Амлодипин Вертекс Таблетки, коробка, 60 шт, 10 мг, для приема внутрь, для взрослых

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Это обеспечивает поступление кислорода к миокарду при спазмах коронарных артерий."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Артериальная гипертензия (монотерапия или в комбинации с другими гипотензивными средствами);"}},{"type":"paragraph","data":{"text":"- стенокардия напряжения вазоспастическая стенокардия (стенокардия Принцметала или вариантная стенокардия) как в монотерапии так и в сочетании с другими антиангинальными средствами."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к амлодипину и другим производным дигидропиридина а также вспомогательным веществам входящим в состав препарата;"}},{"type":"paragraph","data":{"text":"- тяжелая артериальная гипотензия (систолическое АД менее 90 мм рт. сг.);"}},{"type":"paragraph","data":{"text":"- коллапс;"}},{"type":"paragraph","data":{"text":"- шок включая кардиогенный;"}},{"type":"paragraph","data":{"text":"- обструкция выносящего тракта левого желудочка (включая тяжелый аортальный стеноз);"}},{"type":"paragraph","data":{"text":"- гемодинамически нестабильная сердечная недостаточность после инфаркта миокарда;"}},{"type":"paragraph","data":{"text":"- возраст до 18 лет (эффективность и безопасность не установлены);"}},{"type":"paragraph","data":{"text":"- дефицит лактазы непереносимость лактозы синдром глюкозо-галактозной мальабсорбции."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"- Нарушение функции печени;"}},{"type":"paragraph","data":{"text":"- синдром слабости синусового узла (выраженная брадикардия тахикардия);"}},{"type":"paragraph","data":{"text":"- ХСН неишемической этиологии III-IV функционального класса по классификации NYHA;"}},{"type":"paragraph","data":{"text":"- нестабильная стенокардия;"}},{"type":"paragraph","data":{"text":"- мягкая или умеренная степень артериальной гипотензии;"}},{"type":"paragraph","data":{"text":"- аортальный стеноз митральный стеноз;"}},{"type":"paragraph","data":{"text":"- гипертрофическая обструктивная кардиомиопатия;"}},{"type":"paragraph","data":{"text":"- острый инфаркт миокарда (и в течение 1 месяца после перенесенного острого инфаркта миокарда);"}},{"type":"paragraph","data":{"text":"- одновременный прием ингибиторов или индукторов изофермента CYP3A4."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Беременность"}},{"type":"paragraph","data":{"text":"Безопасность применения амлодипина во время беременности не установлена поэтому применение возможно только в том случае когда польза для матери превышает риск для плода и новорожденного."}},{"type":"paragraph","data":{"text":"Период грудного вскармливания"}},{"type":"paragraph","data":{"text":"Опыт применения показывает что амлодипин выделяется в женское грудное молоко. Среднее соотношение молоко/плазма для концентрации амлодипина составило 085 среди 31 кормящей женщины с артериальной гипертензией обусловленной беременностью получавшими амлодипин в начальной дозе 5 мг в сутки. Доза при необходимости корректировалась (в зависимости от средней суточной дозы и веса: 6 мг и 987 мкг/кг соответственно). Предполагаемая суточная доза амлодипина получаемая младенцем через грудное молоко составляет 417 мкг/кг."}},{"type":"paragraph","data":{"text":"Не было выявлено влияния амлодипина на фертильность при исследовании на крысах."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь один раз в сутки запивая необходимым количеством воды (100 мл)."}},{"type":"paragraph","data":{"text":"Начальная доза для лечения артериальной гипертензии и стенокардии составляет 5 мг. Доза максимально может быть увеличена до 10 мг однократно в сутки в зависимости от терапевтического ответа."}},{"type":"paragraph","data":{"text":"При артериальной гипертензии поддерживающая доза может быть 5 мг в сутки."