Описание: прозрачная, вязкая жидкость от бесцветной до коричневато-желтой. Фармакотерапевтическая группа: слабительное средство Код АТХ: А06AD11
Фармакологические свойства
Фармакодинамика
Оказывает гиперосмотическое слабительное действие, стимулирует перистальтику кишечника, улучшает всасывание фосфатов и солей Са2+, способствует выведению ионов аммония.
Лактулоза расщепляется кишечной флорой толстой кишки на низкомолекулярные органические кислоты, что приводит к понижению рН и повышению осмотического давления и, как следствие, увеличению объема кишечного содержимого. Указанные эффекты стимулируют перистальтику кишечника и оказывают влияние на консистенцию стула. В результате восстанавливается физиологический ритм опорожнения толстого кишечника.
При печеночной энцефалопатии эффект приписывается подавлению протеолитических бактерий посредством увеличения количества ацидофильных бактерий (например, лактобактерий), переходу аммиака в ионную форму за счет подкисления содержимого толстой кишки, опорожнению кишечника вследствие снижения рН в толстой кишке и осмотического эффекта, а также уменьшению азотсодержащих токсических веществ путем стимуляции бактерий, утилизирующих аммиак для бактериального белкового синтеза.
Лактулоза как пребиотическое вещество усиливает рост полезных бактерий, таких, как бифидобактерии и лактобактерии, в то время как становится возможным подавление роста потенциально патогенных бактерий, таких, как Clostridium и Escherichia coli, что обеспечивает более благоприятный баланс кишечной флоры.
Фармакокинетика
Абсорбция низкая. После приема внутрь доходит до толстого кишечника в неизмененном виде, где расщепляется кишечной флорой. Полностью метаболизируется при применении в дозах до 40-75 мл. При применении в более высоких дозах частично выводится в неизмененном виде.
Размягчение стула в медицинских целях (геморрой, состояния после операции на толстой кишке и в области анального отверстия).
Печеночная энцефалопатия у взрослых: лечение и профилактика печеночной комы или прекомы.
Противопоказания
галактоземия;
непроходимость, перфорация или риск перфорации желудочно-кишечного тракта;
повышенная чувствительность к любому компоненту препарата;
непереносимость галактозы или фруктозы, дефицит лактазы или глюкозогалактозная мальабсорбция
С осторожностью
ректальные кровотечения недиагностированные;
колостома, илеостома.
Применение при беременности и в период грудного вскармливания
Не предполагается никакого влияния на плод или грудного ребенка, так как системное воздействие лактулозы на беременную или кормящую женщину незначительно.
Дюфалак® можно назначать во время беременности и в период грудного вскармливания.
Не предполагается никакого влияния на репродуктивную функцию, так как системное воздействие лактулозы незначительно.
Способ применения и дозы
Препарат предназначен для приема внутрь, а также, для ректального введения.
Раствор лактулозы можно принимать как в разведенном, так и в неразведенном виде.
Все дозировки должны подбираться индивидуально.
Необходимо сразу проглотить принятую однократную дозу, не задерживая во рту.
В случае назначения однократной суточной дозы, ее необходимо принимать в одно и то же время, например, во время завтрака.
Во время терапии слабительными средствами рекомендуется принимать достаточное количество жидкости (1,5-2 литра, что равно 6-8 стаканам) в день.
Для точного дозирования препарата во флаконах следует использовать прилагаемый мерный стаканчик. При применении препарата в пакетиках необходимо оторвать уголок пакетика и сразу принять содержимое.
Доза при лечении запора или для размягчения стула в медицинских целях
Суточную дозу лактулозы можно принимать однократно, либо разделив ее на две, используя мерный стаканчик.
Через несколько дней начальная доза может быть скорректирована до поддерживающей дозы в зависимости от реакции на прием препарата. Слабительный эффект может проявиться через 2-3 дня после начала приема препарата.
Взрослые и подростки: начальная суточная доза – 15-45 мл (1-3 пакетика), поддерживающая суточная доза– 15-30 мл (1-2 пакетика);
Дети 7-14 лет: начальная суточная доза – 15 мл (1 пакетик), поддерживающая суточная доза – 10-15 мл (1 пакетик*);
Дети 1-6 лет: начальная и поддерживающая суточная доза – 5-10 мл;
Дети до 1 года: начальная и поддерживающая суточная доза – до 5 мл.
