Круглые двояковыпуклые таблетки, покрытые пленочной оболочкой бледно-розового с сероватым оттенком цвета. На поперечном разрезе ядро белого цвета.
Таблетки 40 мг
Круглые двояковыпуклые таблетки, покрытые пленочной оболочкой бледно-коричневого со слегка розоватым оттенком цвета. На поперечном разрезе ядро белого цвета.
Фармакотерапевтическая группа
Желез желудка секрецию понижающее средство — Н2-гистаминовых рецепторов блокатор
Фармакологические свойства
Фармакодинамика.
Фамотидин является конкурентным антагонистом гистамина. Действуя на гистаминовые Н2 — рецепторы париетальных клеток значительно уменьшает вызванную различными раздражителями секрецию хлористоводородной кислоты. Снижается и базальная секреция хлористоводородной кислоты. В меньшей степени угнетается вызванная секреция пепсиногена. Вызывает дозозависимое подавление продукции соляной кислоты и уменьшение активности пепсина. Существенно не изменяет уровень гастрина в плазме. Продолжительность действия препарата при однократном приеме зависит от дозы и составляет от 12 до 24 часов.
Фармакокинетика.
После приема внутрь быстро абсорбируется из ЖКТ. После приема внутрь максимальная концентрация в плазме крови достигается в течение 1-3,5 часов. Связывание с белками плазмы 15-20%. 30-35% фамотидина метаболизируется в печени (с образованием S-оксида). Элиминация, в основном, происходит через почки: 27-40% препарата экскретируется с мочой в неизмененном виде. Период полувыведения — 2,5-4 часа, у пациентов с клиренсом креатинина ниже 30 мл/мин увеличивается до 10-12 часов. Проникает через плацентарный барьер и выделяется с грудным молоком.
Показания к применению
Язвенная болезнь желудка и 12-перстной кишки, профилактика рецидивов;
Эрозивный гастродуоденит;
Функциональная диспепсия, ассоциированная с повышенной секреторной функцией;
Симптоматические и стрессовые язвы ЖКТ;
Рефлюкс-эзофагит;
профилактика рецидивов, связанных с длительным приемом нестероидных противовоспалительных средств;
Синдром Золлингера-Эллисона;
Системный мастоцитоз;
Полиэндокринный аденоматоз,
Профилактика рецидивов кровотечений в послеоперационном периоде;
Профилактика аспирации желудочного сока у больных, которым проводятся операции под общей анестезией (синдром Мендельсона);
Профилактика аспирационного пневмонита;
Диспепсия с эпигастральными или загрудинными болями, возникающими в ночное время или связанными с приемом пищи.
Противопоказания
Беременность, период лактации, повышенная чувствительность к фамотидину и другим блокаторам Н2-гистаминовых рецепторов, детский возраст.
С осторожностью
печеночная и/или почечная недостаточность, цирроз печени с портосистемной энцефалопатией (в анамнезе), иммунодефицит.
Способ применения и дозы
Внутрь, не разжевывая, запивая достаточным количеством воды.
Взрослые:
При язвенной болезни желудка и 12-перстной кишки в фазе обострения, симптоматических язвах, эрозивном гастродуодените обычно назначают по 20 мг 2 раза в сутки или по 40 мг 1 раз в сутки на ночь. При необходимости суточная доза может быть увеличена до 80 — 160 мг. Курс лечения 4-8 недель.
При диспепсии, связанной с повышенной секреторной функцией желудка, назначают по 20 мг 1-2 раза в сутки.
С целью профилактики рецидивов язвенной болезни назначают по 20 мг 1 раз в сутки перед сном.
При рефлюкс-эзофагите 20-40 мг два раза в сутки в течение 6-12 недель.
При синдроме Золлингера-Эллисона дозу препарата и продолжительность курса лечения устанавливают индивидуально. Начальная доза обычно составляет 20 мг каждые 6 часов и может быть увеличена до 160 мг каждые 6 часов.
Для профилактики аспирации желудочного сока при общей анестезии назначают по 40 мг вечером и/или утром перед операцией. Таблетки Фамотидина следует проглатывать не разжевывая, запивая достаточным количеством воды.
При почечной недостаточности, если клиренс креатинина составляет менее 30 мл/мин или содержание креатинина в сыворотке крови более 3 мг/100 мл, суточную дозу препарата необходимо уменьшить до 20 мг.
