артериальная гипертензия (пациентам, которым показана комбинированная терапия) . - снижение риска сердечно-сосудистой заболеваемости и смертности у пациентов с артериальной гипертензией и гипертрофией левого желудочка.
Противопоказания
анурия . - тяжелая почечная недостаточность (КК <30 мл/мин) . - тяжелые нарушения функции печени . - беременность . - период лактации (грудного вскармливания) . - детский и подростковый возраст до 18 лет (эффективность и безопасность не установлены) . - дефицит лактазы, непереносимость лактозы, синдром глюкозо-галактозной мальабсорбции . - повышенная чувствительность к компонентам препарата . - повышенная чувствительность к производным сульфонамида. С осторожностью: нарушения водно-электролитного баланса крови (гипонатриемия, гипохлоремический алкалоз, гипомагниемия, гипокалиемия), двусторонний стеноз почечных артерий, стеноз артерии единственной функционирующей почки, состояние после трансплантации почки, гиперкальциемия, гиперурикемия и/или подагра, отягощенный аллергологический анамнез, бронхиальная астма, системные заболевания соединительной ткани (в т.ч. системная красная волчанка), одновременное применение НПВС, в т.ч., ингибиторов ЦОГ-2, сахарный диабет, нарушение функции печени, нарушения функции почек (КК от 30-50 мл/мин), гиповолемия (в т.ч. на фоне приема диуретиков в высоких дозах), острый приступ закрытоугольной глаукомы.
артериальная гипертензия (пациентам, которым показана комбинированная терапия) . - снижение риска сердечно-сосудистой заболеваемости и смертности у пациентов с артериальной гипертензией и гипертрофией левого желудочка.
Противопоказания
анурия . - тяжелая почечная недостаточность (КК <30 мл/мин) . - тяжелые нарушения функции печени . - беременность . - период лактации (грудного вскармливания) . - детский и подростковый возраст до 18 лет (эффективность и безопасность не установлены) . - дефицит лактазы, непереносимость лактозы, синдром глюкозо-галактозной мальабсорбции . - повышенная чувствительность к компонентам препарата . - повышенная чувствительность к производным сульфонамида. С осторожностью: нарушения водно-электролитного баланса крови (гипонатриемия, гипохлоремический алкалоз, гипомагниемия, гипокалиемия), двусторонний стеноз почечных артерий, стеноз артерии единственной функционирующей почки, состояние после трансплантации почки, гиперкальциемия, гиперурикемия и/или подагра, отягощенный аллергологический анамнез, бронхиальная астма, системные заболевания соединительной ткани (в т.ч. системная красная волчанка), одновременное применение НПВС, в т.ч., ингибиторов ЦОГ-2, сахарный диабет, нарушение функции печени, нарушения функции почек (КК от 30-50 мл/мин), гиповолемия (в т.ч. на фоне приема диуретиков в высоких дозах), острый приступ закрытоугольной глаукомы.
Способ применения и дозы
Принимаю внутрь, независимо от приема пищи. Препарат Лориста Н 100 можно сочетать с другими гипотензивными средствами. Артериальная гипертензия Рекомендуемая доза препарата Лориста Н 100 - 1 таб. (100 мг/12.5 мг) 1 раз/сут. Как правило, препарат назначают при отсутствии адекватного терапевтического эффекта препарата Лориста Н (50 мг/12.5 мг). Максимальный антигипертензивный эффект достигается в течение 3 недель терапии. У пациентов пожилого возраста, у пациентов с нарушением функции почек (КК 30-50 мл/мин), включая пациентов, находящихся на диализе, коррекция начальной дозы не требуется. Снижение риска сердечно-сосудистой заболеваемости и смертности у пациентов с артериальной гипертензией и гипертрофией левого желудочка Начальная и поддерживающая доза лозартана - 50 мг 1 раз/сут. Пациентам, у которых не удалось достичь целевого уровня АД на фоне применения лозартана в дозе 50 мг/сут, требуется подбор терапии путем комбинации лозартана с низкими дозами гидрохлоротиазида (12.5 мг). В случае необходимости возможно увеличение дозы лозартана до 100 мг в сочетании с гидрохлоротиазидом в дозе 12.5 мг/сут. Рекомендуемая доза препарата Лориста Н 100 -1 таб. (100 мг/12.5 мг) 1 раз/сут. Максимальная суточная доза - 1 таб. препарата Лориста Н 100. У пациентов с нарушением функции почек коррекция дозы не требуется. У пациентов пожилого возраста коррекция дозы не требуется.
