Головная боль . мигрень . зубная боль . болезненные менструации . невралгия . боль в спине . мышечная боль . ревматическая боль . боли в суставах . лихорадочные состояния при гриппе и простудных заболеваниях.
Противопоказания
Гиперчувствительность к ибупрофену или любому из компонентов, входящих в состав препарата . полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа и околоносовых пазух, и непереносимость ацетилсалициловой кислоты или других НПВс (в т.ч. в анамнезе) . эрозивно-язвенные заболевания органов ЖКТ (в т.ч. язвенная болезнь желудка ...
НПВС. Оказывает быстрое направленное действие против боли (анальгезирующее), жаропонижающее и противовоспалительное действие. Механизм действия ибупрофена, производного пропионовой кислоты, обусловлен ингибированием синтеза простагландинов – медиаторов боли, воспаления и гипертермической реакции. Неизбирательно блокирует ЦОГ-1 и ЦОГ-2, вследствие чего тормозит синтез простагландинов. Кроме того, ибупрофен обратимо ингибирует агрегацию тромбоцитов. Обезболивающее действие препарата продолжается до 8 ч.
Показания к применению
Головная боль . мигрень . зубная боль . болезненные менструации . невралгия . боль в спине . мышечная боль . ревматическая боль . боли в суставах . лихорадочные состояния при гриппе и простудных заболеваниях.
Противопоказания
Гиперчувствительность к ибупрофену или любому из компонентов, входящих в состав препарата . полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа и околоносовых пазух, и непереносимость ацетилсалициловой кислоты или других НПВс (в т.ч. в анамнезе) . эрозивно-язвенные заболевания органов ЖКТ (в т.ч. язвенная болезнь желудка и двенадцатиперстной кишки, болезнь Крона, язвенный колит) или язвенное кровотечение в активной фазе или в анамнезе (два или более подтвержденных эпизода язвенной болезни или язвенного кровотечения) . кровотечение или перфорация язвы ЖКТ в анамнезе, спровоцированные применением НПВС . тяжелая печеночная недостаточность или заболевание печени в активной фазе . почечная недостаточность тяжелой степени тяжести (Cl креатинина <30 мл/мин), подтвержденная гиперкалиемия . декомпенсированная сердечная недостаточность . период после проведения аортокоронарного шунтирования . цереброваскулярное или иное кровотечение . непереносимость фруктозы, глюкозо-галактозная мальабсорбция, недостаточность сахаразы-изомальтазы . гемофилия и другие нарушения свертываемости крови (в т.ч. гипокоагуляция), геморрагические диатезы . беременность (III триместр) . детский возраст до 6 лет.
Применение при беременности и в период грудного вскармливания
Противопоказано применение препарата в III триместре беременности. Следует избегать применения препарата в I–II триместрах беременности, при необходимости приема препарата следует проконсультироваться с врачом. Имеются данные о том, что ибупрофен в незначительных количествах может проникать в грудное молоко без каких-либо отрицательных последствий для здоровья грудного ребенка, поэтому обычно при кратковременном приеме необходимости в прекращении грудного вскармливания не возникает. При необходимости длительного применения препарата следует обратиться к врачу для решения вопроса о прекращении грудного вскармливания на период применения препарата.
Способ применения и дозы
Внутрь, запивая водой. Пациентам с повышенной чувствительностью желудка рекомендуется принимать препарат во время еды. Только для кратковременного применения. Перед приемом препарата следует внимательно прочитать инструкцию. Взрослым и детям старше 12 лет: внутрь по 1 табл. (200 мг) до 3–4 раз в сутки. Для достижения более быстрого терапевтического эффекта у взрослых доза может быть увеличена до 2 табл. (400 мг) до 3 раз в сутки. Детям от 6 до 12 лет: по 1 табл. (200 мг) до 3–4 раз в день . препарат можно принимать только в случае массы тела ребенка более 20 кг. Интервал между приемом таблеток должен составлять не менее 6 ч. Максимальная суточная доза для взрослых составляет 1200 мг (6 табл.). Максимальная суточная доза для детей от 6 до 18 лет — 800 мг (4 табл.). Если при приеме препарата в течение 2–3 дней симптомы сохраняются или усиливаются, необходимо прекратить лечение и обратиться к врачу.
