Инфекции, вызванные чувствительными к Роцефину возбудителями: сепсис; менингит; диссеминированный боррелиоз Лайма (ранние и поздние стадии заболевания); инфекции органов брюшной полости (перитонит, инфекции желчных путей и желудочно-кишечного тракта); инфекции костей, суставов, мягких тканей, кожи, а также раневые инфекции; инфекции у больных с ослабленным ...
Действующее вещество: Цефтриаксон (Ceftriaxone)Концентрация действующего вещества (мг): 1г
Показания к применению
Инфекции, вызванные чувствительными к Роцефину возбудителями: сепсис; менингит; диссеминированный боррелиоз Лайма (ранние и поздние стадии заболевания); инфекции органов брюшной полости (перитонит, инфекции желчных путей и желудочно-кишечного тракта); инфекции костей, суставов, мягких тканей, кожи, а также раневые инфекции; инфекции у больных с ослабленным иммунитетом; инфекции почек и мочевыводящих путей; инфекции дыхательных путей, особенно пневмония, и инфекции ЛОР-органов; инфекции половых органов, включая гонорею. Периоперационная профилактика инфекций.
Противопоказания
Повышенная чувствительность к цефалоспоринам.
Способ применения и дозы
Стандартный режим дозирования Взрослые и дети старше 12 лет: по 1-2 г один раз в сутки (каждые 24 часа). В тяжелых случаях или при инфекциях, возбудители которых обладают лишь умеренной чувствительностью к цефтриаксону, суточную дозу можно увеличивать до 4 г. Новорожденные (до 2 недель): 20-50 мг/кг массы тела один раз в сутки. Суточная доза не должна превышать 50 мг/кг массы тела. При определении дозы не нужно делать различия между доношенными и недоношенными детьми. Грудные дети и дети младшего возраста (с 15 дней до 12 лет): 20-80 мг/кг массы тела один раз в сутки. Детям с массой тела свыше 50 кг назначают дозы для взрослых. Внутривенные дозы в 50 мг/кг или выше следует вводить капельно в течение не менее 30 минут. Больные старческого возраста: обычные дозы для взрослых, без поправок на возраст. Продолжительность лечения зависит от течения заболевания. Как и всегда при антибиотикотерапии, введение Роцефина следует продолжать больным еще в течение минимум 48-72 часов после нормализации температуры и подтверждения эрадикации возбудителя.
Побочное действие
При применении Роцефина наблюдались следующие Побочное явления, которые исчезали либо самостоятельно, либо после отмены препарата: Желудочно-кишечный тракт (около 2%): мягкий стул илидиарея тошнота, рвота, стоматит, глоссит, нарушение вкуса(менее 1%). Гематологические изменения (около 2%): эозинофилия, лейкопения; менее часто ( меньше 1%): гранулоцитопения, гемолитическая анемия, тромбоцитоз, тромбоцитопения, увеличениетромбопластинового ипротромбинового времени. Описаны отдельныеслучаи агранулоцитоза( меньше 500 клеток/мкл), причем большинство изних развивались после 10дней лечения и применения кумулятивнойдозы 20 г и более. Кожные реакции (около 1%): сыпь, аллергический дерматит, зуд, крапивница, отеки Отдельные случаитяжелых побочных реакций(экссудативная мультиформная эритема(синдром Стивенса-Джонсона), токсическийэпидермальный некролиз(синдром Лайелла)). Прочие(наблюдаются редко): головнаяболь и головокружение, преципитациякальциевых солей цефтриаксона вжелчном пузыре с соответствующейсимптоматикой, панкреатит, увеличение активности печеночных ферментов (АЛТ ACT), ЩФ, гипербилирубинемия, олигурия, увеличение концентрациикреатинина сыворотки, микозы половых путей, вагинит, повышениетемпературы, озноб, повышенное потоотделение, приливы, аллергический пневмонит, бронхоспазм, носовое кровотечение, гематурия, желтуха, снижениепротромбинового времени, судорожный припадок, сердцебиение, сывороточнаяболезнь, а также анафилактические илианафилактоидные реакции. меньше brбольше Описаны очень редкие случаипсевдомембранозного колита (меньше 0.01%) и нарушений свертываемости крови, а такжеобразования конкрементов в почках, главным образом, у детейстарше 3 лет, получавших либо большие суточные дозы препарата (больше 80мг/кг всутки) либо кумулятивные дозы более 10 г, а также имевшихдополнительные факторы риска (ограничение потребления жидкости, постельныйрежим и т.д.). Образование конкрементов в почках можетпротекатьбессимптомно или проявляться клинически, может приводитькпочечной недостаточности и обратимо после прекращения терапииРоцефином. Местные реакции (очень редко): флебит послевнутривенного введения. Его можно избежать, вводя препарат медленно втечение 2-4 минут. Внутримышечная инъекция безприменениялидокаина болезненна.
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