Повышенная
чувствительность к тилорону или любому другому компоненту препарата.
Беременность и период грудного вскармливания. Детский возраст до 7 лет (для
дозировки 60 мг), детский возраст до 18 лет (для дозировки 125 мг).
ядро: крахмал картофельный - 25,500 мг
или 46,000 мг, целлюлоза микрокристаллическая - 60,000 мг или 120,000 мг,
повидон (повидон К30) - 1,500 мг или 3,000 мг, кальция стеарат - 1,500 мг или
3,000 мг, кроскармеллоза (кроскармеллоза натрия) - 1,500 мг или 3,000 мг;
оболочка: гипромеллоза
(гидроксипропилметилцеллюлоза) - 3,4050 мг или 6,8100 мг, титана диоксид -
1,7815 мг или 3,5630 мг, макрогол (полиэтиленгликоль-4000) - 0,4565 мг или
0,9130 мг, полисорбат-80 (твин-80) - 0,0570 мг или 0,1140 мг, краситель
хинолиновый желтый (Е 104) - 0,1235 мг или 0,2470 мг, краситель солнечный закат
желтый (Е 110) - 0,1765 мг или 0,3530 мг.
Описание
Круглые
двояковыпуклые таблетки, покрытые пленочной оболочкой оранжевого цвета. На
поперечном разрезе ядро оранжевого цвета, допускаются незначительные более темные
или более светлые вкрапления.
Фармакотерапевтическая группа
противовирусное
иммуностимулирующее средство – индуктор образования интерферонов.
Фармакологические свойства
Фармакодинамика.
Низкомолекулярный
синтетический индуктор интерферона, стимулирующий образование в организме всех
типов интерферонов (альфа, бета, гамма и лямбда). Основными продуцентами
интерферона в ответ на введение тилорона являются клетки эпителия кишечника,
гепатоциты, Т-лимфоциты, нейтрофилы и гранулоциты. После приема внутрь максимум
продукции интерферона определяется в последовательности кишечник - печень -
кровь через 4-24 ч. Амиксин® обладает иммуномодулирующим и противовирусным
эффектом.
По
данным экспериментальных исследований после однократного перорального введения
препарата Амиксин® в дозе, эквивалентной максимальной суточной дозе для
человека, максимальная концентрация в легочной ткани интерферона лямбда определяется
через 24 часа, интерферона альфа – через 48 часов. Индукция интерферона лямбда
в легочной ткани способствует повышению противовирусной защиты респираторного
тракта при гриппозной и других респираторных вирусных инфекциях.
В
лейкоцитах человека индуцирует синтез интерферона. Стимулирует стволовые клетки
костного мозга, в зависимости от дозы усиливает антителообразование, уменьшает
степень иммунодепрессии, восстанавливает соотношения Т-супрессоров и
Т-хелперов. Эффективен против различных вирусных инфекций, в том числе, против
вирусов гриппа, других острых респираторных вирусных инфекций, вирусов гепатита
и герпесвирусов. Механизм антивирусного действия связан с ингибированием
трансляции вирус-специфических белков в инфицированных клетках, в результате
чего подавляется репродукция вирусов.
Фармакокинетика.
После
приема внутрь быстро всасывается из желудочно-кишечного тракта. Биодоступность
- 60 %. Около 80 % препарата связывается с белками плазмы. Выводится препарат
практически в неизмененном виде через кишечник (70 %) и через почки (9 %). Период
полувыведения (Т1/2) - 48 ч. Препарат не подвергается
биотрансформации и не накапливается в организме.
Показания к применению
В
составе комплексной терапии:
У
детей от 7 до 18 лет:
-
лечение гриппа и других острых респираторных вирусных инфекций (ОРВИ).
У
взрослых:
-
лечение гриппа и других ОРВИ;
-
лечение герпетической инфекции.
Профилактика
гриппа и других ОРВИ у взрослых.
Противопоказания
Повышенная
чувствительность к тилорону или любому другому компоненту препарата.
Беременность и период грудного вскармливания. Детский возраст до 7 лет (для
дозировки 60 мг), детский возраст до 18 лет (для дозировки 125 мг).
Применение при беременности и в период грудного вскармливания
Применение
препарата при беременности противопоказано. При необходимости применения
препарата в период лактации грудное вскармливание следует прекратить.