Побочное действие
Риск возникновения побочных эффектов можно свести к минимуму, если принимать препарат коротким курсом, в минимальной эффективной дозе, необходимой для устранения симптомов. У людей пожилого возраста наблюдается повышенная частота побочных реакций на фоне применения НПВС, особенно желудочно-кишечных кровотечений и перфораций, в некоторых случаях с летальным исходом. Побочное эффекты преимущественно являются дозозависимыми. Нижеперечисленные Побочное реакции отмечались при кратковременном приеме ибупрофена в дозах, не превышающих 1200 мг/сут (6 табл.). При лечении хронических состояний и длительном применении возможно появление других побочных реакций. Оценка частоты возникновения побочных реакций произведена на основании следующих критериев: очень часто (≥ .1/10) . часто (от ≥ .1/100 до <1/10) . нечасто (от ≥ .1/1000 до <1/100), редко (от ≥ .1/10000 до <1/1000), очень редко (<1/10 000), частота неизвестна (данные по оценке частоты отсутствуют). Со стороны крови и лимфатической системы: очень редко — нарушения кроветворения (анемия, лейкопения, апластическая анемия, гемолитическая анемия, тромбоцитопения, панцитопения, агранулоцитоз). Первыми симптомами таких нарушений являются лихорадка, боль в горле, поверхностные язвы в полости рта, гриппоподобные симптомы, выраженная слабость, кровотечения из носа и подкожные кровоизлияния, кровотечения и кровоподтеки неизвестной этиологии. Со стороны иммунной системы: нечасто — реакции гиперчувствительности, неспецифические аллергические реакции и анафилактические реакции, реакции со стороны дыхательных путей (бронхиальная астма, в т.ч. ее обострение, бронхоспазм, одышка, диспноэ), кожные реакции (зуд, крапивница, пурпура, отек Квинке, эксфолиативные и буллезные дерматозы, в т.ч. токсический эпидермальный некролиз (синдром Лайелла), синдром Стивенса-Джонсона, мультиформная эритема), аллергический ринит, эозинофилия . очень редко — тяжелые реакции гиперчувствительности, в т.ч. отек лица, языка и гортани, одышка, тахикардия, артериальная гипотензия (анафилаксия, отек Квинке или тяжелый анафилактический шок). Со стороны ЖКТ: нечасто — боль в животе, тошнота, диспепсия (в т.ч. изжога, вздутие живота) . редко — диарея, метеоризм, запор, рвота . очень редко — пептическая язва, перфорация или желудочно-кишечное кровотечение, мелена, кровавая рвота, в некоторых случаях с летальным исходом, особенно у пациентов пожилого возраста, язвенный стоматит, гастрит . чстота неизвестна — обострение колита и болезни Крона. Со стороны печени и желчевыводящих путей: очень редко — нарушения функции печени, повышение активности печеночных трансаминаз, гепатит и желтуха. Со стороны почек и мочевыводящих путей: очень редко — острая почечная недостаточность (компенсированная и декомпенсированная) особенно при длительном применении, в сочетании с повышением концентрации мочевины в плазме крови и появлением отеков, гематурии и протеинурии, нефритический синдром, нефротический синдром, папиллярный некроз, интерстициальный нефрит, цистит. Со стороны нервной системы: нечасто — головная боль . очень редко — асептический менингит. Со стороны ССС: частота неизвестна — сердечная недостаточность, периферические отеки, при длительном применении повышен риск тромботических осложнений (например инфаркт миокарда), повышение АД. Со стороны дыхательной системы и органов средостения: частота неизвестна — бронхиальная астма, бронхоспазм, одышка. Лабораторные показатели: гематокрит или Hb (могут уменьшаться) . время кровотечения (может увеличиваться) . концентрация глюкозы в плазме крови (может снижаться) . клиренс креатинина (может уменьшаться) . плазменная концентрация креатинина (может увеличиваться) . активность печеночных трансаминаз (может повышаться). При появлении побочных эффектов следует прекратить прием препарата и обратиться к врачу.