Побочное действие
Со стороны пищеварительной системы: сухость во рту, тошнота, рвота, боль в животе, метеоризм, запор, диарея, снижение аппетита; повышение активности «печеночных» ферментов, гепатит, острый панкреатит, холестатическая желтуха.
Со стороны нервной системы: головная боль, головокружение, бессонница, беспокойство, повышенная утомляемость, сонливость, депрессия, спутанность сознания, галлюцинации, нервозность, возбуждение.
Со стороны органов чувств: нечеткость зрительного восприятия, шум в ушах.
Со стороны сердечно-сосудистой системы: брадикардия, аритмия, снижение артериального давления, антриовентрикулярная блокада.
Со стороны опорно-двигательного аппарата: мышечные боли, боли в суставах, мышечные спазмы.
Симптомы: рвота, двигательное возбуждение, тремор, снижение АД, тахикардия, коллапс.
Лечение: при пероральном приеме показана индукция рвоты или/и промывание желудка. Симптоматическая и поддерживающая терапия: при судорогах — в/в диазепам; при брадикардии — атропин; при желудочковых аритмиях — лидокаин. Гемодиализ эффективен.
Взаимодействие с другими лекарственными средствами
Увеличивает всасывание амоксициллина и клавулановой кислоты.
Совместим с 0.18 и 0.9% раствором NaCl, 4 и 5% раствором декстрозы, 4.2% раствором натрия гидрокарбоната.
При одновременном применении с антацидными средствами, содержащими магний и алюминий, сукральфатом происходит снижение интенсивности абсорбции фамотидина, поэтому перерыв между приемом этих препаратов должен составлять не менее 1-2 часов.
Вследствие повышения рН содержимого желудка при одновременном приеме может уменьшиться всасывание кетоконазола и итраконазола.
Лекарственные средства, угнетающие костный мозг, увеличивают риск развития нейтропении.
Перед началом лечения необходимо исключить возможность наличия злокачественного заболевания пищевода, желудка или двенадцатиперстной кишки, поскольку Фамотидин может маскировать симптомы.
Симптомы язвенной болезни 12 — перстной кишки могут исчезать в течение 1-2 недель, терапию следует продолжать до тех пор, пока рубцевание не подтверждено данными эндоскопического или рентгеновского исследования.
Отменяют Фамотидин постепенно из-за риска развития синдрома «рикошета» при резкой отмене.
При длительном лечении у ослабленных больных, а также при стрессе возможны бактериальные поражения желудка с последующим распространением инфекции.
Фамотидин (блокатор Н2-гистаминовых рецепторов) следует принимать через 2 ч после приема итраконазола или кетоконазола во избежание значительного уменьшения их всасывания.
Противодействует влиянию пентагастрина и гистамина на кислотообразующую функцию желудка, поэтому в течение 24 ч, предшествующих тесту, применять Фамотидин не рекомендуется.
Фамотидин подавляет кожную реакцию на гистамин, приводя, таким образом, к ложноотрицательным результатам (перед проведением диагностических кожных проб для выявления аллергической кожной реакции немедленного типа использование Фамотидина рекомендуется прекратить).
Во время лечения следует избегать употребления продуктов питания, напитков и др. ЛС, которые могут вызвать раздражение слизистой оболочки желудка.
Эффективность Фамотидина в ингибировании ночной секреции кислоты в желудке может снижаться в результате курения.
Больным с ожогами может потребоваться увеличение дозы препарата вследствие повышенного клиренса.
В случае пропуска дозы, ее необходимо принять как можно скорее; не принимать, если наступило время приема следующей дозы; не удваивать дозы. При отсутствии улучшений необходима консультация врача.
Влияние на способность управлять автомобилем и движущимися механизмами
В период лечения фамотидином следует соблюдать осторожность при управлении транспортом и при выполнении потенциально опасных видов деятельности, требующих повышенного внимания и быстроты психомоторных реакций.
Форма выпуска
Таблетки, покрытые пленочной оболочкой, 20 мг и 40 мг.
По 10 таблеток в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги алюминиевой печатной лакированной. По 2 или 3 контурных ячейковых упаковки вместе с инструкцией по медицинскому применению лекарственного препарата в пачку из картона.
Условия хранения
При температуре не выше 25 ºС в потребительской упаковке (в пачке картонной).
Хранить в недоступном для детей месте.
Срок годности
3 года. Не применять по истечении срока годности, указанного на упаковке.
Условия отпуска
Отпускают по рецепту.
