болезнь Альцгеймера; - синдром деменции различного генеза; - хроническая цереброваскулярная недостаточность; - ишемический инсульт; - травматические повреждения головного и спинного мозга; - задержка умственного развития у детей; - гиперактивность и дефицит внимания у детей; - эндогенная депрессия, резистентная к антидепрессантам (в составе комплексной терапии).
Действующее вещество: ЦеребролизинКонцентрация действующего вещества (%): 1%
Фармакологические свойства
Ноотропный препарат. Церебролизин содержит низкомолекулярные биологически активные нейропептиды, которые проникают через ГЭБ и непосредственно поступают к нервным клеткам. Препарат обладает органоспецифическим мультимодальным действием на головной мозг, т.е. обеспечивает метаболическую регуляцию, нейропротекцию, функциональную нейромодуляцию и нейротрофическую активность. Метаболическая регуляция: препарат Церебролизин повышает эффективность аэробного энергетического метаболизма головного мозга, улучшает внутриклеточный синтез белка в развивающемся и стареющем головном мозге. Нейропротекция: препарат защищает нейроны от повреждающего действия лактацидоза, предотвращает образование свободных радикалов, повышает переживаемость и предотвращает гибель нейронов в условиях гипоксии и ишемии, снижает повреждающее нейротоксическое действие возбуждающих аминокислот (глутамата). Нейротрофическая активность: препарат Церебролизин - единственный ноотропный пептидергический препарат с доказанной нейротрофической активностью, аналогичной действию естественных факторов нейронального роста (NGF), но проявляющейся в условиях периферического введения. Функциональная нейромодуляция: препарат оказывает положительное влияние при нарушениях когнитивных функций на процессы запоминания.
Показания к применению
болезнь Альцгеймера; - синдром деменции различного генеза; - хроническая цереброваскулярная недостаточность; - ишемический инсульт; - травматические повреждения головного и спинного мозга; - задержка умственного развития у детей; - гиперактивность и дефицит внимания у детей; - эндогенная депрессия, резистентная к антидепрессантам (в составе комплексной терапии).
Применение при беременности и в период грудного вскармливания
С осторожностью следует применять Церебролизин в I триместре беременности и в период лактации. Применение препарата при беременности и в период грудного вскармливания возможно только в том случае, когда предполагаемая польза для матери превосходит потенциальный риск для плода/новорожденного. Результаты экспериментальных исследований не дают оснований полагать, что Церебролизин обладает каким-либо тератогенным действием или оказывает токсическое влияние на плод. Однако аналогичные клинические исследования не проводились.
Способ применения и дозы
Препарат следует применять парентерально. Доза и продолжительность применения зависят от характера и тяжести заболевания, а также возраста пациента. Возможно однократное введение препарата в дозе до 50 мл, однако более предпочтительно проведение курса лечения. Рекомендуемый курс лечения представляет собой ежедневные инъекции в течение 10-20 дней. Показание ДозаОстрые состояния (ишемический инсульт, черепно-мозговая травма, осложнения нейрохирургических операций) от 10 мл до 50 млВ резидуальном периоде мозгового инсульта и травматического повреждения головного и спинного мозга от 5 мл до 50 млПсихоорганический синдром и депрессия от 5 мл до 30 млБолезнь Альцгеймера, деменция сосудистого и сочетанного альцгеймерово-сосудистого генеза от 5 мл до 30 млВ нейропедиатрической практике 0. 1-0. 2 мл/кг массы телаДля повышения эффективности лечения могут быть проведены повторные курсы до тех пор, пока наблюдается улучшение состояния пациента вследствие лечения. После проведения первого курса периодичность проведения инъекций может быть снижена до 2 или 3 раз в неделю. Церебролизин применяют парентерально в виде в/м инъекций (до 5 мл) и в/в инъекций (до 10 мл). Препарат в дозе от 10 мл до 50 мл рекомендуется вводить только посредством медленных в/в инфузий после разведения стандартными растворами для инфузий. Продолжительность инфузий составляет от 15 до 60 мин. После вскрытия ампулы/флакона раствор Церебролизина следует использовать незамедлительно.