Особые указания
Риск возникновения побочных эффектов можно свести к минимуму, если принимать препарат коротким курсом, в минимальной эффективной дозе, необходимой для устранения симптомов. У людей пожилого возраста наблюдается повышенная частота побочных реакций на фоне применения НПВС, особенно желудочно-кишечных кровотечений и перфораций, в некоторых случаях с летальным исходом. Побочное эффекты преимущественно являются дозозависимыми. Нижеперечисленные Побочное реакции отмечались при кратковременном приеме ибупрофена в дозах, не превышающих 1200 мг/сут (6 табл.). При лечении хронических состояний и длительном применении возможно появление других побочных реакций. Оценка частоты возникновения побочных реакций произведена на основании следующих критериев: очень часто (≥ .1/10) . часто (от ≥ .1/100 до <1/10) . нечасто (от ≥ .1/1000 до <1/100), редко (от ≥ .1/10000 до <1/1000), очень редко (<1/10 000), частота неизвестна (данные по оценке частоты отсутствуют). Со стороны крови и лимфатической системы: очень редко — нарушения кроветворения (анемия, лейкопения, апластическая анемия, гемолитическая анемия, тромбоцитопения, панцитопения, агранулоцитоз). Первыми симптомами таких нарушений являются лихорадка, боль в горле, поверхностные язвы в полости рта, гриппоподобные симптомы, выраженная слабость, кровотечения из носа и подкожные кровоизлияния, кровотечения и кровоподтеки неизвестной этиологии. Со стороны иммунной системы: нечасто — реакции гиперчувствительности, неспецифические аллергические реакции и анафилактические реакции, реакции со стороны дыхательных путей (бронхиальная астма, в т.ч. ее обострение, бронхоспазм, одышка, диспноэ), кожные реакции (зуд, крапивница, пурпура, отек Квинке, эксфолиативные и буллезные дерматозы, в т.ч. токсический эпидермальный некролиз (синдром Лайелла), синдром Стивенса-Джонсона, мультиформная эритема), аллергический ринит, эозинофилия . очень редко — тяжелые реакции гиперчувствительности, в т.ч. отек лица, языка и гортани, одышка, тахикардия, артериальная гипотензия (анафилаксия, отек Квинке или тяжелый анафилактический шок). Со стороны ЖКТ: нечасто — боль в животе, тошнота, диспепсия (в т.ч. изжога, вздутие живота) . редко — диарея, метеоризм, запор, рвота . очень редко — пептическая язва, перфорация или желудочно-кишечное кровотечение, мелена, кровавая рвота, в некоторых случаях с летальным исходом, особенно у пациентов пожилого возраста, язвенный стоматит, гастрит . чстота неизвестна — обострение колита и болезни Крона. Со стороны печени и желчевыводящих путей: очень редко — нарушения функции печени, повышение активности печеночных трансаминаз, гепатит и желтуха. Со стороны почек и мочевыводящих путей: очень редко — острая почечная недостаточность (компенсированная и декомпенсированная) особенно при длительном применении, в сочетании с повышением концентрации мочевины в плазме крови и появлением отеков, гематурии и протеинурии, нефритический синдром, нефротический синдром, папиллярный некроз, интерстициальный нефрит, цистит. Со стороны нервной системы: нечасто — головная боль . очень редко — асептический менингит. Со стороны ССС: частота неизвестна — сердечная недостаточность, периферические отеки, при длительном применении повышен риск тромботических осложнений (например инфаркт миокарда), повышение АД. Со стороны дыхательной системы и органов средостения: частота неизвестна — бронхиальная астма, бронхоспазм, одышка. Лабораторные показатели: гематокрит или Hb (могут уменьшаться) . время кровотечения (может увеличиваться) . концентрация глюкозы в плазме крови (может снижаться) . клиренс креатинина (может уменьшаться) . плазменная концентрация креатинина (может увеличиваться) . активность печеночных трансаминаз (может повышаться). При появлении побочных эффектов следует прекратить прием препарата и обратиться к врачу.
