Легалон 140 Капсулы, коробка, 60 шт, 140 мг, для приема внутрь

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"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЦитопротективное.\u003c/i\u003e Силимарин тормозит проникновение в клетку некоторых\nгепатотоксических веществ (яда бледной поганки). "}},{"type":"paragraph","data":{"text":"\u003ci\u003eАнтиоксидантное.\u003c/i\u003e В связи со способностью силимарина связывать\nсвободные радикалы, он обладает антиоксидантной активностью. Прерывается или\nпредупреждается патофизиологический процесс перекисного окисления липидов,\nотвечающий за разрушение клеточных мембран. Силимарин действует\nне только как антиоксидант  - уменьшая степень\nгенерации свободных радикалов, но и как средство, стимулирующее регенерацию системы\nглютатиона, одной из важнейших защитных систем печени."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРегенеративное.\nМембраностабилизирующее.\u003c/i\u003e Силимарин стимулирует\nсинтез белков и фосфолипидов. Мембраны клеток стабилизируются. Собственные\nбелки и фосфолипиды восстанавливают поврежденные структуры гепатоцита. Улучшается\nвосстановительная способность и ускоряется регенерация клеток печени. В\nнеповрежденных клетках такого эффекта не отмечается."}},{"type":"paragraph","data":{"text":"\u003ci\u003eГипохолестеринемическое.\n\u003c/i\u003e\u003ci\u003eС\u003c/i\u003eилимарин нормализует гиперлипидемию, снижает в плазме крови уровень холестерина\nи липопротеинов низкой плотности (LDL)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАнтифиброзное.\u003c/i\u003e Силимарин ингибирует коллагеназу и эластазу в печени, способствуя снижению\nстепени фиброза. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eПротивовоспалительное.\u003c/i\u003e Ключевой особенностью силимарина/силибинина  является способность блокировать 5-липоксигеназный\nпуть и оказывать подавляющее действие на образование лейкотриена."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Основным компонентом силимарина является силибинин. При приеме внутрь силибинин\nбыстро растворяется и поступает в кишечник, затем через систему воротной вены\n85% его поступает в печень и избирательно распределяется в гепатоцитах, где\nметаболизируется путем конъюгации. До 80% активного вещества при первом\nпрохождении через печень выделяется с желчью в соединении с глюкуронидами и\nсульфатами. Вследствие деконъюгации в кишечнике до 40% силибинина,\nвыделившегося с желчью, реабсорбируется и вступает в энтерогепатическую\nциркуляцию, период выведения составляет 6,3 ч.  Биодоступность препарата  Легалон® 140 составляет 85%. "}},{"type":"paragraph","data":{"text":"При приеме расторопши пятнистой плодов экстракта в терапевтических дозах\n(140 мг силимарина 3 раза в сутки) уровень силибинина в желчи одинаковый после\nприема повторных доз и после приема однократной дозы. Результаты показали, что\nсилибинин не кумулирует в организме."}},{"type":"paragraph","data":{"text":"После многоразового приема силимарина внутрь по 140 мг 3 раза в сутки\nдостигается стабильный уровень выделения с желчью."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В комплексной терапии хронических\nвоспалительных заболеваний печени, цирроза печени и токсических поражений печени\n(вызванных токсичными для печени веществами)."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к компонентам\nпрепарата (плодам расторопши пятнистой и/или к другим сложноцветным растениям,\nили к любому из вспомогательных веществ). "}},{"type":"paragraph","data":{"text":"Детский возраст до 12 лет (для данной\nлекарственной формы)."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В ходе\nисследований прямого или косвенного токсического действия на репродуктивную\nфункцию не выявлено. В качестве предупреждающей меры желательно избегать\nприменения препарата во время беременности и в период грудного вскармливания."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Внутрь, после\nеды, запивая достаточным количеством жидкости. По 1 капсуле 3 раза в день.\nПоддерживающая доза - по 1 капсуле 2 раза в день."}},{"type":"paragraph","data":{"text":"Длительность терапии определяет врач."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Частота развития побочных эффектов определена следующим образом:"}},{"type":"paragraph","data":{"text":"Очень часто: > 1/10;"}},{"type":"paragraph","data":{"text":"Часто: < /10 > 1/100;"}},{"type":"paragraph","data":{"text":"Нечасто: < 1/100 > 1/1000;"}},{"type":"paragraph","data":{"text":"Редко: < 1/1000> 1/10000;"}},{"type":"paragraph","data":{"text":"Очень редко: < 1/10000."