Ибупрофен Синтез Таблетки, пачка, 20 шт, 400 мг, для приема внутрь, для тела, для взрослых, в пленочной оболочке

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Жаропонижающее действие обусловлено уменьшением возбудимости терморегулирующих центров промежуточного мозга."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Таблетки Ибупрофена применяются для симптоматического, включая головную боль напряжения и мигрень, суставной, мышечной боли, боли в спине, пояснице, радикулите, боли при повреждении связок, зубной боли, при болезненных менструациях, лихорадочных состояниях, при «простудных» заболеваниях, гриппе, при ревматоидном артрите, остеоартрозе."}},{"type":"paragraph","data":{"text":"Нестероидные противовоспалительные препараты предназначены для симптоматической терапии, уменьшая боль и воспаление на момент использования, на прогрессирование заболевания не влияют."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["гиперчувствительность к любому из ингредиентов, входящих в состав препарата;","эрозивно-язвенные изменения слизистой оболочки желудка или двенадцатиперстной кишки, активное желудочно-кишечное кровотечение;","воспалительные заболевания кишечника в фазе обострения, в т.ч. язвенный колит;","анамнестические данные о приступе бронхообструкции, ринита, крапивницы после приема ацетилсалициловой кислоты или иного нестероидного противовоспалительного препарата (полный или неполный синдром непереносимости ацетилсалициловой кислоты - риносинусит, крапивница, полипы слизистой оболочки носа, бронхиальная астма);","печеночная недостаточность или активное заболевание печени;","почечная недостаточность (клиренс креатинина менее 30 мл/мин), прогрессирующее заболевание почек;","подтвержденная гиперкалиемия;","гемофилия и другие нарушения свертываемости крови (в том числе гипокоагуляция), геморрагические диатезы;","в период после проведения аорто-коронарного шунтирования;","беременность (III триместр);","детский возраст: до 6 лет и от 6 до 12 лет (с массой тела менее 20 кг) - для таблеток 200 мг; до 12 лет - для таблеток 400 мг."]}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказан при беременности (III триместр)."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Взрослые, пожилые и дети старше 12 лет: в таблетках по 200 мг 3-4 раза в сутки; в таблетках по 400 мг 2-3 раза в сутки. Суточная доза составляет 1200 мг (не принимать больше 6 таблеток по 200 мг (или 3 таблеток по 400 мг) в течение 24 ч."}},{"type":"paragraph","data":{"text":"Таблетки следует проглатывать, запивая водой, лучше во время или после еды. Не принимать чаще, чем через 4 часа."}},{"type":"paragraph","data":{"text":"Не превышайте указанной дозы!"}},{"type":"paragraph","data":{"text":"Курс лечения без консультации врача не должен превышать 5 дней."}},{"type":"paragraph","data":{"text":"Если симптомы сохраняются, проконсультируйтесь с врачом."}},{"type":"paragraph","data":{"text":"Не применять у детей моложе 12 лет без консультации врача."}},{"type":"paragraph","data":{"text":"Детям с 6 до 12 лет (с массой тела более 20 кг): по 1 таблетке 200 мг не более 4 раз в день. Интервал между приёмом таблеток не менее 6 часов."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"В рекомендуемых дозах препарат обычно не вызывает побочных эффектов."}},{"type":"paragraph","data":{"text":"Желудочно-кишечный тракт (ЖКТ): НПВП-гастропатия (абдоминальные боли, тошнота, рвота, изжога, снижение аппетита, диарея, метеоризм, запор; изъязвления слизистой оболочки ЖКТ, которые в ряде случаев осложняются перфорацией и кровотечениями; раздражение или сухость слизистой оболочки ротовой полости, боль во рту, изъязвление слизистой оболочки десен, афтозный стоматит, панкреатит."}},{"type":"paragraph","data":{"text":"Гепатобилиарная система: гепатит."}},{"type":"paragraph","data":{"text":"Дыхательная система: одышка, бронхоспазм."}},{"type":"paragraph","data":{"text":"Органы чувств: нарушения слуха: снижение слуха, звон или шум в ушах; нарушение зрения: токсическое поражение зрительного нерва, нечеткость зрительного восприятия, скотома, сухость и раздражение глаз, отек конъюнктивы и век (аллергического генеза)."