Эспа-Липон Концентрат, ампулы, 5 шт, 24 мл, 25 мг/мл, для раствора для инфузий, для взрослых

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Общий"}},{"type":"paragraph","data":{"text":"плазменный клиренс - 10-15 мл/мин."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- диабетическая полинейропатия;"}},{"type":"paragraph","data":{"text":"- алкогольная полинейропатия."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- повышенная чувствительность к компонентам препарата;"}},{"type":"paragraph","data":{"text":"- детский возраст до 18 лет (эффективность и безопасность применения препарата не"}},{"type":"paragraph","data":{"text":"установлены);"}},{"type":"paragraph","data":{"text":"- беременность, период грудного вскармливания (отсутствует достаточный опыт"}},{"type":"paragraph","data":{"text":"применения препарата)."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Внутривенное введение препарата следует проводить с осторожностью у пациентов"}},{"type":"paragraph","data":{"text":"пожилого возраста (старше 75 лет)."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Ввиду отсутствия достаточного клинического опыта применения тиоктовой кислоты"}},{"type":"paragraph","data":{"text":"при беременности и в период грудного вскармливания, применение препарата у"}},{"type":"paragraph","data":{"text":"соответствующей категории пациенток противопоказано."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат предназначен для приготовления раствора для инфузий после"}},{"type":"paragraph","data":{"text":"предварительного разведения в изотоническом растворе хлорида натрия."}},{"type":"paragraph","data":{"text":"Тяжелые формы диабетической или алкогольной полинейропатии"}},{"type":"paragraph","data":{"text":"Один раз в сутки в виде внутривенных капельных инфузий 24 мл раствора в 250 мл"}},{"type":"paragraph","data":{"text":"изотонического раствора хлорида натрия (что соответствует 600 мг альфа-липоевой"}},{"type":"paragraph","data":{"text":"кислоты в сутки). Препарат рекомендуется применять в течение 2-4 недель. Растворы"}},{"type":"paragraph","data":{"text":"для инфузий следует вводить в течение 50 минут."}},{"type":"paragraph","data":{"text":"Приготовленные растворы необходимо хранить в защищенном от света месте и"}},{"type":"paragraph","data":{"text":"использов ать максимально в течение 6 часов после приготовления."}},{"type":"paragraph","data":{"text":"Далее следует перейти на поддерживающую терапию в форме таблеток в дозе 600 мг"}},{"type":"paragraph","data":{"text":"в сутки. Минимальный срок лечения таблетками - 3 месяца."}},{"type":"paragraph","data":{"text":"В некоторых случаях прием препарата предполагает более длительное применение,"}},{"type":"paragraph","data":{"text":"сроки которого определяются лечащим врачом."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"По данным Всемирной организации здравоохранения (ВОЗ) нежелательные эффекты"}},{"type":"paragraph","data":{"text":"классифицированы в соответствии с их частотой развития следующим образом: очень"}},{"type":"paragraph","data":{"text":"часто (≥ 1/10), часто (≥ 1/100, ˂1/10), нечасто (≥ 1/1000, ˂1/100), редко (≥ 1/10000,"}},{"type":"paragraph","data":{"text":"˂1/1000) и очень редко (˂ 1/10000); частота неизвестна (частоту возникновения явлений"}},{"type":"paragraph","data":{"text":"нельзя определить на основании имеющихся данных)."}},{"type":"paragraph","data":{"text":"Со стороны крови и лимфатической системы:"}},{"type":"paragraph","data":{"text":"очень редко: петехиальные кровоизлияния в слизистые оболочки, кожу;"}},{"type":"paragraph","data":{"text":"тромбоцитопатия, геморрагическая сыпь (пурпура), тромбофлебит, гипокоагуляция."}},{"type":"paragraph","data":{"text":"Со стороны иммунной системы:"}},{"type":"paragraph","data":{"text":"очень редко: крапивница, кожная сыпь, зуд, экзема, системные аллергические реакции"}},{"type":"paragraph","data":{"text":"(вплоть до развития анафилактического шока)."}},{"type":"paragraph","data":{"text":"Со стороны обмена веществ и питания:"}},{"type":"paragraph","data":{"text":"очень редко: гипогликемия (в связи с улучшением утилизации глюкозы, симптомы"}},{"type":"paragraph","data":{"text":"которой включают головокружение, повышенное потоотделение, головную боль,"}},{"type":"paragraph","data":{"text":"нарушение зрения); развитие у пациентов с сахарным диабетом аутоиммунного"}},{"type":"paragraph","data":{"text":"инсулинового синдрома, который характеризуется частыми гипогликемиями в условиях"}},{"type":"paragraph","data":{"text":"наличия аутоантител к инсулину."