}},{"type":"paragraph","data":{"text":"При стенокардии напряжения и вазоспастической стенокардии - 5-10 мг в сутки однократно."}},{"type":"paragraph","data":{"text":"Не требуется изменения дозы при одновременном назначении с тиазидными диуретиками бета-адреноблокаторами и ингибиторами АПФ."}},{"type":"paragraph","data":{"text":"Пациенты пожилого возраста"}},{"type":"paragraph","data":{"text":"Амлодипин рекомендуется применять в средней терапевтической дозе коррекции дозы не требуется."}},{"type":"paragraph","data":{"text":"Пациенты с нарушением функции печени"}},{"type":"paragraph","data":{"text":"Несмотря на то что Т\u003csub\u003e1/2 \u003c/sub\u003eамлодипина как и всех БМКК увеличивается у пациентов с нарушениями функции печени коррекции дозы обычно не требуется тем не менее при выраженных нарушениях функции печени может потребоваться меньшая доза препарата (см. раздел \"Особые указания\")."}},{"type":"paragraph","data":{"text":"Пациенты с нарушением функции почек"}},{"type":"paragraph","data":{"text":"Не требуется изменения дозы у пациентов с почечной недостаточностью однако необходимо учитывать возможное незначительное увеличение Т\u003csub\u003e1/2\u003c/sub\u003e."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Классификация частоты развития побочных эффектов согласно рекомендациям"}},{"type":"paragraph","data":{"text":"Всемирной организации здравоохранения (ВОЗ):"}},{"type":"paragraph","data":{"text":"очень часто ≥1/10;"}},{"type":"paragraph","data":{"text":"часто от ≥ 1/100 до < 1/10;"}},{"type":"paragraph","data":{"text":"нечасто от ≥ 1/1000 до < 1/100;"}},{"type":"paragraph","data":{"text":"редко от ≥ 1/10000 до < 1/1000;"}},{"type":"paragraph","data":{"text":"очень редко < 1/10000 включая отдельные сообщения;"}},{"type":"paragraph","data":{"text":"частота неизвестна - по имеющимся данным установить частоту возникновения не представляется возможным."}},{"type":"paragraph","data":{"text":"Нарушения со стороны сердца:"}},{"type":"paragraph","data":{"text":"часто - ощущение сердцебиения;"}},{"type":"paragraph","data":{"text":"очень редко - развитие или усугубление течения XCН нарушения ритма сердца (включая брадикардию желудочковую тахикардию и мерцание предсердий) инфаркт миокарда."}},{"type":"paragraph","data":{"text":"Нарушения со стороны сосудов:"}},{"type":"paragraph","data":{"text":"часто - периферические отеки (лодыжек и стоп) \"приливы\" крови к коже лица;"}},{"type":"paragraph","data":{"text":"нечасто - выраженное снижение АД;"}},{"type":"paragraph","data":{"text":"очень редко - обморок васкулит ортостатическая гипотензия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны мышечной скелетной и соединительной ткани:"}},{"type":"paragraph","data":{"text":"нечасто - артралгия судороги мышц миалгия боль в спине артроз;"}},{"type":"paragraph","data":{"text":"редко - миастения."}},{"type":"paragraph","data":{"text":"Нарушения со стороны нервной системы:"}},{"type":"paragraph","data":{"text":"часто - головная боль головокружение повышенная утомляемость сонливость;"}},{"type":"paragraph","data":{"text":"нечасто - астения общее недомогание гипестезия парестезия периферическая нейропатия тремор бессонница лабильность настроения необычные сновидения повышенная возбудимость депрессия тревога звон в ушах извращение вкуса;"}},{"type":"paragraph","data":{"text":"очень редко - мигрень повышенное потоотделение атаксия апатия ажитация амнезия;"}},{"type":"paragraph","data":{"text":"частота неизвестна - экстрапирамидные нарушения."}},{"type":"paragraph","data":{"text":"Желудочно-кишечные нарушения:"}},{"type":"paragraph","data":{"text":"часто - тошнота боль в эпигастрии;"}},{"type":"paragraph","data":{"text":"нечасто - рвота запор или диарея метеоризм диспепсия сухость слизистой оболочки полости рта;"}},{"type":"paragraph","data":{"text":"редко - гиперплазия десен;"}},{"type":"paragraph","data":{"text":"очень редко - гастрит панкреатит желтуха (обусловленная холестазом) гипербилирубинемия повышение активности \"печеночных\" трансаминаз гепатит."