- генитальные суперинфекции вызванные микроорганизмами чувствительными к клотримазолу;
- санация родовых путей перед родами.
Противопоказания
Повышенная чувствительность к клотримазолу или вспомогательным веществам I триместр беременности. Следует избегать применения таблеток в период менструации.
Белые, продолговатые двояковыпуклые таблетки, закругленные с одного конца и со скошенным краем с другого конца. На одной стороне таблетки гравировка "G".
Фармакотерапевтическая группа
Противогрибковое средство
Фармакологические свойства
Противогрибковое средство широкого спектра действия для вагинального применения. Действие клотримазола связано с нарушением синтеза эргостерола, входящего в состав клеточной мембраны грибов, что изменяет проницаемость цитоплазматической мембраны и вызывает последующий лизис клетки. В малых концентрациях действует фунгистатически, в больших - фунгицидно, причем не только на пролиферирующие клетки. В фунгицидных концентрациях взаимодействует с митохондриальными и пероксидазными ферментами, в результате чего происходит увеличение концентрации перекиси водорода до токсического уровня, что также способствует разрушению грибковых клеток.
Клотримазол проявляет фунгицидную и фунгистатическую активность в отношении дерматомицетов (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), дрожжеподобных и плесневых грибов (Candida spp.,включая Candida albicans; Torulopsis glabrata, рода Rhodotorula, Pityrosporum orbiculare). Активен в отношении возбудителя разноцветного лишая — Pityrosporum orbiculare (Malasseziafurfur). Эффективен в отношении грамположительных бактерий — возбудителя эритразмы Corynebacterium minutissimum, а также Staphylococcus spp., Streptococcus spp., грамотрицательных бактерий — Bacteroides, Gardnerella vaginalis. В высоких концентрациях активен в отношении Trichomonas vaginalis.
Не оказывает влияния на лактобациллы. Первично резистентные варианты чувствительных грибов встречаются очень редко; развитие вторичной резистентности у чувствительных грибов также отмечается в исключительных случаях в терапевтических условиях.
- генитальные суперинфекции вызванные микроорганизмами чувствительными к клотримазолу;
- санация родовых путей перед родами.
Противопоказания
Повышенная чувствительность к клотримазолу или вспомогательным веществам I триместр беременности. Следует избегать применения таблеток в период менструации.
С осторожностью
Период лактации.
Применение при беременности и в период грудного вскармливания
При клинических и экспериментальных исследованиях не было установлено что применение препарата в период беременности или в период кормления грудью оказывает отрицательное влияние на здоровье женщины или плода (ребенка). Однако вопрос о целесообразности назначения препарата должен решаться индивидуально после консультации врача.
Способ применения и дозы
Местно. Только для интравагинального применения.
Вагинальные таблетки по 500 мг вводят однократно вечером во влагалище как можно глубже в положении лежа на спине при слегка согнутых ногах. Повторный курс лечения возможен после консультации врача.
Побочное действие
Зуд жжение и отек слизистой оболочки влагалища выделения из влагалища головная боль гастралгия учащенное мочеиспускание интеркуррентный цистит ощущение жжения в половом члене у полового партнера боль во время полового акта.
Передозировка
Применение препарата в повышенных дозах не вызывает каких-либо реакций и состояний опасных для жизни.
В случае непредусмотренного применения препарата (внутрь) возможны следующие симптомы: анорексия тошнота рвота гастралгии нарушение функции печени; редко - сонливость галлюцинации поллакиурия кожные аллергические реакции.
Специфического антидота нет. Необходимо назначать внутрь активированный уголь. При необходимости лечение симптоматическое.
Взаимодействие с другими лекарственными средствами
При вагинальном введении клотримазол снижает активность амфотерицина В и других полиеновых антибиотиков. При одновременном применении с нистатином активность клотримазола может снижаться.
Особые указания
Для предотвращения урогенитальной реинфекции необходимо одновременное лечение половых партнеров.
При трихомониазе для более успешного лечения совместно с Кандидом следует применять другие лекарственные средства обладающие системным действием (например метронидазол внутрь).
При одновременной инфекции половых губ и прилегающих участков (кандидозный вульвит) следует дополнительно проводить местное лечение препаратом Кандид крем.
В период беременности лечение вагинальными таблетками следует проводить без аппликатора.
У больных с печеночной недостаточностью следует периодически контролировать функциональное состояние печени.
При появлении признаков гиперчувствительности или раздражения лечение прекращают.
При отсутствии эффекта в течение 4 недель следует подтвердить диагноз.
Форма выпуска
Вагинальные таблетки 500 мг.
Условия хранения
В сухом защищенном от света месте при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
4 года. Не применять после истечения срока годности
Условия отпуска
Без рецепта
Производитель
Гленмарк Фармасьютикалз Лтд
Организация, принимающая претензии потребителей
Гленмарк Фармасьютикалз Лимитед
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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