Генитальные инфекции, вызванные дрожжеподобными грибами рода Candida (кандидозный вульвовагинит).
В случае необходимости, пожалуйста, проконсультируйтесь с врачом перед применением лекарственного препарата.
Противопоказания
Повышенная чувствительность к клотримазолу или другим компонентам препарата, особенно к цетостеариловому спирту; - период менструации; - I триместр беременности.
Клотримазол является противогрибковым средством широкого спектра действия для местного применения. Антимикотический эффект активного действующего вещества клотримазола (производное имидазола) связан с нарушением синтеза эргостерина, входящего в состав клеточной мембраны грибов, что изменяет проницаемость мембраны и вызывает последующий лизис клетки. В малых концентрациях действует фунгистатически, а в больших фунгицидно, причем не только на пролиферирующие клетки. В фунгицидных концентрациях взаимодействует с митохондриальными и пероксидазными ферментами, в результате чего происходит увеличение концентрации перекиси водорода до токсического уровня, что также способствует разрушению грибковых клеток.
Эффективен в отношении дерматофитов, дрожжеподобных, плесневых грибов и простейших. Оказывает антимикробное действие в отношении грамположительных (Streptococcus spp., Staphylococcus spp.) и анаэробов (Bacteroides spp., Gardnerella vaginalis). Клотримазол не оказывает влияние на лактобацилы. In vitro в концентрации 0,5-10 мкг/мл клотримазол подавляет размножение бактерий семейства Corinebacteria и грамположительных кокков (за исключением энтерококков); оказывает трихомонацидное действие в концентрации 100 мкг/мл.
Фармакокинетика
При применении клотримазола интравагинально абсорбция составляет 3 – 10 % введен-
ной дозы. Высокие концентрации в вагинальном секрете и низкие концентрации в крови Falz сохраняются в течение 48 – 72 ч. В печени метаболизируется до неактивных метаболитов, выводимых из организма почками и через кишечник.
Показания к применению
Генитальные инфекции, вызванные дрожжеподобными грибами рода Candida (кандидозный вульвовагинит).
В случае необходимости, пожалуйста, проконсультируйтесь с врачом перед применением лекарственного препарата.
Противопоказания
Повышенная чувствительность к клотримазолу или другим компонентам препарата, особенно к цетостеариловому спирту; - период менструации; - I триместр беременности.
С осторожностью
Период грудного вскармливания.
Применение при беременности и в период грудного вскармливания
Применение в I триместре беременности противопоказано. Вопрос о целесообразности применения препарата во II-III триместрах беременности должен решаться индивидуально после консультации врача.
Применение препарата в период грудного вскармливания допускается только в случае, если, по мнению врача, потенциальная польза от применения крема для матери превышает возможный риск для ребенка.
Способ применения и дозы
Местно. Только для интравагинального применения.
В течение 6 последовательных дней, один раз в сутки вечером перед сном вводить содержимое заполненного аппликатора (примерно 5 г) как можно глубже во влагалище, в положении лежа на спине, со слегка согнутыми ногами.
Применение крема вагинального при помощи одноразового аппликатора:
1. Открыть тубу и прикрутить одноразовый аппликатор.
2. Осторожно сжимая тубу, заполнить одноразовый аппликатор, пока поршень не выдавится полностью.
3. Открутить аппликатор от тубы. Вставить аппликатор как можно глубже во влагалище (желательно в положении лежа на спине) и выдавить содержимое аппликатора, нажав на поршень.
4. Извлечь одноразовый аппликатор после использования и выбросить.
Применяйте препарат только согласно тому способу применения и в тех дозах, которые указаны в инструкции по применению.
Повторный курс лечения возможен после консультации с лечащим врачом.
Если после лечения улучшения не наступает или появляются новые симптомы, необходимо проконсультироваться с врачом.
Побочное действие
По данным Всемирной организации здравоохранения (ВОЗ) нежелательные эффекты классифицированы в соответствии с их частотой развития следующим образом: очень часто (≥ 1/10), часто (≥ 1/100, <1/10), нечасто (≥ 1/1000, <1/100), редко (≥ 1/10000, <1/1000) и очень редко (< 1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).
Нарушения со стороны иммунной системы:
частота неизвестна: аллергические реакции с такими симптомами, как крапивница, обмороки, артериальная гипотензия, одышка.