Способ применения и дозы
Амиксин®
принимают внутрь, после еды.
Для
детей от 7 до 18 лет:
При
неосложненных формах гриппа и других ОРВИ - по 60 мг 1 раз в день на 1-й, 2-й и
4-й день от начала лечения. Курсовая доза - 180 мг (3 таблетки).
Для
взрослых:
Для
лечения гриппа и других ОРВИ - по 125 мг в сутки первые 2 дня лечения, затем по
125 мг через 48 часов. На курс - 750 мг
(6 таблеток).
Для
профилактики гриппа и других ОРВИ - по 125 мг 1 раз в неделю в течение 6
недель. На курс - 750 мг (6 таблеток).
Для
лечения герпетической инфекции - первые двое суток по 125 мг, затем через 48
часов по 125 мг. Курсовая доза - 1,25-2,5 г (10-20 таблеток).
При
лечении гриппа и других ОРВИ в случае сохранения симптомов заболевания
более 4-х дней следует
проконсультироваться у врача.
Побочное действие
Возможны
аллергические реакции, диспепсические явления, кратковременный озноб. Если
любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили
любые другие побочные эффекты, не указанные в инструкции, сообщите об этом
врачу.
Передозировка
Случаи
передозировки препарата не известны.
Взаимодействие с другими лекарственными средствами
Совместим
с антибиотиками и лекарственными средствами традиционного лечения вирусных и
бактериальных заболеваний. Клинически значимого взаимодействия Амиксина®
с антибиотиками и средствами традиционного лечения вирусных и бактериальных
заболеваний не выявлено.
Влияние на способность управлять автомобилем и движущимися механизмами
Препарат
не оказывает отрицательного влияния на способность к управлению транспортными
средствами и занятиям другими потенциально опасными видами деятельности,
требующими повышенной концентрации внимания и быстроты психомоторных реакций.
По
6 или 10 таблеток (для дозировки 60 мг) или по 3, 6 или 10 таблеток (для
дозировки 125 мг) в контурной ячейковой упаковке.
1
или 2 контурные ячейковые упаковки вместе с инструкцией по применению в пачке
из картона.
Условия хранения
В
оригинальной упаковке при температуре не выше 30 °С.
Хранить
в недоступном для детей месте.
Срок годности
3
года. Не применять по истечении срока годности, указанного на упаковке.
Условия отпуска
Отпускают
без рецепта.
Производитель
ОАО "Фармстандарт-Лексредства",
305022, Россия, г. Курск, ул. 2-я Агрегатная, 1а/18,
тел./факс: (4712) 34-03-13,
www.pharmstd.ru
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
Начните сравнивать цены и заказывать лекарства прямо в приложении
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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коробка, 10 шт, 125 мг, для приема внутрь, в пленочной оболочке","short":"Таблетки, 10 шт, 125 мг","package":"10 шт, 125 мг"},"prescription":false,"catalog_section_id":88,"manufacturer":{"id":6025,"title":"Отисифарм","slug":"otisifarm","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Таблетки","slug":"105661-amiksin","attributes":{"count":"10 шт","dose":"125 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номер","slug":"","body":[{"type":"paragraph","data":{"text":"ЛСР-000175/08"}}]},{"id":11,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"таблетки,\nпокрытые плёночной оболочкой"}}]},{"id":1,"name":"Состав","slug":"ingredients","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003cb\u003eна одну таблетку\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Тилорон\n- 60,0 мг или 125,0 мг."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные\nвещества:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eядро:\u003c/i\u003e крахмал картофельный - 25,500 мг\nили 46,000 мг, целлюлоза микрокристаллическая - 60,000 мг или 120,000 мг,\nповидон (повидон К30) - 1,500 мг или 3,000 мг, кальция стеарат - 1,500 мг или\n3,000 мг, кроскармеллоза (кроскармеллоза натрия) - 1,500 мг или 3,000 мг;"}},{"type":"paragraph","data":{"text":"\u003ci\u003eоболочка:\u003c/i\u003e гипромеллоза\n(гидроксипропилметилцеллюлоза) - 3,4050 мг или 6,8100 мг, титана диоксид -\n1,7815 мг или 3,5630 мг, макрогол (полиэтиленгликоль-4000) - 0,4565 мг или\n0,9130 мг, полисорбат-80 (твин-80) - 0,0570 мг или 0,1140 мг, краситель\nхинолиновый желтый (Е 104) - 0,1235 мг или 0,2470 мг, краситель солнечный закат\nжелтый (Е 110) - 0,1765 мг или 0,3530 мг."