}},{"type":"paragraph","data":{"text":"Нарушения со стороны крови и лимфатической системы:"}},{"type":"paragraph","data":{"text":"очень редко - тромбоцитопеническая пурпура лейкопения тромбоцитопения."}},{"type":"paragraph","data":{"text":"Нарушения со стороны дыхательной системы органов грудной клетки и средостения:"}},{"type":"paragraph","data":{"text":"нечасто - одышка ринит носовое кровотечение;"}},{"type":"paragraph","data":{"text":"очень редко - кашель боль в грудной клетке."}},{"type":"paragraph","data":{"text":"Нарушения со стороны органа зрения:"}},{"type":"paragraph","data":{"text":"нечасто - диплопия нарушения аккомодации ксерофтальмия конъюнктивит боль в глазах нарушения зрения."}},{"type":"paragraph","data":{"text":"Нарушения со стороны почек и мочевыводящих путей:"}},{"type":"paragraph","data":{"text":"нечасто - учащенное мочеиспускание болезненное мочеиспускание никтурия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны репродуктивной системы и молочных желез:"}},{"type":"paragraph","data":{"text":"нечасто - нарушение эректильной функции;"}},{"type":"paragraph","data":{"text":"очень редко - дизурия полиурия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных тканей:"}},{"type":"paragraph","data":{"text":"редко - дерматит;"}},{"type":"paragraph","data":{"text":"очень редко - ксеродермия алопеция холодный пот нарушение пигментации кожи."}},{"type":"paragraph","data":{"text":"Нарушения метаболизма и питания:"}},{"type":"paragraph","data":{"text":"очень редко - гипергликемия;"}},{"type":"paragraph","data":{"text":"нечасто - анорексия жажда увеличение/снижение массы тела;"}},{"type":"paragraph","data":{"text":"редко - повышение аппетита."}},{"type":"paragraph","data":{"text":"Нарушения со стороны иммунной системы:"}},{"type":"paragraph","data":{"text":"нечасто - кожный зуд сыпь (в том числе эритематозная макулопапулезная сыпь крапивница);"}},{"type":"paragraph","data":{"text":"очень редко - ангионевротический отек мультиформная эритема синдром Стивенса-Джонсона."}},{"type":"paragraph","data":{"text":"Общие нарушения и реакции вместе введения:"}},{"type":"paragraph","data":{"text":"нечасто - озноб гинекомастия боль неуточненной локализации;"}},{"type":"paragraph","data":{"text":"очень редко - паросмия."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы"}},{"type":"paragraph","data":{"text":"Выраженное снижение АД тахикардия чрезмерная периферическая вазодилатация (риск развития выраженной и стойкой артериальной гипотензии в том числе с развитием шока и летального исхода)."}},{"type":"paragraph","data":{"text":"Лечение"}},{"type":"paragraph","data":{"text":"Промывание желудка назначение активированного угля (особенно в первые два часа после передозировки) поддержание функций сердечно-сосудистой системы контроль показателей функции сердца и легких контроль за объемом циркулирующей крови и диурезом придание пациенту горизонтального положения с приподнятыми ногами."}},{"type":"paragraph","data":{"text":"Для восстановления тонуса сосудов - применение сосудосуживающих препаратов (при отсутствии противопоказаний к их применению); для устранения последствий блокады кальциевых каналов - внутривенное введение глюконата кальция."}},{"type":"paragraph","data":{"text":"Гемодиализ неэффективен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Амлодипин может безопасно применяться для терапии артериальной гипертензии вместе с тиазидными диуретиками альфа-адреноблокаторами бета-адреноблокаторами или ингибиторами АПФ. У пациентов со стабильной стенокардией амлодипин можно комбинировать с другими антиангинальными средствами например с нитратами пролонгированного или короткого действия бета-адреноблокаторами."