Побочное действие
Классификация частоты развития побочных эффектов (ВОЗ): очень часто (≥ .1/10), часто (от ≥ .1/100 до <1/10), нечасто (от ≥ . 1/1000 до <1/100), редко (от ≥ .1/10 000 до <1/1000), очень редко (от <1/10 000, включая отдельные сообщения), частота неизвестна (частота не может быть оценена на основе имеющихся данных). Со стороны иммунной системы: редко - анафилактические реакции, ангионевротический отек (включая отек гортани и языка, вызывающий обструкцию дыхательных путей и/или отек лица, губ, глотки), уртикарная сыпь. Со стороны системы кроветворения: нечасто - анемия, пурпура Шенлейн-Геноха, экхимоз, гемолиз, агранулоцитоз, апластическая анемия, гемолитическая анемия, лейкопения, тромбоцитопения. Со стороны нервной системы: часто - головная боль, головокружение, бессонница, повышенная утомляемость . нечасто - мигрень, тревожность, спутанность сознания, депрессия, нарушения сна, нарушение памяти, сонливость, нервозность, парестезия, тремор, обморок. Со стороны сердечно-сосудистой системы: часто - ортостатическая гипотензия (дозозависимая), ощущение сердцебиения, тахикардия . нечасто - AV-блокада II степени, боль за грудиной, инфаркт миокарда, аритмии . редко - васкулит. Со стороны дыхательной системы: часто - кашель, инфекции верхних отделов дыхательных путей, синусит, отек слизистой оболочки носа, заложенность носа . нечасто - фарингит, ларингит, ринит, диспноэ, бронхит, носовое кровотечение. Со стороны пищеварительной системы: часто - диарея, диспепсия, тошнота, рвота, боль в животе . редко - гепатит, нарушение функции печени. Со стороны мочевыделительной системы: нечасто - инфекции мочевыводящего тракта, частое мочеиспускание, никтурия, глюкозурия. Со стороны половой системы: нечасто - ослабление либидо, снижение потенции. Со стороны органов чувств: нечасто - нечеткость зрения, чувство жжения в глазах, конъюнктивит. Со стороны кожных покровов: часто - алопеция, сухость кожи, эритема, фоточувствительность, повышенное потоотделение . нечасто - крапивница, кожный зуд. Со стороны костно-мышечной системы: часто - миалгия, боль в спине . нечасто - артралгия. Прочие: часто - астения, слабость, периферические отеки . нечасто - анорексия, обострение течения подагры. Со стороны лабораторных показателей: часто - гиперкалиемия, незначительное снижение концентрации гемоглобина и гематокрита . нечасто - умеренное повышение концентрации мочевины и креатинина в плазме крови, гипергликемия, гиперурикемия, нарушения со стороны водно-электролитного баланса . редко - повышение активности АЛТ . очень редко - повышение активности ACT и концентрации билирубина.
