Ксилометазолин относится к группе местных сосудосуживающих с... Инструкция
Показания к применению
Острые респираторные заболевания с явлениями ринита (насморка), острый аллергический ринит, поллиноз, синусит, евстахиит, средний отит (для уменьшения отека слизистой носоглотки).
Подготовка больного к диагностическим манипуляциям в носовых ходах.
Противопоказания
Повышенная чувствительность к ксилометазолину и другим компонентам препарата, артериальная гипертензия, тахикардия, выраженный атеросклероз, глаукома, сухой ринит или атрофический ринит, гипертиреоз, состояние после транссфеноидальной гипофизэктомии, хирургические вмешательства на мозговых оболочках (в анамнезе), беременность, детский возраст до 10 лет.
Ксилометазолин относится к группе местных сосудосуживающих средств (деконгестантов) с альфа-адреномиметическим действием, вызывает сужение кровеносных сосудов слизистой носа, устраняя, таким образом, отек и гиперемию слизистой оболочки носоглотки.
Ксилометазолин также уменьшает сопутствующую гиперсекрецию слизи и облегчает дренаж заблокированных выделениями носовых ходов, и, таким образом, улучшает носовое дыхание при заложенности носа.
В терапевтических концентрациях не раздражает слизистую, не вызывает гиперемию. Действие наступает через 2 минуты после применения и продолжается в течение 12 часов.
Исследования in vitro показали, что ксилометазолин подавляет инфекционную активность риновируса человека, вызывающего «простуду».
Фармакокинетика
При местном применении практически не абсорбируется, концентрации в плазме настолько малы, что их невозможно определить современными аналитическими методами.
Показания к применению
Острые респираторные заболевания с явлениями ринита (насморка), острый аллергический ринит, поллиноз, синусит, евстахиит, средний отит (для уменьшения отека слизистой носоглотки).
Подготовка больного к диагностическим манипуляциям в носовых ходах.
Противопоказания
Повышенная чувствительность к ксилометазолину и другим компонентам препарата, артериальная гипертензия, тахикардия, выраженный атеросклероз, глаукома, сухой ринит или атрофический ринит, гипертиреоз, состояние после транссфеноидальной гипофизэктомии, хирургические вмешательства на мозговых оболочках (в анамнезе), беременность, детский возраст до 10 лет.
Не применять препарат при терапии ингибиторами моноаминооксидазы или трициклическими антидепрессантами, включая период 14 дней после их отмены.
С осторожностью
Сахарный диабет; феохромоцитома; заболевания сердечно-сосудистой системы, в т.ч. ИБС, стенокардия III — IV функционального класса; порфирия; период грудного вскармливания; гиперплазия предстательной железы; атеросклероз; при повышенной чувствительности к адренергическим препаратам, сопровождающейся бессонницей, головокружением, аритмией, тремором, повышением артериального давления.
Применение при беременности и в период грудного вскармливания
Применение препарата противопоказано при беременности. В период грудного вскармливания препарат должен применяться только после тщательной оценки соотношения риска и пользы для матери и ребенка, под контролем врача. Не допускается превышать рекомендуемую дозировку.
Способ применения и дозы
Интраназально.
Для взрослых и детей старше 10 лет: По 1 впрыскиванию в каждый носовой ход (при необходимости можно повторить); не следует применять более 3 раз в день.
Продолжительность лечения — не более 10 дней.
Побочное действие
Классификация частоты возникновения нежелательных реакций: очень часто (≥ 1/10); часто (≥ 1/100, ˂1/10); нечасто (≥ 1/1000, ˂ 1/100); редко (≥ 1/10000, ˂ 1/1000); очень редко (˂1/10000).
Нарушения со стороны иммунной системы
Очень редко: реакции гиперчувствительности (ангионевротический отек, сыпь, зуд).
Нарушения со стороны нервной системы
Часто: головная боль.
Редко: бессонница, депрессия (при длительном применении в высоких дозах.
Очень редко: галлюцинации и судороги (преимущественно у детей).
Нарушения со стороны органа зрения
Очень редко: нарушение четкости зрительного восприятия.
Нарушения со стороны сердца
Редко: ощущение сердцебиения, повышение артериального давления.
Очень редко: тахикардия, аритмия.
Нарушения со стороны дыхательной системы, органов грудной клетки и средостения
Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу.
Передозировка
Ксилометазолин при местном введении чрезмерной дозы или при случайном приеме внутрь может вызывать сильное головокружение, нерегулярный пульс, повышенное потоотделение, резкое снижение температуры тела, головную боль, брадикардию, повышение артериального давления, угнетение дыхания, кому и судороги. Вслед за повышением артериального давления может наблюдаться его резкое снижение.
Соответствующие поддерживающие меры должны приниматься при любых подозрениях на передозировку. В некоторых случаях показано незамедлительное симптоматическое лечение под наблюдением врача. Эти меры должны включать наблюдение за пациентом в течение нескольких часов. В случае тяжелого отравления с остановкой сердца реанимационные действия должны продолжаться не менее 1 часа.
