Артериальная гипертензия (в комбинации с другими антигипертензивными средствами: тиазидные диуретики, бета-адреноблокаторы, блокаторы медленных кальциевых каналов или ингибиторы АПФ)
Доброкачественная гиперплазия предстательной железы (как при наличии артериальной гипертензии, так и при нормальном АД)
Противопоказания
Возраст до 18 лет (эффективность и безопасность не установлены)
Повышенная чувствительность к доксазозину, производным хиназолона или другим компонентам препарата
С осторожностью следует применять препарат при аортальном и митральном стенозах, ортостатической гипотензии, нарушениях функции печени.
Селективный конкурентный блокатор постсинаптических 1-адренорецепторов. За счет снижения тонуса мышц сосудов доксазозин уменьшает ОПСС, что приводит к снижению АД.; После однократного приема препарата максимальное снижение АД отмечается в течение 2-6 ч. Гипотензивный эффект сохраняется в течение 24 ч.; В период лечения препаратом Артезин; у больных артериальной гипертензией отсутствуют различия величин АД в положении стоя и лежа. Эффективен при артериальной гипертензии, в т.ч. сопровождающейся метаболическими нарушениями (ожирение, снижение толерантности к глюкозе). Снижает риск развития ИБС.; Применение препарата у пациентов с нормальным АД не сопровождается снижением АД.; При длительном применении Артезина у больных не наблюдается снижения антигипертензивного эффекта.; В период лечения Артезином наблюдается снижение уровня триглицеридов и общего холестерина в плазме крови. Одновременно отмечается рост (на 4-13%) коэффициента ЛПВП/общий холестерин.; При длительном применении препарата наблюдается регрессия гипертрофии левого желудочка, подавление агрегации тромбоцитов и повышение содержания в тканях активного плазминогена.; В связи с тем, что доксазозин блокирует 1-адренорецепторы, расположенные в строме и капсуле предстательной железы и в шейке мочевого пузыря, происходит снижение сопротивления и давления в мочеиспускательном канале, уменьшение сопротивления внутреннего сфинктера, что в свою очередь приводит к значительному улучшению показателей уродинамики и уменьшению симптомов доброкачественной гиперплазии предстательной железы. Препарат эффективен у 66-71% больных, стабильный клинический эффект развивается через 1-2 недели лечения, максимальное действие – через 14 недель. Эффект сохраняется в течение длительного времени.
Показания к применению
Артериальная гипертензия (в комбинации с другими антигипертензивными средствами: тиазидные диуретики, бета-адреноблокаторы, блокаторы медленных кальциевых каналов или ингибиторы АПФ)
Доброкачественная гиперплазия предстательной железы (как при наличии артериальной гипертензии, так и при нормальном АД)
Противопоказания
Возраст до 18 лет (эффективность и безопасность не установлены)
Повышенная чувствительность к доксазозину, производным хиназолона или другим компонентам препарата
С осторожностью следует применять препарат при аортальном и митральном стенозах, ортостатической гипотензии, нарушениях функции печени.
Применение при беременности и в период грудного вскармливания
До настоящего времени опыта применения препарата Артезин; при беременности и в период грудного вскармливания у больных с артериальной гипертензией недостаточно. Поэтому, несмотря на отсутствие тератогенного и эмбриотоксического эффектов по данным экспериментальных исследований, Артезин; можно назначать при беременности и в период грудного вскармливания только после тщательной оценки ожидаемой пользы терапии для матери и возможного риска для плода или грудного ребенка.
Способ применения и дозы
Препарат назначают внутрь 1 раз/сут (утром или вечером), независимо от приема пищи, не разжевывая и запивая достаточным количеством воды.; При артериальной гипертензии начальная суточная доза составляет 1 мг перед сном.; После приема первой дозы пациент должен находиться в постели в течение 6-8 ч. Это необходимо в связи с возможностью развития "феномена первой дозы", особенно на фоне предшествующего приема диуретиков.; При недостаточности терапевтического эффекта через 1-2 недели суточную дозу можно увеличить до 2 мг. В последующем через каждые 1-2 недели можно увеличивать дозу на 2 мг. У большинства больных оптимальный терапевтический эффект достигается при суточной дозе 8 мг. Максимальная суточная доза – 16 мг.; После достижения стойкого терапевтического эффекта дозу обычно снижают (средняя терапевтическая доза при поддерживающей терапии обычно равна 2-4 мг/сут).; При доброкачественной гиперплазии предстательной железы Артезин; назначают в начальной дозе 1 мг/сут для того, чтобы свести к минимуму возможность развития ортостатической гипотензии и/или обморока. При необходимости, в зависимости от показателей уродинамики и наличия симптомов ДГПЖ дозу увеличивают (с интервалом 1-2 недели) до 2-4 мг/сут. Максимальная суточная доза - 8 мг. Рекомендуемая поддерживающая доза - 2-4 мг/сут.; Препарат применяют длительно. Продолжительность лечения определяется лечащим врачом.
