплодотворения (ЭКО))."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"беременность;"}},{"type":"paragraph","data":{"text":"-период кормления грудью;"}},{"type":"paragraph","data":{"text":"-повышенная чувствительность к компонентам препарата."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью применять при артериальной гипертензии сахарном диабете депрессии."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказано."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nРазовая доза препарата при полном нажатии помпы составляет 150 мкг."}},{"type":"paragraph","data":{"text":"-При лечении эндометриоза миомы матки гиперпластических процессов эндометрия:"}},{"type":"paragraph","data":{"text":"Препарат вводят в носовые ходы после их очищения в дозе 900 мкг в сутки."}},{"type":"paragraph","data":{"text":"Суточную дозу препарата вводят равными порциями по одному впрыскиванию в каждый носовой ход 3 раза в день через равные промежутки времени (6-8 часов) утром днем и вечером. Лечение препаратом Бусерелин следует начинать в первый или второй день менструального цикла введение непрерывное на протяжении всего курса лечения."}},{"type":"paragraph","data":{"text":"Курс лечения 4-6 месяцев."}},{"type":"paragraph","data":{"text":"-При лечении бесплодия методом экстракорпорального оплодотворения (ЭКО): Бусерелин спрей вводится интраназально по одному впрыскиванию (150 мкг) в каждую ноздрю 3-4 раза в день через равные промежутки времени. Суточная доза 900 - 1200 мкг. Бусерелин назначается в начале фолликулиновой (на 2-й день менструального цикла) или в середине лютеиновой фазы (21-24 дни) менструального цикла предшествующего стимуляции. Через 14-17 дней при снижении эстрадиола в сыворотке крови пациенток не менее чем на 50 % от исходного уровня отсутствии кист в яичниках толщине эндометрия не более 5 мм начинается стимуляция суперовуляции гонадотропными гормонами под ультразвуковым мониторингом и контролем уровня эстрадиола в сыворотке крови. При необходимости может проводиться коррекция дозы Бусерелина.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nСо стороны ЦНС: головная боль головокружение нервозность усталость нарушение сна сонливость снижение памяти и способности к концентрации внимания эмоциональная лабильность развитие депрессии или ухудшение ее течения."}},{"type":"paragraph","data":{"text":"Со стороны органов чувств: шум в ушах нарушение слуха и зрения (неясное видение) чувство давления на глазное яблоко."}},{"type":"paragraph","data":{"text":"Со стороны эндокринной системы: \"приливы\" крови к коже лица и верхней части грудной клетки повышенное потоотделение сухость влагалища снижение либидо боли внизу живота деминерализация костей редко - менструальноподобное кровотечение (как правило в течение первых недель лечения)."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы (ССС): сердцебиение повышение АД (у больных с артериальной гипертензией)."}},{"type":"paragraph","data":{"text":"Аллергические реакции: крапивница кожный зуд гиперемия кожи очень редко -бронхоспазм анафилактический и/или анафилактоидный шок ангионевротический отек."}},{"type":"paragraph","data":{"text":"Со стороны ЖКТ: тошнота рвота жажда диарея запор нарушение аппетита увеличение или уменьшение массы тела."}},{"type":"paragraph","data":{"text":"Со стороны лабораторных показателей: снижение толерантности к глюкозе гипергликемия; изменения в липидном спектре; увеличение активности сывороточных трансаминаз гипербилирубинемия; тромбоцитопения или лейкопения."}},{"type":"paragraph","data":{"text":"Прочие: в единичных случаях - носовые кровотечения; тромбоэмболия легочной артерии; отеки в области лодыжек и стоп; ослабление или усиление роста волос на голове и на теле; боли в спине суставах."}},{"type":"paragraph","data":{"text":"Местные реакции - раздражение слизистой оболочки носа сухость и боль в носу.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"В настоящее время о случаях передозировки препаратом Бусерелин не сообщалось."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Одновременное применение препарата Бусерелин с препаратами содержащими половые гормоны (например в режиме индукции овуляции) может способствовать возникновению синдрома гиперстимуляции яичников."}},{"type":"paragraph","data":{"text":"При одновременном применении Бусерелин может снижать эффективность гипогликемических средств."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nПациентки с какой-либо формой депрессии в период лечения препаратом Бусерелин должны находиться под тщательным наблюдением врача."}},{"type":"paragraph","data":{"text":"Индукцию овуляции следует проводить под строгим медицинским наблюдением."}},{"type":"paragraph","data":{"text":"В начальной стадии лечения препаратом возможно развитие кисты яичника."}},{"type":"paragraph","data":{"text":"Повторный курс лечения следует начинать только после тщательной оценки соотношения ожидаемой пользы и потенциального риска развития остеопороза."}},{"type":"paragraph","data":{"text":"У пациенток пользующихся контактными линзами возможно появление признаков раздражения глаз."}},{"type":"paragraph","data":{"text":"Учитывая интраназальный способ применения возможно раздражение слизистой оболочки носа иногда носовое кровотечение. Препарат можно применять при рините однако перед его применением следует очистить носовые ходы."}},{"type":"paragraph","data":{"text":"Применение препарата Бусерелин в комбинации с хирургическим лечением при эндометриозе уменьшает размеры патологических очагов и их кровоснабжение воспалительные проявления и следовательно сокращает время операции а послеоперационная терапия улучшает результаты снижая частоту послеоперационных рецидивов и уменьшая образование спаек."}},{"type":"paragraph","data":{"text":"До начала лечения препаратом рекомендуется исключить беременность и прекратить прием гормональных контрацептивов однако в течение первых двух месяцев применения препарата необходимо применять другие (негормональные) методы контрацепции.\n\n"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Спрей назальный дозированный 015 мг/доза: по 175 мл (не менее 187 доз)."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре от 8 до 25° С. Хранить в недоступном для детей месте"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не использовать после срока указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/manufacturer/f_sintez/\"\u003eФ-Синтез, Россия\u003c/a\u003e"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ЗАО \"Фарм-Синтез\""}}]}],"source":null},"description_toggle":false,"short_description":"Синтетический аналог природного ГнРГ. Конкурентно связывается с рецепторами клеток передней доли гипофиза, вызывая кратковременное повышение уровня половых гормонов в плазме крови. 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В результате наблюдается подавление синтеза половых гормонов в яичниках и снижение концентрации эстрадиола (Е2) в плазме крови до постклимактерических значений.","substance":[{"id":1035,"title":"Бусерелин","title_latin":"Buserelinum","slug":"buserelin_1035"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Бусерелин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/71213/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/71213/share_default/"}},"diseases":[{"id":"305","title":"Лейомиома матки","slug":"305-leyomioma_matki"},{"id":"1133","title":"Эндометриоз","slug":"1133-endometrioz"},{"id":"1136","title":"Железистая гиперплазия эндометрия","slug":"1136-zhelezistaya_giperplaziya_endometriya"},{"id":"1155","title":"Женское бесплодие","slug":"1155-zhenskoe_besplodie"},{"id":"1395","title":"Искусственное 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