Взаимодействие с другими лекарственными средствами
Применение ксилометазолина противопоказано пациентам, получающим ингибиторы МАО или трициклические антидепрессанты, включая период 14 дней после их отмены.
Одновременное применение три- или тетрациклических антидепрессантов и симпатомиметических препаратов могут привести к увеличению симпатомиметического эффекта ксилометазолина, поэтому такого сочетания рекомендуется избегать.
Особые указания
Не следует применять в течение длительного времени (более 10 дней).
Длительное (более 10 дней) или чрезмерное применение препарата может вызвать эффект «рикошета» (медикаментозный ринит) и/или атрофию слизистой оболочки носа.
Не следует превышать рекомендованные дозы, особенно у детей и пожилых людей.
Если симптомы заболевания ухудшаются или состояние больного не улучшается в течение 3-х дней применения Ксимелина Эко с ментолом, необходимо проконсультироваться с врачом.
Влияние на способность управлять автомобилем и движущимися механизмами
Ксимелин Эко с ментолом не влияет на способность управлять транспортным средством или оборудованием.
Форма выпуска
Спрей назальный дозированный 140 мкг/доза.
По 10 мл препарата (не менее 60 доз) в пластиковом флаконе, снабженном помповым дозирующим устройством с наконечником и защитным колпачком из полиэтилена. По 1 флакону вместе с инструкцией по применению помещают в картонную пачку.
Условия хранения
При температуре не выше 30 °С.
Хранить в недоступном для детей месте.
Срок годности
2,5 года. Не использовать по истечении срока годности.
Условия отпуска
Без рецепта
Производитель
Такеда ГмбХ, Германия
Takeda GmbH, Germany
Robert-Bosch-Strasse 8, 78224 Singen, Germany
Организация, принимающая претензии потребителей
ООО «Такеда Фармасьютикалс»,
Москва, 119048, ул. Усачева, д.2, стр.1.
тел. + 7 (495) 933 55 11,
факс + 7 (495) 502 16 25
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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номер","slug":"","body":[{"type":"paragraph","data":{"text":"ЛСР-000589/09"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"Cпрей назальный дозированный"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e1 доза содержит:\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eДействующее вещество:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"ксилометазолина гидрохлорид 140 мкг"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"сорбитол 1,96 мг"}},{"type":"paragraph","data":{"text":"касторовое масло гидрированное 350 мкг"}},{"type":"paragraph","data":{"text":"левоментол 42 мкг"}},{"type":"paragraph","data":{"text":"цинеол (эвкалиптол) 28 мкг"}},{"type":"paragraph","data":{"text":"натрия хлорид 728 мкг"}},{"type":"paragraph","data":{"text":"натрия гидрофосфата дигидрат 280 мкг"}},{"type":"paragraph","data":{"text":"натрия дигидрофосфата дигидрат 280 мкг"}},{"type":"paragraph","data":{"text":"динатрия эдетат 70 мкг"}},{"type":"paragraph","data":{"text":"вода очищенная до 140 мкл"}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Прозрачная или слегка опалесцирующая, бесцветная или слегка окрашенная жидкость с характерным запахом"}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Противоконгестивное средство-вазоконстриктор (альфа-адреномиметик)"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Ксилометазолин относится к группе местных сосудосуживающих средств (деконгестантов) с альфа-адреномиметическим действием, вызывает сужение кровеносных сосудов слизистой носа, устраняя, таким образом, отек и гиперемию слизистой оболочки носоглотки."}},{"type":"paragraph","data":{"text":"Ксилометазолин также уменьшает сопутствующую гиперсекрецию слизи и облегчает дренаж заблокированных выделениями носовых ходов, и, таким образом, улучшает носовое дыхание при заложенности носа."}},{"type":"paragraph","data":{"text":"В терапевтических концентрациях не раздражает слизистую, не вызывает гиперемию. Действие наступает через 2 минуты после применения и продолжается в течение 12 часов."}},{"type":"paragraph","data":{"text":"Исследования in vitro показали, что ксилометазолин подавляет инфекционную активность риновируса человека, вызывающего «простуду»."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"При местном применении практически не абсорбируется, концентрации в плазме настолько малы, что их невозможно определить современными аналитическими методами."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Острые респираторные заболевания с явлениями ринита (насморка), острый аллергический ринит, поллиноз, синусит, евстахиит, средний отит (для уменьшения отека слизистой носоглотки)."}},{"type":"paragraph","data":{"text":"Подготовка больного к диагностическим манипуляциям в носовых ходах."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к ксилометазолину и другим компонентам препарата, артериальная гипертензия, тахикардия, выраженный атеросклероз, глаукома, сухой ринит или атрофический ринит, гипертиреоз, состояние после транссфеноидальной гипофизэктомии, хирургические вмешательства на мозговых оболочках (в анамнезе), беременность, детский возраст до 10 лет."}},{"type":"paragraph","data":{"text":"Не применять препарат при терапии ингибиторами моноаминооксидазы или трициклическими антидепрессантами, включая период 14 дней после их отмены."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Сахарный диабет; феохромоцитома; заболевания сердечно-сосудистой системы, в т.ч. ИБС, стенокардия III — IV функционального класса; порфирия; период грудного вскармливания; гиперплазия предстательной железы; атеросклероз; при повышенной чувствительности к адренергическим препаратам, сопровождающейся бессонницей, головокружением, аритмией, тремором, повышением артериального давления."