*Если поддерживающая суточная доза меньше 15 мл, рекомендуется применять препарат во флаконах.
Для точного дозирования у детей до 7 лет рекомендуется применять препарат во флаконах.
Доза при лечении печеночной энцефалопатии (взрослые) Для приема внутрь:
Начальная доза: 3-4 раза в день по 30-45 мл (2-3 пакетика).
Затем переходят на индивидуально подобранную поддерживающую дозу так, чтобы мягкий стул был максимально 2-3 раза в день.
Для ректального введения:
В случае прекоматозного состояния или состояния комы препарат может быть назначен в виде клизмы с удержанием (300 мл препарата/700 мл воды). Клизму следует удерживать в течении 30-60 минут, процедуру следует повторять каждые 4-6 часов, до тех пор, пока не станет возможным назначение препарата перорально.
Безопасность и эффективность применения препарата у детей (до 18 лет) при печеночной энцефалопатии не установлена в связи с отсутствием данных.
Пациенты пожилого возраста и пациенты с почечной или печеночной
недостаточностью
Нет специальных рекомендаций по дозированию, так как системное воздействие лактулозы незначительно.
Побочное действие
В первые дни приема лактулозы возможно появление метеоризма. Как правило, он исчезает через несколько дней.
В случае применения повышенных доз в течение длительного времени при лечении печеночной энцефалопатии у пациента могут развиться нарушения водноэлектролитного баланса вследствие диареи. Нарушения со стороны желудочно-кишечного тракта
Очень часто (≥ 1 / 10): диарея.
Часто (≥ 1 / 100, ˂ 1 / 10): метеоризм, боль в области живота, тошнота, рвота. Другие нарушения
Нечасто (≥ 1 / 1000, ˂ 1 / 100): нарушения водно-электролитного баланса вследствие диареи.
При применении у детей ожидается схожий профиль безопасности по сравнению с таковым у взрослых.
Передозировка
Симптомы: при приеме очень высокой дозы возможны боль в области живота и диарея.
Лечение: прекращение приема препарата или уменьшение дозы. В случае большой потери жидкости вследствие диареи или рвоты может потребоваться коррекция нарушений водно-электролитного баланса
Взаимодействие с другими лекарственными средствами
Исследования по взаимодействию с другими лекарственными препаратами не проводились.
Особые указания
В случае возникновения абдоминальной боли неизвестного происхождения перед началом лечения или отсутствия терапевтического эффекта через несколько дней после начала приема препарата необходимо проконсультироваться с врачом.
Необходимо учитывать, что Дюфалак® может содержать незначительные количества связанных сахаров (например, лактоза, галактоза, эпилактоза и фруктоза).
При приеме доз, рекомендуемых для лечения запора, содержание сахара не должно представлять проблемы для пациентов с сахарным диабетом. При лечении печеночной энцефалопатии обычно назначают более высокие дозы препарата, и содержание в нем сахара должно учитываться в отношении пациентов с сахарным диабетом.
При введении в виде клизмы с удержанием, из-за сильного очистительного эффекта возможно недержание кала, загрязнение постели и перианальное раздражение из-за кислой среды кала. Следует тщательно следить за состоянием гидратации больного.
Содержание остаточных сахаров, присутствующих в препарате Дюфалак®, составляет около 0,075 XE в 5 мл сиропа.
Длительный прием доз, превышающих рекомендуемые в инструкции, или неправильное применение может привести к диарее и нарушению водно-электролитного баланса.
При лечении детей слабительные средства должны применяться в исключительных случаях и под наблюдением врача. Необходимо учитывать, что во время лечения могут возникнуть расстройства рефлекса опорожнения.
Влияние на способность к управлению автомобилем и другими механизмами
Применение препарата Дюфалак® не влияет или оказывает незначительное влияние на способность к управлению автомобилем и механизмами.
Форма выпуска
Сироп 667 мг/мл.
