Препарат для лечения эректильной дисфункции, ингибитор ФДЭ5. Инструкция
Показания к применению
— эректильная дисфункция (неспособность достичь и сохранить эрекцию, необходимую для совершения полового акта).
Противопоказания
Одновременная терапия нитратами или препаратами, которые являются донаторами оксида азота
Комбинация с ингибиторами ВИЧ-протеаз, такими как индинавир или ритонавир
Повышенная чувствительность к компонентам препарата. Препарат не предназначен для применения у детей и подростков в возрасте до 16 лет. С осторожностью следует применять у пациентов с врожденным удлинением интервала QT, с анатомической деформацией полового члена (искривление, кавернозный фиброз, болезнь Пейрони), с заболеваниями, предрасполагающими к приапизму (серповидно-клеточная анемия, множественная миелома, лейкемия), тяжелым нарушением функции печени, заболеванием почек в терминальной стадии, артериальной гипотензией (систолическое давление в покое менее 90 мм рт.ст.), недавно перенесенным инсультом и инфарктом миокарда, нестабильной стенокардией, наследственными дегенеративными заболеваниями сетчатки (например, пигментный ретинит), со склонностью к кровотечениям и с обострением язвенной болезни, аортальным стенозом и идиопатическим гипертрофическим субаортальным стенозом
Препарат для лечения эректильной дисфункции, ингибитор ФДЭ5. Эрекция полового члена представляет собой гемодинамический процесс, в основе которого лежит расслабление гладких мышц пещеристых тел и расположенных в нем артериол. Во время сексуальной стимуляции из нервных окончаний пещеристых тел выделяется оксид азота (NO), активирующий фермент гуанилатциклазу, что приводит к повышению содержания в пещеристых телах циклического гуанозинмонофосфата (цГМФ). В результате происходит расслабление гладких мышц пещеристых тел, что способствует увеличению притока крови в половой член. Варденафил блокирует ФДЭ5, под воздействием которой происходит расщепление цГМФ, в результате этого местное действие эндогенного NO в пещеристых телах во время сексуальной стимуляции усиливается, что обусловливает способность Левитры усиливать реакцию на сексуальную стимуляцию.
Показания к применению
— эректильная дисфункция (неспособность достичь и сохранить эрекцию, необходимую для совершения полового акта).
Противопоказания
Одновременная терапия нитратами или препаратами, которые являются донаторами оксида азота
Комбинация с ингибиторами ВИЧ-протеаз, такими как индинавир или ритонавир
Повышенная чувствительность к компонентам препарата. Препарат не предназначен для применения у детей и подростков в возрасте до 16 лет. С осторожностью следует применять у пациентов с врожденным удлинением интервала QT, с анатомической деформацией полового члена (искривление, кавернозный фиброз, болезнь Пейрони), с заболеваниями, предрасполагающими к приапизму (серповидно-клеточная анемия, множественная миелома, лейкемия), тяжелым нарушением функции печени, заболеванием почек в терминальной стадии, артериальной гипотензией (систолическое давление в покое менее 90 мм рт.ст.), недавно перенесенным инсультом и инфарктом миокарда, нестабильной стенокардией, наследственными дегенеративными заболеваниями сетчатки (например, пигментный ретинит), со склонностью к кровотечениям и с обострением язвенной болезни, аортальным стенозом и идиопатическим гипертрофическим субаортальным стенозом
Применение при беременности и в период грудного вскармливания
Препарат не предназначен для применения у женщин.
