Полусинтетический антибиотик группы рифамицина. Рифабутин об... Инструкция
Показания к применению
Профилактика инфекции, вызываемой комплексом Mycobacterium avium (MAC-инфекция), у лиц со сниженным иммунитетом. Лечение вторичной присоединившейся микобактериальной инфекции (в т.ч. MAC-инфекции). Туберкулез (в составе комбинированной терапии).
Противопоказания
Повышенная чувствительность к рифабутину и другим рифамицинам.
Инструкция
Описание
Рифабутин - лекарственное средство, антибиотик широкого спектра действия, в основном используемый для лечения туберкулеза и профилактики инфицирования ВИЧ-больных бактериями комплекса
Фармакологические свойства
Полусинтетический антибиотик группы рифамицина. Рифабутин обладает широким спектром действия. Механизм действия, вероятно, связан с угнетением синтеза аминокислот за счет ингибирования ДНК-зависимой РНК-полимеразы.
Показания к применению
Профилактика инфекции, вызываемой комплексом Mycobacterium avium (MAC-инфекция), у лиц со сниженным иммунитетом. Лечение вторичной присоединившейся микобактериальной инфекции (в т.ч. MAC-инфекции). Туберкулез (в составе комбинированной терапии).
Противопоказания
Повышенная чувствительность к рифабутину и другим рифамицинам.
Применение при беременности и в период грудного вскармливания
Адекватных и строго контролируемых клинических исследований безопасности применения Рифабутина при беременности и в период лактации (грудного вскармливания) не проводилось, поэтому не следует применять Рифабутин у данной категории пациентов.
Способ применения и дозы
Рифабутин назначают внутрь 1 раз/сутки, независимо от приема пищи. При нетуберкулезной микобактериальной инфекции назначают в суточной дозе 450-600 мг. Продолжительность лечения - 6 мес. При хроническом полирезистентном туберкулезе легких назначают по 300-450 мг/сутки. Продолжительность лечения - 9 мес. При вновь диагностированном туберкулезе легких назначают в дозе 150 мг/сутки в течение 6 мес. Для профилактики MAC-инфекции у пациентов с иммунодепрессией назначают в суточной дозе 300 мг.
Побочное действие
Со стороны пищеварительной системы: тошнота, рвота, повышение уровня печеночных ферментов, желтуха. Со стороны системы кроветворения: лейкопения, тромбоцитопения, анемия. Со стороны костно-мышечной системы: артралгия, миалгия. Со стороны органа зрения: обратимый увеит. Аллергические реакции: лихорадка, сыпь, редко - эозинофилия, бронхоспазм, анафилактический шок.
Передозировка
Лечение: промывание желудка. Показана симптоматическая терапия, возможно назначение диуретиков.
Особые указания
На фоне терапии Рифабутином возможно красно-оранжевое окрашивание мочи, кожи и секретируемых жидкостей. Пациентам, принимающим Рифабутин, не следует носить контактные линзы. В период лечения рекомендуется периодически контролировать количество лейкоцитов, тромбоцитов в периферической крови и активность печеночных ферментов.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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