200 мл, 500 мл или 1000 мл во флакон из полиэтилена высокой плотности белого цвета с навинчивающейся крышкой из полипропилена с контролем первого вскрытия. Поверх крышки надевается колпачок (из полипропилена), служащий мерным стаканчиком. На флакон наклеивают этикетку с инструкцией по применению.
По 15 мл в одноразовых пакетиках из полиэтилена и алюминиевой фольги. По 10 пакетиков вместе с инструкцией по применению в пачку картонную.
Условия хранения
Хранить при температуре не выше 25°С.
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Срок годности
3 года.
Не применять по истечении срока годности, указанного на упаковке.
Условия отпуска
Без рецепта.
Производитель
Эбботт Биолоджикалз Б.В.
Веервег 12,
8121 АА Ольст, Нидерланды
или
АО «ВЕРОФАРМ»
308013, Россия, г. Белгород,
ул. Рабочая, д. 14
Упаковщик, выпускающий контроль качества
Эбботт Биолоджикалз Б.В.
Веервег 12,
8121 АА Ольст, Нидерланды
или
ОАО «Фармстандарт-Лексредства»
305022, Россия, г. Курск,
ул. 2-я Агрегатная, д. 1а/18
или
АО «ВЕРОФАРМ»,
308013, Россия, г. Белгород,
ул. Рабочая, д. 14
Организация, уполномоченная держателем регистрационного удостоверения лекарственного препарата на принятие претензий от потребителей:
ООО «Эбботт Лэбораториз»
125171, г. Москва, Ленинградское шоссе, дом 16 А, стр. 1
Тел.: +7 (495) 258 42 80
Факс: +7 (495) 258 42 81
abbott-russia@abbott.com
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раствора содержит:\u003cbr\u003e\n\u003ci\u003eактивное вещество:\u003c/i\u003eлактулоза 66,7 г. ;\u003cbr\u003e\n\u003ci\u003eвспомогательное вещество:\u003c/i\u003e вода очищенная до 100 мл."}}]},{"id":2,"name":"Описание","slug":"common_description","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003cb\u003eРегистрационный номер:\u003c/b\u003e П N011717/02\u003cbr /\u003e\n\u003cb\u003eТорговое название:\u003c/b\u003e Дюфалак®\u003cbr /\u003e\n\u003cb\u003eМеждународное непатентованное название:\u003c/b\u003e лактулоза\u003cbr /\u003e\n\u003cb\u003eХимическое название:\u003c/b\u003e 4-О-β-D-галактопиранозил-D-фруктофураноза\u003cbr /\u003e\n\u003cb\u003eЛекарственная форма:\u003c/b\u003e сироп\u003cbr /\u003e\n\u003cbr /\u003e\n\u003cb\u003eОписание:\u003c/b\u003e прозрачная, вязкая жидкость от бесцветной до коричневато-желтой.\u003cbr /\u003e\n\u003cb\u003eФармакотерапевтическая группа:\u003c/b\u003e слабительное средство\u003cbr /\u003e\n\u003cb\u003eКод 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Указанные эффекты стимулируют перистальтику кишечника и оказывают влияние на консистенцию стула. В результате восстанавливается физиологический ритм опорожнения толстого кишечника.\u003cbr /\u003e\nПри печеночной энцефалопатии эффект приписывается подавлению протеолитических бактерий посредством увеличения количества ацидофильных бактерий (например, лактобактерий), переходу аммиака в ионную форму за счет подкисления содержимого толстой кишки, опорожнению кишечника вследствие снижения рН в толстой кишке и осмотического эффекта, а также уменьшению азотсодержащих токсических веществ путем стимуляции бактерий, утилизирующих аммиак для бактериального белкового синтеза. \u003cbr /\u003e\nЛактулоза как пребиотическое вещество усиливает рост полезных бактерий, таких, как бифидобактерии и лактобактерии, в то время как становится возможным подавление роста потенциально патогенных бактерий, таких, как Clostridium и Escherichia coli, что обеспечивает более благоприятный баланс кишечной флоры.\u003cbr /\u003e\n\u003cbr /\u003e\n\u003cb\u003eФармакокинетика\u003c/b\u003e\u003cbr /\u003e\nАбсорбция низкая. После приема внутрь доходит до толстого кишечника в неизмененном виде, где расщепляется кишечной флорой. Полностью метаболизируется при применении в дозах до 40-75 мл. При применении в более высоких дозах частично выводится в неизмененном виде."