}}]},{"id":12,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Круглые\nдвояковыпуклые таблетки, покрытые пленочной оболочкой оранжевого цвета. На\nпоперечном разрезе ядро оранжевого цвета, допускаются незначительные более темные\nили более светлые вкрапления. "}}]},{"id":13,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"противовирусное\nиммуностимулирующее средство – индуктор образования интерферонов."}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003cb\u003eФармакодинамика.\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Низкомолекулярный\nсинтетический индуктор интерферона, стимулирующий образование в организме всех\nтипов интерферонов (альфа, бета, гамма и лямбда). Основными продуцентами\nинтерферона в ответ на введение тилорона являются клетки эпителия кишечника,\nгепатоциты, Т-лимфоциты, нейтрофилы и гранулоциты. После приема внутрь максимум\nпродукции интерферона определяется в последовательности кишечник - печень -\nкровь через 4-24 ч. Амиксин\u003csup\u003e®\u003c/sup\u003e обладает иммуномодулирующим и противовирусным\nэффектом."}},{"type":"paragraph","data":{"text":"По\nданным экспериментальных исследований после однократного перорального введения\nпрепарата Амиксин® в дозе, эквивалентной максимальной суточной дозе для\nчеловека, максимальная концентрация в легочной ткани интерферона лямбда определяется\nчерез 24 часа, интерферона альфа – через 48 часов. Индукция интерферона лямбда\nв легочной ткани способствует повышению противовирусной защиты респираторного\nтракта при гриппозной и других респираторных вирусных инфекциях."}},{"type":"paragraph","data":{"text":"В\nлейкоцитах человека индуцирует синтез интерферона. Стимулирует стволовые клетки\nкостного мозга, в зависимости от дозы усиливает антителообразование, уменьшает\nстепень иммунодепрессии, восстанавливает соотношения Т-супрессоров и\nТ-хелперов. Эффективен против различных вирусных инфекций, в том числе, против\nвирусов гриппа, других острых респираторных вирусных инфекций, вирусов гепатита\nи герпесвирусов. Механизм антивирусного действия связан с ингибированием\nтрансляции вирус-специфических белков в инфицированных клетках, в результате\nчего подавляется репродукция вирусов. "}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика.\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"После\nприема внутрь быстро всасывается из желудочно-кишечного тракта. Биодоступность\n- 60 %. Около 80 % препарата связывается с белками плазмы. Выводится препарат\nпрактически в неизмененном виде через кишечник (70 %) и через почки (9 %). Период\nполувыведения (Т\u003csub\u003e1/2\u003c/sub\u003e) - 48 ч. Препарат не подвергается\nбиотрансформации и не накапливается в организме."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В\nсоставе комплексной терапии:"}},{"type":"paragraph","data":{"text":"У\nдетей от 7 до 18 лет:"}},{"type":"paragraph","data":{"text":"-\nлечение гриппа и других острых респираторных вирусных инфекций (ОРВИ)."}},{"type":"paragraph","data":{"text":"У\nвзрослых: "}},{"type":"paragraph","data":{"text":"-\nлечение гриппа и других ОРВИ;"}},{"type":"paragraph","data":{"text":"-\nлечение герпетической инфекции."}},{"type":"paragraph","data":{"text":"Профилактика\nгриппа и других ОРВИ у взрослых."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Повышенная\nчувствительность к тилорону или любому другому компоненту препарата.\nБеременность и период грудного вскармливания. Детский возраст до 7 лет (для\nдозировки 60 мг), детский возраст до 18 лет (для дозировки 125 мг)."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Применение\nпрепарата при беременности противопоказано. При необходимости применения\nпрепарата в период лактации грудное вскармливание следует прекратить."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Амиксин\u003csup\u003e®\u003c/sup\u003e\nпринимают внутрь, после еды."}},{"type":"paragraph","data":{"text":"Для\nдетей от 7 до 18 лет:"}},{"type":"paragraph","data":{"text":"При\nнеосложненных формах гриппа и других ОРВИ - по 60 мг 1 раз в день на 1-й, 2-й и\n4-й день от начала лечения. Курсовая доза - 180 мг (3 таблетки)."