Дегенеративно-дистрофические заболевания суставов и позвоночника: первичный артроз остеоартроз с преимущественным поражением крупных суставов межпозвонковый остеохондроз.
Противопоказания
Повышенная чувствительность детский возраст (эффективность и безопасность не установлены).
Инструкция
Регистрационный номер
ЛСР-009923/08
Торговое название препарата
Артрадол
Лекарственная форма
лиофилизат для приготовления раствора для внутримышечного введения
Состав
Одна ампула содержит:
Хондроитина сульфат натрия (в пересчете на 100 % сухое вещество хондроитина сульфат натрия) - 100 мг.
Описание
Белая или белая с желтоватым оттенком пористая, уплотненная в таблетку масса.
Фармакотерапевтическая группа
Репарации тканей стимулятор
Фармакологические свойства
Фармакодинамика:
Хондроитина сульфат - основной компонент протеогликанов составляющих вместе с коллагеновыми волокнами хрящевой матрикс. Обладает хондропротекторными свойствами; подавляет активность ферментов вызывающих деградацию суставного хряща; стимулирует выработку хондроцитами протеогликанов; усиливает метаболические процессы в хряще и субхондральной кости; оказывает влияние на фосфорно-кальциевый обмен в хрящевой ткани стимулирует ее регенерацию участвует в построении основного вещества костной и хрящевой ткани. Обладает противовоспалительными и анальгезирующими свойствами способствует снижению выброса в синовиальную жидкость медиаторов воспаления и болевых факторов через синовиоциты и макрофаги синовиальной оболочки подавляет секрецию лейкотриена В4 и простагландина Е2. Препарат способствует восстановлению хрящевых поверхностей суставов препятствует коллапсу соединительной ткани; нормализует продукцию суставной жидкости что ведет к улучшению подвижности суставов уменьшению интенсивности болей. Обладая структурным сходством с гепарином потенциально может препятствовать образованию фибриновых тромбов в синовиальном и субхондралыюм микроциркуляторном русле.
Фармакокинетика:
Хондроитина сульфат легко всасывается при внутримышечном введении через 30 мин обнаруживается в значительных концентрациях в крови через 15 мин - в синовиальной жидкости. Максимальная концентрация достигается через 1 ч после введения затем концентрация препарата медленно снижается в течение 2 суток. Препарат накапливается главным образом в хрящевой ткани (максимальная концентрация в суставном хряще достигается через 48 ч). Выводится почками в течение 24 ч.
Показания к применению
Дегенеративно-дистрофические заболевания суставов и позвоночника: первичный артроз остеоартроз с преимущественным поражением крупных суставов межпозвонковый остеохондроз.
Противопоказания
Повышенная чувствительность детский возраст (эффективность и безопасность не установлены).
С осторожностью
Кровотечения и склонность к кровоточивости тромбофлебиты. Беременность период лактации.
Способ применения и дозы
Внутримышечно по 100 мг через день. Перед применением содержимое ампулы растворяют в 1 мл воды для инъекций. При хорошей переносимости дозу увеличивают до 200 мг начиная с 4-ой инъекции. Курс лечения 25-35 инъекций. Повторный курс - через 6 месяцев. Продолжительность повторных курсов лечения устанавливается врачом.
Побочное действие
Аллергические реакции геморрагии в месте инъекции.
Взаимодействие с другими лекарственными средствами
Возможно усиление действия непрямых антикоагулянтов антиагрегантов фибринолитиков что требует более частого контроля показателей свертываемости крови при совместном применении.
Форма выпуска
Лиофилизат для приготовления раствора для внутримышечного введения 100 мг.
Условия хранения
В защищенном от света месте при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
3 года. Не использовать по истечении срока годности.
Условия отпуска
По рецепту
Производитель
Федеральное государственное унитарное предприятие "Курская Биофабрика - фирма "Биок", 305004, г. Курск, ул. Степана Разина, д. 5, Россия
Организация, принимающая претензии потребителей
ООО "Тривиум"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
Начните сравнивать цены и заказывать лекарства прямо в приложении
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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