Нарушения со стороны желудочно-кишечного тракта:
частота неизвестна: боль в животе.
Нарушения со стороны кожи и подкожных тканей:
частота неизвестна: в случае повышенной чувствительности к активному веществу или другому компоненту препарата, такому как цетостеариловый спирт, могут возникнуть аллергические реакции.
Нарушения со стороны почек и мочевыводящих путей: частота неизвестна: учащенное мочеиспускание, интеркуррентный цистит.
Нарушения со стороны половых органов:
частота неизвестна: зуд, жжение, гиперемия и отек слизистой оболочки влагалища, изъязвления слизистой оболочки влагалища, сыпь, боль в области малого таза.
Прочие:
частота неизвестна: головная боль, гастралгия.
Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты не указанные в инструкции, сообщите об этом врачу.
Передозировка
При передозировке возможны следующие симптомы: головокружение, тошнота, рвота. Лечение. Специфического антидота нет. При случайном приеме внутрь следует проводить симптоматическое лечение.
Взаимодействие с другими лекарственными средствами
При вагинальном введении клотримазол снижает активность амфотерицина В и других полиеновых антибиотиков.
При одновременном применении с натамицином и нистатином активность клотримазола может снижаться.
Одновременное применение клотримазола интравагинально и такролимуса, сиролимуса перорально может приводить к повышению концентрации последних в плазме крови, поэтому следует наблюдать за пациентками на предмет развития симптомов их передозировки, при необходимости с измерением концентраций в плазме крови.
Особые указания
Внимательно прочтите инструкцию по применению перед тем, как начать применение препарата. Сохраните инструкцию, она может понадобиться вновь. Если у Вас возникли вопросы, обратитесь к врачу.
Лекарственное средство, которым Вы лечитесь предназначено лично Вам, и его не следует передавать другим лицам, поскольку оно может причинить им вред даже при наличии тех же симптомов, что и у Вас.
При появлении аллергических реакций или раздражения в месте введения препарата лечение прекращают.
Препарат нельзя применять во время менструации, лечение целесообразно начинать после менструации.
При одновременной инфекции половых губ и прилегающих участков (кандидозный вульвит) следует дополнительно проводить местное лечение препаратом клотримазол.
В период беременности лечение вагинальным кремом проводят без аппликатора. Для предотвращения инфицирования необходимо одновременное лечение половых партнеров.
В период лечения рекомендуется воздерживаться от половых контактов.
Во время лечения рекомендуется пользоваться средствами контрацепции. Риск разрыва презерватива или диафрагмы увеличивается при их одновременном использовании с применением препарата. Необходимо использовать надежные методы контрацепции.
Для предотвращения реинфицирования следует соблюдать правила гигиены. Если клинические признаки инфекции сохраняются после завершения лечения, следует провести повторное микробиологическое исследование с целью подтверждения диагноза.
Влияние на способность управлять автомобилем и движущимися механизмами
Препарат не оказывает влияния на способность управлять транспортными средствами и заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Крем вагинальный 2 %.
По 20 г в тубы алюминиевые. Тубу вместе с одноразовыми аппликаторами (3 шт.) для интравагинального введения и инструкцией по применению помещают в пачку картонную.
Условия хранения
При температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Не использовать по истечении срока годности.
Условия отпуска
Отпускают без рецепта.
Производитель
Фарма Вернигероде ГмбХ,
Дорнбергсвег 35, 38855 Вернигероде, Германия.
