Энерион Таблетки, коробка, 60 шт, 200 мг, для приема внутрь, в пленочной оболочке

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Только для взрослых."}},{"type":"paragraph","data":{"text":"Суточная доза препарата: 2-3 таблетки (400 – 600 мг) в два приема (во время завтрака и обеда):"}},{"type":"list","data":{"style":"unordered","items":["1 таблетка во время завтрака и 1 таблетка во время обеда,"]}},{"type":"list","data":{"style":"unordered","items":["Или 1 таблетка во время завтрака и 2 таблетки во время обеда, o Или 2 таблетки во время завтрака и 2 таблетки во время обеда."]}},{"type":"paragraph","data":{"text":"Таблетки следует проглатывать целиком, запивая водой."}},{"type":"paragraph","data":{"text":"Продолжительность лечения не должна превышать 4 недель."}},{"type":"paragraph","data":{"text":"Не превышайте рекомендуемую дозу и продолжительность применения препарата."}},{"type":"paragraph","data":{"text":"Если Ваше состояние ухудшилось или улучшение не наступило через 4 недели, Вам следует обратиться к врачу."}}]},{"id":8,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Частота побочных действий, которые могут возникать во время терапии, приведена в виде следующей градации: очень часто (≥1/10); часто (≥1/100, \u003c1/10); нечасто (≥1/1000, \u003c1/100); редко (≥1/10000, \u003c1/1000); очень редко (\u003c1/10000); неуточненной частоты (частота не может быть подсчитана по доступным данным)."}},{"type":"paragraph","data":{"text":""}},{"type":"paragraph","data":{"text":"Описанные отдельные нежелательные реакции"}},{"type":"paragraph","data":{"text":"Риск развития аллергических реакций повышается из-за присутствия в составе препарата красителя солнечный закат FCF (E110) (см. раздел «Особые указания»)."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу."}}]},{"id":9,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Описанные отдельные нежелательные реакции"}},{"type":"paragraph","data":{"text":"Риск развития аллергических реакций повышается из-за присутствия в составе препарата красителя солнечный закат FCF (E110) (см. раздел «Особые указания»)."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу."}}]},{"id":10,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Клинических исследований по изучению взаимодействий сульбутиамина с другими лекарственными средствами не проводилось."}},{"type":"paragraph","data":{"text":"Взаимодействия, которые стоит принять во внимание:"}},{"type":"paragraph","data":{"text":"o Средства, блокирующие нейромышечную передачу (миорелаксанты): эффект этих препаратов может возрастать при одновременном приеме с тиамином (метаболитом мульбутиамина);"}},{"type":"paragraph","data":{"text":"o Диуретики: увеличивается выведение с мочой тиамина (метаболита сульбутиамина)."}}]},{"id":11,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В состав вспомогательных веществ препарат входит глюкоза, лактоза и сахароза. Вследствие этого данный препарат противопоказан к применению у лиц с лактазной недостаточностью, галактоземией, синдромом глюкозной/галактозной мальабсорбции, сахарозной-изомальтазной недостаточностью, непереносимостью фруктозы."}},{"type":"paragraph","data":{"text":"В состав лекарственного препарата входит краситель солнечный закат FCF (E110). Он может вызвать развитие аллергических реакций (см. раздел «Побочное действие»)."}},{"type":"paragraph","data":{"text":"Искажение результатов лабораторных анализов."}},{"type":"paragraph","data":{"text":"Препарат метаболизируется до тиамина, что может повлиять на результаты анализов:"}},{"type":"paragraph","data":{"text":"o Определение мочевой кислоты фосфорно-вольфрамовым методом: препарат может вызвать ложноположительные результаты;"}},{"type":"paragraph","data":{"text":"o Анализ мочи на уробилиноген с реактивом Эрлиха: может давать ложноположительные результаты."}},{"type":"paragraph","data":{"text":"o Тиамин в больших дозах может повлиять на спектрофотометрическое определение теофиллина в сыворотке крови по методу Шака и Вакслера."}}]},{"id":12,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 °С. Хранить в недоступных для детей местах."}}]},{"id":13,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"3 года. Не применять после истечения срока годности, указанной на упаковке."}}]},{"id":14,"name":"Условия отпуска","slug":"release_condition","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Фармакодинамика: Сульбутиамин является оригинальным соединением, получаемым из тиамина путем ряда структурных модификаций ядра тиамина: образование дисульфидной связи, введение липофильного эфира и открытие тиазольного кольца. Благодаря такой модификации, сульбутиамин: o Хорошо растворим в жирах, что позволяет ему быстро всасываться из желудочно- кишечного тракта и легко проникать через гематоэнцефалический барьер; o Способен накапливаться в клетках ретикулярной формации, гиппокампе и зубчатой извилине, а также клетках Пуркинье и клубочках зернистого слоя коры мозжечка, что подтверждается гистохимическим анализом. В плацебо-контролируемых исследованиях у человека, а также в исследованиях с активным контролем были получены доказательства эффективности лекарственного препарата Энерион® при симптоматическом лечении функциональной астении. Сульбутиамин метаболизируется до тиамина (витамина B1). В комплексе с аденозинтрифосфатом (АТФ) тиамин образует тиамина дифосфат (карбоксилазу или тиамина пирофосфат), который в качестве ко-фермента принимает участие в углеводном обмене. Фармакокинетика Сульботиамин быстро всасывается, концентрация сульбутиамина в плазме крови достигает максимума (Сmax) через 1-2 часа после приема. В дальнейшем концентрация сульбутиамина в крови уменьшается экспоненциально. Сульбутиамин быстро распределяется в организме, при этом в значительно мере попадает в головной мозг, что было продемонстрировано в экспериментах на животных. Период полувыведения (T1/2) – около 5 часов. Сульбутиамин выводится с мочой. 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