Флюкостат Капсулы, 1 шт, 150 мг, противогрибковое средство

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%;"}},{"type":"paragraph","data":{"text":"(для дозировки 150 мг) корпус и крышечка: титана диоксид (Е 171) – 2,0000 %, желатин – до 100 %.\n\n"}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Флюкостат — системный противогрибковый препарат для лечения «молочницы»."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Противогрибковое средство"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Противогрибковый препарат. Флуконазол – представитель класса триазольных противогрибковых средств, является мощным селективным ингибитором синтеза стеролов в клетке грибов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАктивен в отношении\u003c/i\u003e возбудителей оппортунистических микозов, в т.ч. вызванных Candida spp., Cryptococcus neoformans, Microsporum spp., Trichophyton spp. Показана также активность флуконазола на моделях эндемичных микозов, включая инфекции, вызванные Blastomyces dermatitidis, Coccidioides immitis и Histoplasma capsulatum."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Лечение острого вагинального кандидоза, когда местная терапия не применима."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"\n\n• Одновременный прием терфенадина (на фоне многократного приема флуконазола в дозе 400 мг/сут и более) (см. раздел «Взаимодействие с другими лекарственными средствами»);"}},{"type":"paragraph","data":{"text":"• Повышенная чувствительность к флуконазолу и другим компонентам препарата или близким по структуре азольным соединениям;"}},{"type":"paragraph","data":{"text":"• Детский возраст до 18 лет;"}},{"type":"paragraph","data":{"text":"• Период лактации (см. раздел «Применение при беременности и в период грудного вскармливания»);"}},{"type":"paragraph","data":{"text":"• Одновременное применение с препаратами, увеличивающими интервал QT и метаболизирующимися с помощью изофермента CYP3A4, такими как цизаприд, астемизол, эритромицин, пимозид, хинидин и амиодарон (см. раздел «Взаимодействие с другими лекарственными средствами»);"}},{"type":"paragraph","data":{"text":"• Непереносимость галактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция.\n\n"}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\n\n• Нарушение показателей функции печени;"}},{"type":"paragraph","data":{"text":"• Одновременный прием потенциально гепатотоксичных лекарственных средств;"}},{"type":"paragraph","data":{"text":"• Алкоголизм;"}},{"type":"paragraph","data":{"text":"• Проаритмогенные состояния у пациентов с множественными факторами риска (органические заболевания сердца, нарушения электролитного баланса, одновременный прием лекарственных средств, вызывающих аритмии);"}},{"type":"paragraph","data":{"text":"• Нарушение функции почек;"}},{"type":"paragraph","data":{"text":"• Появление сыпи на фоне применения флуконазола у больных с поверхностной грибковой инфекцией и инвазивными/системными грибковыми инфекциями;"}},{"type":"paragraph","data":{"text":"• Одновременное применение терфенадина и флуконазола в дозе менее 400 мг/сут.\n\n"}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"\n\nАдекватных и контролируемых исследований применения флуконазола у беременных женщин не проводилось."}},{"type":"paragraph","data":{"text":"В настоящее время нет доказательств влияния низких доз флуконазола (150 мг однократно для лечения вульвовагинального кандидоза) на повышение частоты неблагоприятных исходов беременности, а также взаимосвязи с возникновением каких-либо специфических пороков развития у ребенка."}},{"type":"paragraph","data":{"text":"При применении высоких доз (400-800 мг/сут) флуконазола описано несколько случаев множественных врожденных пороков у новорожденных, матери которых на протяжении большей части или всего первого триместра получали терапию флуконазолом."}},{"type":"paragraph","data":{"text":"Применение препарата у беременных нецелесообразно, за исключением тяжелых или угрожающих жизни форм грибковых инфекций, если предполагаемая польза для матери превышает возможный риск для плода."}},{"type":"paragraph","data":{"text":"Женщинам детородного возраста следует использовать средства контрацепции."}},{"type":"paragraph","data":{"text":"Флуконазол находится в грудном молоке в такой же концентрации, как и в плазме, поэтому его назначение в период лактации противопоказано.\n\n"}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nВнутрь. Капсулы проглатывают целиком."}},{"type":"paragraph","data":{"text":"При остром вагинальном кандидозе препарат применяют однократно внутрь в дозе 150 мг."}},{"type":"paragraph","data":{"text":"Применение у пожилых людей"}},{"type":"paragraph","data":{"text":"У больных пожилого возраста при отсутствии нарушений функции почек следует придерживаться обычного режима дозирования препарата."}},{"type":"paragraph","data":{"text":"Применение у больных с почечной недостаточностью"}},{"type":"paragraph","data":{"text":"При однократном приеме изменение дозы не требуется.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nКлассификация побочных реакций по органам и системам представлена с указанием частоты их возникновения:"}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного тракта: часто – боль в животе, диарея, рвота*, тошнота; нечасто – метеоризм, диспепсия*, сухость слизистой оболочки полости рта, запор."}},{"type":"paragraph","data":{"text":"Нарушения со стороны печени и желчевыводящих путей: часто – повышение сывороточной активности аминотрансфераз (аланинаминотрансферазы (АЛТ) и аспартатаминотрансферазы (АСТ)), щелочной фосфатазы; нечасто – желтуха*, холестаз, повышение концентрации билирубина; редко - гепатотоксичность, в некоторых случаях с летальным исходом, нарушение функции печени*, гепатит*, гепатоцеллюлярный некроз*, гепатоцеллюлярное повреждение."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожно-жировой клетчатки: часто – сыпь; нечасто – кожный зуд, крапивница, повышенное потоотделение, лекарственная сыпь; редко – эксфолиативные поражения кожи*, включая синдром Стивенса-Джонсона и токсический эпидермальный некролиз, острый генерализованный экзантематозный пустулез, отек лица, алопеция*."}},{"type":"paragraph","data":{"text":"Нарушения со стороны крови и лимфатической системы*: редко – лейкопения, включая нейтропению и агранулоцитоз, тромбоцитопения, анемия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны иммунной системы*: редко – анафилаксия (включая ангионевротический отек, отек лица)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны сердечно-сосудистой системы*: редко - увеличение продолжительности интервала QT на ЭКГ, желудочковая тахикардия по типу «пируэт» (см. раздел «Особые указания»)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны обмена веществ*: редко - повышение концентрации холестерина и триглицеридов в плазме крови, гипокалиемия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны опорно-двигательного аппарата: нечасто - миалгия."}},{"type":"paragraph","data":{"text":"Прочие: нечасто - слабость, астения, повышенная утомляемость, лихорадка, вертиго."}},{"type":"paragraph","data":{"text":"У некоторых больных, особенно с серьезными заболеваниями, такими как ВИЧ-инфекция или рак, при лечении флуконазолом и сходными препаратами наблюдались изменения показателей крови, функции почек и печени, однако клиническое значение этих изменений и их связь с лечением не установлены."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются, или отмечаются любые другие побочные эффекты, не указанные в инструкции, следует немедленно сообщить об этом врачу.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"В связи с возможностью возникновения головокружения и других побочных эффектов, связанных с приемом препарата, в период лечения пациентам рекомендуется воздержаться от управления автотранспортом и занятиями другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания, быстроты психомоторных и двигательных реакций."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В связи с возможностью возникновения головокружения и других побочных эффектов, связанных с приемом препарата, в период лечения пациентам рекомендуется воздержаться от управления автотранспортом и занятиями другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания, быстроты психомоторных и двигательных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы 150 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nХранить при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не использовать по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ОАО \"Фармстандарт-Лексредства\""}}]}],"source":null},"description_toggle":false,"short_description":"Противогрибковый препарат. 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