Способ применения и дозы
Препарат принимают внутрь независимо от приема пищи. Начальная рекомендуемая доза составляет 10 мг за 25-60 мин до сексуального контакта. Можно принимать также в период от 4-5 ч до 25 мин до сексуальной активности. Максимальная частота приема - 1 раз/сут. Для достижения эффективности необходим достаточный уровень сексуальной стимуляции. В зависимости от эффективности и переносимости доза может быть увеличена до 20 мг или снижена до 5 мг/сут. Максимальная суточная доза - 20 мг. Коррекции режима дозирования у пациентов пожилого возраста не требуется. У пациентов с незначительно выраженной печеночной недостаточностью коррекции режима дозирования не требуется. У пациентов с умеренной печеночной недостаточностью начальная доза составляет 5 мг в сутки. В дальнейшем в зависимости от эффективности и переносимости лечения доза может быть увеличена до 10 мг и затем до 20 мг. У пациентов с незначительно выраженными и умеренными нарушениями функции почек коррекции режима дозирования не требуется
Побочное действие
Со стороны ЦНС и периферической нервной системы: ≥ .10% - головная боль . ≥ .1% - головокружение . ≥ .0.1%-<1% - сонливость . ≥ .0.01%-<0.1% - тревога, обморок. Со стороны сердечно-сосудистой системы: ≥ .10% - приливы (периодическое внезапное покраснение лица, ощущение жара) . ≥ .0.1%-<1% - повышение АД, снижение АД, ортостатическая гипотензия . ≥ .0.01%-<0.1% - стенокардия, ишемия миокарда. Со стороны пищеварительной системы: ≥ .1%-<10% - диспепсия, тошнота . ≥ .0.1%-<1% - изменение функциональных тестов печени (повышение АЛТ, АСТ, ГГТП). Со стороны дыхательной системы: ≥ .1%-<10% - застойная гиперемия слизистой оболочки носа (отек слизистой, ринит, ринорея) . ≥ .0.1%-<1% - одышка, носовое кровотечение . ≥ .0.01%-<0.1% - отек гортани. Со стороны органа зрения: ≥ .0.1%-<1% - повышенное слезоотделение, нарушения зрения (яркости зрения) . ≥ .0.01%-<0.1% - повышение внутриглазного давления. Дерматологические реакции: ≥ .0.1%-<1% - отек лица, фотосенсибилизация. Со стороны костно-мышечной системы: ≥ .0.1%-<1% - миалгия, боль в спине, повышение КФК . ≥ .0.01%-<0.1% - повышение мышечного тонуса. Со стороны половой системы: >0.01%-<0.1% - удлинение эрекции или болезненная эрекция, приапизм. Прочие: ≥ .0.01%-<0.1% - реакции повышенной чувствительности. Имеются редкие постмаркетинговые сообщения о случаях развития передней ишемической невропатии зрительного нерва (ПИНЗН), приводящей к нарушению зрения, включая стойкую утрату зрения, связанных по времени с приемом ингибиторов ФДЭ5, в т.ч. и Левитры, у пациентов, многие из которых имеют сопутствующие факторы риска для развития этого состояния, такие как анатомический дефект диска зрительного нерва, возраст старше 50 лет, сахарный диабет, артериальная гипертензия, ИБС, гиперлипидемия и курение. Не установлено, связано ли развитие ПИНЗН непосредственно с применением ингибиторов ФДЭ5, или с имеющимися у пациента сопутствующими сосудистыми факторами риска и анатомическими дефектами, или с комбинацией этих факторов, или с другими причинами. Сообщается о случаях нарушения зрения, включая временную или стойкую утрату зрения, которые связаны по времени с приемом ингибиторов ФДЭ5, в т.ч. и Левитры. Не установлено, связаны ли эти случаи непосредственно с приемом ингибиторов ФДЭ5, или с сопутствующими сосудистыми факторами риска, или с другими причинами.
