Сульфацил-натрия Капли, 1 шт, 5 мл, 20 %, для глаз

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Необходимо прекратить терапию в случае появления симптомов аллергии а также при усилении боли и других признаков инфекционно - воспалительного процесса увеличении количества гнойного отделяемого."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В случае развития затуманивания зрения после инстилляции необходимо воздержаться от управления транспортными средствами и занятий потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций до восстановления четкости зрения."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капли глазные 20 %."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Флакон-капельницу после вскрытия использовать в течение 30 суток."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО \"Славянская аптека\", 601125, Владимирская обл., Петушинский район, п. Вольгинский, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Славянская аптека\""}}]}],"source":null},"description_toggle":false,"short_description":"Противомикробное бактериостатическое средство сульфаниламид. Механизм действия связан с конкурентным антагонизмом с ПАБК и угнетением дигидроптероатсинтетазы что приводит к нарушению синтеза дигидрофолиевой кислоты и в конечном итоге ее активного метаболита тетрагидрофолиевой кислоты необходимой для синтеза пуринов и пиримидинов. Активен в отношении грамположительных и грамотрицательных кокков. Escherichia coli Shigella spp. Vibrio cholerae Clostridium perfringens Bacillus antracis Corynebacterium diphteriae Yersinia pestis Chlamydia spp. Actinomyces israelii Toxoplasma gondii. Возможно развитие резистентности к сульфацетамиду. Проникает в ткани глаза где и оказывает свое специфическое антибактериальное воздействие. Действует преимущественно местно но часть препарата всасывается через воспаленную конъюнктиву и попадает в системный кровоток. Количество препарата попадающее в системный кровоток недостаточно для развития системного терапевтического эффекта но достаточно для сенсибилизации при повторном введении. При местном применении максимальная концентрация (Сmах) сульфаниламидов в роговице (около 3 мг/мл) влаге передней камеры (около 05 мг/мл) и радужке (около 01 мг/мл) достигается за первые 30 мин после аппликации. Некоторое количество (менее 05 мг/мл) сохраняется в тканях глазного яблока в течение 3-4 ч. При повреждении эпителия роговицы пенетрация сульфаниламидов усиливается. Сульфацетамид метаболизируется в печени путем N - ацетилирования метаболиты обладают антибактериальной активностью. 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