Лоперамид акрихин Капсулы, 20 шт, 2 мг

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Повышает тонус анального сфинктера, способствует удержанию каловых масс и урежению позывов к дефекации. Действие развивается быстро и продолжается 4-6 часов."}},{"type":"paragraph","data":{"text":"Фармакокинетика."}},{"type":"paragraph","data":{"text":"При приеме внутрь абсорбция составляет 40 %. Максимальная концентрация в плазме достигается через 2,5 ч после приема капсул. Связь с белками плазмы (преимущественно с альбуминами) - 97 %. Не проникает через гематоэнцефалический барьер. Практически полностью метаболизируется печенью путем конъюгации. Период полувыведения - 9-14 часов (в среднем 9,8 ч). Выводится преимущественно с желчью, незначительная часть выводится почками (в виде конъюгированных метаболитов)."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Симптоматическое лечение острой и хронической диареи различного генеза (аллергического, эмоционального, лекарственного, лучевого; при изменении режима питания и качественного состава пищи, при нарушении метаболизма и всасывания; как вспомогательное средство при диарее инфекционного генеза). Регуляция стула у пациентов с илеостомой."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность, кишечная непроходимость, острый язвенный колит, дивертикулез, диарея на фоне острого псевдомембранозного энтероколита, дизентерии и других инфекций желудочно-кишечного тракта. 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Учитывая, что продолжительность действия Лоперамида-Акрихин больше, чем у налоксона, возможно повторное введение последнего. Симптоматическое лечение: промывание желудка, прием активированного угля (в первые 3 часа после приема препарата), искусственная вентиляция легких.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Опиоидные анальгетики повышают риск развития тяжелого запора."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При отсутствии эффекта после 2-х суток применения Лоперамид-Акрихин необходимо уточнить диагноз и исключить инфекционный генез диареи."}},{"type":"paragraph","data":{"text":"Детям младше 6 лет не рекомендуется назначать в капсулах."}},{"type":"paragraph","data":{"text":"Если при лечении развиваются запоры или вздутие живота, Лоперамид-Акрихин следует отменить. У пациентов с нарушениями функции печени необходим тщательный контроль признаков токсического поражения центральной нервной системы. В период лечения диареи необходимо восполнять потерю жидкости и электролитов."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Во время лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nКапсулы 2 мг."}},{"type":"paragraph","data":{"text":"По 10 капсул в контурную ячейковую упаковку. 1 или 2 контурные ячейковые упаковки вместе с инструкцией по применению помещают в пачку из картона.\n\n"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nВ сухом, защищенном от света месте, при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"\n\nВ сухом, защищенном от света месте, при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nОткрытое акционерное общество «Химико-фармацевтический комбинат «АКРИХИН» (ОАО «АКРИХИН»), Россия"}},{"type":"paragraph","data":{"text":"142450, Московская область, Ногинский район, г. Старая Купавна, ул. Кирова, д. 29."}},{"type":"paragraph","data":{"text":"Телефон/факс: +7 (495) 702-95-03\n\n"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика. Лоперамид, связываясь с опиоидными рецепторами кишечной стенки (стимуляция холин- и адренергических нейронов через гуанин-нуклеотиды), снижает тонус и моторику гладкой мускулатуры кишечника (за счет ингибирования высвобождения ацетилхолина и простагландинов). Замедляет перистальтику и увеличивает время прохождения кишечного содержимого. Повышает тонус анального сфинктера, способствует удержанию каловых масс и урежению позывов к дефекации. Действие развивается быстро и продолжается 4-6 часов. Фармакокинетика. При приеме внутрь абсорбция составляет 40 %. Максимальная концентрация в плазме достигается через 2,5 ч после приема капсул. Связь с белками плазмы (преимущественно с альбуминами) - 97 %. Не проникает через гематоэнцефалический барьер. Практически полностью метаболизируется печенью путем конъюгации. Период полувыведения - 9-14 часов (в среднем 9,8 ч). Выводится преимущественно с желчью, незначительная часть выводится почками (в виде конъюгированных метаболитов).","substance":[{"id":613,"title":"Лоперамид","title_latin":"Loperamidum","slug":"loperamid_613"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Лоперамид акрихин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/9503/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/9503/share_default/"}},"diseases":[{"id":"20","title":"Диарея и гастроэнтерит предположительно инфекционного происхождения","slug":"20-diareya_i_gastroenterit_predpolozhitelno_infektsionnogo_proishozhdeniya"},{"id":"866","title":"Диспепсия (нарушение пищеварения)","slug":"866-dispepsiya_narushenie_pischevareniya"},{"id":"881","title":"Функциональная диарея","slug":"881-funktsionalnaya_diareya"},{"id":"921","title":"Дисфункция после колостомии и 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