}}]},{"id":4,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Запор: регуляция физиологического ритма опорожнения толстой кишки.\u003cbr /\u003e","Размягчение стула в медицинских целях (геморрой, состояния после операции на толстой кишке и в области анального отверстия).\u003cbr /\u003e","Печеночная энцефалопатия у взрослых: лечение и профилактика печеночной комы или прекомы."]}}]},{"id":5,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["галактоземия;\u003cbr /\u003e","непроходимость, перфорация или риск перфорации желудочно-кишечного тракта;\u003cbr /\u003e","повышенная чувствительность к любому компоненту препарата;\u003cbr /\u003e","непереносимость галактозы или фруктозы, дефицит лактазы или глюкозогалактозная мальабсорбция\u003cbr /\u003e"]}},{"type":"paragraph","data":{"text":"\u003ci\u003eС осторожностью\u003c/i\u003e\u003cbr /\u003e"}},{"type":"list","data":{"style":"unordered","items":["ректальные кровотечения недиагностированные;\u003cbr /\u003e","колостома, илеостома."]}}]},{"id":6,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Не предполагается никакого влияния на плод или грудного ребенка, так как системное воздействие лактулозы на беременную или кормящую женщину незначительно.\u003cbr /\u003e\nДюфалак® можно назначать во время беременности и в период грудного вскармливания.\u003cbr /\u003e\nНе предполагается никакого влияния на репродуктивную функцию, так как системное воздействие лактулозы незначительно."}}]},{"id":7,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат предназначен для приема внутрь, а также, для ректального введения.\u003cbr\u003e\nРаствор лактулозы можно принимать как в разведенном, так и в неразведенном виде.\u003cbr\u003e\nВсе дозировки должны подбираться индивидуально.\u003cbr\u003e\nНеобходимо сразу проглотить принятую однократную дозу, не задерживая во рту.\u003cbr\u003e\nВ случае назначения однократной суточной дозы, ее необходимо принимать в одно и то же время, например, во время завтрака.\u003cbr\u003e\nВо время терапии слабительными средствами рекомендуется принимать достаточное количество жидкости (1,5-2 литра, что равно 6-8 стаканам) в день.\u003cbr\u003e\nДля точного дозирования препарата во флаконах следует использовать прилагаемый мерный стаканчик. При применении препарата в пакетиках необходимо оторвать уголок пакетика и сразу принять содержимое.\u003cbr\u003e\n\u003cbr\u003e\n\u003ci\u003eДоза при лечении запора или для размягчения стула в медицинских целях\u003c/i\u003e\u003cbr\u003e\nСуточную дозу лактулозы можно принимать однократно, либо разделив ее на две, используя мерный стаканчик.\u003cbr\u003e\nЧерез несколько дней начальная доза может быть скорректирована до поддерживающей дозы в зависимости от реакции на прием препарата. Слабительный эффект может проявиться через 2-3 дня после начала приема препарата.\u003cbr\u003e\nВзрослые и подростки: начальная суточная доза – 15-45 мл (1-3 пакетика), поддерживающая суточная доза– 15-30 мл (1-2 пакетика);\u003cbr\u003e\nДети 7-14 лет: начальная суточная доза – 15 мл (1 пакетик), поддерживающая суточная доза – 10-15 мл (1 пакетик*);\u003cbr\u003e\nДети 1-6 лет: начальная и поддерживающая суточная доза – 5-10 мл;\u003cbr\u003e\nДети до 1 года: начальная и поддерживающая суточная доза – до 5 мл.\u003cbr\u003e\n\u003cbr\u003e\n*Если поддерживающая суточная доза меньше 15 мл, рекомендуется применять препарат во флаконах.\u003cbr\u003e\nДля точного дозирования у детей до 7 лет рекомендуется применять препарат во флаконах.