Таблетки Рофлокс-Скан - синтетический антибактериальный препарат широкого спектра действия из группы фторхинолонов, содержащий в качестве активного вещества левофлоксацин - левовращающий изомер офлоксацина.
Применение при беременности и в период грудного вскармливания
Препарат Рофлокс-Скан противопоказан для применения у беременных женщин и женщин в период грудного вскармливания.
Способ применения и дозы
Таблетки Рофлокс-Скан принимают внутрь один или два раза в сутки. Таблетки следует проглатывать, не разжевывая и запивая достаточным количеством жидкости (от 0,5 до 1 стакана). При необходимости таблетки можно разламывать по риске. Препарат можно принимать перед едой или в любое время между приемами пищи, так как прием пищи не влияет на абсорбцию препарата. Препарат следует принимать не менее чем через 2 ч до или через 2 ч после приёма препаратов, содержащих магний и/или алюминий, железо, цинк, или сукральфата. Учитывая, что биодоступность левофлоксацина при приеме препарата Рофлокс-Скан в таблетках равна 99-100 %, в случае перевода пациента с внутривенной инфузии препарат Рофлокс-Скан на прием таблеток следует продолжать лечение в той же дозе, которая применялась при внутривенной инфузии. Пропуск приема одной или нескольких доз препаратаЕсли случайно пропущен прием препарата, то надо, как можно скорее, принять очередную дозу и далее продолжать принимать препарат Рофлокс-Скан согласно рекомендованному режиму его дозирования.
Побочное действие
Указанные ниже побочные эффекты представлены в соответствии со следующими градациями частоты их возникновения: очень часто (≥1/10), часто (≥1/100, <1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000), очень редко (<1/10000) (включая отдельные сообщения), частота неизвестна (по имеющимся данным определить частоту встречаемости не представляется возможным). Нарушения со стороны сердцаРедко: синусовая тахикардия, ощущение сердцебиения. Частота неизвестна: удлинение интервала QТ, желудочковые нарушения ритма, желудочковая тахикардия, желудочковая тахикардия типа "пируэт", которые могут приводить к остановке сердца (см. разделы "Передозировка", "Особые указания"). Нарушения со стороны крови и лимфатической системыНечасто: лейкопения (уменьшение количества лейкоцитов в периферической крови), эозинофилия (увеличение количества эозинофилов в периферической крови). Редко: нейтропения (уменьшение количества нейтрофилов в периферической крови), тромбоцитопения (уменьшение количества тромбоцитов в периферической крови). Частота неизвестна: панцитопения (уменьшение количества всех форменных элементов в периферической крови), агранулоцитоз (отсутствие или резкое уменьшение количества 10 гранулоцитов в периферической крови), гемолитическая анемия. Нарушения со стороны нервной системыЧасто: головная боль, головокружение. Нечасто: сонливость, тремор, дисгевзия (извращение вкуса). Редко: парестезия, судороги (см. раздел "Особые указания"). Частота неизвестна: периферическая сенсорная нейропатия, периферическая сенсорномоторная нейропатия (см. раздел "Особые указания"), дискинезия, экстрапирамидныёрасстройства, агевзия (потеря вкусовых ощущений), паросмия (расстройство ощущениязапаха, особенно субъективное ощущение запаха, объективно отсутствующего), включая потерю обоняния, обморок, доброкачественная внутричерепная гипертензия. Нарушения со стороны органа зренияРедко: нарушения зрения, такие как расплывчатость видимого изображения. Частота неизвестна: преходящая потеря зрения, увеит. Нарушения со стороны органа слуха и лабиринтные нарушения Нечасто: вертиго (чувство отклонения или кружения или собственного тела или окружающих предметов). Редко: звон в ушах. Частота неизвестна: снижение слуха, потеря слуха. Нарушения со стороны дыхательной системы, органов грудной клетки и средостенияНечасто: одышка. Частота неизвестна: бронхоспазм, аллергический пневмонит. Нарушения со стороны желудочно-кишечного трактаЧасто: диарея, рвота, тошнота. Нечасто: боли в животе, диспепсия, метеоризм, запор. Частота неизвестна: геморрагическая диарея, которая в очень редких случаях может быть признаком энтероколита, включая псевдомембранозный колит (см. раздел "Особые указания"), панкреатит. Нарушения со стороны почек и мочевыводящих путейНечасто: повышение концентрации креатинина в сыворотке крови. Редко: острая почечная недостаточность (например, вследствие развития интерстициального нефрита). Нарушения со стороны кожи и