Гипопротромбинемия (профилактика и лечение) обусловленная дефицитом витамина К: нарушение свертывания крови вследствие снижения содержания факторов свертывания крови II VII IX X на фоне приема некоторых лекарственных средств (непрямых антикоагулянтов - производных кумарина и индандиона салицилатов некоторых антибиотиков) нарушения всасывания витамина ...
Гиперчувствительность к компонентам препарата гиперкоагуляция тромбоэмболия гемолитическая болезнь новорожденных беременность и период грудного вскармливания.
Антигеморрагическое средство. Представляет собой синтетический аналог витамина К. Является кофактором синтеза протромбина и других факторов свертывания крови (VII, IX, X) в печени, способствует нормализации процесса свертывания крови.
Показания к применению
Гипопротромбинемия (профилактика и лечение) обусловленная дефицитом витамина К: нарушение свертывания крови вследствие снижения содержания факторов свертывания крови II VII IX X на фоне приема некоторых лекарственных средств (непрямых антикоагулянтов - производных кумарина и индандиона салицилатов некоторых антибиотиков) нарушения всасывания витамина К в кишечнике (особенно при обтурационной желтухе) абеталипопротеинемии парентерального питания.
Лечение и профилактика геморрагической болезни новорожденных.
Профилактически при хирургических вмешательствах с возможным сильным паренхиматозным кровотечением.
Противопоказания
Гиперчувствительность к компонентам препарата гиперкоагуляция тромбоэмболия гемолитическая болезнь новорожденных беременность и период грудного вскармливания.
Применение при беременности и в период грудного вскармливания
В экспериментальных исследованиях у животных выявлено неблагоприятное воздействие менадиона натрия бисульфита на плод. Контролируемые исследования применения препарата Викасол у беременных не проводились. Применение менадиона натрия бисульфита при беременности в период родов противопоказано (риск развития гемолитической анемии гипербилирубинемии и ядерной желтухи у плода и новорожденного).
Данные о выделении менадиона натрия бисульфита в грудное молоко отсутствуют. На время применения препарата необходимо прекратить грудное вскармливание.
Способ применения и дозы
Внутримышечно. Гипопротромбинемия (профилактика и лечение), обусловленная дефицитом витамина К.
Разовая доза для детей старше 14 лет и взрослых – 10-15 мг, суточная – 30 мг.
Детям: 1-2 лет – 6 мг/сут, 3-4 лет – 8 мг/сут, 5-9 лет – 10 мг/сут, 10-14 лет – 15 мг/сут.
Продолжительность лечения – 3-4 дня, после 4-дневного перерыва курс при необходимости повторяют.
При хирургических вмешательствах с возможным сильным паренхиматозным кровотечением назначают в течение 2-3 дней перед операцией.
Побочное действие
Аллергические реакции: гиперемия лица кожная сыпь (в том числе эритематозная крапивница) зуд кожи бронхоспазм.
Со стороны системы крови: гемолитическая анемия гемолиз у новорожденных детей с врожденным дефицитом глюкозо-6-фосфатдегидрогеназы.
Местные реакции: боль и отек в месте введения поражение кожи в виде пятен при повторных инъекциях в одно и то же место.
Прочие: гипербилирубинемия желтуха (в т.ч. ядерная желтуха у грудных детей); головокружение транзиторное снижение артериального давления "профузный" пот тахикардия "слабое" наполнение пульса изменение вкусовых ощущений.
Передозировка
Симптомы: гипервитаминоз К проявляющийся гиперпротромбинемией (которая может сопровождаться тромбозами) гемолитической анемией гипербилирубинемией. В единичных случаях особенно у детей развиваются судороги.
Лечение: отмена препарата. Под контролем показателей свертывающей системы крови назначают антикоагулянты.
Взаимодействие с другими лекарственными средствами
Ослабляет эффект непрямых антикоагулянтов - производных кумарина и индандиона.
Нe влияет на антикоагулянтную активность прямых антикоагулянтов (в том числе гепарина).
Одновременное применение е антибиотиками широкого спектра действия хинидином хинином салицилатами в высоких дозах антибактериальными сульфонамидами требует увеличения дозы витамина К (вследствие нарушения его синтеза микрофлорой кишечника).
Одновременное применение с гемолитическими лекарственными средствами увеличивает риск гемолитической анемии.
Особые указания:
Особые указания
Назначение препарата показано лишь в случае когда невозможен прием витамина К внутрь.
Ввиду отложенного наступления гемостатического эффекта препарат не применяют для остановки кровотечений.
При гемофилии и болезни Верльгофа лекарственный препарат неэффективен.
Влияние на способность управлять автомобилем и движущимися механизмами
Во время лечения не рекомендуется управление транспортными средствами а также занятия другими видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Раствор для внутримышечного введения 10 мг/мл.
Условия хранения
В защищенном от света месте при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
2 года.
Не применять по истечении срока годности указанного на упаковке.
Условия отпуска
По рецепту
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Контролируемые исследования применения препарата Викасол у беременных не проводились. Применение менадиона натрия бисульфита при беременности в период родов противопоказано (риск развития гемолитической анемии гипербилирубинемии и ядерной желтухи у плода и новорожденного)."}},{"type":"paragraph","data":{"text":"Данные о выделении менадиона натрия бисульфита в грудное молоко отсутствуют. На время применения препарата необходимо прекратить грудное вскармливание."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутримышечно. 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В единичных случаях особенно у детей развиваются судороги."}},{"type":"paragraph","data":{"text":"Лечение: отмена препарата. Под контролем показателей свертывающей системы крови назначают антикоагулянты."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Ослабляет эффект непрямых антикоагулянтов - производных кумарина и индандиона."}},{"type":"paragraph","data":{"text":"Нe влияет на антикоагулянтную активность прямых антикоагулянтов (в том числе гепарина)."}},{"type":"paragraph","data":{"text":"Одновременное применение е антибиотиками широкого спектра действия хинидином хинином салицилатами в высоких дозах антибактериальными сульфонамидами требует увеличения дозы витамина К (вследствие нарушения его синтеза микрофлорой кишечника)."}},{"type":"paragraph","data":{"text":"Одновременное применение с гемолитическими лекарственными средствами увеличивает риск гемолитической анемии."}},{"type":"header","data":{"text":"Особые указания:","level":3}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Назначение препарата показано лишь в случае когда невозможен прием витамина К внутрь."}},{"type":"paragraph","data":{"text":"Ввиду отложенного наступления гемостатического эффекта препарат не применяют для остановки кровотечений."}},{"type":"paragraph","data":{"text":"При гемофилии и болезни Верльгофа лекарственный препарат неэффективен."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Во время лечения не рекомендуется управление транспортными средствами а также занятия другими видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутримышечного введения 10 мг/мл."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Общество с ограниченной ответственностью \"Эллара\" (ООО \"Эллара\")"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Эллара\""}}]}],"source":null},"description_toggle":false,"short_description":"Антигеморрагическое средство. 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