\u003cbr\u003e\n\u003cbr\u003e\n\u003ci\u003eДоза при лечении печеночной энцефалопатии (взрослые)\u003c/i\u003e\u003cbr\u003e\n\u003ci\u003eДля приема внутрь:\u003c/i\u003e\u003cbr\u003e\nНачальная доза: 3-4 раза в день по 30-45 мл (2-3 пакетика).\u003cbr\u003e\nЗатем переходят на индивидуально подобранную поддерживающую дозу так, чтобы мягкий стул был максимально 2-3 раза в день.\u003cbr\u003e\nДля ректального введения:\u003cbr\u003e\nВ случае прекоматозного состояния или состояния комы препарат может быть назначен в виде клизмы с удержанием (300 мл препарата/700 мл воды). Клизму следует удерживать в течении 30-60 минут, процедуру следует повторять каждые 4-6 часов, до тех пор, пока не станет возможным назначение препарата перорально.\u003cbr\u003e\nБезопасность и эффективность применения препарата у детей (до 18 лет) при печеночной энцефалопатии не установлена в связи с отсутствием данных.\n\u003cbr\u003e\n\u003ci\u003eПациенты пожилого возраста и пациенты с почечной или печеночной\nнедостаточностью\u003c/i\u003e\u003cbr\u003e\nНет специальных рекомендаций по дозированию, так как системное воздействие лактулозы незначительно."}}]},{"id":8,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В первые дни приема лактулозы возможно появление метеоризма. Как правило, он исчезает через несколько дней.\u003cbr\u003e\nВ случае применения повышенных доз в течение длительного времени при лечении печеночной энцефалопатии у пациента могут развиться нарушения водноэлектролитного баланса вследствие диареи.\u003cbr\u003e\n\u003ci\u003eНарушения со стороны желудочно-кишечного тракта\u003c/i\u003e\u003cbr\u003e\nОчень часто (≥ 1 / 10): диарея.\u003cbr\u003e\nЧасто (≥ 1 / 100, ˂ 1 / 10): метеоризм, боль в области живота, тошнота, рвота.\u003cbr\u003e\n\u003ci\u003eДругие нарушения\u003c/i\u003e\u003cbr\u003e\nНечасто (≥ 1 / 1000, ˂ 1 / 100): нарушения водно-электролитного баланса вследствие диареи.\u003cbr\u003e\nПри применении у детей ожидается схожий профиль безопасности по сравнению с таковым у взрослых."}}]},{"id":9,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: при приеме очень высокой дозы возможны боль в области живота и диарея.\u003cbr /\u003e\nЛечение: прекращение приема препарата или уменьшение дозы. В случае большой потери жидкости вследствие диареи или рвоты может потребоваться коррекция нарушений водно-электролитного баланса"}}]},{"id":10,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Исследования по взаимодействию с другими лекарственными препаратами не проводились."}}]},{"id":11,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В случае возникновения абдоминальной боли неизвестного происхождения перед началом лечения или отсутствия терапевтического эффекта через несколько дней после начала приема препарата необходимо проконсультироваться с врачом.\u003cbr /\u003e\nНеобходимо учитывать, что Дюфалак® может содержать незначительные количества связанных сахаров (например, лактоза, галактоза, эпилактоза и фруктоза).\u003cbr /\u003e\nПри приеме доз, рекомендуемых для лечения запора, содержание сахара не должно представлять проблемы для пациентов с сахарным диабетом. При лечении печеночной энцефалопатии обычно назначают более высокие дозы препарата, и содержание в нем сахара должно учитываться в отношении пациентов с сахарным диабетом.\u003cbr /\u003e\nПри введении в виде клизмы с удержанием, из-за сильного очистительного эффекта возможно недержание кала, загрязнение постели и перианальное раздражение из-за кислой среды кала. Следует тщательно следить за состоянием гидратации больного.\u003cbr /\u003e\nСодержание остаточных сахаров, присутствующих в препарате Дюфалак®, составляет около 0,075 XE в 5 мл сиропа.