Пароксетин Таблетки, 30 шт, 20 мг, для приема внутрь, для взрослых

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Обладает бициклической структурой, отличной от структуры других известных антидепрессантов."}},{"type":"paragraph","data":{"text":"Оказывает антидепрессивное и анксиолитическое действие при достаточно выраженном стимулирующем (активизирующем) эффекте."}},{"type":"paragraph","data":{"text":"Антидепрессивное (тимоаналептическое) действие связано со способностью пароксетина избирательно блокировать обратный захват серотонина пресинаптической мембраной, чем обусловлено повышение свободного содержания этого нейромедиатора в синаптической щели и усиление его активности в ЦНС."}},{"type":"paragraph","data":{"text":"Влияние на м-холинорецепторы, α- и β-адренорецепторы незначительно, что определяет крайне слабую выраженность соответствующих побочных эффектов."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Депрессия различной этиологии, в т.ч. состояния, сопровождающиеся тревогой, обсессивно-компульсивные расстройства, панические расстройства, в т.ч. с агорафобией, социофобии, генерализованное тревожное расстройство, посттравматические стрессорные расстройства."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к пароксетину; одновременный прием ингибиторов МАО и период до 14 дней после их отмены; одновременное применение с тиоридазином и пимозидом; беременность; возраст до 18 лет."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"печеночная недостаточность, почечная недостаточность, закрытоугольная глаукома, гиперплазия предстательной железы, мания, патология сердца, эпилепсия, судорожные состояния, применение электроимпульсной терапии; прием препаратов и наличие заболеваний, повышающих риск кровотечения; наличие факторов риска повышенной кровоточивости; пожилой возраст."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказан к применению при беременности. 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Дозу, схему применения и длительность терапии определяют индивидуально, в зависимости от показаний, клинической ситуации, эффективности терапии и возраста пациента."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны свертывающей системы крови: \u003c/i\u003eнечасто - аномальное кровотечение, преимущественно кровоизлияние в кожу и слизистые оболочки; очень редко - тромбоцитопения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы: \u003c/i\u003eчасто - сонливость, тремор, парестезии, бессонница, головокружение, необычные сновидения (в т.ч. кошмарные сновидения); нечасто - спутанность сознания, галлюцинации, экстрапирамидные симптомы; редко - мании, тревога, деперсонализация, панические атаки, синдром \"беспокойных ног\", судороги, акатизия; очень редко - серотониновый синдром; частота неизвестна - суицидальные мысли, суицидальное поведение (во время терапии или в ранние сроки после прекращения лечения)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органа зрения:\u003c/i\u003e часто - нечеткость зрения; нечасто - мидриаз; очень редко - закрытоугольная глаукома."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органа слуха: \u003c/i\u003eчастота неизвестна - шум в ушах."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы: \u003c/i\u003eнечасто - транзиторное повышение или снижение АД, синусовая тахикардия, ортостатическая гипотензия; очень редко - периферические отеки."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы: \u003c/i\u003eочень часто - тошнота, снижение аппетита; часто - сухость во рту, рвота, запор, диарея; редко - повышение активности печеночных трансаминаз; очень редко - желудочно-кишечное кровотечение, гепатит (иногда с желтухой), печеночная недостаточность."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны мочевыделительной системы:\u003c/i\u003e редко - задержка мочеиспускания, недержание мочи."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны половой системы:\u003c/i\u003e очень часто - сексуальная дисфункция; редко - приапизм."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны эндокринной системы: \u003c/i\u003eредко - гипопролактинемия/галакторея и гипонатриемия, которая обусловлена синдромом недостаточной секреции АДГ."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны костно-мышечной системы: \u003c/i\u003eредко - артралгия, миалгия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции:\u003c/i\u003e редко - кожная сыпь; реакции фоточувствительности; очень редко - ангионевротический отек, крапивница/"}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие: \u003c/i\u003eочень часто - астения, холестеринемия, снижение аппетита, усиление потоотделения, зевота, увеличение массы тела; очень редко - периферические отеки."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСиндром \"отмены\" пароксетина:\u003c/i\u003e часто - головокружение, сенсорные нарушения, нарушения сна, тревога, головная боль; нечасто - ажитация, тошнота, тремор, спутанность сознания, усиление потоотделения, диарея."