}},{"type":"paragraph","data":{"text":"В отличие от других БМКК клинически значимого взаимодействия амлодипина (III поколение БМКК) не было обнаружено при совместном применении с нестероидными противовоспалительными препаратами в том числе и с индометацином."}},{"type":"paragraph","data":{"text":"Возможно усиление антиангинального и антигипертензивного действия БМКК при совместном применении с тиазидными и \"петлевыми\" диуретиками ингибиторами АПФ бета-адреноблокаторами и нитратами а также усиление их антигипертензивного действия при совместном применении с альфарадреноблокаторами нейролептиками."}},{"type":"paragraph","data":{"text":"Хотя при изучении амлодипина отрицательного инотропного действия обычно не наблюдали тем не менее некоторые БМКК могут усиливать выраженность отрицательного инотропного действия антиаритмических средств вызывающих удлинение интервала QT (например амиодарон и хинидин)."}},{"type":"paragraph","data":{"text":"Амлодипин может также безопасно применяться одновременно с антибиотиками и гипогликемическими средствами для приема внутрь."}},{"type":"paragraph","data":{"text":"Силденафил"}},{"type":"paragraph","data":{"text":"Однократный прием 100 мг силденафила у пациентов с эссенциальной гипертензией не оказывает влияния на параметры фармакокинетики амлодипина."}},{"type":"paragraph","data":{"text":"Аторвастатин"}},{"type":"paragraph","data":{"text":"Повторное применение амлодипина в дозе 10 мг и аторвастатина в дозе 80 мг не сопровождается значительными изменениями показателей фармакокинетики аторвастатина."}},{"type":"paragraph","data":{"text":"Симвастатин"}},{"type":"paragraph","data":{"text":"Одновременное многократное применение амлодипина в дозе 10 мг и симвастатина в дозе 80 мг приводит к повышению экспозиции симвастатина на 77%. В таких случаях следует ограничить дозу симвастатина до 20 мг."}},{"type":"paragraph","data":{"text":"Этанол (напитки содержащие алкоголь)"}},{"type":"paragraph","data":{"text":"Амлодипин при однократном и повторном применении в дозе 10 мг не влияет на фармакокинетику этанола."}},{"type":"paragraph","data":{"text":"Противовирусные средства (ритонавир)"}},{"type":"paragraph","data":{"text":"Ритонавир увеличивает плазменные концентрации БМКК в том числе и амлодипина."}},{"type":"paragraph","data":{"text":"Нейролептики и изофлуран"}},{"type":"paragraph","data":{"text":"Усиливают антигипертензивное действие производных дигидропиридина."}},{"type":"paragraph","data":{"text":"Препараты кальция"}},{"type":"paragraph","data":{"text":"Могут уменьшить эффект БМКК."}},{"type":"paragraph","data":{"text":"Препараты лития"}},{"type":"paragraph","data":{"text":"При совместном применении БМКК с препаратами лития (для амлодипина данные отсутствуют) возможно усиление проявления их нейротоксичности (тошнота рвота диарея атаксия тремор шум в ушах)."}},{"type":"paragraph","data":{"text":"Циклоспорин"}},{"type":"paragraph","data":{"text":"Исследования одновременного применения амлодипина и циклоспорина у здоровых добровольцев и всех групп пациентов за исключением пациентов после трансплантации почки не проводились. Различные исследования взаимодействия амлодипина с циклоспорином у пациентов после трансплантации почки показывают что применение данной комбинации может не приводить к какому-либо эффекту либо повышать минимальную концентрацию (C\u003csub\u003emin\u003c/sub\u003e) циклоспорина в различной степени до 40%. Следует принимать во внимание эти данные и контролировать концентрацию циклоспорина у этой группы пациентов при одновременном применении циклоспорина и амлодипина."}},{"type":"paragraph","data":{"text":"Дигоксин"}},{"type":"paragraph","data":{"text":"Амлодипин не оказывает влияния на концентрацию в плазме крови дигоксина и его почечный клиренс."