Повышенная чувствительность к производным нитроимидазола и вспомогательным компонентам препарата; органические поражения центральной нервной системы, в том числе эпилепсия; нарушениякроветворения с выраженной лейкопенией; тяжелая печеночная и почечная недостаточность; беременность (I триместр), лактация; детский и подростковый возраст до 12 лет.
Действующее вещество: Ниморазол (Nimorazole)Концентрация действующего вещества (мг): 500
Фармакологические свойства
Таблетки Наксоджин – противопротозойный препарат, который обладает значительной активностью в отношении Entamoeba histolytica, Lamblia intestinalis, Trichomonas vaginalis, а также штаммов Giardia intestinalis. Отмечается также активность препарата Наксоджин в отношении штаммов анаэробных бактерий (включая Gardnerella vaginalis и Bacteroides). В состав препарата входит ниморазол – вещество, относящееся ко второму поколению 5-нитроимидазолов. Механизм действия ниморазола аналогичен таковому всех препаратов, производных 5-нитроимидазола. Ниморазол накапливается к клетках простейших и специфические внутриклеточные ферменты простейших восстанавливают нитрогруппу. После активации препарат нарушает репликацию ДНК и, как следствие, синтез белка внутри микробных клеток, а также угнетает процессы тканевого дыхания. Минимальная концентрация ниморазола, вызывающая гибель трихомонад, равна 0,3-3 мкг/мл.
Повышенная чувствительность к производным нитроимидазола и вспомогательным компонентам препарата; органические поражения центральной нервной системы, в том числе эпилепсия; нарушениякроветворения с выраженной лейкопенией; тяжелая печеночная и почечная недостаточность; беременность (I триместр), лактация; детский и подростковый возраст до 12 лет.
Применение при беременности и в период грудного вскармливания
Строго запрещено применение таблеток Наксоджин во время лактации и беременности (ниморазол может оказывать мутагенное действие).
Способ применения и дозы
Внутрь, после еды.
Побочное действие
Редко: сонливость, головокружение, извращение вкуса, лейкопения, сухость во рту, обложенный язык, глоссит, стоматит, диспепсия, тошнота, рвота, диарея, кожная сыпь, зуд, боль в мочеиспускательном канале, хроматурия, нарушение функции печени, парестезии, обострение психических заболеваний.
Передозировка
Передозировка ниморазола сопровождается развитием головокружения, тошноты и других проявлений со стороны пищеварительной системы. Кроме того, при передозировке возможно появление неврологической симптоматики (парестезий, онемения конечностей и судорог). Если была принята завышенная доза ниморазола, рекомендуется промыть желудок. При необходимости возможно назначение лечения для уменьшения выраженности симптомов отравления.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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