Особые указания
Классификация частоты развития побочных эффектов (ВОЗ): очень часто (≥ .1/10), часто (от ≥ .1/100 до <1/10), нечасто (от ≥ . 1/1000 до <1/100), редко (от ≥ .1/10 000 до <1/1000), очень редко (от <1/10 000, включая отдельные сообщения), частота неизвестна (частота не может быть оценена на основе имеющихся данных). Со стороны иммунной системы: редко - анафилактические реакции, ангионевротический отек (включая отек гортани и языка, вызывающий обструкцию дыхательных путей и/или отек лица, губ, глотки), уртикарная сыпь. Со стороны системы кроветворения: нечасто - анемия, пурпура Шенлейн-Геноха, экхимоз, гемолиз, агранулоцитоз, апластическая анемия, гемолитическая анемия, лейкопения, тромбоцитопения. Со стороны нервной системы: часто - головная боль, головокружение, бессонница, повышенная утомляемость . нечасто - мигрень, тревожность, спутанность сознания, депрессия, нарушения сна, нарушение памяти, сонливость, нервозность, парестезия, тремор, обморок. Со стороны сердечно-сосудистой системы: часто - ортостатическая гипотензия (дозозависимая), ощущение сердцебиения, тахикардия . нечасто - AV-блокада II степени, боль за грудиной, инфаркт миокарда, аритмии . редко - васкулит. Со стороны дыхательной системы: часто - кашель, инфекции верхних отделов дыхательных путей, синусит, отек слизистой оболочки носа, заложенность носа . нечасто - фарингит, ларингит, ринит, диспноэ, бронхит, носовое кровотечение. Со стороны пищеварительной системы: часто - диарея, диспепсия, тошнота, рвота, боль в животе . редко - гепатит, нарушение функции печени. Со стороны мочевыделительной системы: нечасто - инфекции мочевыводящего тракта, частое мочеиспускание, никтурия, глюкозурия. Со стороны половой системы: нечасто - ослабление либидо, снижение потенции. Со стороны органов чувств: нечасто - нечеткость зрения, чувство жжения в глазах, конъюнктивит. Со стороны кожных покровов: часто - алопеция, сухость кожи, эритема, фоточувствительность, повышенное потоотделение . нечасто - крапивница, кожный зуд. Со стороны костно-мышечной системы: часто - миалгия, боль в спине . нечасто - артралгия. Прочие: часто - астения, слабость, периферические отеки . нечасто - анорексия, обострение течения подагры. Со стороны лабораторных показателей: часто - гиперкалиемия, незначительное снижение концентрации гемоглобина и гематокрита . нечасто - умеренное повышение концентрации мочевины и креатинина в плазме крови, гипергликемия, гиперурикемия, нарушения со стороны водно-электролитного баланса . редко - повышение активности АЛТ . очень редко - повышение активности ACT и концентрации билирубина.
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Со стороны системы кроветворения: нечасто - анемия, пурпура Шенлейн-Геноха, экхимоз, гемолиз, агранулоцитоз, апластическая анемия, гемолитическая анемия, лейкопения, тромбоцитопения. Со стороны нервной системы: часто - головная боль, головокружение, бессонница, повышенная утомляемость . нечасто - мигрень, тревожность, спутанность сознания, депрессия, нарушения сна, нарушение памяти, сонливость, нервозность, парестезия, тремор, обморок. Со стороны сердечно-сосудистой системы: часто - ортостатическая гипотензия (дозозависимая), ощущение сердцебиения, тахикардия . нечасто - AV-блокада II степени, боль за грудиной, инфаркт миокарда, аритмии . редко - васкулит. Со стороны дыхательной системы: часто - кашель, инфекции верхних отделов дыхательных путей, синусит, отек слизистой оболочки носа, заложенность носа . нечасто - фарингит, ларингит, ринит, диспноэ, бронхит, носовое кровотечение. 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Со стороны лабораторных показателей: часто - гиперкалиемия, незначительное снижение концентрации гемоглобина и гематокрита . нечасто - умеренное повышение концентрации мочевины и креатинина в плазме крови, гипергликемия, гиперурикемия, нарушения со стороны водно-электролитного баланса . редко - повышение активности АЛТ . очень редко - повышение активности ACT и концентрации билирубина."}}]},{"id":6,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Классификация частоты развития побочных эффектов (ВОЗ): очень часто (≥ .1/10), часто (от ≥ .1/100 до \u003c1/10), нечасто (от ≥ . 1/1000 до \u003c1/100), редко (от ≥ .1/10 000 до \u003c1/1000), очень редко (от \u003c1/10 000, включая отдельные сообщения), частота неизвестна (частота не может быть оценена на основе имеющихся данных). 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