}},{"type":"paragraph","data":{"text":"Центральная и периферическая нервная система: головная боль, головокружение, бессонница, тревожность, нервозность и раздражительность, психомоторное возбуждение, сонливость, депрессия, спутанность сознания, галлюцинации, асептический менингит (чаще у пациентов с аутоиммунными заболеваниями)."}},{"type":"paragraph","data":{"text":"Сердечно-сосудистая система: сердечная недостаточность, тахикардия, повышение артериального давления."}},{"type":"paragraph","data":{"text":"Мочевыделительная система: острая почечная недостаточность, аллергический нефрит, нефротический синдром (отеки), полиурия, цистит."}},{"type":"paragraph","data":{"text":"Аллергические реакции: кожная сыпь (обычно эритематозная или крапивница), кожный зуд, отек Квинке, анафилактоидные реакции, анафилактический шок, бронхоспазм или диспноэ, лихорадка, многоформная экссудативная эритема (в том числе синдром Стивенса-Джонсона), токсический эпидермальный некролиз (синдром Лайелла), эозинофилия, аллергический ринит."}},{"type":"paragraph","data":{"text":"Органы кроветворения: анемия (в т.ч. гемолитическая, апластическая), тромбоцитопения и тромбоцитопеническая пурпура, агранулоцитоз, лейкопения."}},{"type":"paragraph","data":{"text":"Прочие: усиление потоотделения."}},{"type":"paragraph","data":{"text":"Лабораторные показатели:"}},{"type":"list","data":{"style":"ordered","items":["время кровотечения (может увеличиваться);","концентрация глюкозы в сыворотке (может снижаться);","клиренс креатинина (может уменьшаться);","гематокрит или гемоглобин (могут уменьшаться);","сывороточная концентрация креатинина (может увеличиваться);","активность «печеночных» трансаминаз (может повышаться)."]}},{"type":"paragraph","data":{"text":"Если прием препарата вызвал изменение Вашего обычного состояния, прекратите принимать таблетки Ибупрофена и немедленно обратитесь к врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Не превышайте указанной дозы. Если Вы превысили дозу, немедленно обратитесь к врачу или в ближайшее медицинское учреждение. Возьмите с собой упаковку препарата."}},{"type":"paragraph","data":{"text":"Симптомы: боль в животе, тошнота, рвота, заторможенность, сонливость, депрессия, головная боль, шум в ушах, метаболический ацидоз, кома, острая почечная недостаточность, снижение артериального давления, брадикардия, тахикардия, фибрилляция предсердий, остановка дыхания."}},{"type":"paragraph","data":{"text":"Лечение: промывание желудка (только в течение часа после приема), активированный уголь, щелочное питье, форсированный диурез, симптоматическая терапия (коррекция кислотно-основного состояния, артериального давления)."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"В терапевтических дозах ибупрофен не вступает в значимые взаимодействия с широко применяемыми препаратами."}},{"type":"paragraph","data":{"text":"Индукторы ферментов микросомального окисления в печени (фенитоин, этанол, барбитураты, флумецинол, рифампицин, фенилбутазон, трициклические антидепрессанты) увеличивают продукцию гидроксилированных активных метаболитов, повышая риск развития тяжелых интоксикаций."}},{"type":"paragraph","data":{"text":"Ингибиторы микросомального окисления - снижают риск развития гепатотоксического действия."}},{"type":"paragraph","data":{"text":"Снижает гипотензивную активность вазодилататоров и натрийуретический эффект фуросемида и гидрохлоротиазида."}},{"type":"paragraph","data":{"text":"Снижает эффективность урикозурических препаратов. Усиливает действие непрямых антикоагулянтов, антиагрегантов, фибринолитиков (что повышает риск развития кровотечений). Усиливает побочные эффекты минералокортикостероидов, глюкокортикостероидов (повышается опасность желудочно-кишечного кровотечения), эстрогенов, этанола; усиливает гипогликемический эффект производных сульфонилмочевины."}},{"type":"paragraph","data":{"text":"Антациды и колестирамин снижают абсорбцию ибупрофена."}},{"type":"paragraph","data":{"text":"Увеличивает концентрацию в крови дигоксина, препаратов лития и метотрексата."