Коделак Бронхо с чабрецом Эликсир, 100 мл, 10 мг

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Уменьшает\nвязкость мокроты и способствует ее отхождению."}},{"type":"paragraph","data":{"text":"В среднем, при приеме\nвнутрь действие амброксола наступает через 30 мин, продолжительность действия –\n6–12 часов в зависимости от принятой дозы."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНатрия глицирризинат\n(тринатриевая соль глицирризиновой кислоты)\u003c/i\u003e\u003cb\u003e\u003ci\u003e \u003c/i\u003e\u003c/b\u003eобладает\nпротивовоспалительным и противовирусным действием. Оказывает цитопротекторное\nдействие благодаря антиоксидантной и мембраностабилизирующей активности.\nУсиливает действие эндогенных глюкокортикостероидов, оказывая\nпротивовоспалительное и противоаллергическое действие. 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Максимальная концентрация (С\u003csub\u003emax\u003c/sub\u003e) в плазме крови при\nпероральном приеме достигается через 1–3 ч. Объем распределения составляет 552\nл. В терапевтическом интервале концентраций связывание с белками плазмы\nсоставляет 80-90 %. Самые высокие концентрации активного компонента препарата\nнаблюдаются в легких. Амброксол проникает через плацентарный и\nгематоэнцефалический барьеры, выделяется с грудным молоком. Примерно 30 %\nпринятой пероральной дозы подвергается эффекту первичного прохождения через\nпечень. Исследования на микросомах печени человека показали, что изофермент\nCYP3A4 является преобладающей изоформой, ответственной за метаболизм амброксола\nдо дибромантраниловой кислоты. Оставшаяся часть амброксола метаболизируется в\nпечени путем конъюгации с образованием фармакологически неактивных метаболитов.\nТерминальный период полу выведения (Т\u003csub\u003e1/2\u003c/sub\u003e) амброксола из плазмы крови\nсоставляет 10 часов. Общий период полувыведения амброксола и его метаболитов\nсоставляет около 22 ч. Выводится почками: 90 % в виде метаболитов, 10 % в\nнеизмененном виде."}},{"type":"paragraph","data":{"text":"Не обнаружено клинически\nзначимого влияния возраста и пола на фармакокинетику амброксола, поэтому нет\nоснований для – подбора дозировки по этим признакам. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eНатрия глицирризинат (тринатриевая соль глицирризиновой\nкислоты).\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"После перорального\nприема, в кишечнике под влиянием фермента β-глюкуронидазы, продуцируемого\nбактериями нормальной микрофлоры, из глицирризиновой кислоты образуется\nактивный метаболит - β-глицирретовая кислота, которая всасывается в системный\nкровоток. В крови β-глицирретовая кислота связывается с альбумином и\nпрактически полностью транспортируется в печень. Выделение β-глицирретовой\nкислоты происходит преимущественно с желчью, в остаточном количестве – с мочой."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЭкстракт травы тимьяна ползучего (чабреца).\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Действие препарата\nявляется результатом совокупного действия активных веществ экстракта травы\nтимьяна ползучего (чабреца), поэтому проведение фармакокинетических\nисследований не представляется возможным; все вместе компоненты не могут быть\nпрослежены с помощью маркеров или биоисследований."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Заболевания дыхательных\nпутей с образованием вязкой мокроты: острый и хронический бронхит, пневмония,\nхроническая обструктивная болезнь легких (ХОБЛ), бронхоэктатическая болезнь."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная\nчувствительность к компонентам препарата, детский возраст до 2 лет,\nбеременность, период грудного вскармливания."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"При\nпеченочной и/или почечной недостаточности, язвенной болезни желудка и\nдвенадцатиперстной кишки, бронхиальной астме, сахарном диабете. При\nзаболеваниях печени, алкоголизме, черепно-мозговой травме, заболеваниях\nголовного мозга, детском возрасте от 2 лет."