Муколитический препарат. Разжижает мокроту, увеличивает ее объем и облегчает ее отделение. Действие ацетилцистеина связано со способностью его сульфгидрильных групп разрывать внутри- и межмолекулярные дисульфидные связи кислых мукополисахаридов мокроты, что приводит к деполяризации мукопротеидов и уменьшению вязкости мокроты. Сохраняет активность при наличии гнойной мокроты. Увеличивает секрецию менее вязких сиаломуцинов бокаловидными клетками, снижает адгезию бактерий на эпителиальных клетках слизистой оболочки бронхов. Стимулирует мукозные клетки бронхов, секрет которых лизирует фибрин. Аналогичное действие оказывает на секрет, образующийся при воспалительных заболеваниях ЛОР-органов. Оказывает антиоксидантное действие, обусловленное наличием SH-группы, способной нейтрализовать электрофильные окислительные токсины. Ацетилцистеин легко проникает внутрь клетки, деацетилируется до L-цистеина, из которого синтезируется внутриклеточный глутатион. Глутатион - высокореактивный трипептид, мощный антиоксидант и цитопротектор, нейтрализующим эндогенные и экзогенные свободные радикалы и токсины. Ацетилцистеин предупреждает истощение и способствует повышению синтеза внутриклеточного глутатиона, участвующего в окислительно-восстановительных процессах клеток, способствуя детоксикации вредных веществ. Этим объясняется действие ацетилцистеина в качестве антидота при отравлении парацетамолом. Предохраняет альфа1-антитрипсин (ингибитор эластазы) от инактивирующего воздействия НОСl - окислителя, вырабатываемого миелопероксидазой активных фагоцитов. Обладает также противовоспалительным действием (за счет подавления образования свободных радикалов и активных кислородсодержащих веществ, ответственных за развитие воспаления в легочной ткани).
Катаральный и гнойный отит, синусит, в т.ч. гайморит (для облегчения отхождения секрета)
Для удаления вязкого секрета из дыхательных путей при посттравматических и послеоперационных состояниях
Противопоказания
Язвенная болезнь желудка и двенадцатиперстной кишки в фазе обострения
Период лактации
Детский возраст до 2 лет (для гранул для приготовления раствора для приема внутрь)
Детский и подростковый возраст до 18 лет (для шипучих таблеток)
Повышенная чувствительность к ацетилцистеину
Применение препарата в форме гранул для приготовления раствора для приема внутрь у детей в возрасте до 2 лет возможно только при наличии жизненных показаний и при строгом врачебном контроле.
С осторожностью назначают при язвенной болезни желудка и двенадцатиперстной кишки, варикозном расширении вен пищевода, кровохарканьи, легочном кровотечении, фенилкетонурии, бронхиальной астме, заболеваниях надпочечников, печеночной и/или почечной недостаточности, артериальной гипертензии.
Способ применения и дозы
Препарат в форме таблеток шипучих назначают взрослым по 600 мг (1 таб.) 1 раз/сут. Перед применением шипучую таблетку растворяют в 1/3 стакана воды. Гранулы для приготовления раствора для приема внутрь назначают взрослым и детям старше 6 лет - по 200 мг 2-3 раза/сут; детям в возрасте от 2 до 6 лет - по 200 мг 2 раза/сут или по 100 мг 3 раза/сут; детям в возрасте от 1 года до 2 лет - по 100 мг 2 раза/сут. У новорожденных детей препарат применяют только по жизненным показаниям в дозе 10 мг/кг массы тела под строгим контролем врача. Перед применением необходимое количество гранул растворяют в 1/3 стакана воды. Детям первого года жизни дают пить полученный раствор из ложки или бутылочки для кормления. Продолжительность курса лечения устанавливается индивидуально. При острых заболеваниях продолжительность лечения составляет от 5 до 10 дней, при хронических - до нескольких месяцев.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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Оказывает антиоксидантное действие, обусловленное наличием SH-группы, способной нейтрализовать электрофильные окислительные токсины. Ацетилцистеин легко проникает внутрь клетки, деацетилируется до L-цистеина, из которого синтезируется внутриклеточный глутатион. Глутатион - высокореактивный трипептид, мощный антиоксидант и цитопротектор, нейтрализующим эндогенные и экзогенные свободные радикалы и токсины. Ацетилцистеин предупреждает истощение и способствует повышению синтеза внутриклеточного глутатиона, участвующего в окислительно-восстановительных процессах клеток, способствуя детоксикации вредных веществ. Этим объясняется действие ацетилцистеина в качестве антидота при отравлении парацетамолом. Предохраняет альфа1-антитрипсин (ингибитор эластазы) от инактивирующего воздействия НОСl - окислителя, вырабатываемого миелопероксидазой активных фагоцитов. 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