подкожных тканейНечасто: сыпь, зуд, крапивница, гипергидроз. Частота неизвестна: токсический эпидермальный некролиз, синдром Стивенса-Джонсона, экссудативная многоформная эритема, реакции фотосенсибилизации (повышенной чувствительности к солнечному и ультрафиолетовому излучению) (см. раздел "Особые указания"), лейкоцитокластический васкулит, стоматит. Реакции со стороны кожи и слизистых оболочек могут иногда развиваться даже после приема первой дозы препарата. Нарушения со стороны скелетно-мышечной системы и соединительной тканиНечасто: артралгия, миалгияРедко: поражение сухожилий, включая тендинит (например, ахиллова сухожилия), мышечная слабость, которая может быть особенно опасна у пациентов с псевдопаралитической миастенией (myasthenia gravis) (см. раздел "Особые указания"). Частота неизвестна: рабдомиолиз, разрыв сухожилия (например, ахиллова сухожилия. Этот побочный эффект может наблюдаться в течение 48 часов после начала лечения и может носить двухсторонний характер (см. также раздел "Особые указания")), разрыв связок, разрыв мышц, артрит. Нарушения со стороны обмена веществ и питанияНечасто: анорексия. Редко: гипогликемия, особенно у пациентов с сахарным диабетом (возможные признаки гипогликемии: "волчий" аппетит, нервозность, испарина, дрожь). Частота неизвестна: гипергликемия, гипогликемическая кома (см. раздел "Особые указания"). Инфекционные и паразитарные заболеванияНечасто: грибковые инфекции, развитие резистентности патогенных микроорганизмов. Нарушения со стороны сосудовРедко: снижение артериального давления. Общие расстройстваНечасто: астения. Редко: пирексия (повышение температуры тела). Частота неизвестна: боль (включая боль в спине, груди и конечностях). Нарушения со стороны иммунной системыРедко: ангионевротический отек. Частота неизвестна: анафилактический шок, анафилактоидный шок. Анафилактические и анафилактоидные реакции могут иногда развиваться даже после приема первой дозы препарата. Нарушения со стороны печени и желчевыводящих путейЧасто: повышение активности "печеночных" ферментов в крови (например, аланинаминотрансферазы (АЛТ), аспартатаминотрансферазы (ACT)), повышение активности щелочной фосфатазы (ЩФ) и гаммаглутамилтрансферазы (ГГТ). Нечасто: повышение концентрации билирубина в крови. Частота неизвестна: тяжелая печеночная недостаточность, включая случаи развития острой печеночной недостаточности, иногда с фатальным исходом, особенно у пациентов с тяжелым основным заболеванием (например, у пациентов с сепсисом) (см. раздел "Особые указания"), гепатит, желтуха. Нарушения психикиЧасто: бессонница. Нечасто: чувство беспокойства, тревога, спутанность сознания. Редко: психические нарушения (например, галлюцинации, паранойя), депрессия, ажитация (возбуждение), нарушения сна, ночные кошмары. Частота неизвестна: нарушения психики с нарушениями поведения с причинением себе вреда, включая суицидальные мысли и суицидальные попытки. Другие возможные нежелательные эффекты, относящиеся ко всем фторхинолонамОчень редко: приступы порфирии (очень редкой болезни обмена веществ) у пациентов с порфирией.
Передозировка
Симптомы передозировки: нарушения сознания, включая спутанность сознания, головокружение, судороги, галлюцинации, тремор, тошнота, эрозивные поражения слизистой оболочки желудочно-кишечного тракта, удлинение интервала QT. В случае передозировки требуется тщательное наблюдение за пациентом, включая мониторирование электрокардиограммы. Лечение симптоматическое. В случае острой передозировки таблеток Рофлокс-Скан показано промывание желудка и введение антацидов для защиты слизистой оболочки желудка. Левофлоксацин не выводится посредством диализа (гемодиализа, перитонеального диализа и постоянного амбулаторного перитонеального диализа). Специфического антидота не существует.
Особые указания
Противопоказания: гиперчувствительность к левофлоксацину или к другим хинолонам, а также к любому из вспомогательных веществ препарата Рофлокс-Скан, эпилепсия, псевдопаралитическая миастения (myasthenia gravis), поражения сухожилий при приеме фторхинолонов в анамнезе, детский и подростковый возраст до 18 лет (в связи с незавершенностью роста скелета, так как нельзя полностью исключить риск поражения хрящевых точек роста), беременность (нельзя полностью исключить риск поражения хрящевых точек роста у плода), период грудного вскармливания (нельзя полностью исключить риск поражения хрящевых точек роста костей у ребенка).
