Ингибитор H+-K+-АТФ-азы. Блокирует заключительную стадию секреции хлороводородной (соляной) кислоты, снижая базальную и стимулированную (независимо от природы раздражителя) секрецию. При язвенной болезни двенадцатиперстной кишки, ассоциированной с Helicobacter pylori, снижение желудочной секреции повышает чувствительность микроогранизма к антибиотикамПосле приема таблеток терапевтический эффект наступает в течение часа, максимума достигает через 2-4 часа. Через 3-4 дня после окончания приема средства секреция соляной кислоты и прочих веществ приходит в норму. Вещество стабильно, при нейтральном рН не затрагивает оксидазную систему печени, которая зависит от фермента цитохрома Р450. При пероральном приеме действующее вещество быстро всасывается в ЖКТ. Cmax в плазме крови, равная 2-3 мкг на мл достигается через 3 часа. Порядка 98% Пантопразола связывается с белками плазмы. Параллельный прием пищи не влияет на фармакокинетические показатели. При частом и длительном применении этот показатель остается постоянным. Период полувыведения — один час. Лекарство претерпевает реакции метаболизма в печени. Метаболиты выводятся через почки и с каловыми массами. Препарат не кумулируется в организме. Для лиц, страдающих почечной недостаточностью, находящихся на гемодиализе, коррекция дозы не требуется. При циррозе печени период полувыведения увеличивается до 7- 9 часов, максимальная концентрация в 1,5 раза больше. У пожилых людей несколько повышается максимальная концентрация в крови и AUC препарата. Однако коррекция суточной дозы не требуется. При внутривенном введении показатели сходные с приемом таблеток
Показания к применению
Язвенная болезнь желудка или двенадцатиперстной кишки в фазе обострения;
Эрозивный гастрит (в т.ч. ассоциированный с Helicobacter pylori)
Эрозивно-язвенные поражения желудка и двенадцатиперстной кишки, связанные с приемом НПВП
Рефлюкс-эзофагит
Противопоказания
Детский возраст (из-за отсутствия данных о применении препарата в педиатрической практике);
Диспепсия невротического генеза
Злокачественные заболевания ЖКТ
Повышенная чувствительность к пантопразолу
Применение при беременности и в период грудного вскармливания
С осторожностью назначают препарат при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
При язвенной болезни желудка и двенадцатиперстной кишки, эрозивном гастрите препарат назначают по 40-80 мг/сут. Курс лечения при обострении язвенной болезни двенадцатиперстной кишки составляет 2 недели, а язвенной болезни желудка - 4-8 недель. Для профилактики обострений язвенной болезни желудка и двенадцатиперстной кишки назначают по 20 мг/сут. Для эрадикации Helicobacter pylori принимают по 40 мг 2 раза/сут в комбинации с противомикробными средствами. Курс терапии - 7-14 дней. При эрозивно-язвенных поражениях желудка и двенадцатиперстной кишки, связанных с приемом НПВП, назначают по 40-80 мг/сут. Курс лечения - 4-8 недель. Для профилактики эрозивных поражений на фоне длительного применения НПВП - по 20 мг/сут. При рефлюкс-эзофагите назначают по 20-40 мг/сут. Курс терапии составляет 4-8 недель. Для профилактики обострений принимают по 20 мг/сут. У пациентов с выраженными нарушениями функции печени дозу следует снизить до 40 мг 1 раз в 2 дня, при этом необходимо контролировать биохимические показатели крови. При повышении активности печеночных ферментов препарат следует отменить. Таблетки принимают внутрь целиком (не размельчая и не растворяя), запивая достаточным количеством жидкости. Препарат рекомендуют принимать за 1 ч до завтрака, при кратности приема 2 раза/сут вторую дозу - за 1 ч до ужина
Побочное действие
Со стороны ЦНС: головная боль; очень редко - депрессия, слабость, головокружение, нарушение зрения. Со стороны пищеварительной системы: диарея, тошнота, боли в верхней части живота, запор, метеоризм; в единичных случаях (1 случай на 106 пациентов) - тяжелое гепатоцеллюлярное поражение печени с желтухой, нарушения функции печени. Аллергические реакции: кожная сыпь, зуд, гиперемия кожи, анафилактические реакции (вплоть до шока). Прочие: болезненное напряжение молочных желез, гипертермия
Передозировка
Симптомы передозировки у человека не известны. Дозы до 240 мг при в/в введении хорошо переносились
Особые указания
До начала и после окончания терапии обязателен эндоскопический контроль (при необходимости - с биопсией) для исключения злокачественного новообразования желудка или пищевода, т.к. применение препарата может отсрочить постановку правильного диагноза
Для описания товара использована информация от партнера 36.6
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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