Особые указания
Со стороны ЦНС и периферической нервной системы: ≥ .10% - головная боль . ≥ .1% - головокружение . ≥ .0.1%-<1% - сонливость . ≥ .0.01%-<0.1% - тревога, обморок. Со стороны сердечно-сосудистой системы: ≥ .10% - приливы (периодическое внезапное покраснение лица, ощущение жара) . ≥ .0.1%-<1% - повышение АД, снижение АД, ортостатическая гипотензия . ≥ .0.01%-<0.1% - стенокардия, ишемия миокарда. Со стороны пищеварительной системы: ≥ .1%-<10% - диспепсия, тошнота . ≥ .0.1%-<1% - изменение функциональных тестов печени (повышение АЛТ, АСТ, ГГТП). Со стороны дыхательной системы: ≥ .1%-<10% - застойная гиперемия слизистой оболочки носа (отек слизистой, ринит, ринорея) . ≥ .0.1%-<1% - одышка, носовое кровотечение . ≥ .0.01%-<0.1% - отек гортани. Со стороны органа зрения: ≥ .0.1%-<1% - повышенное слезоотделение, нарушения зрения (яркости зрения) . ≥ .0.01%-<0.1% - повышение внутриглазного давления. Дерматологические реакции: ≥ .0.1%-<1% - отек лица, фотосенсибилизация. Со стороны костно-мышечной системы: ≥ .0.1%-<1% - миалгия, боль в спине, повышение КФК . ≥ .0.01%-<0.1% - повышение мышечного тонуса. Со стороны половой системы: >0.01%-<0.1% - удлинение эрекции или болезненная эрекция, приапизм. Прочие: ≥ .0.01%-<0.1% - реакции повышенной чувствительности. Имеются редкие постмаркетинговые сообщения о случаях развития передней ишемической невропатии зрительного нерва (ПИНЗН), приводящей к нарушению зрения, включая стойкую утрату зрения, связанных по времени с приемом ингибиторов ФДЭ5, в т.ч. и Левитры, у пациентов, многие из которых имеют сопутствующие факторы риска для развития этого состояния, такие как анатомический дефект диска зрительного нерва, возраст старше 50 лет, сахарный диабет, артериальная гипертензия, ИБС, гиперлипидемия и курение. Не установлено, связано ли развитие ПИНЗН непосредственно с применением ингибиторов ФДЭ5, или с имеющимися у пациента сопутствующими сосудистыми факторами риска и анатомическими дефектами, или с комбинацией этих факторов, или с другими причинами. Сообщается о случаях нарушения зрения, включая временную или стойкую утрату зрения, которые связаны по времени с приемом ингибиторов ФДЭ5, в т.ч. и Левитры. Не установлено, связаны ли эти случаи непосредственно с приемом ингибиторов ФДЭ5, или с сопутствующими сосудистыми факторами риска, или с другими причинами.
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гидрохлорида тригидрат 5.926 мг, что соответствует содержанию варденафила 5 мг Вспомогательные вещества: кросповидон - 4.35 мг, магния стеарат - 870 мкг, целлюлоза микрокристаллическая - 75.419 мг, кремния диоксид коллоидный безводный - 435 мкг. Состав оболочки: макрогол 400 - 555 мкг, гипромеллоза - 1.664 мг, титана диоксид - 455 мкг, железа оксид желтый - 92 мкг, железа оксид красный - 7 мкг."}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат для лечения эректильной дисфункции, ингибитор ФДЭ5. Эрекция полового члена представляет собой гемодинамический процесс, в основе которого лежит расслабление гладких мышц пещеристых тел и расположенных в нем артериол. Во время сексуальной стимуляции из нервных окончаний пещеристых тел выделяется оксид азота (NO), активирующий фермент гуанилатциклазу, что приводит к повышению содержания в пещеристых телах циклического гуанозинмонофосфата (цГМФ). В результате происходит расслабление гладких мышц пещеристых тел, что способствует увеличению притока крови в половой член. Варденафил блокирует ФДЭ5, под воздействием которой происходит расщепление цГМФ, в результате этого местное действие эндогенного NO в пещеристых телах во время сексуальной стимуляции усиливается, что обусловливает способность Левитры усиливать реакцию на сексуальную стимуляцию."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"— эректильная дисфункция (неспособность достичь и сохранить эрекцию, необходимую для совершения полового акта)."