}},{"type":"paragraph","data":{"text":"Варфарин"}},{"type":"paragraph","data":{"text":"Не оказывает существенного влияния на действие варфарина (протромбиновое время)."}},{"type":"paragraph","data":{"text":"Циметидин"}},{"type":"paragraph","data":{"text":"Циметидин не влияет на фармакокинетику амлодипина."}},{"type":"paragraph","data":{"text":"В исследованиях in vitro амлодипин не влияет на связывание с белками плазмы крови дигоксина фенитоина варфарина и индометацина."}},{"type":"paragraph","data":{"text":"Грейпфрутовый сок"}},{"type":"paragraph","data":{"text":"Одновременный однократный прием 240 мг грейпфрутового сока и 10 мг амлодипина внутрь не сопровождается существенным изменением фармакокинетики амлодипина. Тем не менее не рекомендуется применять грейпфрутовый сок и амлодипин одновременно так как при генетическом полиморфизме изофермента CYP3A4 возможно повышение биодоступности амлодипина и вследствие этого усиление антигипертензивного эффекта."}},{"type":"paragraph","data":{"text":"Алюминий- или магнийсодержащие антациды"}},{"type":"paragraph","data":{"text":"Однократный прием не оказывает существенного влияния на фармакокинетику амлодипина."}},{"type":"paragraph","data":{"text":"Ингибиторы изофермента CYP3A4"}},{"type":"paragraph","data":{"text":"При одновременном применении дилтиазема в дозе 180 мг и амлодипина в дозе 5 мг у пациентов пожилого возраста (от 69 до 87 лег) с артериальной гипертензией отмечается повышение системной экспозиции амлодипина на 57%. Одновременное применение амлодипина и эритромицина у здоровых добровольцев (от 18 до 43 лет) не приводит к значительным изменениям экспозиции амлодипина (увеличение площади под кривой \"концентрация-время\" (AUC) на 22%). Несмотря на то что клиническое значение этих эффектов до конца неясно они могут быть более ярко выражены у пациентов пожилого возраста."}},{"type":"paragraph","data":{"text":"Мощные ингибиторы изофермента CYP3A4 (например кетоконазол итраконазол) могут приводить к увеличению концентрации амлодипина в плазме крови в большей степени чем дилтиазем. Следует с осторожностью применять амлодипин и ингибиторы изофермента CYP3A4."}},{"type":"paragraph","data":{"text":"Кларитромицин (ингибитор изофермента CYP3A4)"}},{"type":"paragraph","data":{"text":"У пациентов принимающих одновременно кларитромицин и амлодипин повышен риск снижения АД. Пациентам принимающим такую комбинацию рекомендуется находиться под тщательным медицинским наблюдением."}},{"type":"paragraph","data":{"text":"Индукторы изофермента CYP3A4"}},{"type":"paragraph","data":{"text":"Данных о влиянии индукторов изофермента CYP3A4 на фармакокинетику амлодипина нет. Следует тщательно контролировать АД при одновременном применении амлодипина и индукторов изофермента CYP3A4."}},{"type":"paragraph","data":{"text":"Такролимус"}},{"type":"paragraph","data":{"text":"При одновременном применении с амлодипином есть риск увеличения концентрации такролимуса в плазме крови. Для того чтобы избежать токсичности такролимуса при одновременном применении с амлодипином следует контролировать концентрацию такролимуса в плазме крови пациентов и корректировать дозу такролимуса в случае необходимости."}},{"type":"paragraph","data":{"text":"Ингибиторы механистической мишени для рапамицина у млекопитающих (mТOR)"}},{"type":"paragraph","data":{"text":"Ингибиторы mTOR такие как сиролимус темсиролимус и эверолимус представляют собой субстраты изофермента CYP3A. Амлодипин является слабым ингибитором изофермента CYP3A. При одновременном применении с ингибиторами mTOR амлодипин может повышать их экспозицию."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходим контроль за массой тела и потреблением натрия назначение соответствующей диеты."}},{"type":"paragraph","data":{"text":"Необходимо поддержание гигиены зубов и частое посещение стоматолога (для предотвращения болезненности кровоточивости гиперплазии десен)."