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата\nКоделак\u003csup\u003e \u003c/sup\u003eБронко с чабрецом эликсир противопоказано при беременности.\nВ случае необходимости приема препарата в период грудного вскармливания,\nкормление грудью следует прекратить."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь,\nво время приема пищи, с небольшим количеством воды."}},{"type":"paragraph","data":{"text":"Взрослым\nи детям старше 12 лет – по 10 мл 4 раза в сутки."}},{"type":"paragraph","data":{"text":"Детям\nот 2 до 6 лет назначают по 2,5 мл эликсира 3 раза в сутки, от 6 до 12 лет – по\n5 мл 3 раза в сутки."}},{"type":"paragraph","data":{"text":"Максимальная\nпродолжительность лечения без консультации врача – 5 дней."}},{"type":"paragraph","data":{"text":"Если\nв период лечения улучшения не наступает или симптомы усугубляются, или\nпоявляются новые симптомы, необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"Применяйте\nпрепарат только согласно тем показаниям, тому способу применения и в тех дозах,\nкоторые указаны в инструкции.\u003cb\u003e\u003c/b\u003e"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические\nреакции."}},{"type":"paragraph","data":{"text":"Редко\n– слабость, головная боль, диарея, сухость во рту и дыхательных путях,\nэкзантемы, ринорея, запор, дизурия. При длительном приеме в высоких дозах –\nгастралгия, тошнота, рвота."}},{"type":"paragraph","data":{"text":"Если\nу Вас отмечаются побочные эффекты, указанные в инструкции, или они\nусугубляются, или Вы заметили любые другие побочные эффекты, не указанные в\nинструкции, сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы\u003cb\u003e: \u003c/b\u003eтошнота, рвота, диарея, диспепсия."}},{"type":"paragraph","data":{"text":"Лечение: искусственная\nрвота, промывание желудка в первые 1-2 часа после приема препарата.\u003cb\u003e\u003c/b\u003e"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"header","data":{"text":"Совместное\nприменение с противокашлевыми лекарственными средствами приводит к затруднению\nотхождения мокроты.","level":4}},{"type":"paragraph","data":{"text":"При одновременном применении с амоксицикллином, цефуроксимом,\nэритромицином, доксициклином амброксол увеличивает их проникновение в\nбронхиальный секрет. "}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Не комбинировать с противокашлевыми средствами."}},{"type":"paragraph","data":{"text":"Пациентам с сахарным диабетом возможно использование\nпрепарата с учетом содержания сорбита в количестве 0,18 ХЕ в 5 мл эликсира."}},{"type":"paragraph","data":{"text":"Содержание абсолютного этилового спирта в\nмаксимальной разовой дозе препарата – 0,24\nграмма, в максимальной суточной дозе препарата – 0,96 грамм."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В\nпериод применения препарата необходимо соблюдать осторожность при выполнении\nпотенциально опасных видов деятельности, требующих повышенной концентрации\nвнимания и быстроты психомоторных реакций (управление транспортными средствами,\nработа с движущимися механизмами, работа диспетчера, оператора)."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3\nгода. Не применять по истечении срока годности.\u003cb\u003e\u003c/b\u003e"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ОАО\n\"Фармстандарт-Лексредства\", 305022, Россия, г. Курск, ул. 2-я\nАгрегатная, 1а/18, тел./факс: (4712) 34-03-13, \u003ca href=\"file:///C:/Users/tnantonova/AppData/Local/Microsoft/Windows/AppData/Local/Microsoft/Windows/Temporary%20Internet%20Files/БАРАНОВ/ИНСТРУКЦИЯ/пенталгин%20Н/Седалит,%20табл%20ппо_Изм%20№_3/Направлены%20в%20МО_11%2010%2011/www.pharmstd.ru\"\u003ewww.pharmstd.ru\u003c/a\u003e"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"Отисифарм\",\nРоссия,"}},{"type":"paragraph","data":{"text":"123112, г. Москва, ул.