Производитель
ООО «Хемофарм», Россия
249032, Калужская обл., г. Обнинск, Киевское шоссе, д. 62.
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[Е172]."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eТаблетки 20 мг\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Круглые двояковыпуклые таблетки, покрытые пленочной оболочкой бледно-розового с сероватым оттенком цвета. На поперечном разрезе ядро белого цвета."}},{"type":"paragraph","data":{"text":"\u003ci\u003eТаблетки 40 мг\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Круглые двояковыпуклые таблетки, покрытые пленочной оболочкой бледно-коричневого со слегка розоватым оттенком цвета. На поперечном разрезе ядро белого цвета."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":" Желез желудка секрецию понижающее средство — Н\u003csub\u003e2\u003c/sub\u003e-гистаминовых рецепторов блокатор "}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eФармакодинамика.\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Фамотидин является конкурентным антагонистом гистамина. Действуя на гистаминовые Н\u003csub\u003e2\u003c/sub\u003e — рецепторы париетальных клеток значительно уменьшает вызванную различными раздражителями секрецию хлористоводородной кислоты. Снижается и базальная секреция хлористоводородной кислоты. В меньшей степени угнетается вызванная секреция пепсиногена. Вызывает дозозависимое подавление продукции соляной кислоты и уменьшение активности пепсина. Существенно не изменяет уровень гастрина в плазме. Продолжительность действия препарата при однократном приеме зависит от дозы и составляет от 12 до 24 часов."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика.\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"После приема внутрь быстро абсорбируется из ЖКТ. После приема внутрь максимальная концентрация в плазме крови достигается в течение 1-3,5 часов. Связывание с белками плазмы 15-20%. 30-35% фамотидина метаболизируется в печени (с образованием S-оксида). Элиминация, в основном, происходит через почки: 27-40% препарата экскретируется с мочой в неизмененном виде. Период полувыведения — 2,5-4 часа, у пациентов с клиренсом креатинина ниже 30 мл/мин увеличивается до 10-12 часов. Проникает через плацентарный барьер и выделяется с грудным молоком."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"list","data":{"style":"ordered","items":["Язвенная болезнь желудка и 12-перстной кишки, профилактика рецидивов;","Эрозивный гастродуоденит;","Функциональная диспепсия, ассоциированная с повышенной секреторной функцией;","Симптоматические и стрессовые язвы ЖКТ;","Рефлюкс-эзофагит;","профилактика рецидивов, связанных с длительным приемом нестероидных противовоспалительных средств;","Синдром Золлингера-Эллисона;","Системный мастоцитоз;","Полиэндокринный аденоматоз,","Профилактика рецидивов кровотечений в послеоперационном периоде;","Профилактика аспирации желудочного сока у больных, которым проводятся операции под общей анестезией (синдром Мендельсона);","Профилактика аспирационного пневмонита;","Диспепсия с эпигастральными или загрудинными болями, возникающими в ночное время или связанными с приемом пищи."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":" Беременность, период лактации, повышенная чувствительность к фамотидину и другим блокаторам Н\u003csub\u003e2\u003c/sub\u003e-гистаминовых рецепторов, детский возраст. "}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"печеночная и/или почечная недостаточность, цирроз печени с портосистемной энцефалопатией (в анамнезе), иммунодефицит."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь, не разжевывая, запивая достаточным количеством воды."}},{"type":"paragraph","data":{"text":"\u003cb\u003eВзрослые:\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри язвенной болезни желудка и 12-перстной кишки в фазе обострения, симптоматических язвах, эрозивном гастродуодените\u003c/i\u003e обычно назначают по 20 мг 2 раза в сутки или по 40 мг 1 раз в сутки на ночь. При необходимости суточная доза может быть увеличена до 80 — 160 мг. Курс лечения 4-8 недель."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри диспепсии, связанной с повышенной секреторной функцией желудка, \u003c/i\u003eназначают по 20 мг 1-2 раза в сутки."}},{"type":"paragraph","data":{"text":"\u003ci\u003eС целью профилактики рецидивов язвенной болезни\u003c/i\u003e назначают по 20 мг 1 раз в сутки перед сном."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри рефлюкс-эзофагите\u003c/i\u003e 20-40 мг два раза в сутки в течение 6-12 недель."