Лекарственный препарат Мидокалм противопоказан в следующих случаях: при миастении; при повышенной чувствительности к лидокаину, если назначаются уколы, или к толперизону; новорожденным деткам до 3 месяцев.
Действующее вещество: Толперизон (Tolperisone)Концентрация действующего вещества (мг): 150
Фармакологические свойства
Миорелаксант центрального действия. Механизм действия полностью не выяснен. Обладает мембраностабилизирующим, местноанестезирующим действием, тормозит проводимость импульсов в первичных афферентных волокнах и двигательных нейронах, что приводит к блокированию спинномозговых моно- и полисинаптических рефлексов. Также, вероятно, вторично тормозит выделение медиаторов путем торможения поступления Ca2+ в синапсы. В стволе мозга устраняет облегчение проведения возбуждения по ретикулоспинальному пути. Усиливает периферический кровоток независимо от влияния ЦНС. В развитии этого эффекта играет роль слабый спазмолитический и адреноблокирующий эффект толперизона.
Лекарственный препарат Мидокалм противопоказан в следующих случаях: при миастении; при повышенной чувствительности к лидокаину, если назначаются уколы, или к толперизону; новорожденным деткам до 3 месяцев.
Применение при беременности и в период грудного вскармливания
Ввиду отсутствия данных о применении при беременности и в период грудного вскармливания назначение препарата Мидокалм в эти периоды не рекомендуется.
Способ применения и дозы
Взрослым: Обычно начиная с 50 мг 2-3 раза в день, постепенно повышая дозу до 150 мг 2-3 раза в день. Для детей: Детям в возрасте от 1 года до 6 лет Мидокалм назначают внутрь в суточной дозе 5 мг/кг (в 3 приема в течение дня); в возрасте 7-14 лет - в суточной дозе 24 мг/кг (в 3 приема в течение дня). Таблетку, покрытую оболочкой, следует растирать, если ребенок не способен проглотить ее. Для детей разрешается только применение таблеток, покрытых оболочкой по 50 мг.
Побочное действие
Мышечная слабость, головная боль, снижение артериального давления, тошнота, рвота, чувство дискомфорта в животе. При уменьшении дозы побочные явления обычно проходят. В редких случаях встречается аллергическая реакция (кожный зуд, эритема, крапивница, ангионевротический отек, анафилактический шок, бронхоспазм).
Передозировка
Данных о передозировке препаратом Мидокалм не поступало. Специфического антидота нет. В случае передозировки рекомендуется промывание желудка, симптоматическая терапия.
Особые указания
Применять препарат необходимо строго следуя рекомендациям лечащего врача во избежание осложнений. Влияние на способность к вождению автотранспорта и управлению механизмамиИсследования не проводились, но за многолетнюю практику применения сведений о влиянии препарата Мидокалм на способность пациентов к выполнению работы, требующей повышенного внимания и быстроты психомоторных реакций, не имеется.
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