Докозанол является противовирусным средством. Исследования invitro показали, что докозанол влияет на слияние вируса с плазматической мембраной, что ингибирует проникновение вируса в клетку и его последующую репликацию. Данный механизм действия делает маловероятным появление штаммов Herpes simplex, резистентных к противовирусным эффектам докозанола, а также защищает от проникновения вируса в здоровые клетки. Исследования in vitro показали, что клетки, подвергнутые воздействию докозанолом, устойчивы к инфекции, вызываемой вирусами с липидной оболочкой, такими как вирус Herpes simplex первого типа.
Показания к применению
Инфекции кожи, вызванные вирусом Herpes simplex типа 1 (в том числе герпес губ) у иммунокомпетентных пациентов.
Противопоказания
Повышенная чувствительность к докозанолу или какому-либо другому компоненту препарата, возраст до 12 лет (отсутствует опыт применения).
Применение при беременности и в период грудного вскармливания
Доклинические исследования на животных не выявили тератогенного и эмбриотоксического действия на плод. Перед применением препарата Эразабан во время беременности или в период грудного вскармливания необходима консультация врача.
Способ применения и дозы
Наружно. Препарат рекомендуется наносить взрослым и детям старше 12 лет 5 раз в сутки (примерно каждые 3 часа) как можно раньше после начала инфекции, наносить тонким слоем на пораженные и граничащие с ними участки кожи. Среднее время выздоровления – 4-6 дней. Крем наносят либо ватным тампоном, либо чистыми руками, чтобы избежать дополнительно инфицирования пораженных участков. Эффективность проводимой данным препаратом терапии зависит от времени начала терапии: чем раньше от момента появления симптомов заболевания начата терапия, тем выше эффективность. В случае начала лечения рецидивирующей инфекции во время продромальной фазы или в самом начале препарат Эразабан предотвращает появление пузырьковых высыпаний и образования корочек. Необходимо проводить полный курс терапии в течение 5 дней, для того, чтобы добиться наибольшего эффекта от проводимой терапии, даже если признаки инфекции исчезают после 1-2 дней лечения. В случае отсутствия заживления лечение может быть продолжено до 10 дней. Коррекции дозы у пожилых пациентов и у пациентов с нарушением функции почек не требуется. В случае сохранения симптомов заболевания более 10 дней, следует обратиться к врачу.
Побочное действие
Головная боль; на участках нанесения препарата: сухость кожи, кожный зуд, сыпь, кратковременное покраснение, болезненность, шелушение, жжение или покалывание. Данные побочные действия, как правило, не требуют отмены препарата. Имеются единичные сообщения о случаяхотека Квинке при наружном применении препарата. Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты не указанные в инструкции, сообщите об этом врачу.
Передозировка
О случаях передозировки препаратом не сообщалось.
Особые указания
Препарат ЭРАЗАБАН предназначен только для наружного применения! Избегать попадания препарата в глаза, нельзя наносить на кожу вблизи глаз. Для достижения максимального терапевтического эффекта необходимо применять препарат уже при первых признаках заболевания (жжение, кожный зуд, покалывание, ощущение напряженности и покраснение). Препарат содержит пропиленгликоль и может вызывать раздражение кожи. Крем нельзя применять пациентам с ослабленным иммунитетом.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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