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Одновременная терапия нитратами или препаратами, которые являются донаторами оксида азота","Комбинация с ингибиторами ВИЧ-протеаз, такими как индинавир или ритонавир","Повышенная чувствительность к компонентам препарата. Препарат не предназначен для применения у детей и подростков в возрасте до 16 лет. С осторожностью следует применять у пациентов с врожденным удлинением интервала QT, с анатомической деформацией полового члена (искривление, кавернозный фиброз, болезнь Пейрони), с заболеваниями, предрасполагающими к приапизму (серповидно-клеточная анемия, множественная миелома, лейкемия), тяжелым нарушением функции печени, заболеванием почек в терминальной стадии, артериальной гипотензией (систолическое давление в покое менее 90 мм рт.ст.), недавно перенесенным инсультом и инфарктом миокарда, нестабильной стенокардией, наследственными дегенеративными заболеваниями сетчатки (например, пигментный ретинит), со склонностью к кровотечениям и с обострением язвенной болезни, аортальным стенозом и идиопатическим гипертрофическим субаортальным стенозом"]}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат не предназначен для применения у женщин."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат принимают внутрь независимо от приема пищи. Начальная рекомендуемая доза составляет 10 мг за 25-60 мин до сексуального контакта. Можно принимать также в период от 4-5 ч до 25 мин до сексуальной активности. Максимальная частота приема - 1 раз/сут. Для достижения эффективности необходим достаточный уровень сексуальной стимуляции. В зависимости от эффективности и переносимости доза может быть увеличена до 20 мг или снижена до 5 мг/сут. Максимальная суточная доза - 20 мг. Коррекции режима дозирования у пациентов пожилого возраста не требуется. У пациентов с незначительно выраженной печеночной недостаточностью коррекции режима дозирования не требуется. У пациентов с умеренной печеночной недостаточностью начальная доза составляет 5 мг в сутки. В дальнейшем в зависимости от эффективности и переносимости лечения доза может быть увеличена до 10 мг и затем до 20 мг. У пациентов с незначительно выраженными и умеренными нарушениями функции почек коррекции режима дозирования не требуется"}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Со стороны ЦНС и периферической нервной системы: ≥ .10% - головная боль . ≥ .1% - головокружение . ≥ .0.1%-\u003c1% - сонливость . ≥ .0.01%-\u003c0.1% - тревога, обморок. Со стороны сердечно-сосудистой системы: ≥ .10% - приливы (периодическое внезапное покраснение лица, ощущение жара) . ≥ .0.1%-\u003c1% - повышение АД, снижение АД, ортостатическая гипотензия . ≥ .0.01%-\u003c0.1% - стенокардия, ишемия миокарда. Со стороны пищеварительной системы: ≥ .1%-\u003c10% - диспепсия, тошнота . ≥ .0.1%-\u003c1% - изменение функциональных тестов печени (повышение АЛТ, АСТ, ГГТП). Со стороны дыхательной системы: ≥ .1%-\u003c10% - застойная гиперемия слизистой оболочки носа (отек слизистой, ринит, ринорея) . ≥ .0.1%-\u003c1% - одышка, носовое кровотечение . ≥ .0.01%-\u003c0.1% - отек гортани. Со стороны органа зрения: ≥ .0.1%-\u003c1% - повышенное слезоотделение, нарушения зрения (яркости зрения) . ≥ .0.01%-\u003c0.1% - повышение внутриглазного давления. Дерматологические реакции: ≥ .0.1%-\u003c1% - отек лица, фотосенсибилизация. Со стороны костно-мышечной системы: ≥ .0.1%-\u003c1% - миалгия, боль в спине, повышение КФК . ≥ .0.01%-\u003c0.1% - повышение мышечного тонуса. Со стороны половой системы: \u003e0.01%-\u003c0.1% - удлинение эрекции или болезненная эрекция, приапизм. Прочие: ≥ .0.01%-\u003c0.1% - реакции повышенной чувствительности. Имеются редкие постмаркетинговые сообщения о случаях развития передней ишемической невропатии зрительного нерва (ПИНЗН), приводящей к нарушению зрения, включая стойкую утрату зрения, связанных по времени с приемом ингибиторов ФДЭ5, в т.