\nТестовская, д.10"}},{"type":"paragraph","data":{"text":"эт. 12, пом. II,\nком.29"}},{"type":"paragraph","data":{"text":"Тел.: +7 (800) 775-98-19"}},{"type":"paragraph","data":{"text":"Факс: +7 (495) 221-18-02"}},{"type":"paragraph","data":{"text":"www.otcpharm.ru\u003cb\u003e\u003c/b\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаКомбинированный препарат для лечения кашля, оказывает муколитическое и отхаркивающее действие, а также обладает противовоспалительной активностью. Действие эликсира Коделак Бронхо с чабрецом обусловлено фармакологическими свойствами его компонентов:Амброксолобладает секретомоторным, секретолитическим и отхаркивающим действием, нормализует нарушенное соотношение серозного и слизистого компонентов мокроты, увеличивает секрецию сурфактанта в альвеолах. Уменьшает вязкость мокроты и способствует ее отхождению. В среднем, при приеме внутрь действие амброксола наступает через 30 мин, продолжительность действия – 6–12 часов в зависимости от принятой дозы.Натрия глицирризинат (тринатриевая соль глицирризиновой кислоты)обладает противовоспалительным и противовирусным действием. Оказывает цитопротекторное действие благодаря антиоксидантной и мембраностабилизирующей активности. Усиливает действие эндогенных глюкокортикостероидов, оказывая противовоспалительное и противоаллергическое действие. Благодаря выраженной противовоспалительной активности, способствует уменьшению воспалительного процесса в дыхательных путях.Экстракт травы тимьяна ползучего (чабреца)содержит комплекс биологически активных веществ, обладающих отхаркивающим, противовоспалительным, противомикробным действием. Кроме того, экстракт травытимьяна ползучего (чабреца) обладает слабыми спазмолитическими и репаративными свойствами.ФармакокинетикаАмброксол.После приема внутрь амброксол быстро и практически полностью абсорбируется из желудочно-кишечного тракта. Максимальная концентрация (Сmax) в плазме крови при пероральном приеме достигается через 1–3 ч. Объем распределения составляет 552 л. В терапевтическом интервале концентраций связывание с белками плазмы составляет 80-90 %. Самые высокие концентрации активного компонента препарата наблюдаются в легких. Амброксол проникает через плацентарный и гематоэнцефалический барьеры, выделяется с грудным молоком. Примерно 30 % принятой пероральной дозы подвергается эффекту первичного прохождения через печень. Исследования на микросомах печени человека показали, что изофермент CYP3A4 является преобладающей изоформой, ответственной за метаболизм амброксола до дибромантраниловой кислоты. Оставшаяся часть амброксола метаболизируется в печени путем конъюгации с образованием фармакологически неактивных метаболитов. Терминальный период полу выведения (Т1/2) амброксола из плазмы крови составляет 10 часов. Общий период полувыведения амброксола и его метаболитов составляет около 22 ч. Выводится почками: 90 % в виде метаболитов, 10 % в неизмененном виде. Не обнаружено клинически значимого влияния возраста и пола на фармакокинетику амброксола, поэтому нет оснований для – подбора дозировки по этим признакам.Натрия глицирризинат (тринатриевая соль глицирризиновой кислоты).После перорального приема, в кишечнике под влиянием фермента β-глюкуронидазы, продуцируемого бактериями нормальной микрофлоры, из глицирризиновой кислоты образуется активный метаболит - β-глицирретовая кислота, которая всасывается в системный кровоток. В крови β-глицирретовая кислота связывается с альбумином и практически полностью транспортируется в печень. Выделение β-глицирретовой кислоты происходит преимущественно с желчью, в остаточном количестве – с мочой.Экстракт травы тимьяна ползучего (чабреца).Действие препарата является результатом совокупного действия активных веществ экстракта травы тимьяна ползучего (чабреца), поэтому проведение фармакокинетических исследований не представляется возможным; все вместе компоненты не могут быть прослежены с помощью маркеров или биоисследований.","substance":[{"id":12,"title":"Амброксол","title_latin":"Ambroxolum","slug":"ambroksol_12"},{"id":1660,"title":"Натрия глицирризинат","title_latin":"Natrii glycyrrhizinas","slug":"natriya_glitsirrizinat_1660"},{"id":1661,"title":"Тимьяна ползучего травы экстракт","title_latin":"Extractum herbae Thymi serpylli","slug":"timyana_polzuchego_travy_ekstrakt_1661"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Коделак Бронхо с чабрецом - фото 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