}},{"type":"paragraph","data":{"text":"Одновременное назначение других НПВП повышает частоту побочных эффектов."}},{"type":"paragraph","data":{"text":"Кофеин усиливает анальгезирующий (обезболивающий) эффект."}},{"type":"paragraph","data":{"text":"При одновременном назначении ибупрофен снижает противовоспалительное и антиагрегантное действие ацетилсалициловой кислоты (возможно повышение частоты развития острой коронарной недостаточности у больных, получающих в качестве антиагрегантного средства малые дозы ацетилсалициловой кислоты, после начала приема ибупрофена)."}},{"type":"paragraph","data":{"text":"Цефамандол, цефоперазон, цефотетан, вальпроевая кислота, пликамицин увеличивают частоту развития гипопротромбинемии при одновременном назначении."}},{"type":"paragraph","data":{"text":"Миелотоксические лекарственные средства усиливают проявления гематотоксичности препарата."}},{"type":"paragraph","data":{"text":"Циклоспорин и препараты золота усиливают влияние ибупрофена на синтез простагландинов в почках, что проявляется повышением нефротоксичности. Ибупрофен повышает плазменную концентрацию циклоспорина и вероятность развития его гепатотоксичных эффектов."}},{"type":"paragraph","data":{"text":"Лекарственные средства, блокирующие канальцевую секрецию, снижают выведение и повышают плазменную концентрацию ибупрофена."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки покрытые плёночной оболочкой 200 мг, 400 мг."}},{"type":"paragraph","data":{"text":"10 таблеток в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги алюминиевой печатной лакированной."}},{"type":"paragraph","data":{"text":"50 таблеток в банки полимерные."}},{"type":"paragraph","data":{"text":"Каждую банку, 2, 5 или 10 контурных ячейковых упаковок с инструкцией по применению помещают в пачку из картона."}}]}],"source":null},"description_toggle":false,"short_description":"Ибупрофен быстро и почти полностью абсорбируется из желудочно-кишечного тракта, его максимальные концентрации в плазме достигаются через 1-2 часа после приема внутрь, в синовиальной жидкости - через 3 часа, связывается с белками плазмы на 99 %. Медленно проникает в полость суставов, задерживается в синовиальной ткани, создавая в ней большие концентрации, чем в плазме. Метаболизм ибупрофена протекает преимущественно в печени. Период полувыведения (Т1/2) из плазмы составляет 2-3 часа. Выводится почками в виде метаболитов (в неизмененном виде выводится не более 1 %), в меньшей степени - с желчью. Ибупрофен полностью выводится за 24 часа. Оказывает противовоспалительное, жаропонижающее и анальгезирующее действие. Подавляет противовоспалительные факторы, снижает агрегацию тромбоцитов. Угнетает циклооксигеназы 1 и 2 типов, нарушает метаболизм арахидоновой кислоты, уменьшает количество простагландинов как в здоровых тканях, так и в очаге воспаления, подавляет экссудативную и пролиферативную фазы воспаления. Снижает болевую чувствительность в очаге воспаления. Вызывает ослабление или исчезновение болевого синдрома, в т.ч. при болях в суставах в покое и при движении, уменьшение утренней скованности и припухлости суставов, способствует увеличению объема движений. Жаропонижающее действие обусловлено уменьшением возбудимости терморегулирующих центров промежуточного мозга.","substance":[{"id":74,"title":"Ибупрофен","title_latin":"Ibuprophenum","slug":"ibuprofen_74"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":{"count":6,"url":"/review/11526-ibuprofen_1/"},"image_alt":"Ибупрофен Синтез - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70995/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70995/share_default/"}},"diseases":[{"id":"554","title":"Мигрень","slug":"554-migren"},{"id":"796","title":"Острая инфекция верхних отделов дыхательных путей неуточненная","slug":"796-ostraya_infektsiya_verhnih_otdelov_dyhatelnyh_putey_neutochnennaya"},{"id":"798","title":"Грипп, вызванный идентифицированным вирусом гриппа","slug":"798-gripp_vyzvannyy_identifitsirovannym_virusom_grippa"},{"id":"853","title":"Другие уточненные 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