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы"}},{"type":"paragraph","data":{"text":"очень редко: изменение или нарушение вкусовых ощущений, судороги, «приливы»."}},{"type":"paragraph","data":{"text":"Со стороны органа зрения:"}},{"type":"paragraph","data":{"text":"очень редко: диплопия, нечеткость зрения."}},{"type":"paragraph","data":{"text":"Со стороны сердца:"}},{"type":"paragraph","data":{"text":"частота неизвестна: при быстром введении препарата возможны боль в области"}},{"type":"paragraph","data":{"text":"сердца, тахикардия."}},{"type":"paragraph","data":{"text":"Со стороны желудо чно-кишечного тракта:"}},{"type":"paragraph","data":{"text":"часто: тошнота, рвота;"}},{"type":"paragraph","data":{"text":"очень редко: боль в животе, диарея."}},{"type":"paragraph","data":{"text":"Со стороны печени и желчевыводящих путей:"}},{"type":"paragraph","data":{"text":"очень редко: повышение активности «печеночных» ферментов."}},{"type":"paragraph","data":{"text":"Общие расстройства и нарушения в месте введения:"}},{"type":"paragraph","data":{"text":"очень редко: слабость, чувство жжения в месте введения, раздражение, гиперемия,"}},{"type":"paragraph","data":{"text":"припухлость."}},{"type":"paragraph","data":{"text":"Прочие:"}},{"type":"paragraph","data":{"text":"очень редко: при быстром введении возможно самопроизвольно проходящее"}},{"type":"paragraph","data":{"text":"повышение внутричерепного давления (возникновение чувства тяжести в голове),"}},{"type":"paragraph","data":{"text":"затруднение дыхания."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: головная боль, тошнота, рвота."}},{"type":"paragraph","data":{"text":"В тяжелых случаях (при приеме тиоктовой кислоты в дозе 10-40 г): психомоторное"}},{"type":"paragraph","data":{"text":"возбуждение или помутнение сознания, генерализованные судороги, выраженные"}},{"type":"paragraph","data":{"text":"нарушения кислотно-щелочного баланса, лактоацидоз, гипогликемия (вплоть до"}},{"type":"paragraph","data":{"text":"развития комы), острый некроз скелетных мышц, синдром диссеминированного"}},{"type":"paragraph","data":{"text":"внутрисосудистого свертывания (ДВС-синдром), гемолиз, подавление деятельности"}},{"type":"paragraph","data":{"text":"костного мозга, полиорганна я недостаточность."}},{"type":"paragraph","data":{"text":"Лечение: при подозрении на существенную передозировку тиоктовой кислотой"}},{"type":"paragraph","data":{"text":"рекомендуется экстренная госпитализация и немедленное применение мер в"}},{"type":"paragraph","data":{"text":"соответствии с общими принципами, принятыми при случайном отравлении. Терапия"}},{"type":"paragraph","data":{"text":"симптоматическая. Лечение генерализированных судорог, лактоацидоза и других"}},{"type":"paragraph","data":{"text":"угрожающих жизни последствий должно проводиться в соответствии с принципами"}},{"type":"paragraph","data":{"text":"современной интенсивной терапии. Специфического антидота нет. Гемодиализ, методы"}},{"type":"paragraph","data":{"text":"гемоперфузии или гемофильтрации в рамках форсированного выведения тиоктовой"}},{"type":"paragraph","data":{"text":"кислоты не эффективны."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Тиоктовая кислота связывает металлы, по этому ее не следует назначать одновременно"}},{"type":"paragraph","data":{"text":"с препаратами, содержащими металлы."}},{"type":"paragraph","data":{"text":"При одновременном применении с инсулином и пероральными гипогликемическими"}},{"type":"paragraph","data":{"text":"средствами наблюдается усиление гипогликемического эффекта."}},{"type":"paragraph","data":{"text":"Тиоктовая (альфа-липоевая) кислота образует с молекулами сахара (например,"}},{"type":"paragraph","data":{"text":"раствор левулозы) трудно растворимые комплексные соединения, следовательно,"}},{"type":"paragraph","data":{"text":"несовместима с раствором глюкозы, фруктозы и декстрозы, раствором Рингера, а"}},{"type":"paragraph","data":{"text":"также с соединениями, взаимодействующими с дисульфидными и SH-группами."}},{"type":"paragraph","data":{"text":"Тиоктовая (альфа-липоевая) кислота (в виде раствора для инфузий) приводит к"}},{"type":"paragraph","data":{"text":"снижению эффективности цисплатина."