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У людей пожилого возраста наблюдается повышенная частота побочных реакций на фоне применения НПВС, особенно желудочно-кишечных кровотечений и перфораций, в некоторых случаях с летальным исходом. Побочное эффекты преимущественно являются дозозависимыми. Нижеперечисленные Побочное реакции отмечались при кратковременном приеме ибупрофена в дозах, не превышающих 1200 мг/сут (6 табл.). При лечении хронических состояний и длительном применении возможно появление других побочных реакций. Оценка частоты возникновения побочных реакций произведена на основании следующих критериев: очень часто (≥ .1/10) . часто (от ≥ .1/100 до \u003c1/10) . нечасто (от ≥ .1/1000 до \u003c1/100), редко (от ≥ .1/10000 до \u003c1/1000), очень редко (\u003c1/10 000), частота неизвестна (данные по оценке частоты отсутствуют). Со стороны крови и лимфатической системы: очень редко — нарушения кроветворения (анемия, лейкопения, апластическая анемия, гемолитическая анемия, тромбоцитопения, панцитопения, агранулоцитоз). Первыми симптомами таких нарушений являются лихорадка, боль в горле, поверхностные язвы в полости рта, гриппоподобные симптомы, выраженная слабость, кровотечения из носа и подкожные кровоизлияния, кровотечения и кровоподтеки неизвестной этиологии. Со стороны иммунной системы: нечасто — реакции гиперчувствительности, неспецифические аллергические реакции и анафилактические реакции, реакции со стороны дыхательных путей (бронхиальная астма, в т.ч. ее обострение, бронхоспазм, одышка, диспноэ), кожные реакции (зуд, крапивница, пурпура, отек Квинке, эксфолиативные и буллезные дерматозы, в т.ч. токсический эпидермальный некролиз (синдром Лайелла), синдром Стивенса-Джонсона, мультиформная эритема), аллергический ринит, эозинофилия . очень редко — тяжелые реакции гиперчувствительности, в т.ч. отек лица, языка и гортани, одышка, тахикардия, артериальная гипотензия (анафилаксия, отек Квинке или тяжелый анафилактический шок). Со стороны ЖКТ: нечасто — боль в животе, тошнота, диспепсия (в т.ч. изжога, вздутие живота) . редко — диарея, метеоризм, запор, рвота . очень редко — пептическая язва, перфорация или желудочно-кишечное кровотечение, мелена, кровавая рвота, в некоторых случаях с летальным исходом, особенно у пациентов пожилого возраста, язвенный стоматит, гастрит . чстота неизвестна — обострение колита и болезни Крона. Со стороны печени и желчевыводящих путей: очень редко — нарушения функции печени, повышение активности печеночных трансаминаз, гепатит и желтуха. Со стороны почек и мочевыводящих путей: очень редко — острая почечная недостаточность (компенсированная и декомпенсированная) особенно при длительном применении, в сочетании с повышением концентрации мочевины в плазме крови и появлением отеков, гематурии и протеинурии, нефритический синдром, нефротический синдром, папиллярный некроз, интерстициальный нефрит, цистит. Со стороны нервной системы: нечасто — головная боль . очень редко — асептический менингит. Со стороны ССС: частота неизвестна — сердечная недостаточность, периферические отеки, при длительном применении повышен риск тромботических осложнений (например инфаркт миокарда), повышение АД. Со стороны дыхательной системы и органов средостения: частота неизвестна — бронхиальная астма, бронхоспазм, одышка. Лабораторные показатели: гематокрит или Hb (могут уменьшаться) . время кровотечения (может увеличиваться) . концентрация глюкозы в плазме крови (может снижаться) . клиренс креатинина (может уменьшаться) . плазменная концентрация креатинина (может увеличиваться) . активность печеночных трансаминаз (может повышаться). При появлении побочных эффектов следует прекратить прием препарата и обратиться к врачу."