Побочное действие
Артериальная гипертензия; В клинических исследованиях наиболее часто наблюдалась, особенно в начале лечения, ортостатическая гипотензия, которая в редких случаях может привести к обмороку.; Со стороны сердечно-сосудистой системы: периферические отеки, обморок.; Со стороны ЦНС и периферической нервной системы: головокружение, головная боль, сонливость.; Со стороны пищеварительной системы: тошнота.; Со стороны дыхательной системы: ринит.; Аллергические реакции: кожная сыпь, крапивница.; Общие реакции: астения, утомляемость, недомогание.; Также отмечались следующие побочные эффекты у пациентов с артериальной гипертензией (причинно-следственная связь с приемом препарата не установлена): брадикардия, тахикардия, ощущение сердцебиения, боль в груди, стенокардия, инфаркт миокарда, нарушение мозгового кровообращения, аритмия.; Доброкачественная гиперплазия предстательной железы; У пациентов с доброкачественной гиперплазией предстательной железы те же побочные эффекты, что и у больных с артериальной гипертензией, а также: Со стороны сердечно-сосудистой системы: снижение АД, ортостатическая гипертензия.; Со стороны ЦНС и периферической нервной системы: сухость во рту, приапизм, гипестезия, парестезии, тремор, импотенция, бессонница, повышенная возбудимость.; Со стороны эндокринной системы: гинекомастия.; Со стороны пищеварительной системы: боли в животе, запор, диарея, диспепсия, метеоризм, потеря аппетита, тошнота, повышение активности печеночных трансаминаз, холестаз, желтуха, гепатит.; Со стороны органов кроветворения: лейкопения, пурпура, тромбоцитопения.; Со стороны костно-мышечной системы: артралгия, мышечные судороги, слабость в мышцах, миалгия.; Со стороны дыхательной системы: бронхоспазм, кашель, одышка, носовое кровотечение.; Дерматологические реакции: алопеция.; Со стороны органов чувств: нечеткость зрительного восприятия, шум в ушах.; Со стороны мочевыделительной системы: дизурия, гематурия, нарушение мочеиспускания, никтурия, полиурия, недержание мочи.; Аллергические реакции: кожная сыпь, крапивница.; Прочие: боль в спине, ощущение жара (приливы крови в коже лица), увеличение массы тела.
Передозировка
Симптомы: выраженное снижение АД, иногда сопровождающееся обмороками.; Лечение: больному необходимо придать горизонтальное положение с приподнятыми ногами. Проводят симптоматическую терапию. Гемодиализ неэффективен.
Особые указания
Особую осторожность следует проявлять при назначении препарата больным с нарушением функции печени, особенно в тех случаях, когда одновременно применяются препараты, способные отрицательно повлиять на функцию печени. В случаях ухудшения показателей функционального состояния печени препарат следует отменить.; С целью предотвращения ортостатических реакций больные должны избегать неожиданных и резких смен положения тела (переход из положения лежа в положение стоя).; Следует соблюдать осторожность при одновременном применении с ингибиторами фосфодиэстеразы (средства для лечения эректильной дисфункции), поскольку у некоторых пациентов это может привести к симптоматической гипотензии.; Эффект "первой дозы" особенно выражен на фоне предшествующей терапии диуретиками и диеты с ограничением натрия.; Перед началом терапии необходимо исключить злокачественные опухоли предстательной железы.; Влияние на способность к вождению автотранспорта и управлению механизмами; В связи с тем, что препарат способен вызывать ортостатические реакции в начале лечения или в период повышения доз, больным целесообразно воздерживаться от всех потенциально опасных видов деятельности, в частности от управления автотранспортом и другими транспортными средствами и механизмами. Прием алкоголя способен усиливать нежелательные реакции.
