Аргосульфан Крем, туба, 40 г, 2 %, для наружного применения

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Рана во время лечения должна быть вся покрыта кремом. Если часть раны откроется, необходимо дополнительно нанести крем. Наложение окклюзионной повязки - возможно, но не является обязательным."}},{"type":"paragraph","data":{"text":"Крем наносится до полного заживления раны или до момента пересадки кожи. В случае применения препарата на инфицированные раны может появиться экссудат. Перед применением крема необходимо промыть рану 0.1% водным раствором хлоргексидина или другим антисептиком."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза - 25 г."}},{"type":"paragraph","data":{"text":"Максимальная продолжительность лечения - 60 дней.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллерические реакции, местные реакции (жжение, зуд, гиперемия кожи). При длительном применении возможны лейкопения, дескваматозный дерматит."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Случаи передозировки не зарегистрированы."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Не рекомендуется применять вместе с другими местными лекарственными средствами. Фолиевая кислота и ее структурные аналоги способны ослаблять противомикробное действие сульфатиазола."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nПри печеночной и/или почечной недостаточности необходимо контролировать концентрацию сульфатиазола в сыворотке крови."}},{"type":"paragraph","data":{"text":"Следует соблюдать осторожность при применении у больных в состоянии шока с обширными ожогами, из-за невозможности сбора полноценного аллергологического анамнеза.\n\n"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не ограничивает психофизической способности, способности управления автотранспортом и обслуживания машинного оборудования в движении."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nКрем для наружного применения 2%."}},{"type":"paragraph","data":{"text":"По 15 г и 40 г в алюминиевые, внутри лакированные литографированные тубы."}},{"type":"paragraph","data":{"text":"По 400 г в коробках из полипропилена (для стационаров)."}},{"type":"paragraph","data":{"text":"1 тубу вместе с инструкцией по применению помещают в картонную пачку."}},{"type":"paragraph","data":{"text":"По 10 коробок из полипропилена вместе с инструкциями по применению по числу коробок помещают в транспортную картонную коробку (для стационаров).\n\n"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nСписок Б."}},{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25°С. Не замораживать."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"\n\n2 года."}},{"type":"paragraph","data":{"text":"Не использовать по истечении срока годности.\n\n"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nФармзавод Ельфа А.О."}},{"type":"paragraph","data":{"text":"ул. В. Поля 21, Еленя Гура, Польша, 58-500\n\n"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"\n\nПредставительства АО Фармзавод Ельфа (Польша)г. Москва:"}},{"type":"paragraph","data":{"text":"Россия 119049, г. Москва, Коровий вал, д.7, стр.1, офис 80\n\n"}}]}],"source":null},"description_toggle":false,"short_description":"Аргосульфан - антибактериальный препарат местного применения, способствующий заживлению ран (ожоговых, трофических, гнойных и т.д.), обеспечивает эффективную защиту ран от инфицирования, сокращает время лечения и время подготовки раны к пересадке кожи, во многих случаях приводит к улучшению состояния, исключающему необходимость проведения трансплантации. Входящий в состав крема сульфаниламид - сульфатиазол серебра, является противомикробным бактериостатическим средством, обладает широким спектром антибактериального бактериостатического действия в отношении грамположительных и грамотрицательных бактерий. Механизм противомикробного действия сульфатиазола -угнетение роста и размножения микробов связан с конкурентным антагонизмом с парааминобензойной кислотой и угнетением дигидроптероатсинтетазы, что приводит к нарушению синтеза дигидрофолиевой кислоты и, в конечном итоге, ее активного метаболита - тетрагидрофолиевой кислоты, необходимой для синтеза пуринов и пиримидинов микробной клетки. Присутствующие в препарате ионы серебра усиливают антибактериальное действие сульфаниламида - они тормозят рост и деление бактерий путем связывания с дезоксирибонуклеиновой кислотой микробной клетки. Кроме того, ионы серебра ослабляют сенсибилизирующие свойства сульфаниламида. Фармакокинетика Содержащийся в препарате сульфатиазол серебра, обладает небольшой растворимостью, в результате чего после местного применения концентрация активного вещества в ране длительно поддерживается на одинаковом уровне. 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