индивидуальная повышенная чувствительность к кетопрофену, ацетилсалициловой кислоте или другому НПВП (в т.ч. указания в анамнезе на бронхоспазм, крапивницу или ринит, вызванные приемом ацетилсалициловой кислоты); заболевания желудочно-кишечного тракта в фазе обострения; желудочно-кишечные кровотечения и перфорация в анамнезе; выраженные нарушения функции ...
Активное вещество: кетопрофен 100 мг (в виде натриевой соли 108 мг). Вспомогательные вещества: глицин – 85 мг. Растворитель: Каждая ампула с растворителем содержит: бензиловый спирт – 0,0625 мл и вода для инъекций – до 2,5 мл.
Фармакологические свойства
ФЛЕКСЕН оказывает противовоспалительное, анальгезирующее и жаропонижающее, антиагрегационное действия. Подавляет активность циклооксигеназ 1 и 2, регулирующих синтез простагландинов. Анальгезирующее действие обусловлено, как центральным, так и периферическим механизмами. Обладает антибрадикининовой активностью, стабилизирует лизосомальные мембраны.
индивидуальная повышенная чувствительность к кетопрофену, ацетилсалициловой кислоте или другому НПВП (в т.ч. указания в анамнезе на бронхоспазм, крапивницу или ринит, вызванные приемом ацетилсалициловой кислоты); заболевания желудочно-кишечного тракта в фазе обострения; желудочно-кишечные кровотечения и перфорация в анамнезе; выраженные нарушения функции почек и печени; нарушения со стороны крови (лейкопения, тромбоцитопения, нарушения гемокоагуляции, гемофилия); купирование болевого синдрома непосредственно перед или сразу после оперативного лечения сердечно-сосудистой системы; выраженная сердечная недостаточность; беременность и кормление грудью; детский возраст (до 18 лет).
Применение при беременности и в период грудного вскармливания
Противопоказано
Способ применения и дозы
Лиофилизат растворяют прилагаемым растворителем и полученный раствор вводят глубоко в мышцу. Внутримышечные инъекции назначают для снятия острого болевого синдрома по 100 мг 1-2 раза в сутки. Длительность парентеральной терапии обычно кратковременна и составляет несколько дней. После достижения необходимого эффекта пациенту назначают капсулы или суппозитории. Максимальная суточная доза препарата не должна превышать 300 мг.
Побочное действие
Со стороны пищеварительной системы: НПВП-гастропатия, боль в животе, диспепсия (тошнота, рвота, изжога, метеоризм, снижение аппетита, диарея), стоматит; изменение вкуса, изъязвление и перфорации слизистой оболочки желудочно-кишечного тракта, десневое, желудочно-кишечное, геморроидальное кровотечение; повышение активности «печеночных» трансаминаз в сыворотке крови, гепатит. Со стороны нервной системы: головная боль, головокружение, бессонница, возбуждение, нервозность, сонливость, депрессия, астения, спутанность или потеря сознания, забывчивость, мигрень, периферическая невропатия. Со стороны органов чувств: шум или звон в ушах, нечеткость зрения, конъюнктивит, сухость слизистой оболочки глаза, боль в глазах, гиперемия конъюнктивы, снижение слуха, вертиго. Со стороны сердечно-сосудистой системы: повышение артериального давления, тахикардия. Со стороны органов кроветворения: редко – агранулоцитоз, анемия, гемолитическая анемия, тромбоцитопения, лейкопения. Со стороны мочевыделительной системы: отечный синдром, цистит, уретрит, нарушение функции почек, интерстициальный нефрит, нефротический синдром, гематурия. Со стороны органов дыхания: диспноэ, бронхоспазм, ринит, отек гортани, носовое кровотечение, кровохарканье, одышка. Со стороны кожных покровов: алопеция, экзема, многоформная экссудативная эритема, в т.ч. синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла), фотодерматит. Аллергические реакции: кожная сыпь (в т.ч. эритематозная, крапивница), зуд кожи, ангионевротический отек, эксфолиативный дерматит, анафилактический шок. Прочие: усиление потоотделения, миалгия, мышечные подергивания, жажда, вагинальное кровотечение, боль и покраснение в месте инъекции.
Передозировка
Симптомы: возможно появление сонливости, тошноты, рвоты, болей в животе, кровотечений, нарушений функции печени и почек. Лечение симптоматическое: не существует специфического антидота.
Особые указания
При одновременном применении кетопрофена и варфарина, а также кумариновых антикоагулянтов или солей лития пациенты должны находиться под строгим наблюдением врача. Следует соблюдать осторожность при назначении препарата больным с язвенными заболеваниями желудочно-кишечного тракта в анамнезе, почечной и печеночной недостаточностью. Во время лечения необходим контроль картины периферической крови и функциональное состояние печени и почек. При нарушении функции почек и печени (повышение активности АЛТ является индикатором НПВП-индуцированной дисфункции печени) необходимо снижение дозы и тщательное наблюдение врача. При необходимости определения 17-кетостероидов препарат следует отменить за 48 ч до исследования. Избегать приема спиртных напитков! При развитии нарушений со стороны органов зрения необходима консультация офтальмолога. В период лечения следует соблюдать осторожность при вождении автотранспорта и занятий другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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