Форма выпуска
Таблетки.
Условия хранения
В сухом, защищенном от света месте, при температуре не выше 25 °C.
Срок годности
4 года. Не использовать по истечении срока годности, указанного на упаковке.
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мезилат 2.44 мг,; в пересчете на доксазозин 2 мг; Вспомогательные вещества: крахмал картофельный, лактоза, целлюлоза микрокристаллическая, повидон, кремния диоксид коллоидный (аэросил), натрия лаурилсульфат (натрия додецилсульфат), магния стеарат."}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Селективный конкурентный блокатор постсинаптических 1-адренорецепторов. За счет снижения тонуса мышц сосудов доксазозин уменьшает ОПСС, что приводит к снижению АД.; После однократного приема препарата максимальное снижение АД отмечается в течение 2-6 ч. Гипотензивный эффект сохраняется в течение 24 ч.; В период лечения препаратом Артезин; у больных артериальной гипертензией отсутствуют различия величин АД в положении стоя и лежа. Эффективен при артериальной гипертензии, в т.ч. сопровождающейся метаболическими нарушениями (ожирение, снижение толерантности к глюкозе). Снижает риск развития ИБС.; Применение препарата у пациентов с нормальным АД не сопровождается снижением АД.; При длительном применении Артезина у больных не наблюдается снижения антигипертензивного эффекта.; В период лечения Артезином наблюдается снижение уровня триглицеридов и общего холестерина в плазме крови. Одновременно отмечается рост (на 4-13%) коэффициента ЛПВП/общий холестерин.; При длительном применении препарата наблюдается регрессия гипертрофии левого желудочка, подавление агрегации тромбоцитов и повышение содержания в тканях активного плазминогена.; В связи с тем, что доксазозин блокирует 1-адренорецепторы, расположенные в строме и капсуле предстательной железы и в шейке мочевого пузыря, происходит снижение сопротивления и давления в мочеиспускательном канале, уменьшение сопротивления внутреннего сфинктера, что в свою очередь приводит к значительному улучшению показателей уродинамики и уменьшению симптомов доброкачественной гиперплазии предстательной железы. Препарат эффективен у 66-71% больных, стабильный клинический эффект развивается через 1-2 недели лечения, максимальное действие – через 14 недель. Эффект сохраняется в течение длительного времени."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Артериальная гипертензия (в комбинации с другими антигипертензивными средствами: тиазидные диуретики, бета-адреноблокаторы, блокаторы медленных кальциевых каналов или ингибиторы АПФ)","Доброкачественная гиперплазия предстательной железы (как при наличии артериальной гипертензии, так и при нормальном АД)"]}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Возраст до 18 лет (эффективность и безопасность не установлены)","Повышенная чувствительность к доксазозину, производным хиназолона или другим компонентам препарата"]}},{"type":"paragraph","data":{"text":"С осторожностью следует применять препарат при аортальном и митральном стенозах, ортостатической гипотензии, нарушениях функции печени."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"До настоящего времени опыта применения препарата Артезин; при беременности и в период грудного вскармливания у больных с артериальной гипертензией недостаточно. Поэтому, несмотря на отсутствие тератогенного и эмбриотоксического эффектов по данным экспериментальных исследований, Артезин; можно назначать при беременности и в период грудного вскармливания только после тщательной оценки ожидаемой пользы терапии для матери и возможного риска для плода или грудного ребенка."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат назначают внутрь 1 раз/сут (утром или вечером), независимо от приема пищи, не разжевывая и запивая достаточным количеством воды.; При артериальной гипертензии начальная суточная доза составляет 1 мг перед сном.; После приема первой дозы пациент должен находиться в постели в течение 6-8 ч. Это необходимо в связи с возможностью развития \"феномена первой дозы\", особенно на фоне предшествующего приема диуретиков.; При недостаточности терапевтического эффекта через 1-2 недели суточную дозу можно увеличить до 2 мг. В последующем через каждые 1-2 недели можно увеличивать дозу на 2 мг. У большинства больных оптимальный терапевтический эффект достигается при суточной дозе 8 мг. Максимальная суточная доза – 16 мг.; После достижения стойкого терапевтического эффекта дозу обычно снижают (средняя терапевтическая доза при поддерживающей терапии обычно равна 2-4 мг/сут).; При доброкачественной гиперплазии предстательной железы Артезин; назначают в начальной дозе 1 мг/сут для того, чтобы свести к минимуму возможность развития ортостатической гипотензии и/или обморока. При необходимости, в зависимости от показателей уродинамики и наличия симптомов ДГПЖ дозу увеличивают (с интервалом 1-2 недели) до 2-4 мг/сут. Максимальная суточная доза - 8 мг. Рекомендуемая поддерживающая доза - 2-4 мг/сут.; Препарат применяют длительно. Продолжительность лечения определяется лечащим врачом."