Организация, принимающая претензии потребителей
115114, г. Москва, ул. Летниковская, д. 16, 6 этаж, комн. 21/1, 23-27 тел.: +7 (499) 579 33 70 факс: +7 (499) 579 33 71 e-mail: info@esparma-gmbh.ru
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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препарата","slug":"","body":[{"type":"paragraph","data":{"text":"Клотримазол"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"Крем вагинальный."}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"100 г крема содержат:"}},{"type":"paragraph","data":{"text":"Действующее вещество: клотримазол - 2,0 г;"}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: сорбитана стеарат - 2,0 г, цетилпальмитат – 3,0 г, цетостеариловый спирт [цетиловый спирт 60 % и стеариловый спирт 40 %] – 10,0 г, полисорбат-60 – 1,5 г, октилдодеканол – 13,5 г, бензиловый спирт – 1,0 г, вода очищенная – 67,0 г."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Однородный крем белого цвета, без запаха."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Противогрибковое средство."}}]},{"id":7,"name":"Фармакологические свойства","slug":"","body":[{"type":"paragraph","data":{"text":"Клотримазол является противогрибковым средством широкого спектра действия для местного применения. Антимикотический эффект активного действующего вещества клотримазола (производное имидазола) связан с нарушением синтеза эргостерина, входящего в состав клеточной мембраны грибов, что изменяет проницаемость мембраны и вызывает последующий лизис клетки. В малых концентрациях действует фунгистатически, а в больших фунгицидно, причем не только на пролиферирующие клетки. В фунгицидных концентрациях взаимодействует с митохондриальными и пероксидазными ферментами, в результате чего происходит увеличение концентрации перекиси водорода до токсического уровня, что также способствует разрушению грибковых клеток. "}},{"type":"paragraph","data":{"text":"Эффективен в отношении дерматофитов, дрожжеподобных, плесневых грибов и простейших. Оказывает антимикробное действие в отношении грамположительных (Streptococcus spp., Staphylococcus spp.) и анаэробов (Bacteroides spp., Gardnerella vaginalis). Клотримазол не оказывает влияние на лактобацилы. In vitro в концентрации 0,5-10 мкг/мл клотримазол подавляет размножение бактерий семейства Corinebacteria и грамположительных кокков (за исключением энтерококков); оказывает трихомонацидное действие в концентрации 100 мкг/мл."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"При применении клотримазола интравагинально абсорбция составляет 3 – 10 % введен-"}},{"type":"paragraph","data":{"text":"ной дозы. Высокие концентрации в вагинальном секрете и низкие концентрации в крови Falz сохраняются в течение 48 – 72 ч. В печени метаболизируется до неактивных метаболитов, выводимых из организма почками и через кишечник."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Генитальные инфекции, вызванные дрожжеподобными грибами рода Candida (кандидозный вульвовагинит)."}},{"type":"paragraph","data":{"text":"В случае необходимости, пожалуйста, проконсультируйтесь с врачом перед применением лекарственного препарата."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к клотримазолу или другим компонентам препарата, особенно к цетостеариловому спирту; - период менструации; - I триместр беременности."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Период грудного вскармливания."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение в I триместре беременности противопоказано. Вопрос о целесообразности применения препарата во II-III триместрах беременности должен решаться индивидуально после консультации врача. "}},{"type":"paragraph","data":{"text":"Применение препарата в период грудного вскармливания допускается только в случае, если, по мнению врача, потенциальная польза от применения крема для матери превышает возможный риск для ребенка. "}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Местно. Только для интравагинального применения."}},{"type":"paragraph","data":{"text":"В течение 6 последовательных дней, один раз в сутки вечером перед сном вводить содержимое заполненного аппликатора (примерно 5 г) как можно глубже во влагалище, в положении лежа на спине, со слегка согнутыми ногами."}},{"type":"paragraph","data":{"text":"Применение крема вагинального при помощи одноразового аппликатора:"}},{"type":"paragraph","data":{"text":"1.\tОткрыть тубу и прикрутить одноразовый аппликатор."}},{"type":"paragraph","data":{"text":"2.\tОсторожно сжимая тубу, заполнить одноразовый аппликатор, пока поршень не выдавится полностью."}},{"type":"paragraph","data":{"text":"3.\tОткрутить аппликатор от тубы. Вставить аппликатор как можно глубже во влагалище (желательно в положении лежа на спине) и выдавить содержимое аппликатора, нажав на поршень. "}},{"type":"paragraph","data":{"text":"4.\tИзвлечь одноразовый аппликатор после использования и выбросить."}},{"type":"paragraph","data":{"text":"Применяйте препарат только согласно тому способу применения и в тех дозах, которые указаны в инструкции по применению."}},{"type":"paragraph","data":{"text":"Повторный курс лечения возможен после консультации с лечащим врачом."