Твердые желатиновые капсулы № 0 желтого цвета (для дозировки 100 мг) и капсулы № 00 с желтым корпусом и оранжевой крышкой (для дозировки 200 мг). Содержимое капсул - гранулированный порошок желтого цвета с белыми вкраплениями.
Фармакотерапевтическая группа
противомикробное средство – нитрофуран
Фармакологические свойства
Противомикробное средство широкого спектра действия - производное 5-нитрофурана. Используют для лечения инфекций желудочно-кишечного тракта. Нифуроксазид блокирует активность дегидрогеназ и угнетает дыхательные цепи, цикл трикарбоновых кислот и другие биохимические реакции в бактериальной клетке. Разрушает мембраны чувствительных бактерий, снижает продукцию токсинов микроорганизмами. Активирует иммунитет, повышает активность фагоцитов и титр комплемента. Эффективен в отношении грамположительных микроорганизмов:
Staphylococcus spp.;
и грамотрицательных микроорганизмов:
Salmonella spp.;
Klebsiella spp.;
Enterobacter spp.;
Escherichia coli;
Shigella spp.;
Proteus spp.;
Haemophilus influenzae;
Campilobacter spp.;
Edwarsiella spp.;
Citrobacter spp.;
Vibrio cholerae;
Yersinia enterocolitica.
Нифуроксазид не оказывает влияния на состояние нормальной микрофлоры кишечника человека. При острой бактериальной диарее восстанавливает эубиоз кишечника. При инфицировании энтеротропными вирусами препятствует развитию бактериальной суперинфекции.
Фармакокинетика
После перорального применения нифуроксазид практически не всасывается в желудочно- кишечном тракте и не оказывает системного действия. Антибактериальную активность в отношении чувствительных видов бактерий проявляет только в просвете кишечника. В неизмененном виде выводится кишечником. Скорость элиминации зависит от дозы препарата и моторики желудочно- кишечного тракта.
Показания к применению
Острая и хроническая диарея инфекционного генеза (без признаков глистной инвазии).
Хронические колиты и энтероколиты.
Противопоказания
Повышенная чувствительность к нифуроксазиду, другим компонентам препарата, другим производным 5-нитрофурана. Дефицит сахаразы/изомальтазы, непереносимость фруктозы, глюкозо-галактозная мальабсорбция.
Детский возраст до 3-х лет (для данной лекформы).
С осторожностью
С осторожностью следует назначать препарат при заболеваниях печени, алкоголизме, черепно-мозговой травме, заболеваниях головного мозга, в период лактации, пациентам детского возраста.
Применение при беременности и в период грудного вскармливания
Отсутствуют данные относительно неблагоприятного влияния на плод при беременности. При необходимости, с осторожностью, препарат можно назначать беременным и женщинам, кормящим грудью.
Способ применения и дозы
Принимать внутрь.
Взрослые и дети старше 7 лет: 2 капсулы по 100 мг или 1 капсула по 200 мг 4 раза в сутки, (800 мг/сут).
Дети 3-7 лет: 2 капсулы по 100 мг или 1 капсула по 200 мг 3 раза в сутки, (600 мг/сут).
Длительность терапии нифуроксазидом - не более 7 суток.
Побочное действие
Аллергические реакции.
Передозировка
Специфических симптомов передозировки не описано. Рекомендуются стандартные меры неотложной помощи.
Взаимодействие с другими лекарственными средствами
Данных о взаимодействии нифуроксазида с другими лекарственными средствами не опубликовано.
Особые указания
При лечении диареи одновременно с терапией нифуроксазидом необходимо проводить регидратационную терапию (пероральную или внутривенную) в соответствии с состоянием пациента и продолжительностью диареи. Во время терапии нифуроксазидом не допускается прием алкоголя.
Влияние на способность управлять автомобилем и движущимися механизмами
Препарат не оказывает негативного влияния на способность управлять транспортными средствами, и/или другими механизмами.
Форма выпуска
Капсулы 100 мг и 200 мг. По 10 капсул (дозировкой 100 мг) или 5, 7, 8 капсул (дозировкой 200мг) помещают в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги алюминиевой печатной лакированной. По 30 капсул (дозировкой 100 мг) или по 16, 28 или 30 капсул (дозировкой 200мг) во флакон из пластика с навинчиваемой крышкой или банку полимерную с навинчиваемой крышкой. По 3 контурные ячейковые упаковки (для дозировки 100 мг) или по 2 контурные ячейковые упаковки по 8 капсул, 4 контурные ячейковые упаковки по 7 капсул или 6 контурных ячейковых упаковок по 5 капсул (для дозировки 200 мг) или 1 флакон или 1 банку вместе с инструкцией по применению помещают в пачку из картона.
Условия хранения
В защищенном от влаги и света месте, при температуре не выше 25°С. Хранить в недоступном для детей месте.
Срок годности
5 лет. Не использовать по истечении срока годности.