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны иммунной системы:\u003c/i\u003eОчень редко - реакции гиперчувствительности, сыпь."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны дыхательных путей:\u003c/i\u003eОчень редко - одышка."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны желудочно-кишечного\nтракта:\u003c/i\u003eРедко - желудочно-кишечные расстройства, мягкий\nстул."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"О случаях передозировки не сообщалось."}},{"type":"paragraph","data":{"text":"Возможно усиление побочного действия препарата. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение\u003c/i\u003e: при передозировке следует провести симптоматическую терапию."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не\nвлияет на способность управлять транспортом или заниматься другими потенциально\nопасными видами деятельности, требующими повышенной концентрации внимания и быстроты\nпсихомоторных реакций."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном\nот света месте, при\nтемпературе не выше 30 \u003csup\u003eо\u003c/sup\u003eС."}},{"type":"paragraph","data":{"text":"Хранить в\nнедоступном для детей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет."}},{"type":"paragraph","data":{"text":"Не применять\nпо истечении срока годности, указанного на упаковке."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без\nрецепта."}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Майлан Фарма»,\nРоссия                     "}},{"type":"paragraph","data":{"text":"109028, Москва,\nСеребряническая наб., д. 29, этаж 9"}},{"type":"paragraph","data":{"text":"тел: +7(495) 660-53-03,"}},{"type":"paragraph","data":{"text":"факс: +7(495) 660-53-06"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ФармакодинамикаРасторопши пятнистой плодов сухой экстракт стандартизирован по содержанию силимарина.Терапевтическое действие силимарина:Дезинтоксикационное.Антитоксическое действие силимарина было выявлено в ходе исследований на различных моделях поражения печени, например, токсином бледной поганки фаллоидином и альфа-аманитином, лантаноидами, четыреххлористым углеродом, галактозамином, тиоацетамидом и гепототоксичным вирусом FV3.Цитопротективное.Силимарин тормозит проникновение в клетку некоторых гепатотоксических веществ (яда бледной поганки).Антиоксидантное.В связи со способностью силимарина связывать свободные радикалы, он обладает антиоксидантной активностью. Прерывается или предупреждается патофизиологический процесс перекисного окисления липидов, отвечающий за разрушение клеточных мембран. Силимарин действует не только как антиоксидант - уменьшая степень генерации свободных радикалов, но и как средство, стимулирующее регенерацию системы глютатиона, одной из важнейших защитных систем печени.Регенеративное. Мембраностабилизирующее.Силимарин стимулирует синтез белков и фосфолипидов. Мембраны клеток стабилизируются. Собственные белки и фосфолипиды восстанавливают поврежденные структуры гепатоцита. Улучшается восстановительная способность и ускоряется регенерация клеток печени. В неповрежденных клетках такого эффекта не отмечается.Гипохолестеринемическое.Силимарин нормализует гиперлипидемию, снижает в плазме крови уровень холестерина и липопротеинов низкой плотности (LDL).Антифиброзное.Силимарин ингибирует коллагеназу и эластазу в печени, способствуя снижению степени фиброза.Противовоспалительное.Ключевой особенностью силимарина/силибинина является способность блокировать 5-липоксигеназный путь и оказывать подавляющее действие на образование лейкотриена.ФармакокинетикаОсновным компонентом силимарина является силибинин. При приеме внутрь силибинин быстро растворяется и поступает в кишечник, затем через систему воротной вены 85% его поступает в печень и избирательно распределяется в гепатоцитах, где метаболизируется путем конъюгации. До 80% активного вещества при первом прохождении через печень выделяется с желчью в соединении с глюкуронидами и сульфатами. Вследствие деконъюгации в кишечнике до 40% силибинина, выделившегося с желчью, реабсорбируется и вступает в энтерогепатическую циркуляцию, период выведения составляет 6,3 ч. Биодоступность препарата Легалон® 140 составляет 85%. При приеме расторопши пятнистой плодов экстракта в терапевтических дозах (140 мг силимарина 3 раза в сутки) уровень силибинина в желчи одинаковый после приема повторных доз и после приема однократной дозы. Результаты показали, что силибинин не кумулирует в организме. 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