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Артериальная гипертензия; В клинических исследованиях наиболее часто наблюдалась, особенно в начале лечения, ортостатическая гипотензия, которая в редких случаях может привести к обмороку.; Со стороны сердечно-сосудистой системы: периферические отеки, обморок.; Со стороны ЦНС и периферической нервной системы: головокружение, головная боль, сонливость.; Со стороны пищеварительной системы: тошнота.; Со стороны дыхательной системы: ринит.; Аллергические реакции: кожная сыпь, крапивница.; Общие реакции: астения, утомляемость, недомогание.; Также отмечались следующие побочные эффекты у пациентов с артериальной гипертензией (причинно-следственная связь с приемом препарата не установлена): брадикардия, тахикардия, ощущение сердцебиения, боль в груди, стенокардия, инфаркт миокарда, нарушение мозгового кровообращения, аритмия.; Доброкачественная гиперплазия предстательной железы; У пациентов с доброкачественной гиперплазией предстательной железы те же побочные эффекты, что и у больных с артериальной гипертензией, а также: Со стороны сердечно-сосудистой системы: снижение АД, ортостатическая гипертензия.; Со стороны ЦНС и периферической нервной системы: сухость во рту, приапизм, гипестезия, парестезии, тремор, импотенция, бессонница, повышенная возбудимость.; Со стороны эндокринной системы: гинекомастия.; Со стороны пищеварительной системы: боли в животе, запор, диарея, диспепсия, метеоризм, потеря аппетита, тошнота, повышение активности печеночных трансаминаз, холестаз, желтуха, гепатит.; Со стороны органов кроветворения: лейкопения, пурпура, тромбоцитопения.; Со стороны костно-мышечной системы: артралгия, мышечные судороги, слабость в мышцах, миалгия.; Со стороны дыхательной системы: бронхоспазм, кашель, одышка, носовое кровотечение.; Дерматологические реакции: алопеция.; Со стороны органов чувств: нечеткость зрительного восприятия, шум в ушах.; Со стороны мочевыделительной системы: дизурия, гематурия, нарушение мочеиспускания, никтурия, полиурия, недержание мочи.; Аллергические реакции: кожная сыпь, крапивница.; Прочие: боль в спине, ощущение жара (приливы крови в коже лица), увеличение массы тела."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: выраженное снижение АД, иногда сопровождающееся обмороками.; Лечение: больному необходимо придать горизонтальное положение с приподнятыми ногами. Проводят симптоматическую терапию. Гемодиализ неэффективен."}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Особую осторожность следует проявлять при назначении препарата больным с нарушением функции печени, особенно в тех случаях, когда одновременно применяются препараты, способные отрицательно повлиять на функцию печени. В случаях ухудшения показателей функционального состояния печени препарат следует отменить.; С целью предотвращения ортостатических реакций больные должны избегать неожиданных и резких смен положения тела (переход из положения лежа в положение стоя).; Следует соблюдать осторожность при одновременном применении с ингибиторами фосфодиэстеразы (средства для лечения эректильной дисфункции), поскольку у некоторых пациентов это может привести к симптоматической гипотензии.; Эффект \"первой дозы\" особенно выражен на фоне предшествующей терапии диуретиками и диеты с ограничением натрия.; Перед началом терапии необходимо исключить злокачественные опухоли предстательной железы.; Влияние на способность к вождению автотранспорта и управлению механизмами; В связи с тем, что препарат способен вызывать ортостатические реакции в начале лечения или в период повышения доз, больным целесообразно воздерживаться от всех потенциально опасных видов деятельности, в частности от управления автотранспортом и другими транспортными средствами и механизмами. Прием алкоголя способен усиливать нежелательные реакции."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте, при температуре не выше 25 °C."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"4 года. 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