ч. и Левитры, у пациентов, многие из которых имеют сопутствующие факторы риска для развития этого состояния, такие как анатомический дефект диска зрительного нерва, возраст старше 50 лет, сахарный диабет, артериальная гипертензия, ИБС, гиперлипидемия и курение. Не установлено, связано ли развитие ПИНЗН непосредственно с применением ингибиторов ФДЭ5, или с имеющимися у пациента сопутствующими сосудистыми факторами риска и анатомическими дефектами, или с комбинацией этих факторов, или с другими причинами. Сообщается о случаях нарушения зрения, включая временную или стойкую утрату зрения, которые связаны по времени с приемом ингибиторов ФДЭ5, в т.ч. и Левитры. Не установлено, связаны ли эти случаи непосредственно с приемом ингибиторов ФДЭ5, или с сопутствующими сосудистыми факторами риска, или с другими причинами."}}]},{"id":8,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Со стороны ЦНС и периферической нервной системы: ≥ .10% - головная боль . ≥ .1% - головокружение . ≥ .0.1%-\u003c1% - сонливость . ≥ .0.01%-\u003c0.1% - тревога, обморок. Со стороны сердечно-сосудистой системы: ≥ .10% - приливы (периодическое внезапное покраснение лица, ощущение жара) . ≥ .0.1%-\u003c1% - повышение АД, снижение АД, ортостатическая гипотензия . ≥ .0.01%-\u003c0.1% - стенокардия, ишемия миокарда. Со стороны пищеварительной системы: ≥ .1%-\u003c10% - диспепсия, тошнота . ≥ .0.1%-\u003c1% - изменение функциональных тестов печени (повышение АЛТ, АСТ, ГГТП). Со стороны дыхательной системы: ≥ .1%-\u003c10% - застойная гиперемия слизистой оболочки носа (отек слизистой, ринит, ринорея) . ≥ .0.1%-\u003c1% - одышка, носовое кровотечение . ≥ .0.01%-\u003c0.1% - отек гортани. Со стороны органа зрения: ≥ .0.1%-\u003c1% - повышенное слезоотделение, нарушения зрения (яркости зрения) . ≥ .0.01%-\u003c0.1% - повышение внутриглазного давления. Дерматологические реакции: ≥ .0.1%-\u003c1% - отек лица, фотосенсибилизация. Со стороны костно-мышечной системы: ≥ .0.1%-\u003c1% - миалгия, боль в спине, повышение КФК . ≥ .0.01%-\u003c0.1% - повышение мышечного тонуса. Со стороны половой системы: \u003e0.01%-\u003c0.1% - удлинение эрекции или болезненная эрекция, приапизм. Прочие: ≥ .0.01%-\u003c0.1% - реакции повышенной чувствительности. Имеются редкие постмаркетинговые сообщения о случаях развития передней ишемической невропатии зрительного нерва (ПИНЗН), приводящей к нарушению зрения, включая стойкую утрату зрения, связанных по времени с приемом ингибиторов ФДЭ5, в т.ч. и Левитры, у пациентов, многие из которых имеют сопутствующие факторы риска для развития этого состояния, такие как анатомический дефект диска зрительного нерва, возраст старше 50 лет, сахарный диабет, артериальная гипертензия, ИБС, гиперлипидемия и курение. Не установлено, связано ли развитие ПИНЗН непосредственно с применением ингибиторов ФДЭ5, или с имеющимися у пациента сопутствующими сосудистыми факторами риска и анатомическими дефектами, или с комбинацией этих факторов, или с другими причинами. Сообщается о случаях нарушения зрения, включая временную или стойкую утрату зрения, которые связаны по времени с приемом ингибиторов ФДЭ5, в т.ч. и Левитры. Не установлено, связаны ли эти случаи непосредственно с приемом ингибиторов ФДЭ5, или с сопутствующими сосудистыми факторами риска, или с другими причинами."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Препарат для лечения эректильной дисфункции, ингибитор ФДЭ5. Эрекция полового члена представляет собой гемодинамический процесс, в основе которого лежит расслабление гладких мышц пещеристых тел и расположенных в нем артериол. Во время сексуальной стимуляции из нервных окончаний пещеристых тел выделяется оксид азота (NO), активирующий фермент гуанилатциклазу, что приводит к повышению содержания в пещеристых телах циклического гуанозинмонофосфата (цГМФ). В результате происходит расслабление гладких мышц пещеристых тел, что способствует увеличению притока крови в половой член. 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