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата противопоказано при беременности. В период грудного вскармливания препарат должен применяться только после тщательной оценки соотношения риска и пользы для матери и ребенка, под контролем врача. Не допускается превышать рекомендуемую дозировку."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Интраназально."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДля взрослых и детей старше 10 лет:\u003c/i\u003e По 1 впрыскиванию в каждый носовой ход (при необходимости можно повторить); не следует применять более 3 раз в день."}},{"type":"paragraph","data":{"text":"Продолжительность лечения — не более 10 дней."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Классификация частоты возникновения нежелательных реакций: очень часто (≥ 1/10); часто (≥ 1/100, ˂1/10); нечасто (≥ 1/1000, ˂ 1/100); редко (≥ 1/10000, ˂ 1/1000); очень редко (˂1/10000)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны иммунной системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: реакции гиперчувствительности (ангионевротический отек, сыпь, зуд)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны нервной системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: головная боль."}},{"type":"paragraph","data":{"text":"Редко: бессонница, депрессия (при длительном применении в высоких дозах."}},{"type":"paragraph","data":{"text":"Очень редко: галлюцинации и судороги (преимущественно у детей)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны органа зрения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: нарушение четкости зрительного восприятия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны сердца\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Редко: ощущение сердцебиения, повышение артериального давления."}},{"type":"paragraph","data":{"text":"Очень редко: тахикардия, аритмия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны дыхательной системы, органов грудной клетки и средостения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: раздражение и/или сухость слизистой оболочки носа, жжение, покалывание, чихание, гиперсекреция слизистой оболочки носоглотки."}},{"type":"paragraph","data":{"text":"Редко: кровотечение из носа."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны желудочно-кишечного тракта\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: тошнота."}},{"type":"paragraph","data":{"text":"Редко: рвота."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие расстройства и нарушения в месте введения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: жжение в месте применения."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Ксилометазолин при местном введении чрезмерной дозы или при случайном приеме внутрь может вызывать сильное головокружение, нерегулярный пульс, повышенное потоотделение, резкое снижение температуры тела, головную боль, брадикардию, повышение артериального давления, угнетение дыхания, кому и судороги. Вслед за повышением артериального давления может наблюдаться его резкое снижение."}},{"type":"paragraph","data":{"text":"Соответствующие поддерживающие меры должны приниматься при любых подозрениях на передозировку. В некоторых случаях показано незамедлительное симптоматическое лечение под наблюдением врача. Эти меры должны включать наблюдение за пациентом в течение нескольких часов. В случае тяжелого отравления с остановкой сердца реанимационные действия должны продолжаться не менее 1 часа."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Применение ксилометазолина противопоказано пациентам, получающим ингибиторы МАО или трициклические антидепрессанты, включая период 14 дней после их отмены."}},{"type":"paragraph","data":{"text":"Одновременное применение три- или тетрациклических антидепрессантов и симпатомиметических препаратов могут привести к увеличению симпатомиметического эффекта ксилометазолина, поэтому такого сочетания рекомендуется избегать."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Не следует применять в течение длительного времени (более 10 дней)."}},{"type":"paragraph","data":{"text":"Длительное (более 10 дней) или чрезмерное применение препарата может вызвать эффект «рикошета» (медикаментозный ринит) и/или атрофию слизистой оболочки носа."}},{"type":"paragraph","data":{"text":"Не следует превышать рекомендованные дозы, особенно у детей и пожилых людей."}},{"type":"paragraph","data":{"text":"Если симптомы заболевания ухудшаются или состояние больного не улучшается в течение 3-х дней применения Ксимелина Эко с ментолом, необходимо проконсультироваться с врачом."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Ксимелин Эко с ментолом не влияет на способность управлять транспортным средством или оборудованием."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Спрей назальный дозированный 140 мкг/доза."}},{"type":"paragraph","data":{"text":"По 10 мл препарата (не менее 60 доз) в пластиковом флаконе, снабженном помповым дозирующим устройством с наконечником и защитным колпачком из полиэтилена. По 1 флакону вместе с инструкцией по применению помещают в картонную пачку."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 30 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2,5 года. Не использовать по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nТакеда ГмбХ, Германия"}},{"type":"paragraph","data":{"text":"Takeda GmbH, Germany"}},{"type":"paragraph","data":{"text":"Robert-Bosch-Strasse 8, 78224 Singen, Germany\n\n"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"\n\nООО «Такеда Фармасьютикалс»,"}},{"type":"paragraph","data":{"text":"Москва, 119048, ул. 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