Не рекомендуется принимать препарат при чувствительности или непереносимости Пиридоксина.
Инструкция
Регистрационный номер
ЛС-001903
Лекарственная форма
раствор для инъекций
Состав
Активное вещество:
пиридоксина гидрохлорид;
Вспомогательное вещество:
вода для инъекций.
Фармакологические свойства
Препарат обладает действием, восполняющим дефицит витамина B6.
Как известно, витамин B6 является незаменимым участником обменных процессов, нормализует и поддерживает деятельность нервной системы. Фосфорилированная форма пиридоксина представляет собой кофермент значительного числа ферментов, которые влияют на неокислительный обмен аминокислот, например, декарбоксилирование или переаминирование.
Данный компонент необходим для обменных процессов триптофана, цистеина, глутаминовой, метионина и прочих аминокислот. Важен он и для обмена гистамина, и для нормализации липидного обмена.
Метаболизм основного вещества происходит в печени, в результате чего образуются фармакологически активные метаболиты: пиридоксальфосфат и пиридоксаминофосфат. Распределяются компоненты в основном в мышечных тканях, а также в печени и нервной системе. Отмечено проникновение препарата в грудное молоко и сквозь плаценту. Вещество выводится с почками, часть – с желчью.
Показания к применению
Препарат используется для лечения и профилактики дефицита витамина B6 при:
B6-гиповитаминозе;
токсикозе беременных;
сидеробластной анемии;
лейкопении;
заболеваниях нервной системы;
морской и воздушной болезни;
атеросклерозе;
сахарном диабете;
дерматитах;
опоясывающем герпесе;
нейродермите;
псориазе;
экссудативном диатезе и так далее.
Противопоказания
Не рекомендуется принимать препарат при чувствительности или непереносимости Пиридоксина.
Применение при беременности и в период грудного вскармливания
При беременности следует применять только после консультации с врачом, в тех случаях, когда предполагаемая польза для матери превышает потенциальный риск для плода.
При необходимости применения в период лактации следует решить вопрос о прекращении грудного вскармливания.
Длительное использование пиридоксина в высоких дозах в период беременности и в период грудного вскармливания может приводить к развитию у детей пиридоксиновой зависимости. Не рекомендуется превышать нормы физиологической потребности в пиридоксине в период беременности (2 мг/сут).
Особые указания
При тяжелых поражениях печени пиридоксин в высоких дозах может вызвать ухудшение ее функции.
При определении уробилиногена с помощью реагента Эрлиха пиридоксин может искажать результаты.
Лекарственное взаимодействие
При одновременном применении с гормональными контрацептивами возможно повышение концентрации пиридоксина в плазме крови.
При одновременном применении пиридоксин потенцирует действие диуретиков.
При одновременном применении с леводопой уменьшаются или полностью угнетаются эффекты леводопы.
При одновременном применении с изоникотингидразидом, пеницилламином, циклосерином возможно уменьшение эффективности пиридоксина.
При одновременном применении с фенитоином, фенобарбиталом возможно уменьшение концентраций в плазме крови фенитоина и фенобарбитала.
Пиридоксин можно применять в сочетании с сердечными гликозидами (пиридоксин способствует повышению синтеза сократительных белков в миокарде), с глутаминовой кислотой, а также калия и магния аспарагинатом.
Пиридоксин предупреждает или уменьшает токсические проявления, в т.ч. поражения печени, наблюдающиеся при применении изониазида и других противотуберкулезных препаратов.
Фармацевтически несовместим с тиамином (B1) и цианокобаламином (В12).
Одновременное применение пиридоксина с циклосерином, этионамидом, гидралазином, азатиоприном, хлорамбуцилом, кортикотропином, циклофосфамидом, циклоспорином, меркаптопурином, изониазидом, пеницилламином может вызвать анемию и невропатию.
Витамины в ампулах, как и Пиридоксин-Виал, инструкция по применению указывает использовать в суточной дозировке 50-150 мг.
Допускается подкожное, внутримышечное или внутривенное введение.
Длительность терапии определяют тяжестью и видом нарушения. При профилактике недостатка витамина B6 в сутки назначается около 40 мг.
Побочное действие
Во время лечения возможно развитие аллергических реакций, гиперсекреции соляной кислоты.
Передозировка
В клинической практике случаев передозировки не установлено.
Взаимодействие с другими лекарственными средствами
Одновременное применение с изониазидом, циклосерином, пеницилламином снижает эффективность пиридоксина. Отмечена фармацевтическая несовместимость витамина В6 с B1 иB12. Данный препарат значительно понижает противопаркинсоническую активность леводопы.
Сочетание с гормональными контрацептивами способно повысить концентрацию пиридоксина в составе плазмы крови. Применение с фенитоином и фенобарбиталом может уменьшить концентрацию в составе плазмы крови этих компонентов.
Особые указания
Требуется проявлять осторожность при назначении этого препарата пациентам, страдающимязвенной болезнью желудка и 12-пёрстной кишки, ишемии сердца.