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: тошнота, рвота, тремор, мидриаз, сухость во рту, раздражительность, нистагм, ажитация, потливость, сонливость, синусовая тахикардия, судороги, брадикардия, повышение АД, узловой ритм. В очень редких случаях, при одновременном приеме с другими психотропными средствами и/или алкоголем возможны изменения на ЭКГ, кома. При выраженной передозировке - серотониновый синдром, редко - рабдомиолиз."}},{"type":"paragraph","data":{"text":"Лечение: промывание желудка, прием активированного уголя. При необходимости проводят симптоматическую терапию. Специфического антидота нет."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении с пароксетином возможно повышение концентрации в плазме крови лекарственных средств, метаболизирующихся при участии изофермента CYP2D6 системы цитохрома Р450 (антидепрессантов, антипсихотических средств производных фенотиазина, антиаритмических препаратов IС класса)."}},{"type":"paragraph","data":{"text":"При одновременном применении средств, индуцирующих или ингибирующих белковый метаболизм, возможны изменения метаболизма и фармакокинетических параметров пароксетина."}},{"type":"paragraph","data":{"text":"При одновременном применении усиливается действие алпразолама вследствие уменьшения его метаболизма в связи с ингибированием изоферментов CYP3A системы цитохрома P450 под влиянием пароксетина."}},{"type":"paragraph","data":{"text":"При одновременном применении с варфарином, пероральными антикоагулянтами возможно увеличение времени кровотечения при неизмененном протромбиновом времени."}},{"type":"paragraph","data":{"text":"При одновременном применении с декстрометорфаном, дигидроэрготамином описаны случаи серотонинового синдрома."}},{"type":"paragraph","data":{"text":"При одновременном применении с интерфероном возможно изменение антидепрессивного действия пароксетина."}},{"type":"paragraph","data":{"text":"Одновременное применение триптофана может вызвать развитие серотонинового синдрома, проявляющегося ажитацией, беспокойством, расстройствами со стороны ЖКТ, включая диарею."}},{"type":"paragraph","data":{"text":"При одновременном применении с перфеназином пароксетин усиливает побочные эффекты со стороны ЦНС вследствие ингибирования метаболизма перфеназина под влиянием пароксетина."}},{"type":"paragraph","data":{"text":"При одновременном применении повышается концентрация в плазме крови трициклических антидепрессантов, возникает риск развития серотонинового синдрома."}},{"type":"paragraph","data":{"text":"Одновременный прием циметидина повышает концентрацию пароксетина в плазме крови."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Во избежание развития злокачественного нейролептического синдрома с осторожностью следует назначать Пароксетин пациентам, принимающим нейролептики."}},{"type":"paragraph","data":{"text":"Лечение Пароксетином назначают спустя 2 недели после отмены ингибиторов МАО."}},{"type":"paragraph","data":{"text":"У пациентов пожилого возраста на фоне приема Пароксетина возможна гипонатриемия."}},{"type":"paragraph","data":{"text":"В некоторых случаях требуется коррекции дозы одновременно применяемых инсулина и/или пероральных гипогликемических препаратов."}},{"type":"paragraph","data":{"text":"При развитии судорог лечение Пароксетином прекращают."}},{"type":"paragraph","data":{"text":"При первых признаках мании следует отменить терапию Пароксетином."}},{"type":"paragraph","data":{"text":"В течение первых нескольких недель терапии Пароксетином следует тщательно наблюдать за состоянием пациента в связи с возможными суицидальными попытками."}},{"type":"paragraph","data":{"text":"Во время терапии Пароксетином следует воздерживаться от приема алкоголя в связи с усилением его токсического эффекта."}},{"type":"paragraph","data":{"text":"Использование в педиатрии"}},{"type":"paragraph","data":{"text":"Применение Пароксетина у детей не рекомендуется, поскольку его безопасность и эффективность у этой группы пациентов не установлены."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Несмотря на то, что пароксетин не ухудшает когнитивные и психомоторные функции, пациенты должны воздерживаться или соблюдать предельную осторожность при управлении автомобилем и занятиях другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте, при температуре не выше 25 °C."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/manufacturer/ozon/\"\u003eОзон, Россия\u003c/a\u003e."}}]}],"source":null},"description_toggle":false,"short_description":"Антидепрессант, селективный ингибитор обратного захвата серотонина. Обладает бициклической структурой, отличной от структуры других известных антидепрессантов. Оказывает антидепрессивное и анксиолитическое действие при достаточно выраженном стимулирующем (активизирующем) эффекте. Антидепрессивное (тимоаналептическое) действие связано со способностью пароксетина избирательно блокировать обратный захват серотонина пресинаптической мембраной, чем обусловлено повышение свободного содержания этого нейромедиатора в синаптической щели и усиление его активности в ЦНС. 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