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри синдроме Золлингера-Эллисона\u003c/i\u003e дозу препарата и продолжительность курса лечения устанавливают индивидуально. Начальная доза обычно составляет 20 мг каждые 6 часов и может быть увеличена до 160 мг каждые 6 часов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДля профилактики аспирации желудочного сока при общей анестезии\u003c/i\u003e назначают по 40 мг вечером и/или утром перед операцией. Таблетки Фамотидина следует проглатывать не разжевывая, запивая достаточным количеством воды."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри почечной недостаточности,\u003c/i\u003e если клиренс креатинина составляет менее 30 мл/мин или содержание креатинина в сыворотке крови более 3 мг/100 мл, суточную дозу препарата необходимо уменьшить до 20 мг."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e сухость во рту, тошнота, рвота, боль в животе, метеоризм, запор, диарея, снижение аппетита; повышение активности «печеночных» ферментов, гепатит, острый панкреатит, холестатическая желтуха."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы:\u003c/i\u003e головная боль, головокружение, бессонница, беспокойство, повышенная утомляемость, сонливость, депрессия, спутанность сознания, галлюцинации, нервозность, возбуждение."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органов чувств:\u003c/i\u003e нечеткость зрительного восприятия, шум в ушах."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e брадикардия, аритмия, снижение артериального давления, антриовентрикулярная блокада."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны опорно-двигательного аппарата:\u003c/i\u003e мышечные боли, боли в суставах, мышечные спазмы."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции:\u003c/i\u003e кожная сыпь, зуд, бронхоспазм, ангионевротический отек, анафилактический шок, токсический эпидермальный некролиз."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органов кроветворения:\u003c/i\u003e лейкопения, тромбоцитопения, агранулоцитоз, панцитопения, гипоплазия, аплазия костного мозга."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны репродуктивной системы:\u003c/i\u003e при длительном приеме больших доз — гиперпролактинемия, гинекомастия, аменорея, снижение либидо, импотенция."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие:\u003c/i\u003e сухость кожи, алопеция, обыкновенные угри, лихорадка."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e рвота, двигательное возбуждение, тремор, снижение АД, тахикардия, коллапс."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e при пероральном приеме показана индукция рвоты или/и промывание желудка. Симптоматическая и поддерживающая терапия: при судорогах — в/в диазепам; при брадикардии — атропин; при желудочковых аритмиях — лидокаин. Гемодиализ эффективен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Увеличивает всасывание амоксициллина и клавулановой кислоты."}},{"type":"paragraph","data":{"text":"Совместим с 0.18 и 0.9% раствором NaCl, 4 и 5% раствором декстрозы, 4.2% раствором натрия гидрокарбоната."}},{"type":"paragraph","data":{"text":"При одновременном применении с антацидными средствами, содержащими магний и алюминий, сукральфатом происходит снижение интенсивности абсорбции фамотидина, поэтому перерыв между приемом этих препаратов должен составлять не менее 1-2 часов."}},{"type":"paragraph","data":{"text":"Вследствие повышения рН содержимого желудка при одновременном приеме может уменьшиться всасывание кетоконазола и итраконазола."}},{"type":"paragraph","data":{"text":"Лекарственные средства, угнетающие костный мозг, увеличивают риск развития нейтропении."}},{"type":"paragraph","data":{"text":"Угнетает метаболизм в печени диазепама, гексобарбитала, пропранолола, лидокаин, фенитоина, теофиллина, непрямых антикоагулянтов."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Перед началом лечения необходимо исключить возможность наличия злокачественного заболевания пищевода, желудка или двенадцатиперстной кишки, поскольку Фамотидин может маскировать симптомы."}},{"type":"paragraph","data":{"text":"Симптомы язвенной болезни 12 — перстной кишки могут исчезать в течение 1-2 недель, терапию следует продолжать до тех пор, пока рубцевание не подтверждено данными эндоскопического или рентгеновского исследования."}},{"type":"paragraph","data":{"text":"Отменяют Фамотидин постепенно из-за риска развития синдрома «рикошета» при резкой отмене."}},{"type":"paragraph","data":{"text":"При длительном лечении у ослабленных больных, а также при стрессе возможны бактериальные поражения желудка с последующим распространением инфекции."}},{"type":"paragraph","data":{"text":"Фамотидин (блокатор Н\u003csub\u003e2\u003c/sub\u003e-гистаминовых рецепторов) следует принимать через 2 ч после приема итраконазола или кетоконазола во избежание значительного уменьшения их всасывания."