\u003cbr /\u003e\nДлительный прием доз, превышающих рекомендуемые в инструкции, или неправильное применение может привести к диарее и нарушению водно-электролитного баланса.\u003cbr /\u003e\nПри лечении детей слабительные средства должны применяться в исключительных случаях и под наблюдением врача. Необходимо учитывать, что во время лечения могут возникнуть расстройства рефлекса опорожнения.\u003cbr /\u003e\n\u003cbr /\u003e\n\u003cb\u003eВлияние на способность к управлению автомобилем и другими механизмами\u003c/b\u003e\u003cbr /\u003e\nПрименение препарата Дюфалак® не влияет или оказывает незначительное влияние на способность к управлению автомобилем и механизмами.\u003cbr /\u003e\n\u003cbr /\u003e\n\u003cb\u003eФорма выпуска\u003c/b\u003e\u003cbr /\u003e\nСироп 667 мг/мл.\u003cbr /\u003e\n200 мл, 500 мл или 1000 мл во флакон из полиэтилена высокой плотности белого цвета с навинчивающейся крышкой из полипропилена с контролем первого вскрытия. Поверх крышки надевается колпачок (из полипропилена), служащий мерным стаканчиком. На флакон наклеивают этикетку с инструкцией по применению.\u003cbr /\u003e\nПо 15 мл в одноразовых пакетиках из полиэтилена и алюминиевой фольги. По 10 пакетиков вместе с инструкцией по применению в пачку картонную."}}]},{"id":12,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25°С.\u003cbr /\u003e\nХранить в недоступном для детей месте!"}}]},{"id":13,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"3 года.\u003cbr /\u003e\nНе применять по истечении срока годности, указанного на упаковке."}}]},{"id":14,"name":"Условия отпуска","slug":"release_condition","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Без рецепта.\u003cbr /\u003e\n\u003cbr /\u003e\n\u003cb\u003eПроизводитель\u003c/b\u003e\u003cbr /\u003e\nЭбботт Биолоджикалз Б.В.\u003cbr /\u003e\nВеервег 12,\u003cbr /\u003e\n8121 АА Ольст, Нидерланды\u003cbr /\u003e\nили\u003cbr /\u003e\nАО «ВЕРОФАРМ»\u003cbr /\u003e\n308013, Россия, г. Белгород,\u003cbr /\u003e\nул. Рабочая, д. 14\n\u003cbr /\u003e\n\u003cb\u003eУпаковщик, выпускающий контроль качества\u003c/b\u003e\u003cbr /\u003e\nЭбботт Биолоджикалз Б.В.\u003cbr /\u003e\nВеервег 12,\u003cbr /\u003e\n8121 АА Ольст, Нидерланды\u003cbr /\u003e\nили\u003cbr /\u003e\nОАО «Фармстандарт-Лексредства»\u003cbr /\u003e\n305022, Россия, г. Курск,\u003cbr /\u003e\nул. 2-я Агрегатная, д. 1а/18\u003cbr /\u003e\nили\u003cbr /\u003e\nАО «ВЕРОФАРМ»,\n308013, Россия, г. Белгород,\u003cbr /\u003e\nул. Рабочая, д. 14\u003cbr /\u003e\n\u003cbr /\u003e\n\u003cb\u003eОрганизация, уполномоченная держателем регистрационного удостоверения лекарственного препарата на принятие претензий от потребителей:\u003c/b\u003e\u003cbr /\u003e\nООО «Эбботт Лэбораториз»\u003cbr /\u003e\n125171, г. Москва, Ленинградское шоссе, дом 16 А, стр. 1\u003cbr /\u003e\nТел.: +7 (495) 258 42 80\u003cbr /\u003e\nФакс: +7 (495) 258 42 81\u003cbr /\u003e\nabbott-russia@abbott.com"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика Оказывает гиперосмотическое слабительное действие, стимулирует перистальтику кишечника, улучшает всасывание фосфатов и солей Са2+, способствует выведению ионов аммония. Лактулоза расщепляется кишечной флорой толстой кишки на низкомолекулярные органические кислоты, что приводит к понижению рН и повышению осмотического давления и, как следствие, увеличению объема кишечного содержимого. Указанные эффекты стимулируют перистальтику кишечника и оказывают влияние на консистенцию стула. В результате восстанавливается физиологический ритм опорожнения толстого кишечника. 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