Повышенная чувствительность к алискирену или любому другому компоненту препарата, тяжелые нарушения функции почек (сывороточный креатинин >150 мкмоль/л
Для женщин и >177 мкмоль/л
Для мужчин и/или скорость клубочковой фильтрации
<30 мл/мин), нефротический синдром, реноваскулярная гипертензия, регулярное проведение процедуры гемодиализа, нарушения функции печени тяжелой степени (более 9 баллов по шкале Child-Pough), детский и подростковый возраст до 18 лет (эффективность и безопасность препарата Расилез не установлена)
Повышенная чувствительность к алискирену или любому другому компоненту препарата, тяжелые нарушения функции почек (сывороточный креатинин >150 мкмоль/л
Для женщин и >177 мкмоль/л
Для мужчин и/или скорость клубочковой фильтрации
<30 мл/мин), нефротический синдром, реноваскулярная гипертензия, регулярное проведение процедуры гемодиализа, нарушения функции печени тяжелой степени (более 9 баллов по шкале Child-Pough), детский и подростковый возраст до 18 лет (эффективность и безопасность препарата Расилез не установлена)
Применение при беременности и в период грудного вскармливания
С осторожностью
Способ применения и дозы
Внутрь, независимо от приема пищи, как в качестве монотерапии, так и в комбинации с другими антигипертензивными средствами. Рекомендуемая начальная доза препарата Расилез составляет 150 мг 1 раз в сутки. Развитие антигипертензивного эффекта наблюдается через 2 нед после начала терапии в дозе 150 мг 1 раз в сутки. При недостаточном контроле АД доза препарата может быть увеличена до 300 мг 1 раз/сут. У пациентов старше 65 лет коррекция дозы препарата не требуется. Применение у детей и подростков в возрасте до 18 лет. Поскольку эффективность и безопасность препарата Расилез у детей и подростков (младше 18 лет) пока не установлены, препарат не рекомендуется применять у данной категории пациентов. У пациентов с нарушениями функции почек (при скорости клубочковой фильтрации более 30 мл/мин) и печени от легкой до умеренной степени (5–9 баллов по Child-Pough) коррекция дозы препарата не требуется.
Побочное действие
Безопасность применения препарата Расилез оценивалась более чем у 7800 пациентов. Частота нежелательных реакций не была связана с полом, возрастом, индексом массы тела или расовой принадлежностью. При применении препарата в дозе до 300 мг общая частота нежелательных реакций была сходной с таковой при использовании плацебо. Нежелательные реакции в целом были умеренно выражены, носили временный характер и редко требовали прекращения терапии препаратом. Наиболее часто при применении препарата Расилез у пациентов наблюдалась диарея. При применении препарата не отмечалось повышения частоты развития сухого кашля, характерного для ингибиторов АПФ. Частота развития сухого кашля на фоне лечения препаратом Расилез (0,9%) была сходной с таковой при приеме плацебо (0,6%). В ходе клинических исследований в группе препарата Расилез частота развития ангионевротического отека была сходна с таковой в группе плацебо или гидрохлоротиазида.
Передозировка
Симптомы: наиболее вероятный и основной симптом — выраженное снижение АД. Лечение: поддерживающая терапия.
Особые указания
У больных сахарным диабетом на фоне терапии алискиреном в комбинации с ингибитором АПФ отмечалось повышение частоты гиперкалиемии (5,5%). При применении препарата Расилез и других препаратов, влияющих на РААС, у пациентов, страдающих сахарным диабетом, необходимо регулярно контролировать электролитный состав плазмы крови и функцию почек.
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