}},{"type":"paragraph","data":{"text":"Противодействует влиянию пентагастрина и гистамина на кислотообразующую функцию желудка, поэтому в течение 24 ч, предшествующих тесту, применять Фамотидин не рекомендуется."}},{"type":"paragraph","data":{"text":"Фамотидин подавляет кожную реакцию на гистамин, приводя, таким образом, к ложноотрицательным результатам (перед проведением диагностических кожных проб для выявления аллергической кожной реакции немедленного типа использование Фамотидина рекомендуется прекратить)."}},{"type":"paragraph","data":{"text":"Во время лечения следует избегать употребления продуктов питания, напитков и др. ЛС, которые могут вызвать раздражение слизистой оболочки желудка."}},{"type":"paragraph","data":{"text":"Эффективность Фамотидина в ингибировании ночной секреции кислоты в желудке может снижаться в результате курения."}},{"type":"paragraph","data":{"text":"Больным с ожогами может потребоваться увеличение дозы препарата вследствие повышенного клиренса."}},{"type":"paragraph","data":{"text":"В случае пропуска дозы, ее необходимо принять как можно скорее; не принимать, если наступило время приема следующей дозы; не удваивать дозы. При отсутствии улучшений необходима консультация врача."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения фамотидином следует соблюдать осторожность при управлении транспортом и при выполнении потенциально опасных видов деятельности, требующих повышенного внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой, 20 мг и 40 мг."}},{"type":"paragraph","data":{"text":"По 10 таблеток в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги алюминиевой печатной лакированной. По 2 или 3 контурных ячейковых упаковки вместе с инструкцией по медицинскому применению лекарственного препарата в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 ºС в потребительской упаковке (в пачке картонной)."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eООО «Хемофарм», Россия\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"249032, Калужская обл., г. Обнинск, Киевское шоссе, д. 62."}},{"type":"paragraph","data":{"text":"Тел.: (48439) 90-500; факс: (48439) 90-525.\n\n"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО «Нижфарм», Россия"}},{"type":"paragraph","data":{"text":"603950, г. Нижний Новгород,"}},{"type":"paragraph","data":{"text":"ул. Салганская, д. 7"}},{"type":"paragraph","data":{"text":"Тел.: (831) 278-80-88; факс: (831) 430-72-28."}},{"type":"paragraph","data":{"text":"Е-mail: \u003ca href=\"mailto:med@stada.ru\"\u003emed@stada.ru\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика.Фамотидин является конкурентным антагонистом гистамина. Действуя на гистаминовые Н2— рецепторы париетальных клеток значительно уменьшает вызванную различными раздражителями секрецию хлористоводородной кислоты. Снижается и базальная секреция хлористоводородной кислоты. В меньшей степени угнетается вызванная секреция пепсиногена. Вызывает дозозависимое подавление продукции соляной кислоты и уменьшение активности пепсина. Существенно не изменяет уровень гастрина в плазме. Продолжительность действия препарата при однократном приеме зависит от дозы и составляет от 12 до 24 часов.Фармакокинетика.После приема внутрь быстро абсорбируется из ЖКТ. После приема внутрь максимальная концентрация в плазме крови достигается в течение 1-3,5 часов. Связывание с белками плазмы 15-20%. 30-35% фамотидина метаболизируется в печени (с образованием S-оксида). Элиминация, в основном, происходит через почки: 27-40% препарата экскретируется с мочой в неизмененном виде. Период полувыведения — 2,5-4 часа, у пациентов с клиренсом креатинина ниже 30 мл/мин увеличивается до 10-12 часов. Проникает через плацентарный барьер и выделяется с грудным молоком.","substance":[{"id":92,"title":"Фамотидин","title_latin":"Famotidinum","slug":"famotidin_92"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Фамотидин хемофарм - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/81076/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/81076/share_default/"}},"diseases":[{"id":"296","title":"Злокачественная тучноклеточная опухоль (мастоцитома, мастоцитоз)","slug":"296-zlokachestvennaya_tuchnokletochnaya_opuhol_mastotsitoma_mastotsitoz"},{"id":"374","title":"Другие уточненные нарушения внутренней секреции поджелудочной железы (в т.ч. синдром Золлингера-Эллисона)","slug":"374-drugie_utochnennye_narusheniya_vnutrenney_sekretsii_podzheludochnoy_zhelezy_v_tch_sindrom_zollingeraellisona"},{"id":"844","title":"Синдром 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