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П/к введение осуществляется в область живота, плеча, ягодицы или бедра. Места введения следует чередовать таким образом, чтобы на протяжении 30-ти суток в одно место проводилось не более одной инъекции. П/к инъекции требуют определенного навыка введения и мер предосторожности. Необходимо избегать попадания иглы в кровеносные сосуды, не массировать место проведения инъекции, а также правильно обращаться с устройствами для введения препарата. Приготовление и введение Хумулина НПХС целью ресуспендирования инсулина, перед использованием флаконы и картриджи препарата Хумулин НПХ рекомендуют раз 10 прокатать в ладонях и столько же раз покачать (поворачивая на 180°) до приобретения препаратом состояния близкого к молоку или однородной жидкости мутного оттенка. Энергично встряхивать препарат не следует, так как образованная таким образом пена может помешать точному набору дозы. Флаконы и картриджи нужно проверять с особой тщательностью. Избегать использования инсулина с хлопьями осадка или белыми частицами, прилипшими к стенкам или дну флакона, образовывая впечатление морозного узора. Конструкция картриджа не допускает смешения в нем его содержимого с прочими инсулинами, также как и повторного заполнения самого картриджа. При использовании флаконов эмульсию набирают в тот инсулиновый шприц, который по объему соответствует вводимому инсулину (например, 100 МЕ/1 мл инсулина = шприц 1 мл) и вводят, согласуясь с рекомендациями врача. При применении картриджей необходимо придерживаться инструкции производителя шприц-ручки по их установке, креплению иглы, а также введению инсулина, например, инструкции на Хумулин НПХ в шприц ручке КвикПен. Сразу после проведения инъекции следует, используя наружный колпачок иглы, извлечь саму иглу и уничтожить ее безопасным образом, после чего закрыть ручку колпачком. Данная процедура обеспечивает дальнейшую стерильность, предупреждает попадание воздуха, предотвращает утечку препарата и его возможное засорение. Иглы и шприц-ручки не подлежат повторному использованию и эксплуатации другими лицами. Флаконы и картриджи используют единожды до завершения препарата, после чего выбрасывают. Возможно введения Хумулина НПХ в сочетании с Хумулином Регуляр. Для чего, с целью предотвращения проникания во флакон инсулина более продолжительного действия, первым в шприц набирают инсулин короткого действия. Данную смесь рекомендуют вводить сразу после смешивания. Для точной дозировки двух инсулинов могут использовать разные шприцы."}}]},{"id":5,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Основным побочным эффектом является гипогликемия, которая в случае тяжелого течения может стать причиной потери сознания и даже смерти (редко). Также существует минимальная вероятность формирования липодистрофии. Аллергические проявления системного характера: генерализованный зуд, одышка, затрудненное дыхание, понижение АД, повышенное потоотделение, учащение пульса. Аллергические проявления местного характера: отечность или зуд в области проведения инъекции (как правило, прекращаются на протяжении нескольких недель), гиперемия."}}]},{"id":6,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Как таковой специфической передозировки Хумулином НПХ нет. Симптомами принято считать проявления гипогликемии, сопровождающиеся повышенным потоотделением, вялостью, тахикардией, головной болью, бледностью кожных покровов, дрожью, спутанностью сознания, рвотой. В некоторых случаях симптоматика, предшествующая гипогликемии (длительный диабет или его интенсивный контроль) может измениться. Проявления гипогликемии легкой степени, как правило, купируются пероральным приемом сахара или глюкозы (декстрозы). В дальнейшем может понадобиться корректировка режима диеты, дозы инсулина или физических нагрузок. Корректировка гипогликемии средней тяжести проводится п/к или в/м инъекцией глюкагона, с дальнейшим пероральным приемом углеводов. Проявления тяжелой гипогликемии могут сопровождаться комой, неврологическими расстройствами или судорогами, которые локализуются в/в инъекцией концентрированной глюкозы (декстрозы) или п/к или в/м введением глюкагона. В дальнейшем, с целью предупреждения повторения симптоматики, необходим прием пищи богатой углеводами."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Гипогликемическое действие Хумулина НПХ снижают пероральные контрацептивы, кортикостероиды, препараты гормонов щитовидной железы, тиазидные диуретики, диазоксид, трициклические антидепрессанты."}},{"type":"paragraph","data":{"text":"Гипогликемическое действие Хумулина НПХ усиливают пероральные гипогликемические препараты, салицилаты (например, \u003ca href=\"https://health.mail.ru/drug/acetylsalicylic_acid/\"\u003eацетилсалициловая кислота\u003c/a\u003e), сульфаниламиды, ингибиторы МАО, бета-адреноблокаторы, этанол и этанолсодержащие препараты."}},{"type":"paragraph","data":{"text":"Бета-адреноблокаторы, клофелин, резерпин могут маскировать проявление симптомов гипогликемии."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФармацевтическое взаимодействие\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Эффекты, возникающие при смешивании инсулина человека с инсулинами животного происхождения или инсулином человека, выпускаемым другими производителями, не изучались."