Детрагель Гель, туба, 40 г, для наружного применения

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Возможность проведения более длительного курса лечения определяется врачом.\nНе превышайте рекомендуемую дозу и продолжительность применения препарата."}}]},{"id":8,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Побочные эффекты приведены в виде следующей градации: очень часто (\u003e1/10); часто (\u003e1/100, \u003c1/10); нечасто (\u003e1/1 000\u003c1/100); редко (\u003e1/10 000, \u003c1/1 000); очень редко (\u003c1/10 000), неуточненной частоты (частота не может быть подсчитана по доступным данным).\nСо стороны кожных покровов:\u003cbr /\u003e\nОчень редко: аллергические реакции замедленного типа (контактный дерматит)\u003cbr /\u003e\nОчень редко: аллергические реакции немедленного типа (кожная сыпь, кожный зуд, крапивница)\u003cbr /\u003e\nСо стороны дыхательной системы, органов грудной клетки и средостения:\u003cbr /\u003e\nОчень редко: бронхоспазм.\u003cbr /\u003e\nПри местном применении эсцина сообщалось о единичных случаях развития острых анафилактических реакций (см. раздел «Особые указания»).\u003cbr /\u003e\nВ случае развития побочных эффектов при применении препарата следует обратиться к врачу."}}]},{"id":9,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Данные о передозировке препарата отсутствуют.\u003cbr /\u003e\nПри передозировке следует незамедлительно обратиться к врачу. Лечение: в случае передозировки действие гепарина может быть нейтрализовано раствором протамина сульфата."}}]},{"id":10,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В настоящий момент нет данных о взаимодействии с другими лекарственными средствами.\nПрепарат нельзя наносить на один и тот же участок кожи одновременно с другими лекарственными препаратами для наружного применения."}}]},{"id":11,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Нанесение геля на слизистые оболочки противопоказано. \u003cbr /\u003eСледует избегать\u003cbr /\u003e\nВ случае развития аллергических реакций применение препарата следует немедленно прекратить и обратиться к врачу.\nЛекарственные средства для местного применения, особенно после длительного применения, оказывают сенсибилизирующее действие. Если это происходит, то лечение препаратом должно быть прекращено и, при необходимости, назначено соответствующее лечение. При продолжительном применении препарата на обширных участках кожи и одновременном применении антикоагулянтов непрямого действия (варфарин, аценокумарол и др.) следует контролировать протромбиновое время и время свертывания крови.\nНе рекомендуется применять препарат Детрагель® при тромбозах глубоких вен.\u003cbr /\u003e\nОпыт применения препарата у детей младше 18 лет отсутствует.\u003cbr /\u003e\nЕсли Ваше состояние ухудшилось или улучшение не наступило через 15 дней, Вам следует обратиться к врачу."}}]},{"id":12,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °С. Хранить в недоступном для детей месте."}}]},{"id":13,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"2 года. Не применять после истечения срока годности."}}]},{"id":14,"name":"Условия отпуска","slug":"release_condition","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]}],"source":null},"description_toggle":false,"short_description":"Фармакотерапевтическая группа Венотонизирующее средство + антикоагулянтное средство прямого действия для местного применения Код ATX С05ВА53 Фармакологические свойства Фармакодинамика Комбинированный препарат, оказывает местное антикоагулянтное, противовоспалительное, венотонизирующее и антиагрегантное действие, снижает проницаемость вен, улучшает микроциркуляцию. Детрагель® содержит 3 действующих вещества гепарин натрия, эссенциальные фосфолипиды и эсцин, которые обладают фармакодинамическим и фармакокинетическим синергизмом. 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Фармакокинетика Сведения по фармакокинетике эсцина и фосфолипидов при наружном применении отсутствуют. Гепарин натрия при местном применении быстро проникает через эпидермис и накапливается в верхних слоях кожи. Незначительное количество гепарина натрия абсорбируется с поверхности кожи в системный кровоток (менее 0,2 % от общего нанесенного количества). Максимальная концентрация (Сmах) в крови отмечается через 8 ч после аппликации. После абсорбции биотрансформируется в печени и в ретикулоэндотелиальной системе. Гепарин натрия выводится в основном с мочой. Период полувыведения (Т1/2) составляет 12 ч. Гепарин не проникает через плацентарный барьер и не выделяется с грудным молоком. 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