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вещество - левофлоксацина гемигидрат 256,23 мг. Вспомогательные вещества (ядро): крахмал кукурузный 33,03 мг, целлюлоза микрокристаллическая 20,00 мг, карбоксиметилкрахмал натрия 7,50 мг, кросповидон 7,50 мг, кремния диоксид коллоидный 7,50 мг, тальк 5,00 мг, стеарат магния 3,25 мг. Вспомогательные вещества (оболочка): Опадрай II розовый (85F540146): 8,50 мг (поливиниловый спирт (частично гидролизованный) 3,400 мг, диоксид титана 2,091 мг, макрогол 4000 1,717 мг, тальк 1,258 мг, железа оксид красный 0,034 мг."}}]},{"id":2,"name":"Описание","slug":"common_description","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Таблетки Рофлокс-Скан - синтетический антибактериальный препарат широкого спектра действия из группы фторхинолонов, содержащий в качестве активного вещества левофлоксацин - левовращающий изомер офлоксацина."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Септицемия неуточненная, хронический синусит, острый синусит, острый бронхит, флегмона, острый перитонит, хронический холецистит, острый холецистит, хронический обструктивный пиелонефрит."}}]},{"id":4,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат Рофлокс-Скан противопоказан для применения у беременных женщин и женщин в период грудного вскармливания."}}]},{"id":5,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Таблетки Рофлокс-Скан принимают внутрь один или два раза в сутки. Таблетки следует проглатывать, не разжевывая и запивая достаточным количеством жидкости (от 0,5 до 1 стакана). При необходимости таблетки можно разламывать по риске. Препарат можно принимать перед едой или в любое время между приемами пищи, так как прием пищи не влияет на абсорбцию препарата. Препарат следует принимать не менее чем через 2 ч до или через 2 ч после приёма препаратов, содержащих магний и/или алюминий, железо, цинк, или сукральфата. Учитывая, что биодоступность левофлоксацина при приеме препарата Рофлокс-Скан в таблетках равна 99-100 %, в случае перевода пациента с внутривенной инфузии препарат Рофлокс-Скан на прием таблеток следует продолжать лечение в той же дозе, которая применялась при внутривенной инфузии. Пропуск приема одной или нескольких доз препаратаЕсли случайно пропущен прием препарата, то надо, как можно скорее, принять очередную дозу и далее продолжать принимать препарат Рофлокс-Скан согласно рекомендованному режиму его дозирования."}}]},{"id":6,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Указанные ниже побочные эффекты представлены в соответствии со следующими градациями частоты их возникновения: очень часто (≥1/10), часто (≥1/100, \u003c1/10), нечасто (≥1/1000, \u003c1/100), редко (≥1/10000, \u003c1/1000), очень редко (\u003c1/10000) (включая отдельные сообщения), частота неизвестна (по имеющимся данным определить частоту встречаемости не представляется возможным). Нарушения со стороны сердцаРедко: синусовая тахикардия, ощущение сердцебиения. Частота неизвестна: удлинение интервала QТ, желудочковые нарушения ритма, желудочковая тахикардия, желудочковая тахикардия типа \"пируэт\", которые могут приводить к остановке сердца (см. разделы \"Передозировка\", \"Особые указания\"). Нарушения со стороны крови и лимфатической системыНечасто: лейкопения (уменьшение количества лейкоцитов в периферической крови), эозинофилия (увеличение количества эозинофилов в периферической крови). Редко: нейтропения (уменьшение количества нейтрофилов в периферической крови), тромбоцитопения (уменьшение количества тромбоцитов в периферической крови). Частота неизвестна: панцитопения (уменьшение количества всех форменных элементов в периферической крови), агранулоцитоз (отсутствие или резкое уменьшение количества 10 гранулоцитов в периферической крови), гемолитическая анемия. Нарушения со стороны нервной системыЧасто: головная боль, головокружение. Нечасто: сонливость, тремор, дисгевзия (извращение вкуса). Редко: парестезия, судороги (см. раздел \"Особые указания\"). Частота неизвестна: периферическая сенсорная нейропатия, периферическая сенсорномоторная нейропатия (см. раздел \"Особые указания\"), дискинезия, экстрапирамидныёрасстройства, агевзия (потеря вкусовых ощущений), паросмия (расстройство ощущениязапаха, особенно субъективное ощущение запаха, объективно отсутствующего), включая потерю обоняния, обморок, доброкачественная внутричерепная гипертензия. Нарушения со стороны органа зренияРедко: нарушения зрения, такие как расплывчатость видимого изображения. Частота неизвестна: преходящая потеря зрения, увеит. Нарушения со стороны органа слуха и лабиринтные нарушения Нечасто: вертиго (чувство отклонения или кружения или собственного тела