Цефазолин плохо всасывается из ЖКТ и поэтому применяется в/м... Инструкция
Показания к применению
Лечение инфекций, вызванных чувствительными микроорганизмами:- бактериальные инфекции верхних и нижних дыхательных путей; - инфекции мочевыводящих путей (в т.ч. острый пиелонефрит); - инфекции кожи и мягких тканей, в т.ч. раневые и ожоговые инфекции; - эндокардит; - септицемия; - инфекции органов брюшной полости и желчевыводящих путей; - инфекции костной ...
новорожденные до 1 месяца (безопасность применения не установлена); - повышенная чувствительность к компонентам препарата; - повышенная чувствительность к другим цефалоспориновым антибиотикам.
Инструкция
Состав
В 1 флаконе содержится: Цефазолин (в форме натриевой соли) 1000 мг
Фармакологические свойства
Цефазолин плохо всасывается из ЖКТ и поэтому применяется в/м или в/в. После в/м введения в дозе 500 мг Cmax в плазме достигается через 1-2 ч составляет 30 мкг/мл. Связывание с белками плазмы составляет около 85%. Цефазолин проникает в костную ткань, в асцитическую жидкость, плевральную и синовиальную жидкости, но не определяется в ЦНС.T1/2 цефазолина из плазмы составляет около 1.8 ч. Цефазолин выводится с мочой в неизмененном виде, главным образом, путем клубочковой фильтрации и в небольшой степени - путем канальцевой секреции. После в/м введения, по крайней мере, 80% дозы после в/м введения выводится через 24 ч. После в/м введения в дозах 500 мг и 1 г Cmax в моче составляет соответственно 1 мг/мл и 4 мг/мл. Имеются данные о высокой концентрации цефазолина в желчи, хотя он выводится этим путем в небольшом количестве.T1/2 из плазмы увеличивается у пациентов с нарушениями функции почек.
Показания к применению
Лечение инфекций, вызванных чувствительными микроорганизмами:- бактериальные инфекции верхних и нижних дыхательных путей; - инфекции мочевыводящих путей (в т.ч. острый пиелонефрит); - инфекции кожи и мягких тканей, в т.ч. раневые и ожоговые инфекции; - эндокардит; - септицемия; - инфекции органов брюшной полости и желчевыводящих путей; - инфекции костной и соединительной тканей (в т.ч. остеомиелит); - сифилис; - гонорея; - мастит. Профилактика инфекции при хирургических вмешательствах.
Противопоказания
новорожденные до 1 месяца (безопасность применения не установлена); - повышенная чувствительность к компонентам препарата; - повышенная чувствительность к другим цефалоспориновым антибиотикам.
Применение при беременности и в период грудного вскармливания
При беременности назначают только по жизненным показаниям (адекватных и строго контролируемых исследований не проведено).
Способ применения и дозы
Цефазолин Сандоз предназначен для в/в (в виде инъекций и инфузий) и в/м введения. Дозы зависят от чувствительности возбудителей, вызвавших инфекцию, и тяжести течения заболевания. Стандартные дозы для лечения: Показания Доза ЧастотаВведений СуточнаяДозаИнфекции легкой степени тяжести 500 мг1 г каждые 8 чКаждые 12 ч 1.5 г2гНеосложненные инфекции мочевыводящих путей 1г каждые 12 ч 2гИнфекции средней степени тяжести и тяжелые инфекции 1 г каждые 6-8 ч 3-4 гИнфекции, угрожающие жизни от 1 г до 1.5 г каждые 6 ч 4-6 гВ редких случаях применялись дозы до 12 г.
Побочное действие
Со стороны пищеварительной системы: потеря аппетита, диарея, боль в животе, тошнота и рвота (в большинстве случаев эти симптомы слабо выражены и исчезают во время или после лечения), дисбактериоз; редко - транзиторный гепатит, холестатическая желтуха, псевдомембранозный энтероколит, транзиторное повышение уровня печеночных трансаминаз, билирубина и/или ЛДГ и ЩФ. Со стороны мочевыделительной системы: транзиторное повышение уровня азота мочевины крови и креатинина сыворотки; редко - нарушение функции почек (при лечении высокими дозами). Со стороны ЦНС: головокружение, общее недомогание, усталость, кошмарные сновидения, нервозность или беспокойство, бессонница, сонливость, слабость, ощущение жара, изменения в восприятии цвета, спутанность сознания, энцефалопатия и эпилептиформные припадки (у пациентов с почечной недостаточностью), асептический менингит. Аллергические реакции: гипертермия, крапивница, кожный зуд, сыпь, ангионевротический отек; редко - экссудативная многоформная эритема (в т.ч. синдром Стивенса-Джонсона), синдром Лайелла, бронхоспазм, анафилактический шок. Лабораторные показатели: транзиторные - лейкоцитоз, гранулоцитоз, моноцитоз, лимфоцитопения, базофилия, эозинофилия, гранулоцитопения, нейтропения, лейкопения, тромбоцитопения, увеличение протромбинового времени; редко – снижение гемоглобина и/или гематокрита, анемия, агранулоцитоз, апластическая анемия, панцитопения, гемолитическая анемия. Местные реакции: флебит в месте в/в инъекции, болезненность в месте введения при в/м введении. Прочие: боль в груди, выпот в плевральную полость, кашель, ринит, гипогликемия, гипергликемия, вагинит, тромбофлебит, суперинфекция, кандидоз.
Передозировка
Передозировка может вызвать головную боль, головокружение и парестезии. В случае хронической почечной недостаточности у пациента могут возникнуть нейротоксические явления, при этом отмечены генерализованные клонико-тонические судороги, повышенная судорожная готовность, тахикардия и рвота. В случаях передозировки препарат нужно отменить, в случае необходимости провести противосудорожное симптоматическое лечение. При токсических реакциях, а также при симптомах передозировки выведения препарата можно ускорить путем гемодиализа. В данном случае перитонеальный диализ будет неэффективным.
Особые указания
С осторожностью применяют при нарушениях функции почек. У пациентов с повышенной чувствительностью к пенициллинам возможны аллергические реакции на цефалоспориновые антибиотики. В период лечения возможна ложноположительная реакция мочи на сахар. Цефазолин выводится при гемодиализе.
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