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"У пациентов с сахарным диабетом, особенно в начале лечения, необходим постоянный"}},{"type":"paragraph","data":{"text":"контроль концентрации глюкозы в плазме крови. В отдельных случаях требуется"}},{"type":"paragraph","data":{"text":"снижение дозы гипогликемических средств. При развитии гипогликемии и при ее"}},{"type":"paragraph","data":{"text":"симптомах (головокружение, повышенное потоотделение, головная боль, расстройство"}},{"type":"paragraph","data":{"text":"зрения, тошнота) следует немедленно прекратить введение препарата."}},{"type":"paragraph","data":{"text":"Описано несколько случаев развития у пациентов с сахарным диабетом на фоне"}},{"type":"paragraph","data":{"text":"приема тиоктовой кислоты аутоиммунного инсулинового синдрома, который"}},{"type":"paragraph","data":{"text":"характеризовался частыми гипогликемиями в условиях наличия аутоантител"}},{"type":"paragraph","data":{"text":"к инсулину. Возможность появления аутоиммунного инсулинового синдрома"}},{"type":"paragraph","data":{"text":"определяется наличием у пациентов гаплотипов HLA-DRB1*0406 и HLA-DRB1*0403."}},{"type":"paragraph","data":{"text":"Во время лечения необходимо строго воздерживаться от употребления алкоголя, так"}},{"type":"paragraph","data":{"text":"как терапевтический эффект тиоктовой (альфа-липоевой) кислоты ослабляется при"}},{"type":"paragraph","data":{"text":"возде йствии алкоголя, а также является фактором риска развития и прогрессирования"}},{"type":"paragraph","data":{"text":"нейропатии."}},{"type":"paragraph","data":{"text":"При появлении симптомов повышенной чувствительности следует немедленно"}},{"type":"paragraph","data":{"text":"прекратить введение препарата."}},{"type":"paragraph","data":{"text":"Препарат является светочувствительным, поэтому ампулы следует доставать из"}},{"type":"paragraph","data":{"text":"у паковки только непосредственно перед использованием."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Влияние на способность управлять транспортными средствами и другими"}},{"type":"paragraph","data":{"text":"механизмами специально не изучалось. Рекомендуется соблюдать осторожность"}},{"type":"paragraph","data":{"text":"при управлении транспортными средствами и другими механизмами и з анятиях"}},{"type":"paragraph","data":{"text":"другими потенциально опасными видами деятельности, требующими повышенной"}},{"type":"paragraph","data":{"text":"концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Концентрат для приготовления раствора для инфузий, 25 мг/мл."}},{"type":"paragraph","data":{"text":"По 12 мл или 24 мл в ампулы темного стекла. По 5 ампул по 12 мл или 24 мл в"}},{"type":"paragraph","data":{"text":"пластиковый поддон. 2 пластиковых поддона с 5 ампулами по 12 мл или 1 пластиковый"}},{"type":"paragraph","data":{"text":"поддон с 5 ампулами по 24 мл вместе с инструкцией по применению помещают в пачку"}},{"type":"paragraph","data":{"text":"картонную."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 °С в защищенном от света месте."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте!"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Срок годности приготовленного для применения раствора после разведения в"}},{"type":"paragraph","data":{"text":"изотоническом растворе натрия хлорида составляет максимум 6 часов при хранении"}},{"type":"paragraph","data":{"text":"его в защищенном от света месте."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности!"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Зигфрид Хамельн ГмбХ,"}},{"type":"paragraph","data":{"text":"Лангес Фельд 13, 31789 Хамельн, Германия."}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"115114, г. Москва, ул. Летниковская, д. 16, оф. 306"}},{"type":"paragraph","data":{"text":"тел.: +7(499) 579-33-70,"}},{"type":"paragraph","data":{"text":"факс: +7(499) 579-33-71"}},{"type":"paragraph","data":{"text":"e-mail: info@esparma-gmbh.ru"}}]}],"source":null},"description_toggle":false,"short_description":"Прозрачный раствор зеленовато-жёлтого цвета.","substance":[{"id":171,"title":"Тиоктовая кислота","title_latin":"Acidum thiocticum","slug":"tioktovaya_kislota_171"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Эспа-Липон - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60684/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/60684/share_default/"}},"diseases":[{"id":"573","title":"Алкогольная 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