}},{"type":"paragraph","data":{"text":"Если после лечения улучшения не наступает или появляются новые симптомы, необходимо проконсультироваться с врачом."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"По данным Всемирной организации здравоохранения (ВОЗ) нежелательные эффекты классифицированы в соответствии с их частотой развития следующим образом: очень часто (≥ 1/10), часто (≥ 1/100, <1/10), нечасто (≥ 1/1000, <1/100), редко (≥ 1/10000, <1/1000) и очень редко (< 1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны иммунной системы:"}},{"type":"paragraph","data":{"text":"частота неизвестна: аллергические реакции с такими симптомами, как крапивница, обмороки, артериальная гипотензия, одышка."}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного тракта:"}},{"type":"paragraph","data":{"text":"частота неизвестна: боль в животе."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных тканей:"}},{"type":"paragraph","data":{"text":"частота неизвестна: в случае повышенной чувствительности к активному веществу или другому компоненту препарата, такому как цетостеариловый спирт, могут возникнуть аллергические реакции. "}},{"type":"paragraph","data":{"text":"Нарушения со стороны почек и мочевыводящих путей: частота неизвестна: учащенное мочеиспускание, интеркуррентный цистит."}},{"type":"paragraph","data":{"text":"Нарушения со стороны половых органов:"}},{"type":"paragraph","data":{"text":"частота неизвестна: зуд, жжение, гиперемия и отек слизистой оболочки влагалища, изъязвления слизистой оболочки влагалища, сыпь, боль в области малого таза."}},{"type":"paragraph","data":{"text":"Прочие:"}},{"type":"paragraph","data":{"text":"частота неизвестна: головная боль, гастралгия."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты не указанные в инструкции, сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При передозировке возможны следующие симптомы: головокружение, тошнота, рвота. Лечение. Специфического антидота нет. При случайном приеме внутрь следует проводить симптоматическое лечение."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При вагинальном введении клотримазол снижает активность амфотерицина В и других полиеновых антибиотиков. "}},{"type":"paragraph","data":{"text":"При одновременном применении с натамицином и нистатином активность клотримазола может снижаться."}},{"type":"paragraph","data":{"text":"Одновременное применение клотримазола интравагинально и такролимуса, сиролимуса перорально может приводить к повышению концентрации последних в плазме крови, поэтому следует наблюдать за пациентками на предмет развития симптомов их передозировки, при необходимости с измерением концентраций в плазме крови."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Внимательно прочтите инструкцию по применению перед тем, как начать применение препарата. Сохраните инструкцию, она может понадобиться вновь. Если у Вас возникли вопросы, обратитесь к врачу."}},{"type":"paragraph","data":{"text":"Лекарственное средство, которым Вы лечитесь предназначено лично Вам, и его не следует передавать другим лицам, поскольку оно может причинить им вред даже при наличии тех же симптомов, что и у Вас."}},{"type":"paragraph","data":{"text":"При появлении аллергических реакций или раздражения в месте введения препарата лечение прекращают. "}},{"type":"paragraph","data":{"text":"Препарат нельзя применять во время менструации, лечение целесообразно начинать после менструации."}},{"type":"paragraph","data":{"text":"При одновременной инфекции половых губ и прилегающих участков (кандидозный вульвит) следует дополнительно проводить местное лечение препаратом клотримазол."}},{"type":"paragraph","data":{"text":"В период беременности лечение вагинальным кремом проводят без аппликатора. Для предотвращения инфицирования необходимо одновременное лечение половых партнеров."}},{"type":"paragraph","data":{"text":"В период лечения рекомендуется воздерживаться от половых контактов."}},{"type":"paragraph","data":{"text":"Во время лечения рекомендуется пользоваться средствами контрацепции. Риск разрыва презерватива или диафрагмы увеличивается при их одновременном использовании с применением препарата. Необходимо использовать надежные методы контрацепции."}},{"type":"paragraph","data":{"text":"Для предотвращения реинфицирования следует соблюдать правила гигиены. Если клинические признаки инфекции сохраняются после завершения лечения, следует провести повторное микробиологическое исследование с целью подтверждения диагноза."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не оказывает влияния на способность управлять транспортными средствами и заниматься другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Крем вагинальный 2 %."}},{"type":"paragraph","data":{"text":"По 20 г в тубы алюминиевые. Тубу вместе с одноразовыми аппликаторами (3 шт.) для интравагинального введения и инструкцией по применению помещают в пачку картонную."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не использовать по истечении срока годности. "}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Фарма Вернигероде ГмбХ,"}},{"type":"paragraph","data":{"text":"Дорнбергсвег 35, 38855 Вернигероде, Германия."}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"115114, г. 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