}}]},{"id":8,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Риск возникновения побочных эффектов можно свести к минимуму, если принимать препарат коротким курсом, в минимальной эффективной дозе, необходимой для устранения симптомов. У людей пожилого возраста наблюдается повышенная частота побочных реакций на фоне применения НПВС, особенно желудочно-кишечных кровотечений и перфораций, в некоторых случаях с летальным исходом. Побочное эффекты преимущественно являются дозозависимыми. Нижеперечисленные Побочное реакции отмечались при кратковременном приеме ибупрофена в дозах, не превышающих 1200 мг/сут (6 табл.). При лечении хронических состояний и длительном применении возможно появление других побочных реакций. Оценка частоты возникновения побочных реакций произведена на основании следующих критериев: очень часто (≥ .1/10) . часто (от ≥ .1/100 до \u003c1/10) . нечасто (от ≥ .1/1000 до \u003c1/100), редко (от ≥ .1/10000 до \u003c1/1000), очень редко (\u003c1/10 000), частота неизвестна (данные по оценке частоты отсутствуют). Со стороны крови и лимфатической системы: очень редко — нарушения кроветворения (анемия, лейкопения, апластическая анемия, гемолитическая анемия, тромбоцитопения, панцитопения, агранулоцитоз). Первыми симптомами таких нарушений являются лихорадка, боль в горле, поверхностные язвы в полости рта, гриппоподобные симптомы, выраженная слабость, кровотечения из носа и подкожные кровоизлияния, кровотечения и кровоподтеки неизвестной этиологии. Со стороны иммунной системы: нечасто — реакции гиперчувствительности, неспецифические аллергические реакции и анафилактические реакции, реакции со стороны дыхательных путей (бронхиальная астма, в т.ч. ее обострение, бронхоспазм, одышка, диспноэ), кожные реакции (зуд, крапивница, пурпура, отек Квинке, эксфолиативные и буллезные дерматозы, в т.ч. токсический эпидермальный некролиз (синдром Лайелла), синдром Стивенса-Джонсона, мультиформная эритема), аллергический ринит, эозинофилия . очень редко — тяжелые реакции гиперчувствительности, в т.ч. отек лица, языка и гортани, одышка, тахикардия, артериальная гипотензия (анафилаксия, отек Квинке или тяжелый анафилактический шок). Со стороны ЖКТ: нечасто — боль в животе, тошнота, диспепсия (в т.ч. изжога, вздутие живота) . редко — диарея, метеоризм, запор, рвота . очень редко — пептическая язва, перфорация или желудочно-кишечное кровотечение, мелена, кровавая рвота, в некоторых случаях с летальным исходом, особенно у пациентов пожилого возраста, язвенный стоматит, гастрит . чстота неизвестна — обострение колита и болезни Крона. Со стороны печени и желчевыводящих путей: очень редко — нарушения функции печени, повышение активности печеночных трансаминаз, гепатит и желтуха. Со стороны почек и мочевыводящих путей: очень редко — острая почечная недостаточность (компенсированная и декомпенсированная) особенно при длительном применении, в сочетании с повышением концентрации мочевины в плазме крови и появлением отеков, гематурии и протеинурии, нефритический синдром, нефротический синдром, папиллярный некроз, интерстициальный нефрит, цистит. Со стороны нервной системы: нечасто — головная боль . очень редко — асептический менингит. Со стороны ССС: частота неизвестна — сердечная недостаточность, периферические отеки, при длительном применении повышен риск тромботических осложнений (например инфаркт миокарда), повышение АД. Со стороны дыхательной системы и органов средостения: частота неизвестна — бронхиальная астма, бронхоспазм, одышка. Лабораторные показатели: гематокрит или Hb (могут уменьшаться) . время кровотечения (может увеличиваться) . концентрация глюкозы в плазме крови (может снижаться) . клиренс креатинина (может уменьшаться) . плазменная концентрация креатинина (может увеличиваться) . активность печеночных трансаминаз (может повышаться). При появлении побочных эффектов следует прекратить прием препарата и обратиться к врачу."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"НПВС. 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