Побочное действие
Побочные эффекты встречающиеся часто (больше1/100, меньше1/10); редко (больше1/1000, меньше1/100); в отдельных случаях (больше1/10 000, меньше1/1000); в единичных случаях (меньше1/10 000). При чрезмерно быстром введении: редко - ощущение жара, потливость, головокружение; в единичных случаях - тахикардия или аритмия. Со стороны пищеварительной системы: редко - потеря аппетита, диспепсия, диарея, запоры, тошнота и рвота. Со стороны ЦНС и периферической нервной системы: редко - возбуждение, проявляющиеся агрессивным поведением, спутанностью сознания, бессонницей; в единичных случаях - большие эпилептические припадки, судороги. Аллергические реакции: в единичных случаях - реакции повышенной чувствительности, проявляющиеся головной болью, болевыми ощущениями в шее, конечностях, нижней части спины, одышкой, ознобом и коллаптоидным состоянием. Местные реакции: редко - гиперемия кожи, зуд и жжение в месте инъекции. По результатам клинических исследований сообщалось о возникновении следующих побочных эффектов: Со стороны сердечно-сосудистой системы: в единичных случаях - артериальная гипертензия, артериальная гипотензия. Со стороны ЦНС и периферической нервной системы: в единичных случаях - усталость, тремор, депрессия, апатия, головокружение. Прочие: в единичных случаях - гипервентиляция, гриппоподобные симптомы (кашель, насморк, инфекции дыхательных путей). Следует учитывать, что некоторые нежелательные эффекты (возбуждение, артериальная гипертензия, артериальная гипотензия, вялость, тремор, депрессия, апатия, головокружение, головная боль, одышка, диарея, тошнота) были выявлены в ходе клинических испытаний и возникали в равной мере как у пациентов, получавших Церебролизин, так и у пациентов группы плацебо.
Передозировка
В настоящее время о случаях передозировки препарата Церебролизин не сообщалось.
Особые указания
При чрезмерно быстром выполнении инъекций возможно ощущение жара, потливость, головокружение. Поэтому препарат следует вводить медленно. Проверена и подтверждена совместимость препарата (в течение 24 ч при комнатной температуре и наличии освещения) со следующими стандартными растворами для инфузий: 0.9% раствор натрия хлорида, раствор Рингера, 5% раствор декстрозы (глюкозы). Допускается одновременное применение Церебролизина с витаминами и препаратами, улучшающими сердечное кровообращение, однако эти препараты не следует смешивать в одном шприце с Церебролизином. Не следует смешивать в одном растворе для инфузий Церебролизин и сбалансированные растворы аминокислот. Следует использовать только прозрачный раствор Церебролизина и только однократно. Влияние на способность к вождению автотранспорта и управлению механизмамиКлинические испытания показали, что Церебролизин не оказывает влияния на способность к управлению транспортными средствами и использованию механизмов.
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Нейротрофическая активность: препарат Церебролизин - единственный ноотропный пептидергический препарат с доказанной нейротрофической активностью, аналогичной действию естественных факторов нейронального роста (NGF), но проявляющейся в условиях периферического введения. Функциональная нейромодуляция: препарат оказывает положительное влияние при нарушениях когнитивных функций на процессы запоминания."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["болезнь Альцгеймера; - синдром деменции различного генеза; - хроническая цереброваскулярная недостаточность; - ишемический инсульт; - травматические повреждения головного и спинного мозга; - задержка умственного развития у детей; - гиперактивность и дефицит внимания у детей; - эндогенная депрессия, резистентная к антидепрессантам (в составе комплексной терапии)."]}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["острая почечная недостаточность; - эпилептический статус; - повышенная чувствительность к препарату."]}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"С осторожностью следует применять Церебролизин в I триместре беременности и в период лактации. 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Аллергические реакции: в единичных случаях - реакции повышенной чувствительности, проявляющиеся головной болью, болевыми ощущениями в шее, конечностях, нижней части спины, одышкой, ознобом и коллаптоидным состоянием. Местные реакции: редко - гиперемия кожи, зуд и жжение в месте инъекции. По результатам клинических исследований сообщалось о возникновении следующих побочных эффектов: Со стороны сердечно-сосудистой системы: в единичных случаях - артериальная гипертензия, артериальная гипотензия. Со стороны ЦНС и периферической нервной системы: в единичных случаях - усталость, тремор, депрессия, апатия, головокружение. Прочие: в единичных случаях - гипервентиляция, гриппоподобные симптомы (кашель, насморк, инфекции дыхательных путей). 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