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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крахмал картофельный- 18,0 мг, магния стеарат- 6,0 мг, сахароза до получения массы содержимого капсулы . 630,0 мг."}},{"type":"paragraph","data":{"text":"капсулы твердые желатиновые №00 [желатин (до 100 %), вода (14-15 %), крышка: краситель пунцовый [Понсо 4R] (0,079801 %), краситель синий патентованный (0,00165 %), краситель солнечный закат (0,093301 %), титана диоксид (0,813158 %),"}},{"type":"paragraph","data":{"text":"корпус: краситель хинолиновый желтый (0,583356 %), краситель солнечный закат (0,002565 %), титана диоксид (0,974035 %)]."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Твердые желатиновые капсулы № 0 желтого цвета (для дозировки 100 мг) и капсулы № 00 с желтым корпусом и оранжевой крышкой (для дозировки 200 мг). Содержимое капсул - гранулированный порошок желтого цвета с белыми вкраплениями."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"противомикробное средство – нитрофуран"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"\n\nПротивомикробное средство широкого спектра действия - производное 5-нитрофурана. Используют для лечения инфекций желудочно-кишечного тракта. Нифуроксазид блокирует активность дегидрогеназ и угнетает дыхательные цепи, цикл трикарбоновых кислот и другие биохимические реакции в бактериальной клетке. Разрушает мембраны чувствительных бактерий, снижает продукцию токсинов микроорганизмами. Активирует иммунитет, повышает активность фагоцитов и титр комплемента. Эффективен в отношении грамположительных микроорганизмов:"}},{"type":"paragraph","data":{"text":"Staphylococcus spp.;"}},{"type":"paragraph","data":{"text":"и грамотрицательных микроорганизмов:"}},{"type":"paragraph","data":{"text":"Salmonella spp.;"}},{"type":"paragraph","data":{"text":"Klebsiella spp.;"}},{"type":"paragraph","data":{"text":"Enterobacter spp.;"}},{"type":"paragraph","data":{"text":"Escherichia coli;"}},{"type":"paragraph","data":{"text":"Shigella spp.;"}},{"type":"paragraph","data":{"text":"Proteus spp.;"}},{"type":"paragraph","data":{"text":"Haemophilus influenzae;"}},{"type":"paragraph","data":{"text":"Campilobacter spp.;"}},{"type":"paragraph","data":{"text":"Edwarsiella spp.;"}},{"type":"paragraph","data":{"text":"Citrobacter spp.;"}},{"type":"paragraph","data":{"text":"Vibrio cholerae;"}},{"type":"paragraph","data":{"text":"Yersinia enterocolitica."}},{"type":"paragraph","data":{"text":"Нифуроксазид не оказывает влияния на состояние нормальной микрофлоры кишечника человека. При острой бактериальной диарее восстанавливает эубиоз кишечника. При инфицировании энтеротропными вирусами препятствует развитию бактериальной суперинфекции."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"После перорального применения нифуроксазид практически не всасывается в желудочно- кишечном тракте и не оказывает системного действия. Антибактериальную активность в отношении чувствительных видов бактерий проявляет только в просвете кишечника. В неизмененном виде выводится кишечником. 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Дефицит сахаразы/изомальтазы, непереносимость фруктозы, глюкозо-галактозная мальабсорбция."}},{"type":"paragraph","data":{"text":"Детский возраст до 3-х лет (для данной лекформы).\n\n"}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eС осторожностью\u003c/i\u003e следует назначать препарат при заболеваниях печени, алкоголизме, черепно-мозговой травме, заболеваниях головного мозга, в период лактации, пациентам детского возраста. "}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Отсутствуют данные относительно неблагоприятного влияния на плод при беременности. При необходимости, с осторожностью, препарат можно назначать беременным и женщинам, кормящим грудью."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nПринимать внутрь."}},{"type":"paragraph","data":{"text":"Взрослые и дети старше 7 лет: 2 капсулы по 100 мг или 1 капсула по 200 мг 4 раза в сутки, (800 мг/сут)."}},{"type":"paragraph","data":{"text":"Дети 3-7 лет: 2 капсулы по 100 мг или 1 капсула по 200 мг 3 раза в сутки, (600 мг/сут)."}},{"type":"paragraph","data":{"text":"Длительность терапии нифуроксазидом - не более 7 суток.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические реакции."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Специфических симптомов передозировки не описано. Рекомендуются стандартные меры неотложной помощи."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Данных о взаимодействии нифуроксазида с другими лекарственными средствами не опубликовано."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При лечении диареи одновременно с терапией нифуроксазидом необходимо проводить регидратационную терапию (пероральную или внутривенную) в соответствии с состоянием пациента и продолжительностью диареи. Во время терапии нифуроксазидом не допускается прием алкоголя."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не оказывает негативного влияния на способность управлять транспортными средствами, и/или другими механизмами."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы 100 мг и 200 мг. По 10 капсул (дозировкой 100 мг) или 5, 7, 8 капсул (дозировкой 200мг) помещают в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги алюминиевой печатной лакированной. По 30 капсул (дозировкой 100 мг) или по 16, 28 или 30 капсул (дозировкой 200мг) во флакон из пластика с навинчиваемой крышкой или банку полимерную с навинчиваемой крышкой. По 3 контурные ячейковые упаковки (для дозировки 100 мг) или по 2 контурные ячейковые упаковки по 8 капсул, 4 контурные ячейковые упаковки по 7 капсул или 6 контурных ячейковых упаковок по 5 капсул (для дозировки 200 мг) или 1 флакон или 1 банку вместе с инструкцией по применению помещают в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от влаги и света месте, при температуре не выше 25°С. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет. Не использовать по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/firm/3688\"\u003eАВВА РУС \u003c/a\u003e(Россия) "}}]}],"source":null},"description_toggle":false,"short_description":"Противомикробное средство широкого спектра действия - производное 5-нитрофурана. Используют для лечения инфекций желудочно-кишечного тракта. Нифуроксазид блокирует активность дегидрогеназ и угнетает дыхательные цепи, цикл трикарбоновых кислот и другие биохимические реакции в бактериальной клетке. Разрушает мембраны чувствительных бактерий, снижает продукцию токсинов микроорганизмами. Активирует иммунитет, повышает активность фагоцитов и титр комплемента. 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