Приём высоких доз пиридоксина при тяжёлых поражениях печени может ухудшить её работу.
Форма выпуска
Раствор для инъекций
Условия хранения
в сухом, защищенном от света месте, при температуре не выше 25 °C.
Срок годности
36 месяцев
Условия отпуска
По рецепту
Производитель
Производитель
ООО «Озон»
Юридический адрес: 445351, Россия, г. Жигулевск, Самарская обл., ул. Песочная, 11.
Адрес для переписки (фактический адрес, в том числе для приема претензий):
445351, Россия, г. Жигулевск, Самарская обл., ул. Гидростроителей, 6.
Для описания товара использована информация от партнера 36.6
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Вещество выводится с почками, часть – с желчью."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Препарат используется для лечения и профилактики дефицита витамина B6 при:"}},{"type":"list","data":{"style":"ordered","items":["B6-гиповитаминозе;","токсикозе беременных;","сидеробластной анемии;","лейкопении;","заболеваниях нервной системы;","морской и воздушной болезни;","атеросклерозе;","сахарном диабете;","дерматитах;","опоясывающем герпесе;","нейродермите;","псориазе;","экссудативном диатезе и так далее."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Не рекомендуется принимать препарат при чувствительности или непереносимости Пиридоксина."}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"При беременности следует применять только после консультации с врачом, в тех случаях, когда предполагаемая польза для матери превышает потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"При необходимости применения в период лактации следует решить вопрос о прекращении грудного вскармливания."}},{"type":"paragraph","data":{"text":"Длительное использование пиридоксина в высоких дозах в период беременности и в период грудного вскармливания может приводить к развитию у детей пиридоксиновой зависимости. Не рекомендуется превышать нормы физиологической потребности в пиридоксине в период беременности (2 мг/сут)."}},{"type":"paragraph","data":{"text":"Особые указания"}},{"type":"paragraph","data":{"text":"При тяжелых поражениях печени пиридоксин в высоких дозах может вызвать ухудшение ее функции."}},{"type":"paragraph","data":{"text":"При определении уробилиногена с помощью реагента Эрлиха пиридоксин может искажать результаты."}},{"type":"paragraph","data":{"text":"Лекарственное взаимодействие"}},{"type":"paragraph","data":{"text":"При одновременном применении с гормональными контрацептивами возможно повышение концентрации пиридоксина в плазме крови."}},{"type":"paragraph","data":{"text":"При одновременном применении пиридоксин потенцирует действие диуретиков."}},{"type":"paragraph","data":{"text":"При одновременном применении с леводопой уменьшаются или полностью угнетаются эффекты леводопы."}},{"type":"paragraph","data":{"text":"При одновременном применении с изоникотингидразидом, пеницилламином, циклосерином возможно уменьшение эффективности пиридоксина."}},{"type":"paragraph","data":{"text":"При одновременном применении с фенитоином, фенобарбиталом возможно уменьшение концентраций в плазме крови фенитоина и фенобарбитала."}},{"type":"paragraph","data":{"text":"Пиридоксин можно применять в сочетании с сердечными гликозидами (пиридоксин способствует повышению синтеза сократительных белков в миокарде), с глутаминовой кислотой, а также калия и магния аспарагинатом."}},{"type":"paragraph","data":{"text":"Пиридоксин предупреждает или уменьшает токсические проявления, в т.ч. поражения печени, наблюдающиеся при применении изониазида и других противотуберкулезных препаратов."}},{"type":"paragraph","data":{"text":"Фармацевтически несовместим с тиамином (B\u003csub\u003e1\u003c/sub\u003e) и цианокобаламином (В\u003csub\u003e12\u003c/sub\u003e)."}},{"type":"paragraph","data":{"text":"Одновременное применение пиридоксина с циклосерином, этионамидом, гидралазином, азатиоприном, хлорамбуцилом, кортикотропином, циклофосфамидом, циклоспорином, меркаптопурином, изониазидом, пеницилламином может вызвать анемию и невропатию."}},{"type":"paragraph","data":{"text":"Аналоги\u003ca href=\"https://yandex.ru/health/apteki/product/97660\" target=\"_blank\"\u003eПиридоксин, раствор для инъекций\u003c/a\u003e29–48 ₽\u003ca href=\"https://yandex.ru/health/apteki/product/97696\" target=\"_blank\"\u003eПиридоксин-Виал, раствор для инъекций\u003c/a\u003eНет в наличии\u003ca href=\"https://yandex.ru/health/apteki/product/97697\" target=\"_blank\"\u003eПиридоксин-СОЛОфарм, раствор для инъекций\u003c/a\u003eНет в наличии"}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Витамины в ампулах, как и Пиридоксин-Виал, инструкция по применению указывает использовать в суточной дозировке 50-150 мг."}},{"type":"paragraph","data":{"text":"Допускается подкожное, внутримышечное или внутривенное введение."}},{"type":"paragraph","data":{"text":"Длительность терапии определяют тяжестью и видом нарушения. 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