Оланзапин-канон Таблетки, 28 шт, 5 мг

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Установлено сродство оланзапина к серотониновым, дофаминовым, мускариновым, адренергическим альфа1 и гистаминовым H1-рецепторам. В экспериментах на животных было выявлено наличие антагонизма оланзапина по отношению к 5НТ, дофаминовым и холинергическим рецепторам. В условиях in vitro и in vivo оланзапин обладает более выраженным сродством и активностью в отношении серотониновых рецепторов, в сравнении с дофаминовыми D2 рецепторами. Оланзапин снижает условный защитный рефлекс (тест, характеризующий антипсихотическую активность) в дозах более низких, чем дозы, вызывающие каталепсию (расстройство, отражающее побочное влияние на моторную функцию). В отличие от других нейролептиков, оланзапин усиливает противотревожный эффект при проведении \"анксиолитического\" теста. 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Нарушения со стороны почек и мочевыводящих путей: нечасто - недержание мочи, редко: задержка начала мочеиспускания, частота неизвестна: повышение мочевой кислоты. Нарушения со стороны половых органов и молочной железы: редко - приапизм. Общие расстройства и нарушения в месте введения: часто - астения, усталость, отеки, редко - гипотермия, частота не известна - лихорадка. Лабораторные и инструментальные данные: очень часто - увеличение концентрации пролактина в плазме, по клинические проявления (например, гинекомастия, галакторея и увеличение молочных желез) редко. У большинства пациентов уровень пролактина спонтанно нормализовался без отмены препарата, часто - увеличение активности креатинфосфокиназы (КФК), общего билирубина, очень редко - увеличение активности щелочной фосфатазы."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Частые симптомы: тахикардия, возбуждение/агрессивность, расстройство артикуляции, различные экстрапирамидные расстройства и нарушения сознания разной степени тяжести (от седативного эффекта до комы). Лечение: специфического антидота для оланзапина не существует. Не рекомендуется провоцирование рвоты. Могут быть показаны стандартные процедуры при передозировке (промывание желудка, назначение активированного угля). Совместное назначение активированного угля приводит к снижению биодоступности оланзапина при приеме внутрь до 50-60%. Показано симптоматическое лечение в соответствии с клиническим состоянием и контроль над функциями жизненно важных органов, включая лечение артериальной гипотонии, нарушения кровообращения и поддержание дыхательной функции. Не следует применять эпинефрин, дофамин и другие симпатомиметики, которые являются агонистами бета-адренорецепторов, так как стимуляция этих рецепторов может усугублять артериальную гипотензию."}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Клиническое улучшение может занимать несколько дней и требует наблюдения за пациентом. Злокачественный нейролептический синдром (ЗНС) (потенциально летальный симптомокомплекс) может развиваться при лечении любыми нейролептиками, включая препарат Оланзапин Канон, однако к настоящему времени нет данных, подтверждающих достоверную связь приема оланзапина с развитием данного состояния. Клинические проявления злокачественного нейролептического синдрома включают значительное повышение температуры тела, ригидность мускулатуры, изменение психического статуса и вегетативные нарушения (нестабильный пульс или артериальное давление, тахикардия, сердечные аритмии, повышенное потоотделение). Дополнительные признаки могут включать увеличение уровня креатинфосфокиназы, миоглобинурию (рабдомиолиз) и острую почечную недостаточность. Клинические проявления злокачественного нейролептического синдрома или значительное повышение температуры тела без других симптомов злокачественного нейролептического синдрома требуют отмены всех нейролептиков, включая препарат Оланзапин Канон. Лечение оланзапином реже сопровождается развитием дискинезии, требующей медикаментозной коррекции, чем при применении галоперидола. Однако следует учитывать риск поздней дискинезии при длительной терапии нейролептиками. При развитии признаков поздней дискинезии рекомендуется снижение дозы или отмена препарата Оланзапин Канон. Следует учитывать, что при переводе на препарат Оланзапин Канон симптомы поздней дискинезии могут развиваться вследствие одномоментной отмены предшествующей терапии. Симптомы поздней дискинезии могут нарастать или манифестировать после отмены препарата. Эффективность при применении при болезни Паркинсона не превышает плацебо (в целях купирования ятрогенных психозов). Не рекомендуется применение препарата Оланзапин Канон при лечении психозов, индуцированных приемом агонистов дофаминовых рецепторов при болезни Паркинсона, у таких пациентов отмечается усиление симптомов паркинсонизма и галлюцинации. Цереброваскулярные нежелательные явления (например, инсульт, транзиторная ишемическая атака), включая летальные исходы, отмечаются у пожилых пациентов с психозом на фоне деменции. В плацебо-контролированных исследованиях отмечались более высокая частота цереброваскулярных нежелательных явлений у пациентов в группе оланзапина, по сравнению с группой плацебо. Данные пациенты имели предшествующие факторы риска (цереброваскулярные нарушения (в анамнезе), транзиторная ишемическая атака, артериальная гипертензия, курение), а также сопутствующие заболевания и/или прием лекарственных препаратов, по времени связанные с цереброваскулярными нарушениями. Эффективность оланзапина у пожилых пациентов с психозом на фоне деменции не установлена. Основными факторами риска повышенной смертности для данной группы пациентов при лечении оланзапином являются возраст ≥ 80 лет, седация, сочетанное применение с бензодиазепинами или наличие патологии легких (например, пневмония с аспирацией или без нее). Не существует достаточных данных, чтобы установить различия в частоте возникновения цереброваскулярных нарушений и/или смертности (по сравнению с плацебо), и в факторах риска у этой группы пациентов при приеме оланзапина внутрь и при внутримышечных инъекциях. Препарат Оланзапин Канон не рекомендован для терапии пациентов с психозом на фоне деменции."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Оланзапин является антипсихотическим средством (нейролептиком) с широким фармакологическим спектром влияния на ряд рецепторных систем. Установлено сродство оланзапина к серотониновым, дофаминовым, мускариновым, адренергическим альфа1 и гистаминовым H1-рецепторам. В экспериментах на животных было выявлено наличие антагонизма оланзапина по отношению к 5НТ, дофаминовым и холинергическим рецепторам. В условиях in vitro и in vivo оланзапин обладает более выраженным сродством и активностью в отношении серотониновых рецепторов, в сравнении с дофаминовыми D2 рецепторами. Оланзапин снижает условный защитный рефлекс (тест, характеризующий антипсихотическую активность) в дозах более низких, чем дозы, вызывающие каталепсию (расстройство, отражающее побочное влияние на моторную функцию). В отличие от других нейролептиков, оланзапин усиливает противотревожный эффект при проведении \"анксиолитического\" теста. Оланзапин обеспечивает статистически достоверную редукцию как продуктивных (бред, галлюцинации и др.), так и негативных расстройств.","substance":[{"id":476,"title":"Оланзапин","title_latin":"Olanzapinum","slug":"olanzapin_476"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Оланзапин-канон - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/16228/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/16228/share_default/"}},"diseases":[{"id":"482","title":"Шизофрения","slug":"482-shizofreniya"},{"id":"483","title":"Шизотипическое расстройство","slug":"483-shizotipicheskoe_rasstroystvo"},{"id":"484","title":"Хронические бредовые расстройства","slug":"484-hronicheskie_bredovye_rasstroystva"},{"id":"485","title":"Острые и преходящие психические 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