или окружающих предметов). Редко: звон в ушах. Частота неизвестна: снижение слуха, потеря слуха. Нарушения со стороны дыхательной системы, органов грудной клетки и средостенияНечасто: одышка. Частота неизвестна: бронхоспазм, аллергический пневмонит. Нарушения со стороны желудочно-кишечного трактаЧасто: диарея, рвота, тошнота. Нечасто: боли в животе, диспепсия, метеоризм, запор. Частота неизвестна: геморрагическая диарея, которая в очень редких случаях может быть признаком энтероколита, включая псевдомембранозный колит (см. раздел \"Особые указания\"), панкреатит. Нарушения со стороны почек и мочевыводящих путейНечасто: повышение концентрации креатинина в сыворотке крови. Редко: острая почечная недостаточность (например, вследствие развития интерстициального нефрита). Нарушения со стороны кожи и подкожных тканейНечасто: сыпь, зуд, крапивница, гипергидроз. Частота неизвестна: токсический эпидермальный некролиз, синдром Стивенса-Джонсона, экссудативная многоформная эритема, реакции фотосенсибилизации (повышенной чувствительности к солнечному и ультрафиолетовому излучению) (см. раздел \"Особые указания\"), лейкоцитокластический васкулит, стоматит. Реакции со стороны кожи и слизистых оболочек могут иногда развиваться даже после приема первой дозы препарата. Нарушения со стороны скелетно-мышечной системы и соединительной тканиНечасто: артралгия, миалгияРедко: поражение сухожилий, включая тендинит (например, ахиллова сухожилия), мышечная слабость, которая может быть особенно опасна у пациентов с псевдопаралитической миастенией (myasthenia gravis) (см. раздел \"Особые указания\"). Частота неизвестна: рабдомиолиз, разрыв сухожилия (например, ахиллова сухожилия. Этот побочный эффект может наблюдаться в течение 48 часов после начала лечения и может носить двухсторонний характер (см. также раздел \"Особые указания\")), разрыв связок, разрыв мышц, артрит. Нарушения со стороны обмена веществ и питанияНечасто: анорексия. Редко: гипогликемия, особенно у пациентов с сахарным диабетом (возможные признаки гипогликемии: \"волчий\" аппетит, нервозность, испарина, дрожь). Частота неизвестна: гипергликемия, гипогликемическая кома (см. раздел \"Особые указания\"). Инфекционные и паразитарные заболеванияНечасто: грибковые инфекции, развитие резистентности патогенных микроорганизмов. Нарушения со стороны сосудовРедко: снижение артериального давления. Общие расстройстваНечасто: астения. Редко: пирексия (повышение температуры тела). Частота неизвестна: боль (включая боль в спине, груди и конечностях). Нарушения со стороны иммунной системыРедко: ангионевротический отек. Частота неизвестна: анафилактический шок, анафилактоидный шок. Анафилактические и анафилактоидные реакции могут иногда развиваться даже после приема первой дозы препарата. Нарушения со стороны печени и желчевыводящих путейЧасто: повышение активности \"печеночных\" ферментов в крови (например, аланинаминотрансферазы (АЛТ), аспартатаминотрансферазы (ACT)), повышение активности щелочной фосфатазы (ЩФ) и гаммаглутамилтрансферазы (ГГТ). Нечасто: повышение концентрации билирубина в крови. Частота неизвестна: тяжелая печеночная недостаточность, включая случаи развития острой печеночной недостаточности, иногда с фатальным исходом, особенно у пациентов с тяжелым основным заболеванием (например, у пациентов с сепсисом) (см. раздел \"Особые указания\"), гепатит, желтуха. Нарушения психикиЧасто: бессонница. Нечасто: чувство беспокойства, тревога, спутанность сознания. Редко: психические нарушения (например, галлюцинации, паранойя), депрессия, ажитация (возбуждение), нарушения сна, ночные кошмары. Частота неизвестна: нарушения психики с нарушениями поведения с причинением себе вреда, включая суицидальные мысли и суицидальные попытки. Другие возможные нежелательные эффекты, относящиеся ко всем фторхинолонамОчень редко: приступы порфирии (очень редкой болезни обмена веществ) у пациентов с порфирией."}}]},{"id":7,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы передозировки: нарушения сознания, включая спутанность сознания, головокружение, судороги, галлюцинации, тремор, тошнота, эрозивные поражения слизистой оболочки желудочно-кишечного тракта, удлинение интервала QT. В случае передозировки требуется тщательное наблюдение за пациентом, включая мониторирование электрокардиограммы. Лечение симптоматическое. В случае острой передозировки таблеток Рофлокс-Скан показано промывание желудка и введение антацидов для защиты слизистой оболочки желудка. Левофлоксацин не выводится посредством диализа (гемодиализа, перитонеального диализа и постоянного амбулаторного перитонеального диализа). 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