}},{"type":"paragraph","data":{"text":"Для\nвзрослых:"}},{"type":"paragraph","data":{"text":"Для\nлечения гриппа и других ОРВИ - по 125 мг в сутки первые 2 дня лечения, затем по\n125 мг через 48 часов. На курс - 750 мг\n(6 таблеток)."}},{"type":"paragraph","data":{"text":"Для\nпрофилактики гриппа и других ОРВИ - по 125 мг 1 раз в неделю в течение 6\nнедель. На курс - 750 мг (6 таблеток)."}},{"type":"paragraph","data":{"text":"Для\nлечения герпетической инфекции - первые двое суток по 125 мг, затем через 48\nчасов по 125 мг. Курсовая доза - 1,25-2,5 г (10-20 таблеток)."}},{"type":"paragraph","data":{"text":"При\nлечении гриппа и других ОРВИ в случае сохранения симптомов заболевания\nболее 4-х дней следует\nпроконсультироваться у врача."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Возможны\nаллергические реакции, диспепсические явления, кратковременный озноб. Если\nлюбые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили\nлюбые другие побочные эффекты, не указанные в инструкции, сообщите об этом\nврачу."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Случаи\nпередозировки препарата не известны."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Совместим\nс антибиотиками и лекарственными средствами традиционного лечения вирусных и\nбактериальных заболеваний. Клинически значимого взаимодействия Амиксина\u003csup\u003e®\u003c/sup\u003e\nс антибиотиками и средствами традиционного лечения вирусных и бактериальных\nзаболеваний не выявлено."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат\nне оказывает отрицательного влияния на способность к управлению транспортными\nсредствами и занятиям другими потенциально опасными видами деятельности,\nтребующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки,\nпокрытые пленочной оболочкой, 60 мг, 125 мг."}},{"type":"paragraph","data":{"text":"По\n6 или 10 таблеток (для дозировки 60 мг) или по 3, 6 или 10 таблеток (для\nдозировки 125 мг) в контурной ячейковой упаковке."}},{"type":"paragraph","data":{"text":"1\nили 2 контурные ячейковые упаковки вместе с инструкцией по применению в пачке\nиз картона."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В\nоригинальной упаковке при температуре не выше 30 °С."}},{"type":"paragraph","data":{"text":"Хранить\nв недоступном для детей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3\nгода. Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают\nбез рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ОАО \"Фармстандарт-Лексредства\","}},{"type":"paragraph","data":{"text":"305022, Россия, г. Курск, ул. 2-я Агрегатная, 1а/18,\nтел./факс: (4712) 34-03-13, "}},{"type":"paragraph","data":{"text":"www.pharmstd.ru"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Фармакодинамика.Низкомолекулярный синтетический индуктор интерферона, стимулирующий образование в организме всех типов интерферонов (альфа, бета, гамма и лямбда). Основными продуцентами интерферона в ответ на введение тилорона являются клетки эпителия кишечника, гепатоциты, Т-лимфоциты, нейтрофилы и гранулоциты. После приема внутрь максимум продукции интерферона определяется в последовательности кишечник - печень - кровь через 4-24 ч. Амиксин®обладает иммуномодулирующим и противовирусным эффектом. По данным экспериментальных исследований после однократного перорального введения препарата Амиксин® в дозе, эквивалентной максимальной суточной дозе для человека, максимальная концентрация в легочной ткани интерферона лямбда определяется через 24 часа, интерферона альфа – через 48 часов. Индукция интерферона лямбда в легочной ткани способствует повышению противовирусной защиты респираторного тракта при гриппозной и других респираторных вирусных инфекциях. В лейкоцитах человека индуцирует синтез интерферона. Стимулирует стволовые клетки костного мозга, в зависимости от дозы усиливает антителообразование, уменьшает степень иммунодепрессии, восстанавливает соотношения Т-супрессоров и Т-хелперов. 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