Дисциркуляторная энцефалопатия, синдром вегетативной дистонии, тревожные состояния при невротических и неврозоподобных состояниях, абстинентный синдром при алкоголизме с преобладанием неврозоподобных и вегетативно-сосудистых расстройств, ишемическая болезнь сердца (профилактика приступов), состояния после острой интоксикации антипсихотическими средствами, ...
Мекси 6 - антиоксидантный препарат, регулирующий метаболические процессы в миокарде и сосудистой стенке. Механизм действия обусловлен антиоксидантным и мембранопротекторным свойствами. Подавляет перекисное окисление липидов, повышает активность супероксидазы, оказывает влияние на физико-химические свойства мембраны.
Фармакологические свойства
Сукцинат этилметилгидроксипиридина - мембранопротектор, обладающий также антигипоксическим, стресспротекторным, ноотропным, противоэпилептическим и анксиолитическим действием. Повышает содержание полярных фракций липидов (фосфотидилсерина и фосфотидилинозита и др.) в мембране, уменьшает отношение холестерол/фосфолипиды, уменьшает вязкость липидного слоя и увеличивает текучесть мембраны, активирует энергосинтезирующие функции митохондрий и улучшает энергетический обмен в клетке и, таким образом, защищает аппарат клеток и структуру их мембран. Вызываемое препаратом изменение функциональной активности биологической мембраны приводит к конформационным изменениям белковых макромолекул синаптических мембран, вследствие чего он оказывает модулирующее влияние на активность мембраносвязанных ферментов, ионных каналов и рецепторных комплексов, в частности, бензодиазепиновый, ГАМК, ацетилхолиновый, усиливая их способности к связыванию с лигандами, повышая активность нейромедиаторов и активацию синаптических процессов. Усиливает компенсаторную активацию аэробного гликолиза и снижает степень угнетения окислительных процессов в цикле Кребса в условиях гипоксии с увеличением аденозинтрифосфорной кислоты (АТФ) и креатинфосфата, активирует энергосинтезирующую функцию митохондрий.
Показания к применению
Дисциркуляторная энцефалопатия, синдром вегетативной дистонии, тревожные состояния при невротических и неврозоподобных состояниях, абстинентный синдром при алкоголизме с преобладанием неврозоподобных и вегетативно-сосудистых расстройств, ишемическая болезнь сердца (профилактика приступов), состояния после острой интоксикации антипсихотическими средствами, астенические состояния, а также для профилактики развития соматических заболеваний под воздействием экстремальных факторов и нагрузок, воздействие экстремальных (стрессорных) факторов.
Противопоказания
Гиперчувствительность, острая печеночная и/или почечная недостаточность, беременность, лактация, детский возраст.
Применение при беременности и в период грудного вскармливания
Противопоказано
Способ применения и дозы
Внутрь, по 1 таблетке 3 раза в сутки, начальная доза по 1-2 таблетке 1-2 раза в сутки с постепенным повышением до получения терапевтического эффекта. Максимальная суточная доза 6 таб/сутки. Длительность лечения - 2-8 недель. При необходимости возможно проведение повторных курсов.
Побочное действие
Тошнота, сухость во рту, диарея, сонливость, аллергические реакции, гиперсекреция хлористоводородной кислоты (НСl), онемение, появление чувства сдавления в конечностях, снижение лактации (иногда это используют как лечебный эффект).
Передозировка
В связи с низкой токсичностью передозировка маловероятна. При случайной передозировке возможно возникновение сонливости и седации. Лечение, как правило, не требуется - симптомы исчезают самостоятельно в течение суток. В тяжелых случаях при бессоннице - нитразепам 10 мг, оксазепам 10 мг или диазепам 5 мг.
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