}},{"type":"paragraph","data":{"text":"Режим дозирования для пациентов пожилого возраста такой же как и для пациентов других возрастных групп. При увеличении дозы необходимо тщательное наблюдение за пациентами пожилого возраста."}},{"type":"paragraph","data":{"text":"Пациентам с малой массой тела пациентам невысокого роста и пациентам с выраженным нарушением функции печени может потребоваться меньшая доза препарата."}},{"type":"paragraph","data":{"text":"Несмотря на отсутствие у БМКК синдрома \"отмены\" перед прекращением лечения рекомендуется постепенное уменьшение доз."}},{"type":"paragraph","data":{"text":"На фоне применения амлодипина у пациентов с ХСН III и IV функционального класса по классификации NYHA неишемического генеза. отмечалось повышение частоты развития отека легких несмотря на отсутствие признаков ухудшения сердечной недостаточности."}},{"type":"paragraph","data":{"text":"Для лечения стенокардии препарат можно применять как средство монотерапии или в комбинации с другими ангиангинальными средствами в том числе у пациентов рефракторных к лечению нитратами и/или бета-адреноблокаторами в адекватных дозах."}},{"type":"paragraph","data":{"text":"Эффективность и безопасность применения препарата при гипертоническом кризе не установлена."}},{"type":"paragraph","data":{"text":"Амлодипин не влияет на плазменные концентрации ионов калия глюкозы триглицеридов общего холестерина липопротеинов высокой плотности мочевой кислоты креатинина и азота мочевой кислоты."}},{"type":"paragraph","data":{"text":"Амлодипин может применяться при лечении пациентов с бронхиальной астмой сахарным диабетом подагрой а также в тех случаях когда пациент предрасположен к вазоспазму/вазоконстрикции."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не было сообщений об отрицательном влиянии амлодипина на способность управлять транспортными средствами и механизмами. Тем не менее вследствие возможного чрезмерного понижения АД развития головокружения сонливости и других побочных явлений следует внимательно относиться к индивидуальному действию препарата в указанных ситуациях особенно в начале лечения и при изменении режима дозирования."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки 5 мг и 10 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить в защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Акционерное общество \"ВЕРТЕКС\" (АО \"ВЕРТЕКС\"), г. Санкт-Петербург, Дорога в Каменку, д.62, лит. А, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"ВЕРТЕКС\""}}]}],"source":null},"description_toggle":false,"short_description":"Селективный блокатор кальциевых каналов II класса. Антигипертензивное действие обусловлено прямым расслабляющим влиянием на гладкие мышцы сосудов. Предполагается, что антиангинальное действие амлодипина связано с его способностью расширять периферические артериолы; это приводит к уменьшению ОПСС, рефлекторная тахикардия при этом не возникает. В результате происходит снижение потребности миокарда в кислороде и потребления энергии сердечной мышцей. С другой стороны, амлодипин, по-видимому, вызывает расширение коронарных артерий крупного калибра и коронарных артериол как интактных, так и ишемизированных участков миокарда. Это обеспечивает поступление кислорода к миокарду при спазмах коронарных артерий.","substance":[{"id":87,"title":"Амлодипин","title_latin":"Amlodipinum","slug":"amlodipin_87"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":{"count":25,"url":"/review/3928-amlodipin_1/"},"image_alt":"Амлодипин Вертекс - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60540/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60540/share_default/"}},"diseases":[],"other_packages":[{"id":114522,"title":"Амлодипин Вертекс","subtitle":{"full":"Таблетки, 20 шт, 10 мг","short":"Таблетки, 20 шт, 10 мг","package":"20 шт, 10 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