применяется для устранения тревоги, страха, внутреннего напряжения, повышенной раздражительности, снижения настроения, в том числе на фоне соматических заболеваний, особенно кардиоваскулярной природы.
Противопоказания
шоковые состояния, миастения, тяжелые нарушения функций печени и/или почек, гиперчувствительность. Не рекомендуется использовать в возрасте до 18 лет.
Действующее вещество: ЭтифоксинКонцентрация действующего вещества (мг): 50 мг
Фармакологические свойства
Анксиолитик (транквилизатор). Этифоксина гидрохлорид принадлежит к производным бензоксазина. Как анксиолитическое средство этифоксин оказывает автономное регулирующее действие. В исследованиях in vitro и in vivo у крыс и мышей было показано, что анксиолитическая активность этифоксина обусловлена двойным механизмом его действия (прямого и опосредованного) на ГАМК-А рецепторы, улучшающим ГАМК-ергическую передачу импульса. При прямом воздействии на ГАМК-А-рецептор путем аллостерической модуляции этифоксин связывается преимущественно с субъединицами β2- или β3-рецептора; исследования показали, что этифоксин связывается с ГАМК-А-рецептором на участках, отличных от места связывания бензодиазепинов. Непрямое действие обеспечивается посредством увеличения синтеза нейростероидов (с помощью активации митохондриального белка-транслокатора), таких как аллопрегнанолон, также являющегося положительным аплостерическим модулятором ГАМК-А рецептора.
Показания к применению
применяется для устранения тревоги, страха, внутреннего напряжения, повышенной раздражительности, снижения настроения, в том числе на фоне соматических заболеваний, особенно кардиоваскулярной природы.
Противопоказания
шоковые состояния, миастения, тяжелые нарушения функций печени и/или почек, гиперчувствительность. Не рекомендуется использовать в возрасте до 18 лет.
Применение при беременности и в период грудного вскармливания
ВсасываниеПосле приема внутрь препарат быстро всасывается из ЖКТ. Время достижения Cmax в крови составляет 2-3 ч. РаспределениеПроникает через плацентарный барьер. МетаболизмБыстро метаболизируется в печени до образования нескольких метаболитов. Один из метаболитов - диэтилэтифоксин - является активным. ВыведениеT1/2 этифоксина составляет около 6 ч, T1/2 активного метаболита - 20 ч. Выводится преимущественно с мочой в виде метаболитов и в небольших количествах в неизмененном виде; также выводится с желчью.
Способ применения и дозы
внутрь, с небольшим количеством воды. Доза препарата определяется врачом, индивидуально, в зависимости от состояния больного. Обычно назначается по 1 капсуле 3 раза в день, или по 2 капсулы 2 раза в день. (150-200 мг/сут) Продолжительность лечения - от нескольких дней до 4-6 недель, в зависимости от состояния больного.
Побочное действие
незначительная сонливость, появляющаяся в первые дни приема и обычно исчезающая самостоятельно в процессе лечения; редко возможны кожные высыпания, а также аллергические реакции в виде крапивницы и отека Квинке.
Передозировка
Симптомы: вялость, чрезмерная сонливость. Лечение: при необходимости проводится симптоматическая терапия. Специфический антидот отсутствует.
Особые указания
При возникновении кожных или аллергических реакций, а также осложнений со стороны печени, прием препарата следует прекратить. В случае пропуска приема препарата не следует удваивать дозу при следующем приеме. Предписанную врачом дозу превышать не следует. Не рекомендуется принимать препарат при употреблении алкогольных напитков. Использование в педиатрииНе рекомендуется использовать препарат у детей и подростков в возрасте до 18 лет. Влияние на способность к вождению автотранспорта и управлению механизмамиВ связи с риском возникновения сонливости следует избегать управления автотранспортом и деятельности, требующей повышенного внимания, например, управления различными механизмами.
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