}}]},{"id":7,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Перевод больного на другой тип инсулина или на препарат инсулина с другим торговым названием должен происходить под строгим врачебным наблюдением. Изменения активности инсулина, его типа (например, Регуляр, М3), видовой принадлежности (свиной, инсулин человека, аналог инсулина человека) или метода производства (ДНК-рекомбинантный инсулин или инсулин животного происхождения) могут привести к необходимости коррекции дозы."}},{"type":"paragraph","data":{"text":"Необходимость коррекции дозы может потребоваться уже при первом введении препарата инсулина человека после препарата инсулина животного происхождения или постепенно в течение нескольких недель или месяцев после перевода."}},{"type":"paragraph","data":{"text":"Потребность в инсулине может снизиться при недостаточной функции надпочечников, гипофиза или щитовидной железы, при почечной или печеночной недостаточности."}},{"type":"paragraph","data":{"text":"При некоторых заболеваниях или при эмоциональном напряжении потребность в инсулине может увеличиться."}},{"type":"paragraph","data":{"text":"Коррекция дозы может также потребоваться при увеличении физической нагрузки или при изменении обычной диеты."}},{"type":"paragraph","data":{"text":"Симптомы-предвестники гипогликемии на фоне введения инсулина человека у некоторых больных могут быть менее выражены или отличаться от тех, которые наблюдались у них на фоне введения инсулина животного происхождения. При нормализации уровня глюкозы в крови, например в результате интенсивной терапии инсулином, могут исчезнуть все или некоторые симптомы-предвестники гипогликемии, о чем больные должны быть проинформированы."}},{"type":"paragraph","data":{"text":"Симптомы-предвестники гипогликемии могут измениться или быть менее выраженными при длительном течении сахарного диабета, диабетической невропатии или при одновременном применении бета-адреноблокаторов."}},{"type":"paragraph","data":{"text":"В ряде случаев местные аллергические реакции могут быть вызваны причинами, не связанными с действием препарата, например раздражением кожи очищающим агентом или неправильным проведением инъекций."}},{"type":"paragraph","data":{"text":"В редких случаях развития системных аллергических реакций требуется немедленное проведение лечения. Иногда может потребоваться смена инсулина либо проведение десенсибилизации."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eВлияние на способность к управлению транспортными средствами и механизмами\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Во время гипогликемии у больного может ухудшаться способность к концентрации внимания и уменьшаться скорость психомоторных реакций. Это может представлять опасность в ситуациях, при которых эти способности особенно необходимы (вождение автомобиля или управление механизмами). Следует рекомендовать больным принимать меры предосторожности во избежание гипогликемии во время вождения автомобиля. Это особенно важно для пациентов со слабовыраженными или отсутствующими симптомами-предвестниками гипогликемии или при частом развитии гипогликемии. В таких случаях врач должен оценить целесообразность вождения пациентом автомобиля."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Препарат следует хранить в холодильнике при температуре от 2° до 8°C, не допускать замораживания, беречь от прямого воздействия света. Срок годности - 2 года."}},{"type":"paragraph","data":{"text":"Находящийся в употреблении препарат во флаконе или в картридже следует хранить при комнатной температуре (от 15° до 25°С) не более 28 дней."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Препарат отпускается по рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/manufacturer/eli_lilli/\"\u003eЭли Лилли энд Компани, США\u003c/a\u003e"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ДНК-рекомбинантный инсулин человека. Является препаратом инсулина средней продолжительности действия. Основным действием препарата является регуляция метаболизмаглюкозы. Кроме того, он обладает анаболическим действием. В мышечной и других тканях (за исключением головного мозга) инсулин вызывает быстрый внутриклеточный транспорт глюкозы и аминокислот, ускоряет анаболизм белков. Инсулин способствует преобразованию глюкозы в гликоген в печени, ингибирует глюконеогенез и стимулирует преобразование избытка глюкозы в жир. Хумулин НПХ является препаратом инсулина средней продолжительности действия. Начало действия препарата – через 1 ч после введения, максимальный эффект действия – между 2 и 8 ч, продолжительность действия – 18-20 ч. Индивидуальные различия в активности инсулина зависят от таких факторов как доза, выбор места инъекции, физическая активность больного.","substance":[{"id":762,"title":"Инсулин-изофан человеческий генно-инженерный","title_latin":null,"slug":"insulinizofan_chelovecheskiy_gennoinzhenernyy_762"},{"id":2074,"title":"Инсулин-изофан [человеческий генно-инженерный]","title_latin":"Insulinum isophanum [humanum biosyntheticum]","slug":"insulinum_isophanum_humanum_biosyntheticum"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Хумулин nph - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/15853/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/15853/share_default/"}},"diseases":[],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Похожие товары","type":"similar","products":[{"id":97684,"title":"Протафан 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