Противопротозойное средство, оказывает также иммунодепрессивное и противовоспалительное действие. Вызывает гибель бесполых эритроцитарных форм всех видов плазмодиев. Оказывает гаметоцидное действие, за исключением Plasmodium falciparum (проявляет антигаметоцидное действие).
Показания к применению
Малярия (профилактика и лечение всех видов)
Внекишечный амебиаз
Амебный абсцесс печени
Системная красная волчанка (хроническая и подострая формы)
Ревматоидный артрит
Склеродермия
Фотодерматоз
Противопоказания
Гиперчувствительность
Печеночная недостаточность
Почечная недостаточность
Угнетение костномозгового кроветворения
Тяжелые нарушения ритма
Псориатический артрит
Нейтропения
Порфиринурия
Беременность
Лактация
С осторожностью - дефицит глюкозо-6-фосфатдегидрогеназы, ретинопатия, эпилепсия.
Применение при беременности и в период грудного вскармливания
Препарат противопоказан при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
Внутрь, для профилактики малярии - по 0.5 г в первую неделю 2 раза, затем 1 раз всегда в один и тот же день недели.; Лечение малярии проводят по следующей схеме: 1 день однократно 1 г, через 6-8 ч - 0.5 г, на 2 и 3 день лечения - по 0.75 г ежедневно в один прием.; При амебиазе - по 0.5 г 3 раза/сут в течение 7 дней, затем - по 0.25 г 3 раза/сут в течение еще 7 дней, в дальнейшем - по 0.75 г 2 раза в неделю в течение 2-6 мес.; При ревматоидном артрите - по 0.5 г 2 раза/сут в течение 7 дней, затем - по 0.5 г ежедневно в течение 12 мес.; При системной красной волчанке - ежедневно, по 0.25-0.5 г.; При фотодерматозе - по 0.25 г ежедневно в течение недели, затем - по 0.5-0.75 г еженедельно.
Побочное действие
Со стороны пищеварительной системы: тошнота, рвота, гастралгия.; Со стороны нервной системы: головокружение, головная боль, нарушения сна, психозы, эпилептические припадки.; Со стороны сердечно-сосудистой системы: поражение миокарда с изменениями на ЭКГ, снижение АД.; Со стороны органов чувств: при длительном применении - помутнение роговицы, поражение сетчатки, нарушение зрения, звон в ушах.; Аллергические реакции: дерматит, фотосенсибилизация.; Прочие: миалгия, лейкопения, изменение цвета кожи и волос.
Передозировка
Симптомы: рвота, нарушение сознания, расстройство зрения, судороги, коллапс, угнетение дыхательного центра, вплоть до смертельного исхода (в течение 2 ч с момента угнетения дыхания).; Лечение: вызов рвоты, промывание желудка, прием внутрь активированного угля в дозе, в 5 раз превышающей предполагаемую дозу хлорохина; перитонеальный диализ, плазмаферез.
Особые указания
Во время лечения необходимы систематические осмотры окулиста и проведение общих анализов крови.
Для описания товара использована информация от партнера 36.6
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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